• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.20 no.4
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• pp.282-294
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• 2010

The purpose of SAICM (Strategic Approach to International Chemicals Management) is to minimize the health and environmental hazards from the production and the consumption of chemicals by improving the chemicals management capability of developing countries and implementing a system of the risk assessment and the management based on the precautionary principle until 2020. To achieve this purpose, the UN has prescribed the principles, objectives and establishment of an action plan for the chemicals management strategy which must be carried out at international, local, and national levels, and requested the implementation of the Global Plan of Action (GPA) comprising of 273 recommendations in 36 work areas. SAICM is currently based on voluntary participation, but is expected to become the basic framework of international order in relation to chemicals management in the future. This study aims to analyze the practice in the occupational safety and health area relating to implement 273 recommendations of the GPA, and propose complementary measures for the system in order to provide political advices for establishing future plans to manage industrial chemicals. Twenty three areas of total 36 work areas and 161 items of 273 recommendations have relevance to occupational safety and health areas. We have found that, as a national implementation level, 157 of 161 industrial safety and health items are being implemented at a satisfactory level in regard to the implementation of the GPA, while 4 items, including the ratification of the ILO Conventions 170, 174, 184, and support for GHS (Globally Harmonized System of Classification and Labeling of chemicals) implementation of developing countries, require additional complementary measures for the system and operation.

• Environmental Analysis Health and Toxicology
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• v.18 no.2
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• pp.137-143
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• 2003

To validate and to estimate the chemical hazard playa very important role to environment and human health. The detection of many synthetic chemicals used in industry that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. In this resepct, the clastogenicity of 8 synthetic chemicals was evaluated with bone marrow micronucleus assay in mice. The positive control, mitomycin C(2mg/kg,i.p.) revealed significant induction ratio of percentage of micronucleated polychromatic erythrocytes/l,000 polychromatic erythrocytes compared to carboxymethylcellulose control. The chemicals with relatively high LD$\_$50/ value such as phenylisocyanate (CAS No. 103-71-9), m-aminochlorobenzene (CAS No. 108-42-9) and 2-chloro-4-nitroaniline (CAS No. 121-87-9) revealed no significant induction of micronucleated polychromatic erythrocytes in mice. From this results, 8 synthetic chemicals widely used in industry have revealed no significant micronucleus induction of clastogenicity in mice in this experiment.

• Environmental Mutagens and Carcinogens
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• v.24 no.2
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• pp.99-107
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• 2004

The validation of many synthetic chemicals that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. In this respect, the regulation and evaluation of the chemical hazard playa very important role to environment and human health. The clastogenicity of 11 synthetic chemicals was evaluated in Chinese hamster lung (CHL) fibroblast in vitro. Benzoyl chloride (CAS No. 98-88-4) induced chromosomal aberrations with statistical significance at the concentration of 31-123 $\mug/ml$ and 43 $\mug/ml$ in the absence and presence of S-9 metabolic activation system, respectively. 2-Propyn-l-o1 (CAS No. 107-19-7) and 2-Phenoxy ethanol (CAS No. 122-99-6) revealed clastogenicity only at the highest concentration in the presence of S-9 mixture. However, 1-naphthol (CAS No. 90-15-3) which is one of the most cytotoxic chemical among 11 chemicals tested revealed no clastogenicity both in the presence and absence of S-9 metabolic activation system. From the results of chromosomal aberration assay with 11 synthetic chemicals in CHL fibroblast in vitro, Benzoyl chloride (CAS No. 98-88-4), 2-Propyn-l-01 (CAS No. 107-19-7) and 2-Phenoxy ethanol (CAS No. 122-99-6) revealed positive clastogenic results in this study.

