• Structural Monitoring and Maintenance
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• 제9권4호
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• pp.359-371
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• 2022

Bridges are critical to the civil engineering infrastructure network as they facilitate movement of people, the transportation of goods and services. Given the aging of bridge infrastructure, federal officials mandate visual inspections biennially to identify necessary repair actions which are time, cost, and labor-intensive. Additionally, the expansion joints of bridges are rarely monitored due to cost. However, expansion joints are critical as they absorb movement from thermal effects, loadings strains, impact, abutment settlement, and vehicle motion movement. Thus, the need to monitor bridge expansion joints efficiently, at a low cost, and wirelessly is desired. This paper addresses bridge joint monitoring needs to develop a cost-effective, real-time wireless system that can be validated in a full-scale bridge structure. To this end, a wireless expansion joint monitoring was developed using commercial-off-the-shelf (COTS) sensors. An in-service bridge was selected as a testbed to validate the performance of the developed system compared with traditional displacement sensor, LVDT, temperature and humidity sensors. The short-term monitoring campaign with the wireless sensor system with the internet protocol version 6 over the time slotted channel hopping mode of IEEE 802.15.4e (6TiSCH) network showed reliable results, providing high potential of the developed system for effective joint monitoring at a low cost.

• Journal of Ginseng Research
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• 제39권4호
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• pp.314-321
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• 2015

Background: Ginseng belongs to the genus Panax. Its main active ingredients are the ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract. To understand the effects of ginsenoside Re (GRe) on GI motility, the authors investigated its effects on the pacemaker activity of ICCs of the murine small intestine. Methods: Interstitial cells of Cajal were dissociated from mouse small intestines by enzymatic digestion. The whole-cell patch clamp configuration was used to record pacemaker potentials in cultured ICCs. Changes in cyclic guanosine monophosphate (cGMP) content induced by GRe were investigated. Results: Ginsenoside Re ($20-40{\mu}M$) decreased the amplitude and frequency of ICC pacemaker activity in a concentration-dependent manner. This action was blocked by guanosine 50-[${\beta}-thio$]diphosphate [a guanosine-5'-triphosphate (GTP)-binding protein inhibitor] and by glibenclamide [an adenosine triphosphate (ATP)-sensitive $K^{+}$ channel blocker]. To study the GRe-induced signaling pathway in ICCs, the effects of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (a guanylate cyclase inhibitor) and RP-8-CPT-cGMPS (a protein kinase G inhibitor) were examined. Both inhibitors blocked the inhibitory effect of GRe on ICC pacemaker activity. L-NG-nitroarginine methyl ester ($100{\mu}M$), which is a nonselective nitric oxide synthase (NOS) inhibitor, blocked the effects of GRe on ICC pacemaker activity and GRe-stimulated cGMP production in ICCs. Conclusion: In cultured murine ICCs, GRe inhibits the pacemaker activity of ICCs via the ATP-sensitive potassium ($K^{+}$) channel and the cGMP/NO-dependent pathway. Ginsenoside Re may be a basis for developing novel spasmolytic agents to prevent or alleviate GI motility dysfunction.

• 디지털융복합연구
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• 제19권6호
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• pp.419-427
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• 2021

본 연구의 목적은 예비고령층과 고령층의 건강정보 획득경로와 경로별 인식 및 활용실태를 확인하기 위함이다. 연구대상자는 예비고령층 200명, 고령층 200명으로, 구조화된 설문지를 이용한 대면조사를 시행하였으며, MINITAB17을 활용하여, 카이제곱 검정(chi-square test)과 피셔의 정확검정(Fisher's exact test)을 실시하였다. 연구결과 대상군의 건강정보 획득경로는 전문의료인을 통한 획득은 비슷한 수준인 반면, 대중매체와 인터넷 사이트를 통한 획득 빈도는 예비고령층이 높았다. 특히, 인터넷 사이트를 통한 건강정보 획득은 고령층보다 4배 이상 높았다. 경로별 건강정보 활용내용은 예비고령층이 건강검진 및 예방에 집중한 반면, 고령층은 예방뿐만 아니라 질환치료 등 건강과 관련된 전반적인 정보를 탐색하고 활용하였다. 획득된 건강정보에 대해 두 군 모두 긍정적인 인식을 보였다. 본 연구결과를 통하여 향후 고령층을 대상으로 한 건강관련 정보의 전달에 있어 인터넷 사이트를 포함한 모든 경로가 유용하게 사용될 수 있음을 확인하였다. 또한, 고령층의 자가건강관리의 향상을 위한 다양한 컨텐츠 개발에 연령적 특성과 경로별 활용 건강정보 영역을 고려할 것을 제언한다.

