• Korean Journal of Pharmacognosy
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• v.40 no.3
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• pp.184-189
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• 2009

A simple and reliable reverse phase HPLC method of Coptidis Rhizoma and Salviae Miltiorrhizae Radix were developed to determine pharmacologically active marker compounds. The water-extract of two natural medicines were evaluated by the HPLC methods. The stability test for two extract were examined for five months. However, no significant change in the content of the marker compounds of each extract observed during the time of investigation.

• Journal of Korean Tunnelling and Underground Space Association
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• v.13 no.1
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• pp.51-69
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• 2011

This paper presents the effect of tunneling on bridge pile foundation being operated using three-dimensional numerical modeling. Also the parametric study on the depth of tunnel of which the diameter was 10 m was carried out in order to evaluate the behaviors of pile foundation due to the tunnel excavation. This paper expresses the changes of vertical and horizontal displacement, movement of soil and stress of the pile. Based on the results obtained from the numerical analysis some insights into the changes of pile foundation behaviors due to variations of tunneling location were mentioned and discussed.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.21 no.6
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• pp.499-505
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• 2011

This paper presents optimal design of controllable magnetorheological suspension unit for a tracked vehicle. As a first step, a double-rod type MR suspension unit is designed on the basis of the Bingham model of commercially available MR fluid, and its damping characteristics are evaluated with respect to the intensity of the magnetic field. Subsequently, the governing equation of motion of the MR suspension system featuring the MR valve is established. Then, the optimization problem to find optimal geometric dimensions of the MR supension unit is formulated by considering an objective function which is related to damping torque and control energy. The first order optimization method intergrated with a commercial finite element method(FEM) software is adopted to obtain optimal solution of the system. The performance characteristics of the optimized MR susepnsion unit is then evaluated and compared with initial one.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.9 s.186
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• pp.61-67
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• 2006

Sandwich structures, which are composed of a thick core between two faces, are commonly used in many engineering applications because they combine high stiffness and strength with low weight. Accordingly, the usage of sandwich structure is very widely applied to the aircraft, the automobile and marine industry, etc., because of these advantages. In this paper, we have investigated the buckling protection of an inner structure plate and the useful corrugated configuration for contact, and the fabrication method of the inner structure plate for large area using the continuous molding process. Also, we have guaranteed the accuracy of the molding process through the micro corrugated mold fabrication and secured the accuracy and analyzed aspect properties of the inner structure plate fabricated for a large area using the partial mold process. We have compared molding simulation according to the aspect thickness of the corrugated configuration with the molding experiment results.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.20 no.12
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• pp.1161-1167
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• 2010

This paper presents experimental performance evaluation of a magnetorheological(MR) damper for integrated isolation mount for ultra-precision manufacturing system. The vibration sources of the ultra-precision manufacturing system can be classified as follows: the one is the environmental vibration from the floor and the other is the transient vibration occurred from stage moving. The transient vibration occurred from the stage moving has serious adverse effect to the process because the vibration scale is quite larger than other vibrations. Therefore in this research, a semi-active MR damper, which can control the transient vibration, is adopted. Also the stage needs to be isolated from tiny vibrations from the floor. For this purpose, a dry-frictionless MR damper is required. In order to achieve this goal, a novel type of MR damper is originally designed and manufactured in this work. Subsequently, the damping force characteristics of MR damper are evaluated by simulation and experiment. In addition, the vibration control performance of the MR damper associated with the stage mass is evaluated.

• Journal of Oriental Neuropsychiatry
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• v.17 no.3
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• pp.175-181
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• 2006

The purpose of this study is to investigate the clinical application of oriental medical therapy for Insomnia due to Qi and Blood deficiency and insufficiency of Heart. In this case, we treated the patient with insomnia by oriental medical therapy, specially Insamyaogyung-tang(人蔘養榮湯) and Gong-jin-dan(拱辰丹), And we checked patient's sleeping time. In result, at the first time, the patient slept only one hour. After oriental medical therapy, the patient slept over 6 hours, Conclusionally oriental medical therapy, specially Insamyaogyung-tang(人蔘養榮湯) and Gong-jin-dan(拱辰丹) is very helpful for the patient of insomnia due to Qi and Blood deficiency, and insufficiency of Heart.

