• International journal of advanced smart convergence
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• v.12 no.2
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• pp.90-95
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• 2023

With the rapid development of deep learning and artificial intelligence, generative models have achieved remarkable success in the field of image generation. By combining the stable diffusion method with Web UI technology, a novel solution is provided for the application of AI painting generation. The application prospects of this technology are very broad and can be applied to multiple fields, such as digital art, concept design, game development, and more. Furthermore, the platform based on Web UI facilitates user operations, making the technology more easily applicable to practical scenarios. This paper introduces the basic principles of Stable Diffusion Web UI technology. This technique utilizes the stability of diffusion processes to improve the output quality of generative models. By gradually introducing noise during the generation process, the model can generate smoother and more coherent images. Additionally, the analysis of different model types and applications within Stable Diffusion Web UI provides creators with a more comprehensive understanding, offering valuable insights for fields such as artistic creation and design.

• Journal of Digestive Cancer Research
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• v.10 no.2
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• pp.74-81
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• 2022

Colorectal peritoneal metastasis has been an incurable disease for centuries. However, since the new millennium, recent advancements in therapies are achieved with modern chemotherapeutic agents, target agents, and immune checkpoint blockade introduction. Modern chemotherapies, from a nearly nonexistent median survival if untreated, have raised the duration to 16 months with target agents. Experts have once again surpassed its limit by introducing intraperitoneal chemotherapy and cytoreductive surgery (CRS). Numerous clinical trials regarding CRS and hyperthermic intraperitoneal chemotherapy have now opened new doors in peritoneal carcinomatosis treatment, even securing complete remission. In addition, up-to-date modalities, such as pressurized intraperitoneal aerosol chemotherapy and immunotherapies, showed promising results at an early stage.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.592-594
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• 2023

차량 탐지와 차량 추적 기술은 교통관리 시스템, 자율주행 자동차 시스템 및 이를 응용한 보안 감시 시스템, 군사 작전 및 안전 등 다양한 산업 분야에서 활용되고 있다. 본 논문에서는 차량 탐지는 YOLOv7 모델을, 차량 추적은 DeepSORT 알고리즘을 사용하여 도로의 차량들에 대해 탐지 및 추적을 순차적으로 진행하였다. 실험환경은 차량 탐지 데이터 셋(dataset)을 직접 라벨링(labeling) 하여 실험하였고, 차량 추적은 차량 탐지에서 학습해서 얻은 체크포인트(checkpoint) 모델을 가중치로 설정하여 실험을 진행하였다. 차량 탐지 실험결과는 validation 과 test 에서 높은 정확도를 확인할 수 있었고, 차량 추적은 Namsa 비디오 및 Seohaegyo 비디오에서도 차량 추적이 잘 되고 있음을 확인할 수 있었다.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.11a
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• pp.634-636
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• 2007

병렬/분산 시스템의 신뢰도를 높이기 위해서는 결함 내성 기능을 갖추는 것이 필수적이다. 본 논문에서는 원격으로 프로세스에 대해 주기적으로 검사점을 만들고 예기치 않은 장애가 발생했을 경우 이를 신속히 가장 최근의 상태로 복원시켜 시스템의 안정성을 높일 수 있는 프레임워크에 대해서 연구한다.

• Biomolecules & Therapeutics
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• v.32 no.1
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• pp.1-12
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• 2024

Adverse drug reactions (ADRs) are an inherent aspect of drug use. While approximately 80% of ADRs are predictable, immune system-mediated ADRs, often unpredictable, are a noteworthy subset. Skin-related ADRs, in particular, are frequently unpredictable. However, the wide spectrum of skin manifestations poses a formidable diagnostic challenge. Comprehending the pathomechanisms underlying ADRs is essential for accurate diagnosis and effective management. The skin, being an active immune organ, plays a pivotal role in ADRs, although the precise cutaneous immunological mechanisms remain elusive. Fortunately, clinical manifestations of skin-related ADRs, irrespective of their severity, are frequently rooted in immunological processes. A comprehensive grasp of ADR morphology can aid in diagnosis. With the continuous development of new pharmaceuticals, it is noteworthy that certain drugs including immune checkpoint inhibitors have gained notoriety for their association with ADRs. This paper offers an overview of immunological mechanisms involved in cutaneous ADRs with a focus on clinical features and frequently implicated drugs.

• Journal of Chest Surgery
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• v.36 no.12
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• pp.952-960
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• 2003

It has been reported that p53 regulates the G2-M checkpoint transition through cyclin Bl, and it has been suggested that p53 plays an important role in the development and progression of various malignancies. The aim of this study is to clarify the role of the cell cycle regulators, cyclin B1 and p53 in patients with esophageal squamous cell carcinoma (ESCC). Material and Method: Tissue samples from 46 patients with ESCC were included in this study. Expression levels of cyclin Bl and p53 in samples of normal squamous epithelium, dysplasia, and tumor cells from patients with ESCC were analyzed by immunohistochemical study Result: Several cells in the basement layer of normal epithelium expressed cyclin B1. The number of cyclin B1 positive cells tended to increase as the degree of dysplasia increased from low grade to high grade. More than 10% of tumor cells were cyclin B1 positive in 19 patients (41.3%). Several clinicopathologic parameters, including tumor stage (p<0.05), pathologic Iymph node status (p<0.05) and invasion of Iymphatic vessels (p<0.05), were correlated with the overexpression of cyclin B1. Elevated expression levels of cyclin B1 also correlated with a poor prognosis in patient with ESCC in univariate analysis (p<0.05) and multivariate analysis (p<0.05), In contrast, p53 expression exhibited significant correlation with the level of cyclin B1 expression, but was not associated with prognostic parameters in patients with ESCC. Conclusion: These findings suggest that cyclin B1 is involved in the pathogenesis of carcinoma of the esophagus and that elevated levels of cyclin B1 expression, but not p53 expression, may indicate a poor prognosis for patients with ESCC.

