• 대한통합의학회지
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• 제10권3호
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• pp.95-105
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• 2022

Purpose : This study aims to systematically review the methods of occupational therapy intervention in children with autism spectrum disorders having sleep disorders and evaluate the improvements with intervention effects, based on experimental studies of children with sleep disorders. Methods : Studies published overseas from January 2011 to June 2021 were searched from a total of two databases. Science Direct and OTseeker. The five selected studies were analyzed by dividing them into age, number, intervention period, intervention type, intervention effect, evaluation tool, research design type, and evidence level. Results : The total number of subjects was 182, 95 subjects in ther experimental group, and 87 in the control group. The interventions included weighted blankets, swimming, and sleep education for parents. Ther interventions were found to increase total sleep time, improve mood when waking up, reduce sleep anxiety, reduce sleep time, reduce the number of waking up of during sleep, and reduce sleep resistance behavior. Conclusion : Many people have sleep disorders, with or without disabilities, and the number is gradually increasing. Consequently, research on occupational therapy intervention in children with autism spectrum disorder are actively conducted in foreign countries, and these interventions have a positive effect. Based on the results of this study, it can be concluded that such occupational therapy intervention studies are necessary for children with autism spectrum disorder with sleep disorders in Korea. In addition, further research on the quality of life of parents of children with autism spectrum disorders due to sleep disorders and their methods are required.

• 한국콘텐츠학회논문지
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• 제11권8호
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• pp.221-230
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• 2011

이 연구는 요인분석을 통해 아동 청소년 행동평가척도(Korean-Child Behavior Checklist: K-CBCL)가 자폐 범주성 장애 아동의 정서와 행동적 문제를 평가하는 도구로 타당한지를 알아보기 위해 실시되었다. 이를 위해 자폐 범주성 장애 아동 248명을 대상으로 K-CBCL을 측정하고 요인분석을 실시하였다. 확인하고자 하는 요인 모델은 2요인 모델로 위축, 신체증상, 불안/우울의 내재화 문제와 비행과 공격성의 외현화 문제였다. 확인적 요인분석 결과, K-CBCL의 2요인 모델의 적합도 지수는 표준화적합지수 .964, 비교 적합지수 .975, 근사오차평균자승이중근은 .091로 나타나 모델의 부합도 기준을 만족하는 것으로 나타났다. 확인적 요인분석을 통해 2요인 모델의 적합성을 확인한 후, 하위 요인들의 문항내적합치도를 알아보았다. 위축, 사회적 미성숙, 비행의 하위 요인의 문항내적합치도는 낮게 나타났으나, 내재화 문제, 외현화 문제, 총 문제행동 척도는 문항내적합치도가 적합한 수준으로 나타났다. K-CBCL은 자폐 범주성 장애 아동의 정서와 행동적 문제를 평가한 도구로 타당한 도구임을 논의하였다.

• Clinical and Experimental Pediatrics
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• 제62권11호
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• pp.405-409
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• 2019

A structured review study of drug interventions on sleep disorders in patients with autism spectrum disorders (ASD) has not been published to date. This systematic review aimed to investigate drug interventions for the treatment of sleep disorders in children with ASD. The Web of Science, PubMed, and Scopus databases were searched until March 2019. Study quality was assessed using the Delphi checklist. Due to the heterogeneity of the findings, a meta-analysis was not possible. Drug interventions for the treatment of sleep disorders in patients with ASD included melatonin, atomoxetine, and risperidone. Atomoxetine had no effect on sleep disorders in patients with ASD. A total of 10 studies were reviewed. Melatonin appears to be useful for the treatment of sleep problems in patients with ASD, but further studies are needed to determine the effects of other drugs.

