• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.3
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• pp.187-198
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• 2006

The aromatic hydrocarbons (AHs), which include benzene, polycyclic aromatic hydrocarbons, and dioxin, are important chemical and environmental contaminants in industry that usually cause various diseases. Over the years, numerous studies have described and evaluated the adverse health effects induced by AHs. Currently, "Omics" technologies, transcriptomics and proteomics, have been applied in AH toxicity studies. Proteomics has been used to identify molecular mechanisms and biomarkers associated with global chemical toxicity. It could enhance our ability to characterize chemical-induced toxicities and to identify noninvasive biomarkers. The proteomic approach (e.g. 2-dimensional electrophoresis [2-DE]), can be used to observe changes in protein expression during chemical exposure with high sensitivity and specificity. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) and electrospray ionization-quadrupole (ESI-Q)-TOF MS/MS are recognized as the most important protein identification tools. This review describes proteomic technologies and their application in the proteomic analysis of AH toxicity.

• Transactions of the Korean hydrogen and new energy society
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• v.28 no.2
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• pp.166-173
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• 2017

For commercialization of hydrogen refuelling station (HRS), we need to reduce the clearance distance for jet fire in the real entities in the HRS. Thus, we revisited the current regulations of clearance distance for jet fire in the law. The law in korea has been set up by replica of japan, not by our own scientific basis. Recently, sandia lab developed Hydrogen Risk Assessment Model (HyRAM) tools and we simulated a series of circumstances such as 10 to 850 bar with several leak hole sizes. In 850 bar with 10 mm diameter hole leak cases, it shows $4,981kW/m^2$ at 12 m separation from leak source and $1,774kW/m^2$ at 17 m separation from leak source. In 850 bar with 1 mm diameter leak hole, it shows $0.102kW/m^2$ at 12 m separation and $0.044kW/m^2$ at 17 m separation. Current law may be acceptable with 1 mm hole size with 850 bar.

• Food Science of Animal Resources
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• v.29 no.4
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• pp.513-522
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• 2009

HACCP is a scientific and systematic program that identifies specific hazards and gives measures for their control to ensure the safety of foods. Based on the Livestock Products Processing Act, the HACCP system is now being applied to Korean livestock products since December 1997, and Korea is accelerating its application from farm to table, including in farms, slaughterhouses, livestock product industries, retail markets, and transportation. The transport of livestock and its products is one of the vulnerable sectors in terms of food safety in Korea. Meats are transported in trucks in the form of carcasses or packaged meats in boxes. Carcasses may be exposed to microbiological, physical, and chemical hazards from the environment or through cross-contamination from other meats. Poor cleaning or maintenance of vehicles and tools may also raise the exposure of carcasses to microbiological or chemical hazards. HACCP application and its acceleration in distribution, particularly in transport, is regarded as critical to the provision to consumers of ultimately safe livestock products. To achieve this goal, steady efforts to develop practical tools for HACCP application should be carried out.

• KSBB Journal
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• v.31 no.4
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• pp.193-199
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• 2016

Global warming caused from the heavy consumption of fossil fuel is one of the biggest problems to be solved. Biofuel has been gained more attention as an alternative to reduce the consumption of fossil fuel. Recently, butanol produced from the genus Clostridium has been considered as one of the promising alternatives for gasoline, fossil based fuel. Nevertheless, the lack of the genome-engineering tools for the genus Clostridium is the major hurdle for the economic production of butanol. More recently, genome engineering tools have been developed for metabolic engineering of butanol-producing Clostridium species, which includes genome scale network model and genome editing tools on the basis of mobile group II introns and CRISPR/Cas system. In this study, the genome engineering tools for butanol-producing Clostridium species have been reviewed with a brief future perspective.

• Journal of the Korean Society of Safety
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• v.35 no.2
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• pp.17-27
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• 2020

To identify the relationship between types of employment(regular and non-regular group) and departments classification (administration, product and research group) and the levels of recognition of chemical substances, a total of 117 workers in cosmetics workplaces. Mainly, regular group and research group showed higher recognition of chemical substances (PPE, ventilation, chemical management, hazards in handling chemicals, skin contact) than non-regular group and administration, product group, but In some cases, production and administrative groups were high. Descriptive statistics(SAS ver9.2)was performed. the results of recognition of chemical substances were analyzed the mean and standard deviation by t-test, and anova, (P=0.05). These results cosmetics manufacturing workplaces have normal level of the perception of chemical substances. In most of the employment types, the regular workers showed high recognition, and the working departments showed high recognition in the research and production groups. Therefore, OEM and ODM cosmetics manufacturers regularly identify characteristics and needs of workplaces and workers, and suggest the development of experience and practiced education programs and risk assessment tools that can raise worker awareness.