• Journal of Plant Biotechnology
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• v.33 no.4
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• pp.233-236
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• 2006

Human serum albumin (HSA) is the most abundant protein in plasma and is the most often used intravenous protein in many human therapies. However, HSA is currently extracted only from plasma because commercially feasible recombinant expression systems are not available. This study attempted to develop an efficient system for recombinant HSA production by chloroplast transformation of tobacco. A HSA cDNA was isolated from a cDNA library constructed with human liver tissue. Chloroplast transformation vectors were constructed by introducing various regulatory elements to HSA regulatory sequences. Vectors were delivered by particle bombardment into leaf explants and chloroplast-transformed plants were subsequently regenerated into whole plants. Southern blot analysis confirmed that the HSA cDNA was incorporated between rps12 and orf70B of the chloroplast genome as designed. Western blot analysis revealed that hyper-expression and increasing the stability of HSA were achieved by modification of the regulatory sequences using the psbA5'UTRs in combination with elements of the 14 N-terminal amino acids of the GFP and the FLAG tag. However, only plants transformed with the vector containing all of these elements were able to accumulate HSA.

• Pediatric Infection and Vaccine
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• v.5 no.1
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• pp.136-138
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• 1998

Shigella spp. cause classic bacillary dysentery that rarely result in extraintestinal complications. Urinary tract infections(UTIs) due to Shigella spp. are rare, and Shigella sonnei UTIs are extremely rare. We report a case of symptomatic UTI due to S. sonnei. A 9-year-old female presented with a history of fever, abdominal pain, loose form diarrhea, vomiting, and dysuria for 1 day. S. sonnei was identified from urine culture and stool culture result was no Salmonella and Shigella isolated. She was treated with gentamicin and cefuroxime intravenously for 5 days, which suscessfully controlled clinical features of infections.

• Journal of Applied Biological Chemistry
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• v.63 no.2
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• pp.117-123
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• 2020

We examined the anti-inflammatory effect of the peel extract of the newly bred Korean apple (Malus domestica Borkh.) cultivar Green ball. To test its possible use as anti-inflammatory functional material, Raw 264.7 macrophages were treated with pro-inflammatory lipopolysaccharide (LPS) in the presence or absence of Green ball apple peel ethanol extract (GBE). Notably, up to 500 ㎍/mL of GBE did not result in any signs of inhibition on cellular metabolic activity or cytotoxicity in Raw 264.7 macrophages. Supplementation with GBE to LPS-treated Raw 264.7 macrophage significantly suppressed various pro-inflammatory responses in a dose-dependent manner, including i) nitric oxide (NO) production, ii) accumulation of inducible NO synthase and cyclooxygenase-2, iii) phosphorylation of nuclear factor-kappa B (NF-κB) subunit p65, and iv) expression of pro-inflammatory biomarker genes, including tumor necrosis factor alpha, interleukin 1 beta, interleukin 6, monocyte chemoattractant protein-1, and prostaglandin E synthase 2.

• Design & Manufacturing
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• v.2 no.4
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• pp.48-53
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• 2008

We injection molded a thin type of plate and wedge type of plate with micro prizm patterns on its surface and investigated the fidelity of replication of the micro pattern depending on the process parameter such as mold temperature, melt temperature, injection rate or packing pressure. The size of the $90^{\circ}$ prizm pattern is $50{\mu}m$ and the size of the plate is about $335mm{\times}213mm$ and $400mm{\times}400mm$. The thicknesses are 2.6mm and 0.7mm at each edge of the wedge type of plate and 1mm at each edge of the thin type of plate. The fidelity of the replication turned out quite different according to the process parameters and location of the patterns on the plate. We measured the cavity pressure and temperature in real-time during the molding to analyze the effect of the local melt pressure and temperature on the micro pattern replication.