A najor current challenge and constraint in cervical cancer research is the development of vaccines against human papilloma virus (HPV) epitopes. Although many studies are done on epitope identification on HPVs, no computational work has been carried out for high risk forms which are considered to cause cervical cancer. Of all the high risk HPVs, HPV 16, HPV 18 and HPV 45 are responsible for 94% of cervical cancers in women worldwide. In this work, we computationally predicted the promiscuous epitopes among the E6 proteins of high risk HPVs. We identified the conserved residues, HLA class I, HLA class II and B-cell epitopes along with their corresponding secondary structure conformations. We used extremely precise bioinformatics tools like ClustalW2, MAPPP, NetMHC, Epi,Jen, EpiTop 1.0, ABCpred, BCpred and PSIPred for achieving this task. Our study identified specific regions 'FAFR(K)DL' followed by 'KLPD(Q)LCTEL' fragments which proved to be promiscuous epitopes present in both human leukocyte antigen (HLA) class I, class II molecules and B cells as well. These fragments also follow every suitable character to be considered as promiscuous epitopes with supporting evidences of previously reported experimental results. Thus, we conclude that these regions should be considered as the important for design of specific therapeutic vaccines for cervical cancer.
Journal of the Korean Institute of Telematics and Electronics B
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v.28B
no.11
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pp.852-858
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1991
An adaptive hierarchical classifier(AHCL) for Korean character recognition using a neural net is designed. This classifier has two neural nets: USACL (Unsupervised Adaptive Classifier) and SACL (Supervised Adaptive Classifier). USACL has the input layer and the output layer. The input layer and the output layer are fully connected. The nodes in the output layer are generated by the unsupervised and nearest neighbor learning rule during learning. SACL has the input layer, the hidden layer and the output layer. The input layer and the hidden layer arefully connected, and the hidden layer and the output layer are partially connected. The nodes in the SACL are generated by the supervised and nearest neighbor learning rule during learning. USACL has pre-attentive effect, which perform partial search instead of full search during SACL classification to enhance processing speed. The input of USACL and SACL is a directional edge feature with a directional receptive field. In order to test the performance of the AHCL, various multi-font printed Hangul characters are used in learning and testing, and its processing its speed and and classification rate are compared with the conventional LVQ(Learning Vector Quantizer) which has the nearest neighbor learning rule.
The study utilizes remote sensing as the main monitoring means. With different spatial high-resolution, multichannel ASTER remote sensing image as the main information in Beijing city zone; with regional border and statistical data as auxiliary factor a study between the thermal space distribution character and the underground medium is analyzed based on the GIS logical algorithm and synthetic analysis technology. Results show thermal forming mechanism and the rule of distribution is mainly related to the underground medium and the change of the city distribution. Different underground medium has different degree and intensity influence on the thermal space distribution. Furthermore, urban greenbelt and water areas can reduce the thermal effect and large-scale greenbelt creates green island effect. In addition, Road net, residential area, population density, heat resources and so on have some positive effect on the thermal distribution, which increase the local temperature and intensity on the other hand. It is important to study the thermal distribution and its related factors, which contributes to the plan, construction and development of the city.
This study analyzed research trends in the field of Practical Arts (Technology & Home Economics) education. From 958 articles published between 2010 and 2018 in the Journal of Korean Practical Arts Education (JKPAE), Journal of Korean Home Economics Education Association (JHEEA), and Korean Journal of Technology Education Association (KJTEA), 958 keywords were extracted and analyzed using NetMiner 4. When the general network structure was analyzed, keywords such as practical arts education, curriculum, textbook, home economics education, and students were high in the degree centrality and closeness centrality, and textbook, practical arts education, curriculum, student, home economics education, and invention were high in the node betweenness centrality. The cluster analysis showed that a four-cluster solution was most appropriate: cluster 1, technology and experiential learning activities; cluster 2, curriculum studies and practical problem; cluster 3, relationships; and cluster 4, creativity and character education. The three journals showed differences in the knowledge network structure: The topics of JKPAE and JKHEEA focused on general content knowledge and curriculum, while the topics of KJTEA were spread across invention and creativity education, and curriculum studies.
