• Pediatric Infection and Vaccine
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• v.16 no.2
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• pp.175-182
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• 2009

Purpose : A number of countries have experienced an increase in pertussis during the past decade. In particular, there has been an increase in the incidence rate among adolescents and adults. To learn more about the current epidemiology of pertussis, we studied the prevalence and clinical characteristics of pertussis in children in Cheonan, South Korea. Methods : We collected nasopharyngeal aspirates of 118 patients who were treated for respiratory symptoms at Dankook Univeristy Hospital between March 2008 and September 2009. We performed multiplex PCR for detection of Bordetella pertussis in those aspirates. Results : Of the 118 patients, 10 (8%) were positive by PCR for B. pertussis. Six episodes occurred during the period July to September 2009. Nine of the 10 patients were less than 3 months old. Seven of them had not received DTaP vaccine. The mean duration of coughing before diagnosis was 10.9${\pm}$5.2 days. Ten patients (100%) had paroxysmal cough and 8 (80%) had post-tussive vomiting. Only one patient had fever. One who had complications that include pneumonia, atelectasis and pneumomediastinum developed an absolute increase in leukocyte count (84,400/$mm^3$). There was a statistically significant relation between vaccine being received and development of complications (P =0.033). Conclusion : We suspect that there was an epidemic of pertussis between July and September 2009. Further investigation by a pediatric or nationwide surveillance system is needed to monitor the changing epidemiology for pertussis.

• Pediatric Infection and Vaccine
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• v.25 no.2
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• pp.72-81
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• 2018

Purpose: This prospective study aimed to investigate the therapeutic efficacy of lamivudine in children with chronic hepatitis B virus (HBV) infection. Methods: During July 2003 through October 2015, children with chronic hepatitis B who visited our institution were included in this study. Fifty-five patients, who received first-line treatment of lamivudine (3 mg/kg, 100 mg maximum) for over three months, were enrolled. After initiating lamivudine, alanine aminotransferase (ALT), HBV-DNA, and HBV markers were followed up at 1 month, 3 months, and every 3 months, thereafter. The treatment endpoint was determined as 1) normalization of ALT, 2) HBeAg seroconversion, and 3) anti-HBe positivity for twelve consecutive months. Results: Thirty-one male (56.4%) and 24 female (43.6%) patients were included. The mean age at treatment initiation was 8.1 years. The mean duration of treatment was 23.4 months. ALT normalization was found in 98.2% (54 of 55). Anti-HBe seroconversion was found in 70.6% (36/51). Loss of HBsAg was found in 10.9% (6/55). All biochemical responses occurred under age seven. The rate of virologic response (defined as HBV-DNA <2,000 IU/mL) at six months after treatment initiation was 78.7% (37/47). At twelve months after reaching treatment endpoint, 87.2% (34/39) maintained their virologic response. Resistance to lamivudine was found in 16.4% (9/55). Conclusions: Lamivudine treatment in Korean pediatric patients with chronic hepatitis B showed better outcomes compared with other studies that implemented similar protocols in foreign populations. Further studies are needed to investigate the efficacy of newly recommended antiviral drugs on the Korean pediatric population.

• Clinical and Experimental Pediatrics
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• v.48 no.10
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• pp.1082-1089
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• 2005

Purpose : Abdominal obesity is encountered as a risk factor for cardiovascular diseases. However, the anthropometric cut-off value to estimate the cardiovascular risk, has not been suggested. This study was designed to find the relationship between the abdominal fat and various parameters of obesity to find the cardiovascular risk factors related to abdominal obesity and to establish practical methods to measure them. Methods : Twenty seven obese Korean adolescents of moderate to severe degree and 22 healthy adolescents were enrolled. The body mass index(BMI), arm circumference and skinfold thickness were measured. Furthermore, blood lipid, sugar, insulin and four different cytokines' levels were checked and the distribution of body composition was measured by bioelectrical impedance analysis. The subcutaneous and intra-abdominal fat thickness by abdominal ultrasonography(US) and the total and intra-abdominal fat area by abdominal computerized tomography(CT) were measured in the obese group. Results : The most accurate method to measure abdominal fat in children is abdominal CT and the fat mass measured by bioelectrical impedance was strongly correlated with it(r=0.954). It was also correlated with arm circumference, fat thickness measured by abdominal US, BMI, aspartate aminotransferase(AST), alanine aminotransferase(ALT) and triglyceride level. Conclusion : Abdominal CT is the most accurate method to measure intra-abdominal fat, and it can be replaced by abdominal US for cost effectiveness. The screening methods that can be used at school or in outpatient basis include bioelectrical impedance, waist/hip ratio, and arm circumference. The cardiovascular risk factors include leptin, triglyceride and insulin level.

