• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.3
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• pp.1105-1118
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• 2014

In this paper, a new reversible data hiding method based on a dual binary tree of embedding levels is proposed. Four neighborhood pixels in the upper, below, left and right of each pixel are used as reference pixels to estimate local complexity for deciding embeddable and non-embeddable pixels. The proposed method does not need to record pixels that might cause underflow, overflow or unsuitable for embedment. This can reduce the size of location map and release more space for payload. Experimental results show that the proposed method is more effective in increasing payload and improving image quality than some recently proposed methods.

• Journal of the Korean Chemical Society
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• v.51 no.4
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• pp.352-355
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• 2007

A new phenanthrene derivative 3,7-dihydroxy-2,4,6-trimethoxyphenanthrene was isolated from the all plant of Bulbophyllum odoratissimum, and its structure was elucidated by extensive spectral studies and chemical transformation. The compound displayed cytotoxicity against the growth of human leukemia cell lines K562 and HL-60, human lung adenocarcinoma A549, human hepatoma BEL-7402 and human stomach cancer cell lines SGC-7901 with IC50 values of 14.23, 10.02, 3.42, 15.36 and 1.13 mg/ml respectively.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.667-671
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• 2016

Oridonin, an ent-kaurane diterpenoid compound isolated from the traditional Chinese herb Rabdosia rubescens, has shown various pharmacological and physiological effects such as anti-tumor, anti-bacterial, and anti-inflammatory properties. However, the effect of oridonin on human ovarian cancer cell lines has not been determined. In this study, we demonstrated that oridonin inhibited ovarian cancer cell proliferation, migration and invasion in a dose-dependent manner. Furthermore, we showed oridonin inhibited tumor growth of ovarian cancer cells (SKOV3) in vivo. We then assessed mechanisms and found that oridonin specifically abrogated the phosphorylation/activation of mTOR signaling. In summary, our results indicate that oridonin is a potential inhibitor of ovarian cancer by blocking the mTOR signaling pathway.

• Bulletin of the Korean Chemical Society
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• v.31 no.8
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• pp.2211-2214
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• 2010

The whole plant of Euphorbia helioscopia is an important traditional Chinese medicine. Fom its BuOH soluble extract, one new lactam (1), three new terpenoids (2-4) including a new naturally occurring compound, and three known compounds were isolated. Their structures were identified by spectroscopic evidences. In particular, the absolute configurations of side chain of compounds 1 and 2 were determined using computational methods.

• Journal of Power Electronics
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• v.17 no.5
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• pp.1256-1267
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• 2017

A fault tolerant structure and its corresponding control strategy for electromagnetic stirring power supplies are proposed in this paper. The topology structure of the electromagnetic stirring power supply contains two-stages. The fore-stage is the PWM rectifier. The back-stage is the fault tolerant inverter, which is a two-phase three-bridge orthogonal inverter circuit while operating normally. When the power switch devices in the inverter are faulty, the structure of the inverter is reconfigured. The two-phase half bridge inverter circuit is constructed with the remaining power switch devices and DC-link capacitors to keep the system operating after cutting the faulty power switch devices from the system. The corresponding control strategy is proposed to let the system work under both normal and fault conditions. The reliability of the system is improved and the requirement of the electromagnetic stirring process is met. Finally, simulation and experimental results verify the feasibility of the proposed fault tolerant structure and corresponding control strategy.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5725-5728
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• 2012

Growing evidence shows that deregulation of the circadian clock plays an important role in the development of malignant tumors, including gliomas. However, the molecular mechanisms of gene chnages controlling circadian rhythm in glioma cells have not been explored. Using real time polymerase chain reaction and immunohistochemistry techniques, we examined the expression of two important clock genes, cry1 and cry2, in 69 gliomas. In this study, out of 69 gliomas, 38 were cry1-positive, and 51 were cry2-positive. The expression levels of cry1 and cry2 in glioma cells were significantly different from the surrounding non-glioma cells (P<0.01). The difference in the expression rate of cry1 and cry 2 in high-grade (grade III and IV) and low-grade (grade 1 and II) gliomas was non-significant (P>0.05) but there was a difference in the intensity of immunoactivity for cry 2 between high-grade gliomas and low-grade gliomas (r=-0.384, P=0.021). In this study, we found that the expression of cry1 and cry2 in glioma cells was much lower than in the surrounding non-glioma cells. Therefore, we suggest that disturbances in cry1 and cry2 expression may result in the disruption of the control of normal circadian rhythm, thus benefiting the survival of glioma cells. Differential expression of circadian clock genes in glioma and non-glioma cells may provide a molecular basis for the chemotherapy of gliomas.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.2
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• pp.167-176
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• 2023