• Journal of Technologic Dentistry
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• v.32 no.3
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• pp.221-232
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• 2010

Purpose: It is necessary for dental technicians exposed to hazardous chemicals in the dental laboratories to be informed of the various harmful effects of chemicals for their health and safety. The purposes of this study was to investigate the actual condition of the use of MSDS in dental laboratories and the recognition rate of MSDS for dental technicians. Methods: 231 dental technicians who were self-written questionnaire. The results were analyzed by SPSS 12.0. The answers to the questionnaire underwent frequency analysis, chi-square test and correlation analysis were performed to investigate association between health effects and recognition rate of chemical information. Results: The results from the effects of damage caused by chemicals 60.7%, and when it was less than 2 years working experience 47.6%. Currently any dental laboratories(rooms) was not furnished MSDS(0%) and even similar data furnishing rate was only 17.3%. Answer rate of 'Do not know about MSDS' was 73.6%. In addition to, education in the types and characteristics of chemicals(74.5%) does not receive all the higher education. For the question of 'To prevent human risks and accidents, is to provide chemical information needed', the answer rate of 'needed' was 87.2%. Moreover, the answer rate of 'To provide chemical information that could prevent accidents' was 76.6%. Therefore it was found that dental technicians need to be provided for chemical information. In addition, they wanted to get education related to chemicals used in the workplace(80.5%), and 90.9% was answered that they was willing to keep MSDS in they workplace. Conclusion: This study investigated the current dental laboratories(rooms) and the MSDS for the awareness and recognition of workers was very low, education was not being conducted properly. The dental laboratories(rooms) of the compact characteristics of the MSDS was not reasonably accessible and the furnishing location, dental laboratories(rooms) for the real item was needed for improvement. MSDS for dental technicians through education and promotion of information about chemicals and chemicals was to prevent health problems caused by the MSDS that will raise awareness of the necessity.

• Safety and Health at Work
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• v.11 no.2
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• pp.152-158
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• 2020

Background: The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) was developed to enhance chemical classification and hazard communication systems worldwide. However, some of the elements such as building blocks and data sources have the potential to cause "disharmony" to the GHS, particularly in its classification results. It is known that some countries have developed their own lists of classified chemicals in accordance with the GHS to "standardize" the classification results within their respective countries. However, the lists of classified chemicals may not be consistent among these countries. Method: In this study, the lists of classified chemicals developed by the European Union, Japan, Malaysia, and New Zealand were selected for comparison of classification results for carcinogenicity, germ cell mutagenicity, and reproductive toxicity. Results: The findings show that only 54%, 66%, and 37% of the classification results for each Carcinogen, Mutagen and Reproductive toxicants hazard classes, respectively are the same among the selected countries. This indicates a "moderate" level of consistency among the classified chemicals lists. Conclusion: By using classification results for the carcinogenicity, germ cell mutagenicity, and reproductive toxicity hazard classes, this study demonstrates the "disharmony" in the classification results among the selected countries. We believe that the findings of this study deserve the attention of the relevant international bodies.

• Journal of Environmental Science International
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• v.19 no.6
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• pp.715-735
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• 2010

This study is designed to assess the priority order of the chemicals to cause to generate occupational diseases in order to understand the fundamental data required for the preparation of health protective measure for the workers dealing with chemicals. The 41 types of 51 ones of chemicals to cause to generate the national occupational diseases were selected as the study objects by understanding their domestic use or not, and their occupational diseases' occurrence or not among 110,608 types of domestic and overseas chemicals. To assess their priority order the sum of scores was acquired by understanding the actually classified condition based on a perfect score of physical riskiness(90points) and health toxicity(92points) as a classification standard by GHS, the priority order on GHS riskiness assessment, GHS toxicity assessment, GHS toxic xriskiness assessment(sum of riskiness plus toxicity) was assessed by multiplying each result by each weight of occupational disease's occurrence. The high ranking 5 items of chemicals for GHS riskiness assessment were turned out to be urethane, copper, chlorine, manganese, and thiomersal by order. Besides as a result of GHS toxicity assessment the top fives were assessed to be aluminum, iron oxide, manganese, copper, and cadium(Metal) by order. On the other hand, GHS toxicity riskiness assessment showed that the top fives were assessed to be copper, urethane, iron oxide, chlorine and phenanthrene by order. As there is no material or many uncertain details for physical riskiness or health toxicity by GHS classification though such materials caused to generate the national occupational diseases, it is very urgent to prepare its countermeasure based on the forementioned in order to protect the workers handling or being exposed to chemicals from health.