• Journal of Korean Home Economics Education Association
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• v.31 no.1
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• pp.1-19
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• 2019

The purposes of this study were to concretely reveal the effect of the parents' child-rearing attitude perceived by adolescents and the school life adaptation on the problem behavior, and to verify the moderating effect of the ego-resilience on the relationship between the parents' child-rearing attitude and the school life adaptation and the adolescent problem behavior. This study analyzed a total of 2,107 students in the first year of high school, which was the 4th year data(2013) of Korea Children Youth Panel Survey(KCYPS) 2010. The reliability, descriptive statistics, t-test, and hierarchical regression analysis were conducted using SPSS WIN 22.0. The results were as follows. First, the effect of the parents' child-rearing attitude(supervision, affection, reasonable explanation, excessive interference, excessive expectation, and inconsistency), school life adaptation(relationship with teacher, relationship with friend, school regulation, and learning activity), and ego-resilience on the adolescent problem behavior was analyzed. As a result, the relationship with friend(-) had the highest influence on the adolescent problem behavior, followed by learning activity(-), inconsistency(+), ego-resilience(-), excessive interference(+), and supervision(-). However, the remaining sub-variables did not have any significant influence on the adolescent problem behavior. Second, the moderating effect of the ego-resilience on the relationship among the parents' child-rearing attitude, adaptation to school life, and adolescent problem behavior. The ego-resilience was found to moderate the effects of parents' positive child-rearing attitude, interpersonal relationships, and school adaptation on the adolescent problem behavior. However, the moderating effect was not significant for the effect of negative child-rearing attitude on the adolescent problem behavior. Therefore, various ego-resilience enhancement programs need to be developed and researched as a part of the safety education through the home economics class.

• Clinical and Experimental Pediatrics
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• v.51 no.1
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• pp.78-83
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• 2008

Purpose : Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Although survival rate of osteosarcoma patients has markedly improved, about 20-30% of patients still have a relapse. This study was aimed to find factors that influence postrelapse survival of osteosarcoma in childhood and adolescents. Methods : Between 1985 and 2004, of 461 patients who were diagnosed and treated as osteosarcoma in Korean Cancer Center Hospital, 180 patients with recurrent osteosarcoma were retrospectively reviewed. We examined survival rates and analyzed prognostic factors, such as relapse site, post-relapse treatment methods, pathologic response to neoadjuvnat chemotherapy, metastasis at first diagnosis, and relapse free interval. Results : The overall recurrence rate of patients with osteosarcoma was 39%. The 5-year and 10-year postrelapse survival rates in the recurrent osteosarcoma were 13% and 4%, respectively. The 5-year post-relapse survival rate was influenced by site of relapse (lung, 39%; local, 0%; lung & bone, 25%; others, 12%; P<0.05), relapse-free interval (<12 months, 13%; ${\geq}12$ months, 44%, P<0.05), and post-relapse treatment methods (with surgery, 38%; without surgery, 11%; P<0.05). Conclusion : The survival rate of recurrent case is very low after 10 years, so new second-line chemotherapy and active treatment is needed to increase survival. Aggressive surgery with the removal of recurrence sites combined with multi-agent chemotherapy could either cure patients with recurrent osteosarcoma or significantly prolong their survival.

