• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.9
• /
• pp.4247-4250
• /
• 2016

Background: Pax8 and peroxisome proliferator-activated receptor gamma 1 gene (Pax8-$PPAR{\gamma}1$) are important factors in tumors. Several studies have suggested that follicular thyroid cancer may arise from Pax8- $PPAR{\gamma}1$ rearrangement. In order to have a better understanding of the association between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer, we conducted the presenmt meta-analysis. Materials and Methods: The information was extracted from PubMed, EMBASE and Web of Science. Statistic analysis was performed with Stata12.0 software. Odds ratios (ORs) were calculated using a fixed-effects model. We also performed heterogeneity and publication bias analyses. Results: Nine studies including 198 follicular thyroid cancer patients and 268 controls were considered eligible. The frequency of Pax8-$PPAR{\gamma}1$ rearrangement was significantly higher in the follicular thyroid cancer group than in the control group, with a pooled OR of 6.63 (95%CI=3.50-12.7). In addition, through subgroup analysis, the OR between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer was 6.04 (95%CI = 3.18-11.5) when using benign tumor tissues as controls. The OR for the method subgroup was 9.99 (95% CI =4.86-20.5) in the RT-PCR. Conclusions: The final results demonstrated that Pax8-$PPAR{\gamma}1$ rearrangement has significant association with follicular thyroid cancer.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.17 no.3
• /
• pp.9-21
• /
• 2017

The purpose of this study is to identify the current situation and actual condition of the video security industry, The research method was based on interviews with twelve specialists, and examined the market trends, the problems of the video security industry, the improvement plan and the government promotion strategy. The problem with the domestic video security industry is that there are the decline in overseas exports and the slowdown in exports to China, insufficient measures to overcome certification barriers due to the strengthening of national certification system, domestic demand growth slowed, expansion of domestic market share of Chinese products, lack of high-tech development of domestic products, lack of expertise in technology development and operation and inadequate legislation for revitalizing the video security industry. The improvement plan is as follows. Need to implement export expansion support policy, need to build tailored response system for each country, need improvement of security related demand creation system, take measures such as domestic industrial protection policy, certification barriers and tariff barriers, induce future core technology to create high added value. The government also needs to actively support human resources development, and induce stabilization of relevant laws and institutions. This study will contribute to the development of related industries by suggesting the development direction of the video security industry.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.13
• /
• pp.5487-5492
• /
• 2014

Ultrasonography is non-invasive and can give useful clues in the diagnosis of cervical lymphadenopathy, However, differential diagnosis is difficult in some situations even combined with color Doppler imaging. The present study was conducted to evaluate the clinical value of real time elastography in patients with unexplained cervical lymphadenopathy using a quantitative method. From May 2011 to February 2012, 39 enlarged lymph nodes from 39 patients with unexplained cervical lymphadenopathy were assessed. All the patients were examined by both B-mode ultrasound, color Doppler flow imaging and elastography. The method of analyzing elasto-graphic data was the calculation of the 10 parametres ("mean", "sd", "area%", "com", "kur", "ske", "con", "ent", "idm", "asm") offered by the software integrated into the Hitachi system. The findings were then correlated with the definitive tissue diagnosis obtained by lymph node dissection or biopsy. Final histology revealed 10 cases of metastatic lymph nodes, 11 cases of lymphoma, 12 cases of tuberculosis and 6 cases of nonspecific lymphadenitis. The significant distinguishing features for conventional ultrasound were the maximum short diameter (p=0.007) and absent of echogenic hilum (p=0.0293). The diagnostic accuracy was 43.6% (17/39 cases) and there were 17 patients with equivocal diagnosis. For elastography, "mean" (p=0.003), "area%" (p=0.009), "kurt" (p=0.0291), "skew" (p=0.014) and "cont" (p=0.012) demonstrated significant differences between groups. With 9 of the 17 patients with previous equivocal diagnoses (52.9%) definite and correct diagnoses could be obtained. The diagnostic accuracy for conventional ultrasound combined elastography was 69.2% (27/39 cases). There were differences in the diagnostic sensitivity of the two methods (p=0.0224). Ultrasound combined with elastography demonstrated higher rates of conclusive and accurate diagnoses in patients with unexplained cervical lymphadenopathy than conventional ultrasound. The quantitative program showed good correlation with the pathology of different lymph node diseases.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.9
• /
• pp.5219-5223
• /
• 2013

The number of axillary lymph nodes involved and retrieved are important prognostic factors in breast cancer. The purpose of our study was to investigate whether the lymph node ratio (LNR) is a better prognostic factor in predicting disease-free survival (DFS) for breast cancer patients as compared with pN staging. The analysis was based on 804 breast cancer patients who had underwent axillary lymph node dissection between 1999 and 2008 in Sun Yat-Sen University Cancer Center. Optimal cutoff points of LNR were calculated using X-tile software and validated by bootstrapping. Patients were then divided into three groups (low-, intermediate-, and high-risk) according to the cutoff points. Predicting risk factors for relapse were performed according to Cox proportional hazards analysis. DFS was estimated using the Kaplan-Meier method and compared by the log-rank test. The 5-year DFS rate decreased significantly with increasing LNRs and pN. Univariate analysis found that the pT, pN, LNR, molecule type, HER2, pTNM stage and radiotherapy well classified patients with significantly different prognosis. By multivariate analysis, only LNR classification was retained as an independent prognostic factor. Furthermore, there was a significant prognostic difference among different LNR categories for pN2 category, but no apparent prognostic difference was seen between different pN categories in any LNR category. Therefore, LNR rather than pN staging is preferable in predicting DFS in node positive breast cancer patients, and routine clinical decision-making should take the LNR into consideration.