• Journal of the Society of Disaster Information
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• v.9 no.1
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• pp.50-55
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• 2013

Self-Prevention Plan Review Report and Review Standards Process Safety Management(PSM), Safety Management System(SMS), including the contents of the safety management system audit standards, notices and guidelines on the screening form and were analyzed. Were expected through the interview and screening personnel in the screening process to identify problems prior research so that it can be reflected in the. Also divided into methods such as document review and on-site implementation status of the review written Emergency Preparedness Plan depending on the item proposed. Toxic Chemicals Control Act(TCCA) Self-Prevention Plan Review Regulations. However, the substantial approval process, and do not enable the system performance lacked Self-Prevention Plan Review. Review half configuration to enhance the professionalism and efficiency of the work of this research was performed.

• Korean Journal of Hazardous Materials
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• v.6 no.2
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• pp.1-6
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• 2018

The use of chemicals to enhance and improve life is a widespread practice worldwide. But alongside the benefits of these products, there is also the potential for adverse effects to people or the environment. Thus, If anyone handles hazardous chemicals, they should adhere to specific criteria for hazardous chemicals. This study used hazard statement(H-code) and precautionary statement(P-code) to set specific criteria for handling chemicals. According to the UN GHS, hazard statement means a statement assigned to a hazard class and category that describes. And a precautionary statement is a phrase which describes recommended measures that should be taken to minimize or prevent adverse effects resulting from exposures to a hazardous product, or improper storage or handling of a hazardous product. The study suggests the treatment criteria(Public Notice) of 785 types of hazardous chemicals managed by the Chemical Control Act.

• Journal of Adhesion and Interface
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• v.22 no.1
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• pp.8-15
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• 2021

In this study, a polyol was prepared using Jeffamine D-400 as a propylene glycol-based diamine to impart flexibility to the urethane-modified epoxy, and a urethane-modified epoxy was synthesized using the polyol. Urethane-modified epoxy synthesized with existing Bisphenol A diglycidyl ether (BADGE) epoxy, a curing agent, and a curing accelerator are mixed to prepare an epoxy adhesive, and shear strength is measured by measuring adhesion strength. As a result, shear strength and shear elongation tended to increase. These results are due to the high crosslinking density. It is believed that it can be applied to structural adhesives that are restricted in use.

• Journal of Environmental Health Sciences
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• v.44 no.6
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• pp.572-580
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• 2018

Objectives: Human biomonitoring (HBM) is a measurement of the chemicals and their metabolites in human biological samples and has been successfully employed to determine the exposure levels of environmental chemicals. In this study, we analyzed seasonal variations of the blood or urinary levels of chemicals, and assessed that these differences could affect the results of association study. Methods: The Korea National Environmental Health Survey (KoNEHS) is a nationwide survey that analyzes exposure levels of environmental pollutants, 19 kinds of chemicals including heavy metals and organic chemicals, and the exposure factors in the general population. Based on KoNEHS data, we analyzed the levels of chemicals concentrations over the total survey period (2012-2014) and each season, and assessed the association of thyroid measures with phthalate metabolite and BPA. Results: Exposure levels of blood mercury and lead were lower in summer compare to winter. Bisphenol A and PAHs metabolites were higher in spring and summer, but lower in autumn. VOCs metabolites were generally lower in summer and autumn. Phthalate metabolites were higher in all other seasons than in winter. Pyrethroid metabolite, 3-PBA, was higher in summer and autumn. Regarding seasonal variation of chemical exposures, the statistical significance and size of effects between thyroid measures and phthalate and BPA were changed with season. Conclusion: Seasonal variations of chemical exposure and health outcome should be considered for interpreting biomonitoring results from a public health context.