Browse > Article
http://dx.doi.org/10.5668/JEHS.2018.44.6.572

Seasonal Variations of Exposure to Environmental Chemicals: Implication from the Korean National Environmental Health Survey (2012-2014)  

Hwang, Moon-Young (Environmental Health Research Division, National Institute of Environmental Research)
Ryu, Jung-Min (Environmental Health Research Division, National Institute of Environmental Research)
Kown, Young-Min (Environmental Health Research Division, National Institute of Environmental Research)
Hong, Soo-Yeon (Environmental Health Research Division, National Institute of Environmental Research)
Park, Choong-Hee (Environmental Health Research Division, National Institute of Environmental Research)
Publication Information
Journal of Environmental Health Sciences / v.44, no.6, 2018 , pp. 572-580 More about this Journal
Abstract
Objectives: Human biomonitoring (HBM) is a measurement of the chemicals and their metabolites in human biological samples and has been successfully employed to determine the exposure levels of environmental chemicals. In this study, we analyzed seasonal variations of the blood or urinary levels of chemicals, and assessed that these differences could affect the results of association study. Methods: The Korea National Environmental Health Survey (KoNEHS) is a nationwide survey that analyzes exposure levels of environmental pollutants, 19 kinds of chemicals including heavy metals and organic chemicals, and the exposure factors in the general population. Based on KoNEHS data, we analyzed the levels of chemicals concentrations over the total survey period (2012-2014) and each season, and assessed the association of thyroid measures with phthalate metabolite and BPA. Results: Exposure levels of blood mercury and lead were lower in summer compare to winter. Bisphenol A and PAHs metabolites were higher in spring and summer, but lower in autumn. VOCs metabolites were generally lower in summer and autumn. Phthalate metabolites were higher in all other seasons than in winter. Pyrethroid metabolite, 3-PBA, was higher in summer and autumn. Regarding seasonal variation of chemical exposures, the statistical significance and size of effects between thyroid measures and phthalate and BPA were changed with season. Conclusion: Seasonal variations of chemical exposure and health outcome should be considered for interpreting biomonitoring results from a public health context.
Keywords
Biomonitoring; seasonal variation; thyroid measures; phthalates; bisphenol A;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Park CH, Hwang MY, Kim HJ, Ryu SD, Lee KJ, Choi KH, Paek DM. 2016. Early snapshot on exposure to environmental chemicals among Korea adults- results of the first Korean National Environmental Health Survey (2009-2011). Int J. Hyg Environ Health. 219: 398-404.   DOI
2 Masih A, Lall AS, Taneja A, Singhvi R. 2017. Exposure profiles, seasonal variation and health risk assessment of BTEX in indoor air of homes at different microenvironment of a terai province of northern India. Chemosphere. 176: 8-17.   DOI
3 Smith MN, Workman T, McDonald KM, et al. Seasonal and occupational trends of five organophosphate pesticides in house dust. J Expo Sci Environ Epidemiol. 2016; 27:372-378.
4 Weiss L, Arbuckle TE, Fisher M, et al. Temporal variability and sources of triclosan exposure in pregnancy. Int J Hyg Environ Health. 2015; 218: 507-513.   DOI
5 Wu L, Zhou X, Zhao D, Feng T, Zhou J, Wang TSJ, Wang C. 2017. Seasonal variation and exposure risk assessment of pesticide residues in vegetables from Xinjiang Uygur Autonomous Region of China during 2010-2014. J Food Composition and Analysis. 58: 1-9.   DOI
6 Behall KM, Scolfield DJ, Hallfrisch JG, Kelsay JL, Reiser S. 1984. Seasonal variation in plasma glucose and hormone levels in adult men and women. Am J Clin Nutri. 1352-1356.
7 Lips P, Hackeng L, Jongen MJM, Van Ginkel FC, Netelenbos JC. 1983. Seasonal variation in serum concentrations of parathyroid hormone in elderly people. J Clin Endocrinol and Metabol. 204-206.
8 Choi WH, Kim SJ, Baek YW, Choi KH, Lee KJ, Kim SK, Yu SD, Choi KH. 2017. Exposure to environmental chemicals among Korean adults-updates from the second Korean National Environmental Health Survey (2012-2014). Int. J. Hyg. Environ. Health 220: 29-35.
9 Roberto S, Giancarlo C, Michele B, Guido G, Luisa SL, Alberto Z, Guiseppe O. 1998. Seasonal variations in home and ambulatory blood pressure in the PAMELA population.
10 Romano ME, Kalloo G, Etzel T, Braun JM. 2017. Seasonal variation in exposure to endocrine-disrupting chemicals. Epidemiology. 28(5): e42-e43.   DOI
11 Park CH, Choi WH, Hwang MY, Lee YM. Kim SJ, Ryu SD, Lee IA, Paek DM, Choi KH. 2017. Association between urinary phthalate metabolites and bisphenol A levels, and thyroid hormones among Korean adults population-Korean National Environmental Health Survey (KoNEHS) 2012-2014. Sci. Total Environ. 584-585: 950-957.   DOI
12 Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. 2005. Urinary creatinine concentrations in the U.S. population: implication for urinary biologic monitoring measurements. Environ Health Perspect. 113: 192-200.   DOI
13 Lakind JS, Sobus JR, Goodman M, Barr DB, Furst P, Albertini RJ, Arbuckle TE, Schoeters G, Tan YM, Teeguarden J, Tornero-Velez R, Weisel CP. 2014. A proposal for assessing study quality: Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument. Environ Int. 73, 195-207.   DOI
14 질병관리본부. 2017. 계절에 따른 식품 및 영양소 섭취 현황. 주간 건강과 질병. 제10권. 49호: 1333-1337.