• Korean Journal of Remote Sensing
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• v.30 no.1
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• pp.149-160
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• 2014

Recently studies on application development and utilization using sensors and devices embedded in smartphones have flourished at home and abroad. This study aimed to analyze the accuracy of the images of smartphone to determine three-dimension position of close objects prior to the development of photogrammetric system applying smartphone and evaluate the feasibility to use. First of all, camera calibration was conducted on autofocus and infinite focus. Regarding camera calibration distortion model with balance system and unbalance system was used for the decision of lens distortion coefficient, the results of calibration on 16 types of projects showed that all cases were in RMS error by less than 1 mm from bundle adjustment. Also in terms of autofocus and infinite focus on S and S2 model, the pattern of distorted curve was almost the same, so it could be judged that change in distortion pattern according to focus mode is very little. The result comparison according to autofocus and infinite focus and the result comparison according to a software used for multi-image processing showed that all cases were in standard deviation less than ${\pm}3$ mm. It is judged that there is little result difference between focus mode and determination of three-dimension position by distortion model. Lastly the checkpoint performance by total station was fixed as most probable value and the checkpoint performance determined by each project was fixed as observed value to calculate statistics on residual of individual methods. The result showed that all projects had relatively large errors in the direction of Y, the direction of object distance compared to the direction of X and Z. Like above, in terms of accuracy for determination of three-dimension position for a close object, the feasibility to use smartphone camera would be enough.

• Journal of Gastric Cancer
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• v.5 no.4 s.20
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• pp.260-265
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• 2005

Purpose: The protein kinase Chk1 is required for cell cycle arrest in response to DNA damage and is shown to play an important role in the G2/M checkpoint. The aim of this study was to investigate the relationship between microsatellite instability and frameshift mutation of the Chk1 gene in gastric cancers. Materials and Methods: The microsatellite instability was analyzed in 95 primary gastric carcinomas by using microdissection and 6 microsatellite markers. We also peformed single strand conformational polymorphism and sequencing to detect frameshift mutation of the Chk1 gene. Results: We found positive microsatellite instability in 19 (20%) of the 95 gastric cancers, 13 high- and 6 low-frequency microsatellite instability cases. The frameshift mutation of Chk1, which resulted in a truncated Chk1 protein, was detected in two high-frequency microsatellite instability cases. Conclusion: These data suggest that the microsatellite instability may contribute to the development of gastric carcinomas through inactivation of Chk1.

• KSBB Journal
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• v.30 no.4
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• pp.175-181
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• 2015

Cells proliferate via repeating process that growth and division. This process is G1, S, G2 and M four phases consists. Monitoring the progression of the cell cycle is a specific step that to be a continuous process is repeated to adjust the start of the next step. At this time, this process is called a Checkpoint. Currently, there are three known checkpoints that G1-S phase, G2-M phase, and the M phase. In this study, we confirmed that cell cycle arrest effects by ethanol extracts of Artemisia annua Linne (AAE) in Hep3B liver cancer cells. AAE was regulated proteins which involved in cell cycle such as pAkt, pMDM2, p53, p21, pCDK2 (T14/Y15). AAE induced cell cycle arrest in G1 checkpoint through phosphorylation of CDK2. Akt and p53 upstream is inhibited by AAE and p53 activated by non-activated pMDM2, p53 inhibitor. Thereby, activated p53 is transcript to p21 and activated p21 protein is combined with Cyclin E-pCDK2 complex. Therefore, we confirmed that AAE-induced cell cycle arrest was occurred by p21-Cyclin E-pCDK2 complex by inhibition of pAkt signal. Because of this cell cycle can't pass to S phase from G1 phase.

• Journal of KIISE:Databases
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• v.28 no.3
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• pp.494-511
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• 2001

In the environment that database management systems manage disk spaces for storing databases directly, this paper proposes a correct and efficient scheme of performing pending actions for the removal of database files. As for performing pending actions, upon performing recovery, the recovery process must identify unperformed pending actions of not-yet-terminated transactions and then perform those actions completely. Making the recovery process identify those actions through the analysis of log records in the log file is the basic idea of this paper. This scheme, as an extension of the execution of transactions, fuzzy checkpoint, and recovery of ARIES, uses the following methods: First, to identify not-yet-terminated transactions during recovery, transactions perform pending actions after writing 'pa_start'log records that signify both the commit of transactions and the start of executing pending actions, and then write 'eng'log records. Second, to restore pending-actions-lists of not-yet-terminated transactions during recovery, each transaction records its pending-actions-list in 'pa_start'log record and the checkpoint process records pending-actions-lists of transactions that are decided to be committed in 'end_chkpt'log record. Third, to identify the next pending action to perform during recovery, whenever a page is updated during the execution of pending actions, transactions record the information that identifies the next pending action to perform in the log record that has the redo information against the page.