• Journal of Society of Preventive Korean Medicine
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• v.14 no.1
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• pp.111-123
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• 2010

Backgrounds : Stroke is characterized by loss of brain functions due to a disturbance in the blood vessels supplying blood to the brain, and classified into hemorrhage and ischemia. Stroke is known to be affected by genetic factors and other diseases such as hypertension and cardiovascular diseases. However, the distinctive association between stroke and genetic variations has not discovered yet. Objectives : This study investigated the effects of fibrinogen level and genetic variations in FGA (Fibrinogen alpha chain) gene on stroke in Korean stroke patients and controls. Methods : DNA samples from 674 stroke patients diagnosed by Oriental medical hospitals and 267 controls were used in this study. Two common single nucleotide polymorphism(SNP) with high minor allele frequency(MAF), rs2070011G/A of promoter region and nonsynonymous rs6050A/G of exon 5 in FGA gene, were targeted for Taqman genotyping. Because the TOAST classification is important to the factors and symptoms of stroke, ischemic patients were further classified into five subtypes using diagnosis and clinical data. One-way ANOVA and chi-square test were used for clinical data and genetic association, respectively. Haploview v4.1 program was used for linkage disequilibrium(LD), haplotype and haplotype block analysis. Results : The levels of red blood cells and fibrinogen from clinical data were shown to be significant factors for the sub-groups of TOAST classification. No significant associations of stroke, hemorrhage, ischemic and subtypes of TOAST with rs2070011 and rs6050 of FGA gene were found(P > 0.05). However, rs2070011 in promoter region and nonsynonymous rs6050 in exon 5 which produce the amino acid change from threonine to alanine showed a haplotype block and three haplotypes of A-G, G-A, A-A, suggesting that rs2070011 and rs6050 might be co-segregated in generic recombination. Although A-A haplotype of stroke patients showed 64-69% low frequency compared to controls, there was no significant association between stroke and haplotype(P > 0.05). Conclusion : This study showed that there was no significant association between stroke and two SNP of rs2070011G/A and nonsynonymous rs6050A/G in FGA gene. However, these two SNP compose a haplotype block and three haplotypes of A-G, G-A, A-A. This finding suggests that rs2070011 and rs6050 are so close as to be positioned as linkage disequilibrium. Nevertheless, no significant association between haplotypes and stroke was found.

• IMMUNE NETWORK
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• v.2 no.4
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• pp.227-232
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• 2002

Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by diverse clinical manifestations and autoantibody production, which is known to be strongly influenced by genetic factors. Previous studies have revealed the associations of SLE with HLA class II alleles and antiphospholipid antibody system (anticardiolipin antibody (aCL) and anti-${\beta}_2$ glycoprotein I antibody (anti-${\beta}_2$ GPI)). Therefore, we studied the associations of HLA class II alleles with SLE and antiphospholipid antibody system. Methods: The genotyping for HLA-DRB1 and DQB1 alleles were performed in 61 SLE patients and 100 controls by the polymerase chain reaction (PCR)-sequence specific oligonucleotide probe method. ELISA tests for aCL and anti-${\beta}_2$ GPI were performed in 39 of the 61 SLE patients. The results were evaluated statistically by Chi-square test. Results: The frequencies of the HLA-$DRB1^*15$ and $DQB1^*06$ in SLE patients were significantly higher than those in controls. HLA-$DRB1^*12$ was significantly lower in SLE patients than controls. Nine of 39 patients were positive for aCL (IgG) and three were positive for aCL (IgM). One of 39 patients were positive for anti-${\beta}_2$ GPI (IgG) and none of them positive for anti-${\beta}_2$ GPI (IgM). Association of aCL with HLA class II alleles was not observed in our study. Conclusion: According to our results, it was found that HLA-$DRB1^*15$ and $DQB1^*06$ were associated with genetic susceptiblility and $DRB1^*12$ was associated with resistance to SLE in Korean population. No Association of aCL with HLA class II alleles was observed and the positive rate for anti-${\beta}_2$ GPI was very low.

• Advances in pediatric surgery
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• v.8 no.2
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• pp.126-132
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• 2002

