• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 춘계학술대회
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• pp.331-334
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• 1996

The present study was performed to investigate gait characteristics of 30-39 year-old normal adults and 9-10 year-old children. The results focused on joint motions in the sagittal plane and ground reaction forces. The results will play an important role as a valuable data to determine normal and abnormal gait patterns as well as gait characteristics of Korean people.

• 한국운동역학회지
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• 제16권2호
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• pp.145-151
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• 2006

A large interindividual variability and some abnormally kinematic patterns at the lower extremity were the main features of the gait in children with Down syndrome. The purposes of this study were to investigate the gait asymmetry and biomechanical difference between dominant leg and non dominant leg in children with Down syndrome. Seven boys with Down Syndrome(age: $120{\pm}0.9yrs$, weight $34.4{\pm}8.4kg$, leg length: $68.7{\pm}5.0cm$) participated in this study. A 10.0 m ${\times}$ 1.3 m walkway with a firm dark surface was built and used for data collection. Three-dimensional motion analyses were performed to obtain the joint angles and range of motions. The vertical ground reaction forces(%BW) and impulses($%BW{\cdot}s$) were measured by two force plates embedded in the walkway. Asymmetry indices between the legs were computed for all variables. After decision the dominant leg and the non dominant leg with max hip abduction angle, paired samples t-test was employed for selected kinematic and ground reaction force variables to analyze the differences between the dominant leg and the non dominant leg. The max hip abduction angle during the swing phase showed most asymmetry, while the knee flexion angle at initial contact showed most symmetry in walking and running. The dominant leg showed more excessive abduction of hip in the swing phase and more flat-footed contact than the non dominant leg. Vertical peak force in running showed more larger than those of in walking, however, vertical impulse showed more small than walking due to decrease of support time. In conclusion, the foot of dominant leg contact more carefully than those of non dominant leg. And also, there are no significant difference between the dominant leg and the non dominant leg in kinematic variables and ground reaction force due to large interindividual variability.

• Child Health Nursing Research
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• 제13권3호
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• pp.257-264
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• 2007

Purpose: The purpose of this study was to develop an effective obesity management program for elementary school children, based on the motivation theory. Method: This study was a methodological study. A child obesity management program, based on the motivation theory was developed, a web site was made and children with obesity participated in the internet program. After the children finished the program, they evaluated the clinical validity of the program. The clinical validity was tested from Jun 12 to 16, 2006. The participants were 6 students. The evaluation tool was Keller's IMMS(Instructional Material Motivation Survey). Data were evaluated using $means{\pm}SD$ for four major components A,R,C,S (Attention, Relevance, Confidence, Satisfaction), based on ARCS in the motivation theory. Results: The program developed in this study was named 'ARCS children obesity escape', and the URL is 'http://www.119kid.co.kr'. Regarding the four components of ARCS, the overall reaction of participants showed that they were very highly motivated by this program. Conclusion: Utilizing the ARCS motivation strategies for solving obesity problems for children is an effective method to motivate the management of obesity, and can increase achievement motivation, attention, relevance, confidence, and satisfaction with the management of obesity. Thus, the program developed in this study is expected to reduce obesity in children, and become an important guide for obesity management and health improvement for children.

• Pediatric Infection and Vaccine
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• 제19권1호
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• pp.28-36
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• 2012

목 적 : 이 연구는 경기서부지역의 감염성 설사의 원인 바이러스의 역학 및 지역적 유병율에 대한 정보 제공을 위해 실시되었다. 방 법 : 2009년 1월부터 12월까지 가톨릭대학교 부천성모병원에 급성 설사로 입원한 10세 미만 환아를 대상으로 흔한 세균성 병원체가 없는 310개의 대변 검체에서 rotavirus, parechovirus, adenovirus, astrovirus, enterovirus, norovirus의 유무를 PCR과 RT-PCR을 이용하여 확인하였다. 결 과 : parechovirus (16%)가 가장 흔한 것으로 나타났으며, adenovirus (15%), astrovirus (14%), rotavirus (13%), enterovirus (5%)의 순으로 검출되었다. 단일 감염은 55.8%에서, 중복 감염은 3.2%에서 나타났다. 바이러스성 장염은 전체적으로 두 차례의 유행 시기를 보였으며, 84.6%는 2세 이하에서 발생하였다. 결 론 : parechovirus, adenovirus, astrovirus, enterovirus는 기존에 시행 중인 진단방법으로는 과소평가되어 있으나 소아 설사의 중요한 원인이다.