• KIPS Transactions on Software and Data Engineering
• /
• v.5 no.11
• /
• pp.555-562
• /
• 2016

Semantic Role Labeling (SRL) is to determine the semantic relation of a predicate and its argu-ments in a sentence. But Korean semantic role labeling has faced on difficulty due to its different language structure compared to English, which makes it very hard to use appropriate approaches developed so far. That means that methods proposed so far could not show a satisfied perfor-mance, compared to English and Chinese. To complement these problems, we focus on suffix information analysis, such as josa (case suffix) and eomi (verbal ending) analysis. Korean lan-guage is one of the agglutinative languages, such as Japanese, which have well defined suffix structure in their words. The agglutinative languages could have free word order due to its de-veloped suffix structure. Also arguments with a single morpheme are then labeled with statistics. In addition, machine learning algorithms such as Support Vector Machine (SVM) and Condi-tional Random Fields (CRF) are used to model SRL problem on arguments that are not labeled at the suffix analysis phase. The proposed method is intended to reduce the range of argument instances to which machine learning approaches should be applied, resulting in uncertain and inaccurate role labeling. In experiments, we use 15,224 arguments and we are able to obtain approximately 83.24% f1-score, increased about 4.85% points compared to the state-of-the-art Korean SRL research.

• The Journal of Advanced Prosthodontics
• /
• v.14 no.1
• /
• pp.1-11
• /
• 2022

PURPOSE. The maximum width between the mesial and distal labial transitional line angles, described as "esthetic width" herein, could significantly influence the visual perception of the teeth and smile. This study aimed to conduct biometric research on esthetic width and to explore whether regular distribution exists in the esthetic width of human teeth. MATERIALS AND METHODS. A total of 4,264 maxillary and mandibular anterior teeth were measured using the Geomagic studio software program. The proportions of maxillary to mandibular homonymous teeth and proportions between the adjacent teeth were calculated. Bilateral symmetry and the correlation between the esthetic and mesiodistal widths were both accounted for during the measurement procedures. RESULTS. The mean esthetic widths were 6.773 ± 0.518 mm and 4.329 ± 0.331 mm for maxillary and mandibular central incisors, respectively, 5.451 ± 0.487 mm and 5.008 ± 0.351 mm for maxillary and mandibular lateral incisors, respectively, and 3.340 ± 0.353 mm and 5.958 ± 0.415 mm for maxillary and mandibular canines, respectively. Except for the mandibular canines, no significant difference in esthetic width was found among homonymous teeth from the same jaw. A high linear correlation was found between the esthetic and mesiodistal widths of the same tooth, except for the maxillary canines. Esthetic width proportions among different tooth categories showed some regular patterns, which were similar to those of the mesiodistal width. CONCLUSION. Esthetic width is regularly distributed among the teeth in the Chinese population. This could provide an important reference for anterior dental restorations and dimension recovery in esthetic reconstruction of anterior teeth.

• KIPS Transactions on Software and Data Engineering
• /
• v.11 no.12
• /
• pp.499-508
• /
• 2022

A lot of research has been carried out on the Hangeul generation model using deep learning, and recently, research is being carried out how to minimize the number of characters input to generate one set of Hangul (Few-Shot Learning). In this paper, we propose a CKFont2 model using only 14 letters by analyzing and improving the CKFont (hereafter CKFont1) model using 28 letters. The CKFont2 model improves the performance of the CKFont1 model as a model that generates all Hangul using only 14 characters including 24 components (14 consonants and 10 vowels), where the CKFont1 model generates all Hangul by extracting 51 Hangul components from 28 characters. It uses the minimum number of characters for currently known models. From the basic consonants/vowels of Hangul, 27 components such as 5 double consonants, 11/11 compound consonants/vowels respectively are learned by deep learning and generated, and the generated 27 components are combined with 24 basic consonants/vowels. All Hangul characters are automatically generated from the combined 51 components. The superiority of the performance was verified by comparative analysis with results of the zi2zi, CKFont1, and MX-Font model. It is an efficient and effective model that has a simple structure and saves time and resources, and can be extended to Chinese, Thai, and Japanese.