This study aims to explore the impact of Rehmannioside D (RD) on ovarian functions of rats with diminished ovarian reserve (DOR) and its underlying mechanisms of action. A single injection of cyclophosphamide was performed to establish a DOR rat model, and fourteen days after the injection, the rats were intragastrically administrated with RD for two weeks. Rat estrus cycles were tested using vaginal smears. Ovarian tissues were histologically evaluated, the number of primordial, mature, and atretic follicles was calculated, and the apoptotic rate of granulosa cells. Follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E₂) levels were determined by ELISA assays. Protein levels of Forkhead Box O1 (FOXO1), KLOTHO, Bcl-2, and Bax were investigated in ovarian tissues of DOR rats. The binding between FOXO1 and KLOTHO was verified by ChIP assay. High-dose administration of RD into DOR rats improved their estrus cycles, increased ovarian index, enhanced the number of primordial and mature follicles, reduced the number of atretic follicle number, and ovarian granulosa cell apoptosis in addition to inhibiting FSH and LH levels and upregulating E₂ expression. FOXO1 and KLOTHO were significantly suppressed in DOR rats. FOXO1 knockdown partially suppressed the protective effects of RD on DOR rats, and KLOTHO overexpression could restore RD-induced blockade of DOR development despite knocking down FOXO1. FOXO1 antibody enriched KLOTHO promoter, and the binding between them was reduced in DOR group compared to that in sham group. RD improved ovarian functions in DOR rats and diminished granulosa cell apoptosis via the FOXO1/KLOTHO axis.

• Structural Engineering and Mechanics
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• v.42 no.2
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• pp.269-289
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• 2012

Free vibration and dynamic responses of piles semi-rigidly connected with the superstructures are investigated. Timoshenko beam theory is employed to characterize the pile partially embedded in a two-parameter elastic foundation. The formulations for the method of reverberation-ray matrix (MRRM) are then derived to investigate the dynamics of the pile with surface cracks, which are modeled as massless rotational springs. Comparison with existent numerical and experimental results indicates the proposed method is very effective and accurate for dynamic analysis, especially in the high frequency range. Finally, the effects of some physical parameters on the natural frequencies, frequency responses and transient responses of the piles are studied.

• Wind and Structures
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• v.6 no.2
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• pp.151-164
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• 2003

On the basis of the first Lyapunov stability theory, this paper develops a dynamic stability criterion for elastic structural systems under arbitrary dynamic loads, and shows the stability criterion using energy variation. After the dynamic stability criterion is validated through a classic example, it is used for the dynamic stability investigation of practical guyed masts under random wind loads. The criterion is reliable, simple and of advantage for structures with large number of elements and nodes. The slack guys and internal resonance between guys and mast are two main factors which induces the dynamic instability of guyed masts, at the same time, some dynamic stability characteristics of guyed masts are found.

• Bulletin of the Korean Chemical Society
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• v.33 no.2
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• pp.571-574
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• 2012

In present study, CdSe quantum dots (QDs) were prepared with a novel but simple, effective and exercisable method. Nine different types of carbohydrate molecules were used to modify CdSe QDs. D-mannose (Man)-coated quantum dots were prepared for labeling human hepatoma (HepG2) cells, because of the high expression of mannose receptor (MR) on HepG2 cells. The uptake characteristics of CdSe QDs-Man were investigated in HepG2 cells. The absorption rate result of MTT assay in 48 h suggested the extremely low cytotoxicity of CdSe QDs-Man. The presence of quantum dots was confirmed with fluorescence microscopy. These results were encouraging regarding the application of QDs molecules for early detection of HepG2 cells.