Uiwon-gun (1661-1722) and Sim Ikchang (1652-1725) were people of the upper classes of the Joseon Dynasty, who's belts woven with thread were found in their graves. The purpose of this study is to find a term suitable for the belts of these two people and to reveal the characteristics of the two belts and decipher the 8-character text marked on Shim Ikchang's belt to understand its meaning. The terms used during the Joseon Dynasty related to woven belts include "Gwangdaho", "Daeja", "Bunhapdae", "Sagagda", "Bangseungah", and "Samunjikdae". Among these terms, "Gwangdahoe" is the most suitable to indicate the belts of for both belts. The belts are made of a silk fabric of narrow width. The size of Uiwon-gun's belt is 2.8×199cm, and because it is folded in half lengthwise and sewn, the original width is 8cm. It was woven in the imitation gauze technique. Sim Ik-chang's belt measures 10.5×258cm and is decorated with a woven net at the end. There are water and mountain patterns on both ends of the belt, with 11 lines of flower patterns equally spaced between. The belt is damask, the inscription part is made of brocade with letters expressed in golden thread. The meaning of the inscription is "Made in Hanbu. May you live a long and healthy life".
To investigate the relationships between ocean environmental characteristics, the time-series data of temperature and salinity observed at a station near at Hanlim set net in 1995 and 1996 are analyzed, and the results are as follow ; 1. In hanlim set net, the diurnal range of temperature and salinity variation in summer is very large and the amplitude of short-period fluctuation of temperature and salinity is very large. That is, not only the water of the middle and bottom layers (low temperature and high salinity) but also the coalstal water (high temperature and low salinity) appears alternatively depending on the current direction 2. from the result of mooring for 22 days in Hanlim set net, the mean speed and direction of tidal current in neap tide were 9.1 cm/sec and south westward in ebb time, and 11.6 cm/sec and north or northeastward in flood time, respectively. The highest speed of the current was 15cm/sec in ebb time, and 22.6 cm/sec in flood time. The mean speed and direction of tidal current in spring tide were 10.4 cm/sec, and southwestward in ebb time, and 12.3 cm/sec, and north or northestward in flood time, respectively. The highest speed of the current was 19.4 cm/sec in ebb time, and 20 cm/sec in flood time respectively. The mean speed of the current in flood time was larger than that in ebb time. The velocity vector along the major axis of semidiurnal tide ($M_2$) component was 1.5 times larger than that of diurnal tide ($K_1$), The major directions of two compornants were northwestward and east-southeastward and residiual current were 3.25 cm/sec and northwestward-directed. Result of TGPS Buoy tracer for 3 days between Biyang-Do and Chgui-Do showed that the mean speed was 1.6 knot in ebb time and 1.3 knot in flood time. Direction of tidal was southwestward in ebb time and northeastward in flood time respectively. The maximum current speed was 4.8 knot in ebb time and 3.7 knot in flood time respectively. The mean speed and direction of tidal in of offshore were 1.7 knot and northwestward in flood time. The residual current appeared 0.3 knot northeastward.
Journal of the Korea Academia-Industrial cooperation Society
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v.16
no.11
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pp.8046-8056
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2015
The purpose of this study is the study of factors affecting the life satisfaction of disabled children parents. Survey data metropolitan area and Gyeonggi-do special schools, day shelter, Disabled Welfare, especially on the national branch in Korea Funny disabled parent meetings, through 389 branches were collected material wealth targeting parents with disabilities. Statistical analysis SPSS 19.0 program utilizes factor analysis, reliability analysis. And parents of children with disabilities and environmental factors are the demographic characteristics in order to analyze the impact on life satisfaction as a control variable, and the environmental factors as independent variables were performed hierarchical regression analysis. Results are crazy and the positive(+) influence a religious presence and the average monthly income of demographic characteristics in the satisfaction of life, environmental factors all had significant influence on life satisfaction. In other words, family support, disability, social networks, personal nature had a positive(+) influence on life satisfaction of disabled children parents, the relative influence of these factors include family support, disability, social networks, net of personality. It was in. The result is handicapped parents receive emotional support and help from family, the lower the degree of disability of the child, as participation in meetings or disability welfare various programs and handicapped parents, and the more it has a positive character increased satisfaction in life that can be interpreted.
