• 생태와환경
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• 제37권1호통권106호
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• pp.57-63
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• 2004

서낙동강에서 $^{14}C$법으로 1996년 1월부터 10월까지 식물플랑크톤의 1차 생산성을 측정하였다. 서낙동강은 수심이 얕고, 국내 호수와 하천 중에서 가장 수질오염이 심한 곳으로 진광층의 깊이는1.4${\sim}$2.1 m 범위였다. 식물플랑크톤의 chi-a 농도는 67${\sim}$894 ${\mu}g\;L^{-1}$ 범위였고, 8월에는 chi-a 농도가 크게 증가하였다. 최대 물질생산성은 수표면 ${\sim}$0.4 m 깊이에서 나타났으며 2.1${\sim}$4.3 mg C mg $chl-a^{-1}$ 범위였다. 광합성 (P)-광(I)의 관계에서 식물플랑크톤의 광합성 저해는 높은 고광에서 현저히 저해되었으나 Microcystis가 대발생한 기간에는 광저해 현상이 나타나지 않았다. Chl-a 당 식물플랑크톤의 1차 생산성은 입사 광에너지의 양에 비례하였으며 면적 당 1차 생산성은 chl-a현존량과 직선적으로 비례하여 식물플랑크톤의 1차 생산성은 결과적으로 생물량과 광의 함수였다. 과거 자료를 수집한 결과. 낙동강 하구 지역에서 식물플랑크톤의 생산성은 하구둑 건설(1987년) 이후 해가감에 따라 점진적으로 증가하여 이 지역의 부영양화 현상을 반영하였다. 식물플랑크톤의 연 생산성 개념에서 평균 10 ${\mu}g\;chl-a\;L^{-1}$의 생물량 증가는 30 mg C $m^{-2}\;day^{-1}의 단위면적 당 생산성 증가를 가져왔다.

• Molecules and Cells
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• 제26권4호
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• pp.396-403
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• 2008

The first ORF of the ARV S1133 S1 segment encodes the nonstructural protein p10, which is responsible for the induction of cell syncytium formation. However, p10-dependent signaling during syncytium formation is fully unknown. Here, we show that dominant negative RhoA, Rho inhibitor C3 exoenzyme, ROCK/Rho-kinase inhibitor Y-27632 and Rac1 inhibitor NSC23766 inhibit p10-mediated cell fusion. p10 over-expression is concomitant with activation and membrane translocation of RhoA and Rac1, but not cdc42. RhoA and Rac1 downstream events, including JNK phosphorylation and transcription factor AP-1 and $NF-{\kappa}B$ activation, as well as MLC expression and phosphorylation are simultaneously activated by p10. p10 point mutant T13M possessed 20% fusion-inducing ability and four p10 fusion-deficient mutants V15M, V19M, C21S and L32A reduced or lost their ability to activate RhoA and Rac1 signaling. We conclude that p10-mediated syncytium formation proceeds by utilizing RhoA and Rac1-dependent signaling.

• 생약학회지
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• 제7권1호
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• pp.69-71
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• 1976

New or noteworthy medicinal plants were found in Korea, such as 1. Magnolia sieboldii K. KOCH f. dupliflora $C_{HI}$ (Magnoliaceae) 2. Peucedanum insolens $K_{ITAGAWA}$ (Umbelliferae) 3. Panax japonicus C.A. $M_{EYER}$ (Araliaceae) 4. Phytolacca americana L. (Phytolaccaceae) 5. Polygonum ellipticum $M_{IGO}$ (Polygonaceae).

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 추계학술발표대회 및 bio-venture fair
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• pp.317-320
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• 2000

The optimal temperature and pH for both mycelial growth and exe-biopolymer production by Cordyceps millitaris in shake flask culture were found to be $20^{\circ}C$ and 6.0, respectively. Sucrose (4%) and corn steep powder (1%) were the most suitable carbon and nitrogen source for mycelial growth and exo-biopolymer production. The maximum specific growth rate $(0.142h^{-1})$ was achieved when sucrose was used as the sole carbon source. Exo-biopolymer production was increased with the increase in C/N molar ratio concentration, probably due to the facilitated carbon uptake. Under the optimal culture conditions, the maximum mycelial growth exe-biopolymer concentration were reached to around 13.3 g dry cell weigh/l and 3.33 g/l, respectively.