• 대한소아치과학회지
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• 제32권2호
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• pp.207-216
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• 2005

Mutans streptococci는 치아우식증과 관련이 있다고 보고되고 있으며, 이 streptococci 종 중에서 S. mutans나 S. sobrinus가 인간의 치아우식증에서 가장 일반적으로 나타난다. 치아우식증에서 이 세균종의 분포는 인종과 지역에 따라 다양하다. 본 연구에서는 2-6세인 52명의 치아우식증 환자에서 비우식부위와 우식부위로부터 치태를 채취하여 DNA를 추출한 후 dex와 gtf 유전자에 기초한 S. mutans와 S. sobrinus에 특이한 primer를 제작한 후 PCR을 시행하여 S. mutans와 S. sobrinus의 분포도를 조사하여 다음과 같은 결과를 얻었다. 1. 어린이 치아우식증 환자에서 S. mutans나 S. sobrinus가 발견된 어린이는 37명(71.2%)이었다. 2. 이들 어린이 중에서, S. mutans 또는 S. sobrinus가 비우식부위에서만 발견된 어린이는 3명(5.8%), 우식부위에서만 발견된 어린이는 22명(42.3%), 두 부위 모두에서 발견된 어린이는 12명(23.1%)이었다. 3. S. mutans나 S. sobrinus가 나타난 비우식부위 치태는 15개(28.8%), 우식부위치태는 34개(65.4%)였다. 4. 비우식부위의 경우 S. mutans만 출현한 어린이는 52명 중 8명(15.4%), S. sobrinus만 출현한 어린이는 6명(11.5%), 두 세균종이 같이 출현한 어린이는 1명(1.9%)이었다. 5. 우식부위에서 S. mutans만 출현한 어린이는 52명 중 24명(46.2%), S. sobrinus만 출현한 어린이는 2명(3.8%), 두 세균종이 같이 출현한 어린이는 8명(15.4%)이었다. 6. S. mutans는 gtf에 기초한 primer, S. sobrinus는 dex에 기초한 primer가 PCR에서 효과적으로 각각의 세균을 검출하였다. 이상의 결과로 미루어 우리나라 어린이의 경우 치아우식증은 MS와 밀접한 연관성이 있으며, MS중에서도 S. mutans가 중요하다고 판단된다. 한편 S. mutans와 S. sobrinus의 동반출현은 치아우식증과 더욱 밀접한 관련이 있는 것으로 보인다.

• Clinical and Experimental Pediatrics
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• 제56권11호
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• pp.477-481
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• 2013

Purpose: Ureaplasma colonization is related with perinatal complications in preterm infants. Little is known about the difference in virulence among various Ureaplasma urealyticum serovars. The aim of this study was to determine U. urealyticum serovars of preterm infants in order to assess whether any of the serovars were associated with bronchopulmonary dysplasia (BPD). Methods: Three hundred forty-four preterm infants with a gestational age less than 34 weeks admitted to Gangnam Severance Hospital neonatal intensive care unit from July 2011 to December 2012 were included in this study. Tracheal and gastric aspirations were conducted on infants to confirm Ureaplasma colonization. Ureaplasma colonization was confirmed in 9% of infants, of these, serovars were determined by real-time polymerase chain reaction. Results: A total of 31 infants (gestational age, $29.3{\pm}3.1$ weeks; birth weight, $1,170{\pm}790g$) were U. urealyticum positive. The Ureaplasma positive group treated for more days with oxygen and ventilation than the negative group (P<0.05). Histologic chorioamnionitis and moderate to severe BPD were more frequent in the Ureaplasma positive group than in the negative group (P<0.05). U. urealyticum isolates were either found to be a mixture of multiple serovars (32%), serovar 9 alone or combined with other serovars (39%), serovar 11 (26%), 2 (13%), 8 (10%), 10 (13%), and 13 (25%). No individual serovars were significantly associated with moderate to severe BPD and chorioamnionitis. Conclusion: This is the first study to describe the distribution of U. urealyticum serovars from Korean preterm infants. Ureaplasma -colonized infants showed higher incidence of BPD and chorioamnionitis.

• Clinical and Experimental Pediatrics
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• 제56권5호
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• pp.224-226
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• 2013

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is characterized by a severe idiosyncratic reaction including rash and fever, often with associated hepatitis, arthralgias, lymph node enlargement, or hematologic abnormalities. The mortality rate is approximately 10%, primarily owing to liver failure with massive or multiple disseminated focal necrosis. Here, we report a case of a 14-year-old girl treated with vancomycin because of a wound infection by methicillin-resistant Staphylococcus aureus, who presented with non-specific symptoms, which progressed to acute liver failure, displaying the hallmarks of DRESS syndrome. With the presence of aggravated hepatic encephalopathy and azotemia, the patient was refractory to medical treatments, she received a living-donor liver transplantation, and a cure was achieved without any sign of recurrence. Vancomycin can be a cause of DRESS syndrome. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal disease.