15 Heudorf U, Mersch-Sundermann V, Angerer J. 2007. Phthalate: Toxicology and exposure. Int J. Hyg Environ Health. 210: 623-634.   DOI
16 Engstrom A, Michaelsson K, Suwanzono Y, Wolk A, Vahter M, Akesson A. 2011. Long-term cadmium exposure and the association with bone mineral density and factures in a population-based study among women. J Bone & Mineral Reseach. 26(3): 486-495.   DOI
17 강공언, 김남송, 신은상. 2011. 익산지역 대기 중 PM10과 PM2.5의 계절별 특성. 한국환경보건학회지 37: 29-43.
18 Lee BK and Hieu NT. 2011. Seasonal variation and sources of heavy metals in atmospheric aerosols in a residential area of Ulsan, Korea. Aerosol and air Quality Research. 11: 679-688.   DOI
19 Ho KF, Lee SC, Guo H, Tsai WY. 2004. Seasonal and diurnal variations of volatile organic compounds (VOCs) in the atmosphere of Hong Kong. Sci of Tot Environ. 332: 155-166.   DOI
20 Erythropel HC, Maric M, Nicell JA, Leask RL, Yargeau V. 2014. Leaching of the plasticizer di(2-ethylhexyl) phthalate (DEHP) from plastic containers and the question of human exposure. Appl Microbiol Biotechnol. 98: 9967-9981.   DOI
21 lee JY, Shin HJ, Bae SY, Kim YP, Kang CH. 2008. Seasonal variation of particulate size distributions of PAHs at Seoul, Korea. Air Qual Atmos Health. 1: 57-68.   DOI
22 Martorell I, Nieto A, Nadia M, Perello G, Marce RM, Domingo JL. 2012. Human exposure to polycyclic aromatic hydrocarbons (PAHs) using data from a duplicate diet study in Catalonia, Spain. Food and Chem Toxicol. 50(11): 4103-4108.   DOI
23 Imai K, Yoshinaga J, Yoshikane M, Shiraishi H, Mieno MN, Yoshiike M, Nozawa S, Iwamoto T. 2014. Pyrethroid insecticide exposure and semen quality of young Japanese men. Reprod Toxicol 43:38-44. doi:10.1016/j.reprotox.2013.10.010   DOI
24 Saillenfait AM, Ndiaye D, Sabate JP. 2015. Pyrethroids: Exposure and health effects-An update. Int J Hyg Environ Health. 218: 281-292.   DOI
25 Hays SM, Aylward L, Lakind JS. 2007. Introduction to the Biomonitoring Equivalents pilot projects: Development of quidlines for the derivation and communication of Biomonitoring Equivalents. Regul Toxicol and Phramacol. 47: 96-109.   DOI
26 Kommission Human-Biomonitoring des Umweltbundesamtes, 1996. Human-biomonitoring: Definitionen, Moglichkeiten und Voraussetzungen. Bundesgesundheitsbl 39, 213-214.
27 National Research Council, 2006. Human biomonitoring for environmental chemicals. In: Committee on Human Biomonitoring for Environmental Toxicants. The National Academies Press, Washington, DC.
28 Angerer, J., Bolt, HM., Bruning, T., Drexler, H., Eikmann, T., Ewers, U., Gieler, U., Greim, H., Hallier, E., Letzel, S., Mersch-Sundermann, V.H., Neuberger, M., Nowak, D., Rudiger, H.W., 2004. Uber das Biological Monitoring, den Unwillen Gesundheitsrisiken rational abzuschatzen und die Lust an radikalen Massnahmen. Umweltmed. Forsch. Prax. 9, 61-64.
29 Hays SM, Becker RA, Leung HW, Aylward LL, Pyatt DW. 2007. Biomonitoring equivalents: A screening approach for interpreting biomonitoring results from a public health risk perspective. Regulatory Toxicol & Parmarcol. 47: 96-109.   DOI
30 Angerer, J., Bird, M.G., Burke, T.A., Doerrer, N.G., Needham, L., Robison, S.H., Sheldon, L., Zenick, H., 2006. Meeting Report: Strategic Biomonitoring Initiatives: Moving the Science Forward. Toxicol. Sci. published online June 19th, 2006, doi:10.1093/toxsci/kfl042.
31 박충희, 유승도. 2014. 국민환경보건기초조사의 현황 및 전망. 한국환경보건학회지. 40(1): 1-9.   DOI
32 CDC (Centers for Disease Control and Prevention). 2015. Fourth National Report on Human Exposure to Environmental Chemicals, Update Tables. Washington, DC: CDC.
33 Health Canada. 2013. Second Report on Human Biomonitoring of Environmental Chemicals in Canada: Results of the Canadian Health Measures Survey Cycle 2 (2009-2011).