• 제목/요약/키워드: Chemical test

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Development of kNN QSAR Models for 3-Arylisoquinoline Antitumor Agents

  • Tropsha, Alexander;Golbraikh, Alexander;Cho, Won-Jea
    • Bulletin of the Korean Chemical Society
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    • 제32권7호
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    • pp.2397-2404
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    • 2011
  • Variable selection k nearest neighbor QSAR modeling approach was applied to a data set of 80 3-arylisoquinolines exhibiting cytotoxicity against human lung tumor cell line (A-549). All compounds were characterized with molecular topology descriptors calculated with the MolconnZ program. Seven compounds were randomly selected from the original dataset and used as an external validation set. The remaining subset of 73 compounds was divided into multiple training (56 to 61 compounds) and test (17 to 12 compounds) sets using a chemical diversity sampling method developed in this group. Highly predictive models characterized by the leave-one out cross-validated $R^2$ ($q^2$) values greater than 0.8 for the training sets and $R^2$ values greater than 0.7 for the test sets have been obtained. The robustness of models was confirmed by the Y-randomization test: all models built using training sets with randomly shuffled activities were characterized by low $q^2{\leq}0.26$ and $R^2{\leq}0.22$ for training and test sets, respectively. Twelve best models (with the highest values of both $q^2$ and $R^2$) predicted the activities of the external validation set of seven compounds with $R^2$ ranging from 0.71 to 0.93.

옥상녹화 및 인공지반녹화용 구리시트 방근재의 성능평가에 관한 연구 (A Study on the Performance Appraisal for Copper Sheet as Root Barrier Material Appling to Green Roof System)

  • 조일규;권시원;곽규성;오상근
    • 한국건축시공학회:학술대회논문집
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    • 한국건축시공학회 2007년도 춘계학술논문 발표대회
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    • pp.5-8
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    • 2007
  • Selection of proper root barrier as destination part of greening is very important in Root penetration resistance plan. To select proper root barrier, it need to understand composition of greening part, size, kind of plant, connection with waterproofing layer. In this point of view, we have establish greening on the roof or concrete structure, not been understand the structural mechanism. It means that we misunderstood about purpose of greening and using it. So, chosen materials and construction method was not proper for greening, it caused water leakage and decrease performance of concrete structure. Therefore, we examine the practical use of copper sheet considering environmental condition for green roof. Watertightness by water of greening part, root penetration resistance test by root penetration, bacteria resistance by must or bacteria in soil, chemical resistance by rain and chemical agent of fertilizer, and load resistance by soil depth, sire of plant. These suggested test methods could be referred as guideline to test in green roof system because of not exist any performance appraisal guideline or standard. Consequently, it should be analysis as technical and institutional subdividing test methods and it need to study constantly as varied angles.

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전갈(全蝎) 약침액(藥鍼液)의 항돌연변이(抗突然變異) 및 항암(抗癌) 효과(效果) (The antimutagenic effect and genetic safety of Buthus martensi Karsch aqua-acupuncture solution (BMKAS))

  • 김소형;김갑성
    • Journal of Acupuncture Research
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    • 제17권3호
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    • pp.151-167
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    • 2000
  • Objective : The aim of this study is to determine the antimutagenic effect and genetic safety of Buthus martensi Karsch aqua-acupuncture solution(BMKAS) against various chemical carcinogens. Method : Ames(Salmonella typhimurium) test and Rec assay(Bacillus subtilis) were used as indicators for DNA damage and antimutagenesis. Furthermore, the levels of umu operon expression by measuring the ${\beta}$-galactosidase activity wete monitored with the SOS umu test using S. typhimurium 1535 containing plasmid pSK1002. And the host-mediated assay was used to investigate the mutagenicity and antimutagenicity of BMKAS inducing various chemical carcinogens after the activation with in vivo metabolic systems. Results : From the results, BMKAS did not atfect DNA of S. typhimurium and B. subtilis strains and showed no mutagenicity at the all concentrations of tested solution. Furthermore BMKAS dose-dependently protected the mutagenecity by AF-2, 2-AA and B[a]P. These phenomena was also similar to that after metabolic activation of BMKAS in in vivo system. Conclusion : These results suggested that BMKAS did not show the mutagenicity and protected the mutagenesis against various chemical carcinogens by four different methods used in this study.