• Cartoon and Animation Studies
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• s.45
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• pp.235-258
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• 2016

As the first class Teaching Artists system is about to be brought to effect, the ability required for Teaching Artists to design educational contents, develop and manage education programs is not much different from that of a museum Educator. This system is necessary for resolving problems in existing Arts and Culture Education, such as overlapping programs and adjusting difficulty levels by age to meet the demand of educatee. It also deals with drawbacks in production-oriented curriculum originating from the preference in some subject. In addition, as progress in science and technology makes rapid changes in digital media and its subculture, increasing need for novel and interdisciplinary curriculum in the field of Arts and Culture Education puts further emphasis on the importance of this system. In this study, we focus on clarifying the significance of Educator as a professional and proposing curriculum for the system, trying to avoid restricting our discussion to current Arts Instructor Supporting Project which are merely aimed at supporting children and adolescents to grow up to enjoy culture and arts. Capacity for designing curriculum for culture and arts, the kernel of qualification for the first class Teaching Artists, requires a variety of comprehensive expertise and qualification such as doing preliminary research on contents related to animation, curating, determining potential of educational contents, organizing educational contents for appropriate educatee, understanding esthetic property and its role in education, and appreciating and enjoying cultural contents. Therefore, Teaching Artists plays roles not only in developing and running educational programs but also in supporting and cooperating with culture and arts institutions, designing and managing creative programs, combining and communicating with different social groups, and emphasizing mutual interchange in culture.

• Journal of People, Plants, and Environment
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• v.23 no.3
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• pp.267-276
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• 2020

Background and objective: Agro-healing is crucial with urban farming in the domestic. It is beyond the conventional agriculture. This study was carried out to assess the 2010s researches on domestic agro-healing and predict the future direction of agro-healing development. Methods: Among the articles published from 2010 to 2018, we collected some articles by searching keywords including agro-healing, garden activity, gardening, horticultural activity, horticultural program, horticultural therapy, plant effect, plant environment, plant growing program, plant impact, social gardening, urban agriculture and vegetable garden activity, selected 83 articles that were evaluated in advance, and analyzed by frequency analysis, t-test, and one-way ANOVA with SPSS 20.0. Results: Agro-healing journal articles were published the most in 2010, and have declined since then. In the classification according to the academic society, most of the journal articles were published by the Society for People, Plants, and Environment. The main targets of domestic agro-healing related to activities and programs were preschoolers, children and adolescents, accounting for 52.4% of the total. By the characteristics of the subjects, agro-healing programs and studies were conducted with special participants who needed special care compared to the general participants. The dependent variables were classified into six areas according to their attributes and the share of psychological and emotional areas was highest (42.6%) among them. In terms of the composition of the program, the share of those with 9-12 sessions was highest (36.7%) and the share of those with more than 20 participants was also highest (39.8%). Conclusion: It is recommended to operate agro-healing programs or industries focusing on the socially disadvantaged including those who have special needs or the underprivileged, but in order to create income for farms and expand the demand for agro-healing, it will be necessary to spread the perception that anyone without any physical or emotional issue can be the targets of and experience agro-healing. To meet the different needs of targets of agro-healing, it will be necessary to conduct objective and practical studies on broader areas and in the process the healing functions of agriculture and the strength of agro-healing needs to be further highlighted.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7303-7307
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• 2015

Background: Leukemia is a common cancer among children and adolescents. Wilms' tumor gene (WT1) is highly expressed in patients with acute leukemia. It is found as a tumor associated antigen (TAA) in various types of hematopoietic malignancies and can be employed as a useful marker for targeted immunotherapy and monitoring of minimal residual disease (MRD). In this regard, WT1 is a transcription factor that promotes gene activation or repression depending on cellular and promoter context. The purpose of this study was assessment of WT1 gene expression in patients with acute leukemia, measurement of IL-12 and C3 levels in serum and evaluation of the relationship between them. Materials and Methods: We evaluated the expression of WT1 mRNA using real-time quantitative RT-PCR and serum levels of IL-12 and C3 using ELISA and nephelometry in peripheral blood of 12 newly diagnosed patients with acute leukemia and 12 controls. Results: The results of our study showed that the average wT1 gene expression in patients was 7.7 times higher than in healthy controls (P <0.05). In addition, IL-12 (P = 0.003) and C3 (P <0.0001) were significantly decreased in the test group compared to controls. Conclusions: WT1 expression levels are significantly higher in patients compared with control subjects whereas serum levels of interleukin-12 and C3 are significantly lower in patients. Wt1 expression levels in patients are inversely related with serum levels of IL-12 and C3.