• Journal of Venture Innovation
• /
• v.6 no.3
• /
• pp.73-93
• /
• 2023

This study provides a prospect for the fast growing the smartwatch market by investigating the relationship between the satisfaction and the continuous use intention of Apple watch users, as well as the factors influencing their satisfaction. Based on the TAM, this study uses system quality, information quality, and self-efficacy as independent variables, perceived usefulness, perceived ease of use, and satisfaction as mediators, and continuous use intention as the dependent variable. We analyze the data of 256 individuals who completed an online survey with SPSS 26.0 and AMOS 26.0 software. This study conducts several tests and analyses to empirically evaluate the data including reliability analysis, factor analysis, feasibility analysis, path analysis, hypothesis verification, and mediation analysis. Our results investigate which factors may influence consumers' intention to continuously using Apple Watch devices in the future. In summary, satisfaction has a positive effect on the intention to continuously use smartwatchs. Perceived usefulness and perceived ease of use have a positive effect on satisfaction. Among the three factors (system quality, information quality, and self-efficacy), only self-efficacy has no significant impact on perceived usefulness but had a positive effect on perceived ease of use. In addition, system quality and information quality positively affect perceived usefulness, perceived ease of use, satisfaction, and continuous intention to use an Apple Watch. Taking the Apple Watch as the subject of our research topic, this study provides theoretical value by exploring the impact of user's satisfaction with their smartwatch on their continuous usage intention. This study further explains the influence of system quality, information quality, and self-efficacy on user satisfaction. Additionally, this research offers valuable insight to practitioners by confirming that information quality, system quality, and self-efficacy are important features for enhancing satisfactory user experiences which in turn may increase users' intention to continued using smartwatches.

• Information Systems Review
• /
• v.19 no.3
• /
• pp.1-21
• /
• 2017

The Internet of Things (IoT) analysis aims to verify the technical characteristics, performance expectations, and adoption intentions of IoT. This work refers to IoT data from foreign and domestic publications and websites as well as aims to benefit related organizations by referring to reports from agencies. The literature review summarizes the relevant theories and background of the unified theory of acceptance and use of technology. The SPSS 22.0 software and structural equation models (smart PLS 2.0) are used in the data analysis. Technical statistics analysis, reliability analysis, validity analysis, structural equation models, and statistical methods are employed to test the research hypotheses, that is, the technical characteristics of IoT will have positive effects on its performance expectations. This study introduces the characteristics and expected performance of IoT to present relevant IoT guidelines for companies that aim to adopt such technology.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.12
• /
• pp.4773-4780
• /
• 2014

Background: To investigate the effects of small interference RNA (siRNA) targeting BCR/ABL mRNA on proliferation and apoptosis in the K562 human chronic myeloid leukemia (CML) cell line and to provide a theoretical rationale and experimental evidence for its potential clinical application for anti-CML treatment. Materials and Methods: The gene sequence for BCR/ABL mRNA was found from the GeneBank. The target gene site on the BCR/ABL mRNA were selected according to Max-Planck-Institute (MPI) and rational siRNA design rules, the secondary structure of the candidate targeted mRNA was predicted, the relevant thermodynamic parameters were analyzed, and the targeted gene sequences were compared with BLAST to eliminate any sequences with significant homology. Inhibition of proliferation was evaluated by MTT assay and colony-formation inhibiting test. Apoptosis was determined by flow cytometry (FCM) and the morphology of apoptotic cells was identified by Giemsa-Wright staining. Western blotting was used to analyze the expression of BCR/ABL fusion protein in K562 cells after siRNA treatment. Results: The mRNA local secondary structure calculated by RNA structure software, and the optimal design of specific siRNA were contributed by bioinformatics rules. Five sequences of BCR/ABL siRNAs were designed and synthesized in vitro. Three sequences, siRNA1384, siRNA1276 and siRNA1786, which showed the most effective inhibition of K562 cell growth, were identified among the five candidate siRNAs, with a cell proliferative inhibitory rate nearly 50% after exposure to 12.5nmol/L~50nmol/L siRNA1384 for 24,48 and 72 hours. The 50% inhibitory concentrations ($IC_{50}$) of siRNA1384, siRNA1276 and siRNA1786 for 24hours were 46.6 nmol/L, 59.3 nmol/L and 62.6 nmol/L, respectively, and 65.668 nmol/L, 76.6 nmol/L, 74.4 nmol/L for 72 hours. The colony-formation inhibiting test also indicated that, compared with control, cell growth of siRNA treated group was inhibited. FCM results showed that the rate of cell apoptosis increased 24 hours after transfecting siRNA. The results of annexinV/PI staining indicated that the rate of apoptosis imcreased (1.53%, 15.3%, 64.5%, 57.5% and 21.5%) following treamtne with siRNAs (siRNA34, siRNA372, siRNA1384, siRNA1276 and siRNA1786). Morphological analysis showed td typical morphologic changes of apoptosis such as shrunken, fragmentation nucleus as well as "apoptotic bodies" after K562 cell exposure to siRNA. Western blot analysis showed that BCR/ABL protein was reduced sharply after a single dose of 50nmol/L siRNA transfection. Conclusions: Proliferation of K562 cells was remarkbly inhibited by siRNAs (siRNA1384, siRNA1276 and siRNA1786) in a concentration-dependent manner in vitro, with effective induction of apoptosis at a concentration of 50 nmol/L. One anti-leukemia mechanism in K562 cells appeared that BCR/ABL targeted protein was highly down-regulated. The siRNAs (siRNA1384, siRNA1276 and siRNA1786) may prove valuable in the treatment of CML.