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13K Chemical Tanker의 기관 제어 불능상태 IMO 2세대 안정성 평가에 관한 실험적 연구 (An Experimental Study on IMO 2nd Generation Stability Assessment in Dead Ship Condition of 13K Chemical Tanker)

  • 이상범;문병영
    • 대한조선학회논문집
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    • 제59권2호
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    • pp.89-95
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    • 2022
  • The stability of the existing ships has been evaluated through numerical calculations in the steady-state, but recently the IMO proposed a new stability assessment criteria that the stability is evaluated in the state in which environmental loads from such as waves and wind act like the loads under actual ship operating conditions. In this study, IMO 2nd generation stability assessment method and procedure were summarized for the dead ship condition, and Direct Stability Assessment (DSA) was performed on 13K chemical tanker through basin model test. The model test is performed in the ocean engineering basin to implement wave and wind loads, and environmental conditions for waves were set height and period of the incident wave, considering the regular wave and wind generation range reproducible in the ocean engineering basin. In addition, to consider the effect of wind speed, the Beaufort Scale for wind speed was applied in the model test.

Verification of mechanical failure mode through corrosion test of a pump for soil sterilizer injection

  • Han-Ju Yoo;Jooseon Oh;Sung-Bo Shim
    • 농업과학연구
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    • 제50권4호
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    • pp.817-828
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    • 2023
  • Deteriorating soil physical properties and increasing soil pathogens due to the continuous cultivation of field crops are the leading causes of productivity deterioration. Crop rotation, soil heat treatment, and chemical control are used as pest control methods; however, each has limitations in wide application to domestic agriculture. In particular, chemical control requires improvement due to direct exposure to sterilizing solution, odor, and high-intensity work. To improve the overall domestic agricultural environment, the problems of time and cost, such as field maintenance and cultivation scale, must be addressed; therefore, mechanization technology for chemical control must be secured to derive improvement effects in a short period. Most related studies are focused on the control effect of the DMDS (dimethyl disulfide) sterilizer, and research on the performance of the sterilization spray device has been conducted after its introduction in Korea, but research on the corrosion suitability of the material is lacking. This study conducted a corrosion test to secure the corrosion resistance of a soil sterilizer injection pump, and a mechanical failure mode by corrosion by the material was established. The corrosion test comprised operation and neglect tests in which the sterilizing solution was circulated in the pump and remained in the pump, respectively. As a result of the corrosion test, damage occurred due to the weakening of the mechanical strength of the graphite material, and corrosion resistance to aluminum, stainless steel, fluororubber, and PPS (polyphenylene sulfide) materials was confirmed.

중온화 액상형 화학첨가제 개발과 이를 적용한 중온 아스팔트의 성능 평가 (Development and Performance Evaluation of Liquid-type Chemical Additive for Warm-Mix Asphalt)

  • 백철민;양성린;황성도
    • 한국도로학회논문집
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    • 제15권4호
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    • pp.107-116
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    • 2013
  • PURPOSES: The liquid-type chemical warm-mix asphalt (WMA) additive has been developed. This study evaluates the basic properties of the additive and the mechanical properties of WMA asphalt and mixture manufactured by using the newly developed chemical additive. METHODS: First, the newly developed WMA additive was applied to the original asphalt by various composition of additive components and dosage ratio of additive. These WMA asphalt binders were evaluated in terms of penetration, softening point, rotational viscosity, and PG grade. Based on the binder test results, one best candidate was chosen to apply to the mixture and then the mechanical properties of WMA mixture were evaluated for moisture susceptibility, dynamic modulus, and rutting and fatigue resistance. RESULTS : According to the binder test, WMA asphalt binders showed the similar properties to the original asphalt binder except the penetraion index of WMA additive was a little higher than original binder. From the Superpave mix design, the optimum asphalt content and volumetric properties of WMA mixture were almost the same with those of hot mix asphalt (HMA) mixture even though the production and compaction temperatures were $30^{\circ}C$ lower for the WMA mixture. From the first set of performance evaluation, it was found that the WMA mixture would have some problem in moisture susceptibility. The additive was modified to improve the resistance to moisture and the second set of performance evaluation showed that the WMA mixture with modified chemical additive would have the similar performance to HMA mixture. CONCLUSIONS : Based on the various laboratory tests, it was concluded that the newly developed chemical WMA additve could be successfully used to produce the WMA mixture with the comparable performance to the HMA mixture. These laboratory evaluations should be confirmed by applying this additive to the field and monitoring the long-term performance of the pavement, which are scheduled in the near future.