• Clinical and Experimental Pediatrics
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• 제63권1호
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• pp.8-13
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• 2020

Autism spectrum disorder is a common neurodevelopmental disorder with an unknown etiology. The correlation between neonatal jaundice and the risk of developing autism spectrum disorder was investigated previously. Some studies showed significant associations, whereas others demonstrated no association. In this meta-analysis, we pooled the results of observational studies to examine the association between neonatal jaundice and the risk of autism spectrum disorder among children. We identified all studies published through April 2018 by conducting a literature search using Web of Science, PubMed, and Scopus databases as well as the reference lists of the retrieved studies. The pooled odds ratios (ORs), rate ratio (RR), and their 95% confidence intervals (CIs) were calculated as random effect estimates of association among studies. We conducted a subgroup analysis to explore any potential sources of intergroup heterogeneity. The pooled estimates of OR and RR showed a considerable correlation between neonatal jaundice and ASD among children (OR, 1.35; 95% CI, 1.02-1.68) and (RR, 1.39; 95% CI, 1.05-1.74). A larger effect size was shown in the pooled estimated crude OR than in the adjusted OR (1.75 [0.96-2.54] vs. 1.19 [1.07-1.30]). This study showed that neonatal jaundice may be associated with ASD and may increase the risk of ASD among children.

• Clinical and Experimental Pediatrics
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• 제62권4호
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• pp.126-130
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• 2019

Purpose: In this meta-analysis, relevant case-control and cohort studies were pooled to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children. Methods: A search for relevant studies in major databases, including Web of Science, PubMed, and Scopus, was performed up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs) were extracted from eligible studies to determine the association among studies. Results: The pooled estimates of ORs and RRs indicated a significant association between preeclampsia and ASD [(OR, 1.36; 95% CI, 1.12-1.60) and (RR, 1.30; 95% CI, 1.20-1.41)]. Conclusions: Despite existing controversy, our findings indicated that preeclampsia was associated with an increased risk of ASD among children.

• Clinical and Experimental Pediatrics
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• 제63권9호
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• pp.368-372
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• 2020

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by impairments in social interaction and verbal and nonverbal communication. Purpose: Determine the association between use of assisted reproduction technology (ART) and the risk of ASD among children. Methods: This case-control study included 300 participants (100 cases, 200 controls). The control group included women with a child aged 2-10 years without ASD, while the cases were women with a child aged 2-10 years with ASD. We used a researcher-made questionnaire. Data were analyzed using Stata ver. 14 at the 0.05 significance level. Results: In the univariate analysis, there was significant association between child sex, delivery mode, history of preterm delivery, history of using ART, and maternal age at child's birth and the risk of ASD. After the adjustment for other variables, this association was significant for male sex (2.66; 95% confidence interval [CI], 1.11-4.31; P=0.001) and history of using ART (4.03; 95% CI, 1.76-9.21; P=0.001). Therefore, after the adjustment for confounder variables, there was no significant association between ART and the risk of ASD among children (4.98; 95% CI, 0.91-27.30; P=0.065). Conclusion: After the adjustment for other variables, risk factors for ASD were male sex and history preterm delivery. Thus, there was no significant association between ART and the risk of ASD among children.

• ETRI Journal
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• 제44권4호
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• pp.613-623
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• 2022

Autism spectrum disorder (ASD) is a developmental disorder associated with cognitive and neurobehavioral disorders. It affects the person's behavior and performance. Autism affects verbal and non-verbal communication in social interactions. Early screening and diagnosis of ASD are essential and helpful for early educational planning and treatment, the provision of family support, and for providing appropriate medical support for the child on time. Thus, developing automated methods for diagnosing ASD is becoming an essential need. Herein, we investigate using various machine learning methods to build predictive models for diagnosing ASD in children using facial images. To achieve this, we used an autistic children dataset containing 2936 facial images of children with autism and typical children. In application, we used classical machine learning methods, such as support vector machine and random forest. In addition to using deep-learning methods, we used a state-of-the-art method, that is, automated machine learning (AutoML). We compared the results obtained from the existing techniques. Consequently, we obtained that AutoML achieved the highest performance of approximately 96% accuracy via the Hyperpot and tree-based pipeline optimization tool optimization. Furthermore, AutoML methods enabled us to easily find the best parameter settings without any human efforts for feature engineering.