Inguinal hernia is a major surgical disease in pediatric surgery, occurring in 3.5% to 5% of all mature newborns and 9% to 11% of all premature babies. The objective of this study is to analyze the predisposing factors in association with recurrences of inguinal hernias in infants and children. In the period from January 1995 to September 2001, 1,575 infants and children who had primary inguinal hernias or recurrent inguinal hernias operated on at the Department of Pediatric Surgery at Seoul National University Hospital were evaluated retrospectively. We evaluated the data by medical records and by telephone interview. The sex, age, location of hernia, comorbidity, prematurity, incarceration, interval to operation after incarceration, postoperative complications were analyzed as predisposing factors in associated with hernia recurrence. Operative findings of recurrent inguinal hernia were reviewed. The data were statistically analyzed with Pearson Chi-Square test and Fisher-exact test. A total of eighteen (1.14%) out of 1,575 patients underwent an operation due to recurrent inguinal hernia. In 5 (27.8%) out of 18 recurred patients, institution of the primary herniorrhaphy was our hospital and in the other 13 (72.2%) was outside hospital. No impact on the development of recurrences was seen for sex, age, interval to operation after incarceration, and postoperative complications. The significant predisposing factors of recurrent inguinal hernias were left inguinal hernias (p=0.002), comorbidity (p=0.002), prematurity (p=0.006), incarceration (p=0.017) and technical error of first herniorrhaphy. We expect that knowledge for predisposing factors of recurrent inguinal hernias and experienced skill of pediatric surgeons will decrease recurrence rate in primary inguinal hernia.

• Journal of Korea Entertainment Industry Association
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• v.13 no.7
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• pp.397-408
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• 2019

Purpose: The purpose of this study was to examine the effects of team-based learning(TBL) program on problem solving ability, self-directed learning and learning motivation of nursing students in a adult nursing course. Methods: This study was quasi-experimental study by using nonequivalent control group pretest-posttest design. Participants were 132 nursing students consisting of each experiment group 66 and control group 66. The experiment group was provided TBL program for 2 hours per session during 6 sessions and control group was provided lecture. Data were collected by questionnaires from April 20 to June 19, 2018. Data was analyzed by a chi-square test, t-test and ANCOVA using IBM SPSS 21.0 program. Results: The mean scores of problem solving ability(F=9.179, p=.003), self-directed learning(F=7.447, p=.007) and learning motivation(F=7.974, p=.006) were significantly higher in experiment group than those in control group. Conclusion: TBL program in a adult nursing course was effective in problem solving ability, self-directed learning and learning motivation of nursing students.

• Health Policy and Management
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• v.32 no.2
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• pp.190-204
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• 2022

Background: In Korea, the population is rapidly aging, and the types of households for the elderly are also diversifying. The self-rated health of the elderly is a valuable health indicator that can comprehensively represent the overall quality of life along with physical, mental, and functional health. On the other hand, studies on the association between household type and self-rated health of the elderly are still insufficient. Thus, this study analyzed the association between household type and self-rated health by gender in Korean older adults. Methods: Using data from the analysis of the National Survey of Older Koreans 2017, 10,299 elderly people aged 65 and over were targeted. For the accuracy of the analysis data, 9,910 people were selected as the study sample by excluding proxy responses, those diagnosed with dementia, and non-response. And technical analysis, univariate analysis using the Rao-Scott chi-square test, and logical regression analysis involving survey characteristics were conducted by gender. Results: According to the adjusted model with all variables, in both men and women, the odds ratio of self-rated health 'bad' in 'couple (with ill spouse)' was significantly higher than 'couple (with spouse)'. It was 2.54 (95% confidence interval [CI], 2.05-3.15) for men and 2.11 (95% CI, 1.70-2.62) for women. In addition, the odds ratio of self-rated health 'bad' in 'living with adult children' was 1.43 (95% CI, 1.09-1.87) for men and 1.42 (95% CI, 1.15-1.75) for women, which was more significant in women than men. Conclusion: This study states that there is an association between gender, household type, and self-rated health of the elderly, and the health of a spouse and cohabitation with children have a significant effect on self-rated health. As a result, in order to improve the health status of the elderly, health promotion and health care policies involving the characteristics of the elderly's gender and household type are needed.

• The Journal of the Korea Contents Association
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• v.17 no.5
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• pp.479-490
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• 2017

The objective of this study is to examine the association of social networks and medical care utilization of elderly living alone depending on self-rated health status, and also to measure the moderating effects of welfare services for elderly. To this purpose, the data which was collected from the 2014 National Survey on Elderly in Korea was analyzed by Chi-square test and Poisson regression. According to the results, social networks and elderly welfare services affected to medical care utilization of elderly living alone, only who aware of their self-rated health status as bad. With this group, the frequency of contact with family and participation in lifelong education had a significant effect on increasing medical care utilization. In contrast, the frequency of contact with neighbors and the participation in elderly employment program were significant to reduce the utilization of medical care. Furthermore, the moderating effects of elderly welfare services were also measured that formal social gathering has an effect of increasing the medical care utilization of elderly living alone by expansion of their social networks. Based on these results, this study consequently has an implication for suggesting expansion of elderly welfare services, which might be an alternative to social networks of elderly living alone, and also for seeking the direction of political intervention that helps health promotion and disease prevention through the research of medical care utilization.