• 지역사회간호학회지
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• 제31권1호
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• pp.24-33
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• 2020

Purpose: The purpose of this study was to examine the mediating effect of self-esteem and social support on the relationship between anxiety and health-related quality of life (HRQoL) in the elderly. Methods: The Korea adult psycho-social anxiety survey data were collected from August to September 2015 by the Korea Institute for Health. The subjects were 1,035 elderly people who were aged 65 or older at the time of the data survey. The data were analyzed by t-test, chi-square, Pearson correlation coefficient, and parallel redundant mediated model for PROCESS macro using SPSS 23.0. Results: They scored an average of 37.93±7.58 for anxiety, 28.59±3.45 for self-esteem, 17.25±4.11 for social support, and 0.88±0.11 for HRQoL. The direct effect of anxiety on HRQoL and the indirect effect of anxiety mediated with self-esteem and social support about HRQoL were statistically significant. Conclusion: These results indicate that in order to increase the HRQoL of the elderly, it is necessary to develop an intervention program that focuses not only on reducing anxiety but also on improving self-esteem and social support.

• 동의생리병리학회지
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• 제24권6호
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• pp.942-949
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• 2010

Morus alba L., a kind of Oriental medicinal herbs, has been traditionally used to treat pulmonary asthma and congestion. According to recent studies, extracts of M. alba L. have showed anti-inflammatory, anti-oxidant, anti-tumor and hypoglycemic effects. However, the molecular mechanisms on how it acts as a death-inducer in cancer cells have not been fully understood. In this study, we investigated the cell death effects of methylene chloride extracts of M. alba L. (MEMA) in A549 human lung carcinoma cells. It was shown that MEMA induced the apoptotic cell death proved by increased sub-G1 phase cell population, apoptotic body formation and chromatin condensation. MEMA treatment induced the expression of death receptor-related proteins such as death receptor (DR) 4, DR5, Fas and FasL, which further triggered the activation of caspase-8 and the cleavage of Bid in a concentration-dependent manner. However, MEMA reduced anti-apoptotic Bcl-2 and Bcl-xL expression which contributed to the loss of mitochondrial membrane potential (MMP), and the activations of caspase-9 and caspase-3. Meanwhile, the morphological study indicated a characteristic finding of autophagy, such as the formation of autophagosomes in MEMA-treated cells. Furthermore, markers of autophagy, namely, the increased MDC-positive cells, conversion of microtubule-associated protein light chain 3 (LC3)-I to LC3-II and increased beclin-1 accumulation, were observed. Taken together, these findings demonstrated that MEMA triggered both autophagy and apoptosis in A549 cancer cells. They might suggest that M. alba L. could be a prospective clinical application to treat human lung cancers.

• 대한환경공학회지
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• 제32권5호
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• pp.461-468
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• 2010

본 연구는 창원시 지역의 빗물의 계절적 수질변화와 저류조의 경과일수에 따른 수질 변화를 조사 연구하였다. 빗물의 계절적 수질 변화를 보면 전체적인 오염물질의 농도는 봄철 및 겨울철이 높았다. 내리는 빗물과 저류조 빗물의 수질을 비교하였을 때 pH의 경우, 내리는 빗물은 pH 4.3, 저류조의 빗물은 pH 6.0을 나타내었고, 탁도의 경우는 1.82 NTU에서 14.61 NTU로 대략 8배 정도로 크게 증가하였다. 저류조의 경과 일수에 따른 수질 변화는 과망간산칼륨소비량이 초기 강우에서 먹는 물 수질기준을 초과하여 검출되었고, 증발잔류물은 초기우수에서 116 mg/L 검출되었으나 저류시간 6일 경과 후부터 34일까지는 70~80 mg/L로 저류시간이 길어져도 농도의 변화는 크지 않았다.