• 대한가정학회지
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• 제36권5호
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• pp.107-123
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• 1998

Mothers play a major role in children's consumer socialization but little is known about differences in mother's consumer socialization tendencies and the antecedents causing the differences. This study addresses two research questions: First, what are the underlying dimensions of mother's consumer socialization? Second, what are the antecedent variables causing differences in mother's consumer socialization tendencies; can parental style, consumption-related attitudes (attitude toward marketplace and ads., attitude toward consumerism and consumption-oriented attitude) be used as a conceptual basis for hypothesizing these differences? The findings of this research were as follows: 1. Factor analysis suggested five underlying dimensions of mother's consumer socialization of children; Mother-child communication about consumption, Mediation of media, Reaction to purchase requests, Restriction of allowances and Restriction of consumption. 2. The differences in the mother's consumer socialization tendencies among different parental groups matched the differences in child-rearing behaviour suggested by Developmental Psychology and this provided support for expected relationships between general-consumer socialization tendencies, as measured by mothers' behaviour. 3. Differences were found on all factors according to mothers consumption-related attitude. This provided support for the expectation that mothers' consumption related attitudes are important antecedent variables causing differences in consumer socialization tendencies. Some implications and directions for future research were discussed.

• Journal of Genetic Medicine
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• 제12권1호
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• pp.38-43
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• 2015

Purpose: Spinocerebellar ataxias (SCAs) are progressive neurodegenerative disorders with diverse modes of inheritance. There are several subtypes of SCAs. SCA 8, SCA 12, and SCA 17 are the less common forms of SCAs with limited information available on their epidemiological profiles in Korea. The purpose of this study was to investigate the prevalence of SCA8, SCA12, and SCA17 in Korea. Materials and Methods: Ninety-six unrelated Korean patients were enrolled and showed normal trinucleotide repeats through polymerase-chain reaction (PCR) for the genes ATXN1, ATXN2, ATXN3, CACNA1A, and ATXN7, which correspond to SCA1, SCA2, SCA3, SCA6, and SCA7, respectively. PCR products from patients were further analyzed by capillary electrophoresis using fluorescence labeled primers for the genes ATXN8OS, PPP2R2B, and TBP, which correspond to SCA8, SCA12, and SCA17. Results: Three patients had 104, 97, and 75 abnormal expanded repeats in the ATXN8OS gene, the causative gene for SCA8. None of the patients exhibited abnormal repeats in SCA12 and SCA17. Normal trinucleotide repeat ranges of the cohort in this study were estimated to be 17-34 copies (average, $24{\pm}4copies$) for SCA8, 7-18 copies (average, $13{\pm}3copies$) for SCA12, and 26-43 copies (average, $35{\pm}2copies$) for SCA17. Conclusion: This study demonstrated that SCA8, SCA12, and SCA17 are rare in Korean patients with SCA, and further genetic studies are warranted to enhance the mutation detection rate in the Korean SCA population.

• Pediatric Infection and Vaccine
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• 제20권1호
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• pp.28-35
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• 2013

목 적 : 2000년이후human metapneumovirus (hMPV)는 하기도 호흡기 감염을 일으키는 주요 바이러스로 인식되고 있다. 급성 호흡기 감염으로 입원한 소아 환자들에서의 hMPV의 역학 및 임상적 특징, 그리고 혈액학적 특징 및 hMPV에 감염되지 않은 환자와의 비교, 중복 감염등을 통해 hMPV의 특징을 파악하고자 하였다. 방 법 : 2010년 2월부터 2012년 1월까지 급성 호흡기 증상으로 입원한 환아 1,554명의 비인두 흡인을 통해 객담 검체를 채취하여 RT-PCR을 시행 후 hMPV가 검출된 99명의 환아들의 임상 기록지를 후향적으로 검토하여 이들의 임상 증상 및 검사 소견을 분석 비교 하였다. 결 과 : 1,554명 중 1,004명(64.6%)에서 호흡기 바이러스가 검출되었다. 그 중 hMPV가 양성인 환자는 99명으로 양성 검체의 9.8%였다. hMPV에 감염된 환자의 평균 연령은 25.0개월이었으며 해마다 유행 정도는 다르나 4월부터 6월에 주로 발현하였으며 발열기간이 다른 바이러스 보다 길고 호흡기 증중을 보였으며, 천명(wheezing)이 특징적 임상 증상이었다. 진단으로 폐렴이 가장 많았지만, 12개월 이하의 연령군에서는 모세기관지염이 가장 흔하였다. 혈액학적 검사소견은 ESR (erythrocyte sedimentation rate), CRP (C-reactive protein) 모두 hMPV에 감염된 환자군에서 정상 범위 보다 상승된 소견을 보였다. hMPV의 단독 감염과 중복 감염을 비교해 보았을 때 임상증상 및 혈액 검사 소견에서 통계학적 차이를 보이지 않았다. 결론 : hMPV는 폐렴을 일으키는 주요 원인 바이러스이며 13개월 이상부터 48개월 이하의 연령에서 호발하며 평균 연령은 25개월이며 4월에서 6월까지 유행하는 양상을 보였다. 천명이 임상적 특징이며, hMPV에 대하여 우리나라에서의 보고는 점차 증가되고 있으나 아직은 생물학적, 유전학적 특징과 관련된 임상 분석이 더 필요하다.