• Journal of Korean Medical classics
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• v.27 no.4
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• pp.21-27
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• 2014

Objectives : Among the translations of the verse "Sa-gi is on the upper side, Tak-gi is on the middle side, Cheong-gi is on the under side(邪氣在上, 濁氣在中, 淸氣在下)" in the texts of Miraculous Pivot(靈樞) Nine needles and Twelve sources(九鍼十二原), the meanings of 'Ham-maek(陷脈)' and 'Joong-maek(中脈)' have contradictory versions. Methods : This study will identify the actual meaning of this verse through analysis of the phrase "夫氣之在脈也", followed by examination of the relationship between the meaning of "three-stratum puncture(三刺)" in the chapters Miraculous Pivot Handling needle(官鍼), Miraculous Pivot Jong-si(終始) and the meaning of "刺有三變" of Miraculous Pivot Longevity and character(壽夭剛柔), after which its application in later periods will be discussed. Results : The words 'Sa-gi', 'Tak-gi' and 'Cheong-gi' in the phrase "夫氣之在脈也" of Miraculous Pivot Nine needles and Twelve sources each correspond to the words 'yang pathogens(陽邪)', 'yin pathogens(陰邪)' and 'essence derived from food(穀氣)' of Miraculous Pivot 終始, respectively. Conclusions : The Upper-Middle-Lower of the phrase "夫氣之在脈也" in Nine needles and Twelve sources indicates the three levels of depth, in which 'Sa-gi', 'Tak-gi' and 'Cheong-gi' each dwell. 'Ham-maek' and 'Joong-maek' are categorizations according to the depth of needling.

• The Journal of Pediatrics of Korean Medicine
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• v.26 no.1
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• pp.1-15
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• 2012

$CheongGiGeoYangTang$ has been used for anti-allergenic purpose. However there was no experimental study about its effect. Therefore, this study was designed to investigate the anti-allergenic effect of $CheongGiGeoYangTang$. Methods Modifiability of RBL-2H3 mast cells' IL-4, IL-13 was analyzed by qRT-PCR and ELISA. Also, the suppressive effect of GATA-1, GATA-2, NF-AT1, NF-AT2, AP-1 and NF-${\kappa}B$ p65 transcription factors was observed by western blotting. OVA-specific IgE, IL-4 and IL-13 production in ovalbumin allergy model was examined as well. Results It was showed that the RBL-2H3 mast cells treated with $CheongGiGeoYangTang$ extract(CGGYT) was significantly suppressed mRNA expression, production of IL-4 and IL-13, and prominently inhibited the expression of transcription factors including GATA-1, GATA-2, NFAT-1, NFAT-2, c-Fos and NF-${\kappa}B$ p65 but not c-Jun. The administration of CGGYT was suppressed the amount of OVA-specific IgE, IL-4 and IL-13 in OVA/alum-sensitized mice. Conclusions We considered CGGYT would regulate the allergic inflammation as inhibition of IL-4 and IL-13 production in activated mast cells and Th2 cells.