• Korean Journal of Health Education and Promotion
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• v.21 no.3
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• pp.101-116
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• 2004

Korea has the highest traffic accident occurrence rate in the world. It means that we are forced to face a tremendous amount of economic loses and great cost of life. Even though this phenomenon consistently has arose as a public issue every year and many researchers have emphasized the importance of safety education as the fundamental solution, we are still trying to make a long-lasting and effective traffic safety education programs for children and adolescents. The purpose of this study was to test the effectiveness of web-based learning for traffic safety in Korea middle school. For this purpose, the instructive model was constructed based on the ASSURE model and a special web-site of education was developed on behalf of practical use of multi-media learning materials for the traffic safety. The research subject was represented by 259 students from second grade in 2 middle schools located in Seoul Korea. The traffic safety education program using web-site was preceded to the 136 students as a case group for 45 minutes total 3 times. Other 126 students are control group those who did not get with this program. The survey was conducted before and after the education. The results of this study were as follow: 1. The knowledge analysis from the comparison between before and after of the lesson showed case group and control group scored average at 11.25 points and 10.97 points. However, after they attended programs, case group scored 13.57 points and control group scored 10.85 points. The difference from the result of the case group was statistically significant(p<0.001). 2. The attitude analysis from the comparison between before and after of the lesson showed case group and control group scored averages at 29.59 points and 28.21 points. However, after they attended program, case group scored 37.23 points and control group scored 32.71 points. The difference from the result of the case group was statistically significant(p<0.05). 3. Regarding the domain analysis by means of web-based traffic safety education, only the case group had a statistically significant score in the case of knowledge 'safe utilization of bicycle' and 'The Characteristic of Automobile and Safer Mode of Walking for Pedestrian'(p<0.01, p< 0.001), and in the case of attitude 'safe walking and crossing' 'The Characteristic of Automobile and Safer Mode of Walking for Pedestrian'(p<0.01, p<0.001). 4. Web based instruction for traffic safety was effective in terms of improving students' knowledge and attitude for traffic safety.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.5
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• pp.535-542
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• 2007

Ameloblastoma, a benign tumor of odontogenic type, represents 10% of all tumors of the jaw. It is localized in the mandible(80%) and in the maxilla(20%). In every case, the selection of the surgical treatment must consider some fundamental elements, including the age and general state of health the clinicopathological variant, and the localization and extent of the tumor. This study was invested the clinicopathological findings of 23 patients with ameloblastoma which had been diagnosed by biopsy during the period of 1987 to 2005 at Chonnam National University Hospital. And it contained the statistical analysis according to the treatment methods and the clinicopathological findings such as sex, age, location, chief complaints, duration, radiographic findings, histologic findings, treatment methods. The results obtained are were follows. The age of patient ranged from 10 to 91 years(means, 35.9 years) at biopsy. Thirteen(57%) of the 23 subjects were males, and 10(43%) were females. Twenty(87%) of the 23 ameloblastomas were located in the mandible. Swelling was the most common symptom and was experienced by 20(87%) patients. Radiographically, 11(48%) of the 23 tumors were unilocular with a well-demarcated border and 12(52%) were multilocular. The most common histologic pattern was plexiform and acanthomatous rather then follicular. Conservative treatment was performed 7 cases(30%), radical treatment 11 cases(48%), and combined treatment 5 cases(22%). Follow-up period ranged from 2.1 years to 22 years(mean 5.1 years). Based on the above results, surgical excision after marsupialization was found to be useful as a preliminary treatment of the large cystic ameloblastoma in children and adolescents. On the contrary, the lesion with a soap bubble appearance, the one with ineffective marsupialization was subjected to extensive excision of the tumor with a wide margin of normal bone.