• Proceedings of the Materials Research Society of Korea Conference
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• 2012.05a
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• pp.51-51
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• 2012

There is a growing interest in innovative chemical synthesis in microreactors owing to high efficiency, selectivity, and yield. In microfluidic systems, the low-volume spatial and temporal control of reactants and products offers a novel method for chemical manipulation and product generation. Glass, silicon, poly(dimethylsiloxane) (PDMS), and plastics have been used for the fabrication of miniaturized devices. However, these materials are not the best due to either of low chemical durability or expensive fabrication costs. In our group, we have recently addressed the demand for economical resistant materials that can be used for easy fabrication of microfluidic systems with reliable durability. We have suggested the use of various specialty polymers such as silicon-based inorganic polymers and fluoropolymer, flexible polyimide (PI) films that have not been used for microfluidic devices, although they have been used for other areas. And inexpensive lithography techniques were used to fabricate Lab-on-a-Chip type of microreactors with differently devised microchannel design. These microreactors were demonstrated for various synthetic reactions: liquid, liquid-gas organic chemical reactions in heterogeneous catalytic processes, syntheses of polymer and non-trivial inorganic materials. The microreactors were inert, and withstand even harsh conditions, including hydrothermal reaction. In addition, various built-in microstructures inside the microchannels, for example Pd decorated peptide nanowires, definitely enhance the uniqueness and performance of microreactors. These user-friendly Lab-on-a-Chip devices are useful alternatives for chemist and chemical engineer to conventional chemical tools such as glass.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.9
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• pp.89-95
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• 2001

Ceramic tool has to equip with not only high toughness and strength but also low thermal expansion and good thermal conductivity which leads to the high thermal shock resistance. These characteristics make it have longer tool life under thermal stress condition. In this study, commercial Si$_3$N$_4$ceramic cutting tool and home-made SiC based ceramic cutting tools which have different sintering time and chemical composition are tested under various cutting speed and the feed rate increase, the cutting force and the flank wear growth ratio increase, too. The performance of home-made SiC based ceramic cutting tool shows the possibility to be a new ceramic tool.

• Nuclear Engineering and Technology
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• v.56 no.1
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• pp.222-232
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• 2024

New modular factory-built methodologies implemented in the construction and industrial plant industries may bring down costs for modular reactors. A factory-built environment brings about benefits such as; improved equipment, tools, quality, shift patterns, training, continuous improvement learning, environmental control, standardisation, parallel working, the use of commercial off shelf equipment and much of the commissioning can be completed before leaving the factory. All these benefits combine to reduce build schedules, increase certainty, reduce risk and make financing easier and cheaper.Currently, the construction and industrial chemical plant industries have implemented successful modular design and construction techniques. Therefore, the objectives of this paper are to understand and analyse the state of the art research in these industries through a systematic literature review. The research can then be assessed and applied to modular reactors.The literature review highlighted analysis methods that may prove to be useful. These include; modularisation decision tools, stakeholder analysis, schedule, supply chain, logistics, module design tools and construction site planning. Applicable research was highlighted for further work exploration for designers to assess, develop and efficiently design their modular reactors.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.907-910
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• 1997

With increasing the needs for micro and precision parts, micro machining technology has been studied to fabricate a small part with high density such as electronics, optics, communications, and medicine industry more than before. But there are many problems to be solved requiring a high-level technology. So this research presents the new method to fabricate a small part through applying chemical mechanical micro machining (C3M) for the Al wafer. Al(thickness I ,u m) was sputtered on the Si substrate. Al is widely used as a lightweight material. However form defect such as burr has a bad effect on products. To improve machinability of ductile material, oxide layer was formed on the surface of AI wafcr before grooving by chemical reaction with HN03(10wt%). And then workpieces were machined to compare conventional micro-machining process with newly suggested method at different machining condition such as load and feed rate. To evaluate whether or not the machinability was improved by the effect of chemical condition, such as the size, the width of grooves 'and burr generation were measured. Finally, it is confirmed that C3M is one of the feasible tools for micro machining with the aid of effect of the chemical reaction.

• Membrane and Water Treatment
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• v.1 no.1
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• pp.61-74
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• 2010

This paper will integrate models at different levels (from filtration, backwashing to chemical cleaning and membrane lifetime) that can be used to minimize overall operating costs of a dead-end ultra filtration process that is used for the purification of surface water. Integration of the models leads to a multi-level optimization problem (at different levels different objectives should be reached). This problem is solved as a MINLP. Systematic modelling and optimization of membrane systems is not extensively discussed in the scientific literature. In this paper the first steps are taken in the formulation of proper models and the use of systems engineering tools to come to real optimal operating conditions. The optimized variables are used to calculate fouling profiles which can subsequently be used as inputs for a control system that actually enforces the profiles to a real pilot plant.