• The Journal of Korean Academic Society of Nursing Education
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• v.4 no.2
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• pp.236-248
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• 1998

This survey study was attempted for two purposes : 1) to grasp Korea National Open University(KNOU) students' changing aspects for their education need through comparison analyses with 1996 data ; 2) to establish foundation of the systematic network formation by investgating students' opinion about network framework. Among randomly assigned 4,500 students, 1,505 KNOU nursing students who allowed to participate in the study completed the questionnaires. The data were collected by mail. For the comparison 1996 data were also used. The data were analyzed using descriptive statistics, chi-square test, and t-test. Results of this study were as follows 1. The admission purposes of the KNOU nursing students were 'in order to get a bachelor's degree (70.7%)', 'to do studying and working simultaneously(43.0%)', or 'to be admitted for the graduate school (41%)' etc. Comparing the admission purposes by age, the investigator found 4 items which are 'small amount of tuition', 'graduate school admission', 'aspiration for the university', 'promotion or commencement of work' showed statistically significant differences. These 4 items were also found to show significant differences by marital status. 2. In relation to the learning media, the study showed most students(74%) got effective informations from the school newspaper(36.5%) or peer group(37.7%). The result showed that few students (0.7%) used the computer for communication. The research indicated that KNOU nursing students have tendency to rely on printed materials more than on broadcasting media. This is almost the same result as that of 1996. 3. The results revealed that 12.4% of the respondents had ever experienced unregistration or temporary withdrawal. The most common reason for the unregistration was 'due to family affairs or their job (71.3%)'. There were no change for this aspects with 1996. 4. As for the professors-students network formation. The result revealed that 38.5% students among respondents had heard of the network formation. 78.7% of respondents, however, positively responed that they would willingly participate in the networking if it is made. Especially the students showed much interest in 'the improvement for the understanding of study' and 'strengthening of the relations between professors and students'.

• The Journal of the Korea Contents Association
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• v.17 no.4
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• pp.72-82
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• 2017

The purpose of this paper was to explore university students' perceptions on NEST(Native English-speaking Teacher)s and NNEST(Nonnative English-speaking Teacher)s who taught in an English camp of A university. 172 university students participating in the English camp during the vacation were asked to fill out a questionnaire including the satisfaction with the camp, NESTs' and NNESTs' general teaching qualifications, class management, and teaching contents. The data were analyzed through frequency, Pearson's Chi-square test and Fisher exact test. The research found that students were satisfied with NESTs' and NNESTs' classes in the camp. The students recognized that NESTs offered interesting classes while NNESTs prepared and taught the classes well. They also pointed out that NESTs instantly managed classes while NNESTs tended to rely on textbooks and offered more materials in classes. They realized that NNESTs focused more on English speaking, gave students more feedbacks about students' outcomes, and communicated with students more effectively. The paper provides pedagogical implications for more effective NESTs' and NNESTs' teaching.

• Journal of Digital Convergence
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• v.13 no.1
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• pp.383-396
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• 2015

This study aims to identify factors related to rescreening the private health screening center. Data from private health screening center with seven district centers were analyzed. The number of subjects was 70,250 from 2008 through 2015. Socio-demographic characteristics, morbidity, history, physical measurement, laboratory test, and health behavior factors were analyzed the association with health rescreening using chi-square test and negative binominal regression. 19.2% of subjects were recheck their health status on each year from 2008 to 2012. The socio-demographic characteristics related to reuse private health screening center were male, 30-40 aged, Daegu, Gwangju, Jeonnam and Gyeongnam region residents. And overweight and pre-hypertension were also factors association with number of using the private health screening program. People who control their health risk factors such as alcohol intake, smoking and mental health and execute physical exercise tend to use health screening program regularly. Our finding suggest that customer relationship management can execute and private health screening center enable their strategic plan based on data-evidence.

• The Journal of the Korea Contents Association
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• v.18 no.6
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• pp.453-460
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• 2018

This study was to identify the prevalence rate of the limitation of activity, the reasons for activity limitation, association with activity limitation and general characteristics among older adults in Korea's population. Data were extracted from the $7^{th}$ Korea National Health and Nutrition Examination Survey. The number of participants were 1,578 older adults who aged 65 years over. SPSS program (version 18.0) was used for analyzing on frequency, Chi-square test, and logistic regression analysis of the data. The total prevalence rate of activity limitation among Korea's population was 19.6% in 2016. The prevalence rate of the reasons for activity limitation in Korea was highest for neck and back problems(19.8%), followed by arthritis and rheumatism(17.1%). The prevalence rate of activity limitation was statistically significant associated with age and education level, respectively. In conclusion, Age, educational level, and musculoskeletal diseases such as problems related to back and neck, arthritis and rheumatism could be significant risk factors for activity limitations in older adults who aged 65 years over. These findings could be useful as evidence-based data for relieving the prevalence rate of activity limitation and the prevention and management of activity limitations in Korea population.