• 재활치료과학
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• 제10권4호
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• pp.7-24
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• 2021

목적 : 본 연구는 자폐스펙트럼장애 아동의 문제행동 개선을 위한 긍정적 행동지원 중재 연구 중 단일대상연구 설계를 적용한 문헌의 특성을 살펴보고 질적 수준을 알아보는 것이다. 연구방법 : 본 연구는 문헌연구로써, 분석 대상은 2011년부터 2020년까지 국내에서 게재된 9편의 단일대상연구 논문이었고, 대상 논문을 연구방법의 내용에 따라 일반적 특성과 질적 수준으로 나누어 분석하였다. 결과 : 대상 논문을 분석한 결과, 연구 대상은 취학 전 아동과 초등학령기 아동이 동일한 비율로 나타났고, 연구 설계는 중다 기초선 설계 중 행동 간 중다기초선 설계 연구가 가장 많았다. 모든 논문에서 사회적 타당도, 중재 충실도, 관찰자 신뢰도를 제시하고 있었고, 문제행동은 자해 및 공격행동, 방해행동, 자리이탈행동, 음식 거부 및 구강자극 행동 순으로 나타났으며, 종속변인은 부분 간격 기록법으로 측정한 연구가 가장 많았다. 중재 효과 확인 결과, 중재, 유지는 중재 결과가 효과적이었으나, 일반화의 결과와 효과를 제시한 연구는 제한적이었다. 분석 논문의 질적 수준은 모든 연구에서 높은 질적 수준을 보이고 있었다. 결론 : 본 연구를 통해 자폐스펙트럼장애 아동의 문제행동을 위한 긍정적 행동지원 중재 연구 중 단일대상연구 설계를 적용한 논문의 내용과 질적 수준을 확인하고 긍정적 행동지원 중재가 자폐스펙트럼장애아동의 근거기반 중재를 위한 효과적인 중재임을 확인할 수 있었다.

• 정신신체의학
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• 제23권2호
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• pp.129-135
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• 2015

연구목적 지난 20년 동안 아동에 있어 과체중(overweight)의 유병률이 증가하였다. 또한 자폐스펙트럼장애(Autism spectrum disorder, ASD)를 진단 받는 아동의 숫자도 매해 증가하고 있다. ASD를 진단받은 아동의 비만(obesity)에 대한 연구가 미국에서는 활발하게 이루어지고 있으나, 한국에서는 많은 연구가 수행되지는 않았다. 따라서 이 연구의 목적은 ASD를 지닌 아동의 과체중 및 비만의 유병률 및 실태를 알아보고자 한다. 방 법 2012년부터 2015년까지의 3세에서 18세 사이의 소아 청소년을 대상으로 대전 건양대학교병원 정신건강의학과 외래에 내원한 소아 청소년 환자의 의무기록을 조사하였다. 각각의 의무기록으로부터 진단적, 의학적, 인구학적 정보를 추출하였다. 신체질량지수인 Body mass index(BMI)는 병원에서 시행하여 의무기록에 기입되어 있는 키와 체중으로 토대로 계산 하였다. 나이와 성별을 보정한 BMI z-score을 사용하였다. 결 과 ASD를 지닌 아동 군에서 ASD를 지니지 않은 군보다 더 높은 BMI 값을 가지고 있으며, 이는 통계적으로 유의하였다(p=0.032). 또한 ASD를 지닌 아동들이 ASD를 지니지 않은 아동에 비해 비교적 더욱 과체중 및 비만인 것으로 나타났다. 유병률에 있어서는 ASD가 있는 아동(35%)이 ASD가 없는 아동(19%)에 비해 과체중 및 비만인 것으로 간주되었다. 결 론 ASD를 지닌 아동과 지니지 않은 대상에 대한 과체중 및 비만에 관한 연구로서, ASD를 지닌 아동이 그렇지 않은 군에 비해 더욱 과체중 및 비만을 지니고 있음을 보여주었다. 향후 ASD 비만에 대한 유발 및 보호인자에 대한 장기적이고 심화된 연구가 필요하겠다.

• 대한장애인치과학회지
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• 제6권1호
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• pp.1-9
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• 2010