• 한국수산과학회지
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• 제43권1호
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• pp.25-32
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• 2010

A Sanitary survey in an Important shellfish-growing area of Biin Bay in Seocheon-gun Korea, was conducted to evaluate bay conditions and compliance with the bacteriological criteria for areas designated for the production of shellfish for export. Seawater samples were collected monthly at 55 sampling stations established in the survey area from January 2006 to December 2008. Bacteriological water quality did not change in response to a small rainfall (10.0 mm), but it increased abruptly in response to rainfall to 62.5 mm The most probable number (MPN) value for total coliforms and fecal coliforms in 1, 980 seawater samples ranged from <1.8 to >1, 600 MPN/100mL and from <1.8 to 330 MPN/100mL, respectively. The geometric mean and estimated $90^{th}$ percentile value for total coliforms ranged from 2.0 to 10.3 MPN/100mL and from 7.0 to 42.6 MPN/100mL respectively. The geometric mean and estimated percentile value for fecal coliforms ranged from 1.8 to 4.0 MPN/100mL and from 1.9 to 18.3 MPN/100mL, respectively. Accordingly, the bacteriological water quality of Biin Bay met the National Shellfish Sanitation Program (NSSP) and Korea Shel1fish Sanitation Program(KSSP) criteria for areas designated for shellfish production for export in Korea.

• 대한의용생체공학회:의공학회지
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• 제41권3호
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• pp.138-145
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• 2020

Adipocytes are the main constituent of adipose tissue. Understanding the molecular basis of adipogenesis is pivotal to finding the therapeutic targets for treatment of obesity. Melatonin is associated with obesity and its mechanism is currently under intensive investigation. The objective of this study was to investigate the effect of melatonin on adipogenesis in differentiating preadipocytes. 3T3-L1 preadipocytes were cultured in Dulbecco's modified Eagle's medium (DMEM) containing 5% calf serum at 37℃ with 5% CO₂ in a humidified incubator. Differentiation was induced using DMEM with 10% fetal bovine serum supplemented with MDI two days after cell confluence (day 0). Cells were treated with 0, 10 and 100 μM melatonin on either day 0 or day 5. 72 hours after each treatment, lipid accumulation was measured by oil red O staining. Proteins were resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and transferred to membranes. As a result, lipid accumulation decreased with melatonin treatment. ERK pathway, activated when differentiation is induced, also decreased with an increase in melatonin concentration. Furthermore, the expression of key adipogenic factors, C/EBPα, C/EBPβ, and PPARγ, were reduced by melatonin treatment. These results imply that melatonin may inhibit the process of adipogenesis and may have a role as a new anti-obesity agent.

• 한국초전도학회:학술대회논문집
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• 한국초전도학회 1999년도 High Temperature Superconductivity Vol.IX
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• pp.210-213
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• 1999

Magnetoresistance and magnetization of Sr$_{l-x}K_xBiO_3$ were both measured as functions of temperature and magnetic field. Resistivity goes to zero at T=10.1K and the overall superconducting transition behavior under applied magnetic fields is similar to that of other BiO based superconductors. Also, below T<5K we have observed the reappearance of finite resistivity with a power law temperature dependence( ${\rho}$ ${\sim}$T$^1$); the reentrant superconducting transition of resistivity. Contrary to the Josephson weak link effect in polycrystalline samples, which gives the depression of the superconducting state with increasing electrical current or magnetic field, the superconducting state for T<5K is resumed by applying a higher current or magnetic field. Magnetic susceptibility( ${\chi}$ ) of Sr$_{l-x}K_xBiO_3$ for T<5K also shows similar trends to that observed in transport measurements: increase of ${\chi}$ (paramagnetic-like behavior) at a low magnetic fields(B=50 Oe) and, the resumption of perfect diamagnetism at high fields.