Street Style, occurred in British and America, has been expressed the character of the new generation by repeating developments and changes. Nowadays, pop music reflects the phase of society. and simultaneously it has influence on from culture to society. Rock Music was rooted in Country 8l western of America. Upon Country & Western, Afro-Americans Rhythm & Blues was added, and that was the birth of Rockabilly. Rockabilly developed to Rock'n 'roll and it started to change to various forms of Rock since 1950s. As the commercial impact and the breakthrough of teenagers emotion, the rock culture comprised the base of the youth culture. However. it formed the anti-establishment culture against the established value, accepting working class subculture. The teenager culture was affected by the Rock culture, also found relief in the opulence provided by the established generation, imitating it as it was. Simultaneously, it had a contrary aspect as anti-establishment form under the banner of revolt against languor in richness. The youth culture created street style that was escaped from high fashion, every time Rock music had changes. Since Street style was based on resistance of established culture and it fully refused vogue, it was indifferent from high fashion. The results of this study were as following. First, every time Rock music had changes, the new youth culture was concomitant with, the youth culture created street style. Secondly, rockahibilly style was characterized as diamond shaped design, embroidery, extra wide shirt collar, vivid contrast color . Rockers style was represented as metal studs, beads, denim, leather jacket, boots. Fusion of hippies style and Psychedelic, long hair, beads. worn denim were elements of headbangers style. Punks style was characterized as ripped T-shirt. rooster hair, over decorated jacket, short skirt. net or plastic T-shirt. Lastly, the firm relation between popular art and fashion was proved by examining the history of Rock Music and Street Style.
As the current stage of the fashion begins to follow the styles of the past the study on he past costume is getting more importance and as the methodology of the study the accurately ap-proached study through the rehabilitation of the past costume is more needed than the simple re-arrangement of the historical documents. By this methodology this study can be positioned as a re-creation activity. The results of the study are as follows. 1) Style: The S-line silhouette remains be-cause of the straight silhouette or the blossom style bodice. This dress has various types of sil-houette but generally it forms one silhouette and is one-piece. 2) color and Material: The material varies hile the color is divided as the main color of ivory and the stress color of brown. This shows not only that the material has been varied but also that they tried to reduce the monotony. 3) Pattern and Sewing: The simple external figure and the previous stage typically shows the movement to the simplicity of the contemporary and the num-ber of patterens is plenty and the sewing method is also complex. 4) Detail. To overcome the simplicity of the style and to show the characteristics of the afternoon dress the skunk fur the net the sash, and the bow are used. 5) Structural Characteristics: The front open-ing the back opening and the side opening coexists in one-pieced dress and this forms unique structure and complex fastening device. The ribbon tape and casing not only finish the seam but also fix the shape of the dress. Synthetically the 1913-14 afternoon dress has the characteristics of transitional stage in which the characteristics of the costume of 1910s and the remnants of the characteristics of the pre-vious costume style and shows the character-istics of afternoon dress well in terms of the ma-terial the structure and the detail.
This study conducts data visualization of common climax patterns of Korean blockbuster films to analyze shots and evaluate scene (subplot unit) arrangement. For this purpose, a model of editing patterns is used to analyze how many climax patterns a film contains. Moreover, a system, which automatically collects shot images and classifies shot sizes of collected data, is designed to demonstrate that a single scene is composed based on a climax pattern. As a scene is a subplot and thus its arrangement cannot fully be analyzed only by climax patterns, dialogues of starring actors are also used to identify scenes, and the result is compared with data visualization results. It detects dialogues between particular actors and visualizes dialogue formation in a network form. Such network visualization enables the arrangement of main subplots to be analyzed, and the box office performance of a film can be explained by the density of subplots. The study of two types comparison analysis is expected to contribute to planning, plotting, and producing films.
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