• Korean Journal of Acupuncture
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• 제33권4호
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• pp.204-212
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• 2016

Objectives : The aim of the study is to investigate the effects of moxibustion on the pain behavior and expression of TRPM8 in the dorsal root ganglion(DRG) in the rat model of ambient cold(AC) exposed osteoarthritis(OA). Methods : OA was induced by the injection of $50{\mu}l$ of 2% monosodium iodoacetate(MIA) into the knee joint cavity. To examine the level of pain, weight bearing forces(WBFs) of affected limb was measured. For the AC exposure, the animals were housed in 6 h/day at $4^{\circ}C$ for 14 days after MIA injection. Moxibustion treatment was performed at EX-LE4 and EX-LE5 with 5 cons(1, 7 or 10 mg) per day for 13 days from 5 days after MIA injection. The expressions of TRPM8 in DRG were measured by western blotting analysis. Results : The WBFs of MIA-AC group were decreased significantly compared to MIA group at 2, 3, 6, 7, 8 and 9 days after arthritis induction. After the first 6 h-AC exposure, expressions of TRPM8 in MIA-AC group were increased significantly compared to those of naive group. After moxibustion treatment, only the WBFs of 7 mg treated group were restored significantly. Moreover, the over-expressions of TRPM8 were attenuated by the moxibustion treatment in AC exposed rats. Conclusions : The data suggest that AC can increase arthritic knee pain via up-regulated TRPM8 and moxibustion treatment improve the arthritic pain via modulation of TRPM8 expression in DRG in the rat model of AC exposed MIA induced arthritis.

• 한국전산구조공학회논문집
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• 제31권6호
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• pp.359-366
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• 2018

국내 고도성장기 이후 본격 건설되기 시작한 사회 기반 시설물은 노후화가 빠르게 진행되고 있다. 특히 사고 발생 시 대량 인명 피해로 직결될 수 있는 교량, 터널 등의 대형 구조물들에 대한 안전성 평가가 필요하다. 하지만, 기존의 유선 센서 기반의 SHM을 개선한 무선 스마트 센서네트워크는 짧은 신호도달거리로 인해 경제적이고 효율적인 시스템 구축이 힘들다. 따라서 LoRa LPWAN시스템은 사물인터넷의 확산과 더불어 저전력 장거리통신이 각광을 받고 있으며, 이를 구조건전성 모니터링에 응용함으로써 경제적이면서도 효율적인 SHM 구축이 가능하다. 본 연구에서는 LoRa LPWAN의 구조건전성 모니터링에 적용 가능성을 검토하고 비면허 통신 대역을 사용함으로 인해 발생하는 채널간의 충돌을 해결하면서 대역폭을 효율적으로 활용할 수 있는 채널 기반의 LoRa 네트워크 운영방법을 제안한다.

• 국제지역연구
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• 제13권3호
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• pp.239-267
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• 2009

공공보건정책사업에 대한 투자는 국민들의 건강수준을 향상시켜 미래의 의료비 절감효과가 나타날 것이며 질병부담 감소로 인한 생산성 손실이 감소할 것이며, 이러한 공공보건정책사업에 의한 건강증진효과는 경제성장을 촉발시키는 원동력이 될 것으로 사료된다. 본 논문에서는 공공보건정책사업의 투자효과를, 사업시행의 결과로 국민들의 질병으로 인한 사회경제적 비용이 감소했는지의 여부와 그 정도로 측정했으며, 특히 구축된 시계열 자료를 토대로 미시적 분석을 수행하기 위해, 질병으로 인한 사회경제적 비용규모가 가장 큰 5대 질환군 및 각 연령대별 인구집단을 대상으로 시행된 공공보건정책사업의 건강증진효과와 이들 효과가 경제성장에 미친 영향을 분석하였다. 분석결과를 요약하면, 질환별로는 호흡기계, 소화기계, 순환기계 및 감염성 질환 등에서 정책효과가 유의했고, 연령대별로는 0~9세, 10~19세, 40~49세, 50~59세, 60~69세 및 70세 이상 연령대에서 유의한 효과를 보였다. 아울러 이들 질병으로 인한 사회경제적 비용의 절감은 실질국내총생산의 증가에 통계적으로 유의하게 영향을 미쳤음을 알 수 있었다.

• 한국산학기술학회논문지
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• 제18권5호
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• pp.608-616
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• 2017

본 연구의 목적은 느낌이 다른 3가지 감성적인 음악이 감성과 주의각성에 미치는 영향을 뇌파 측정을 통해 비교하고자 하였다. 연구 방법은 20대부터 50대까지 다양한 실험군에게 2채널 뇌파측정기를 이용하여 Fp1과 Fp2에서 청취전 배경뇌파를 측정하고 청취중과 청취후의 뇌파를 측정하여 상호 비교 하였다. 연구 결과는 1)시간이 경과함에 따라 Fp1, Fp2의 알파, SMR, 저베타, 고베타, ${\alpha}/-{\beta}$가 유의하게 증가했고, Fp2의 세타, $_{\theta}/SMR$이 유의하게 증가했다. 2)장송곡의 델타를 제외한 모든 곡들의 청취중 뇌파와 청취후 뇌파는 Fp2가 우세했으나 장송곡은 Fp1의 델타파가 우세했으며, 3)알파값이 눈에 띄게 높아지고 활동성이 증가한 음악은 프랠류드였다. 이는 편안한 느낌의 프랠류드가 뇌의 이완과 더불어 활성을 유도하며, 무거운 느낌의 장송공은 좌뇌의 활동성을 저하 시키는 것으로 판단된다. 이 연구 결과로 음악을 청취하고 감성의 변화를 느끼는 것은 음악이 실제로 뇌의 활동성에 영향을 미쳐 감성적인 변화와 주의 각성의 차이를 유도하기 때문인 것으로 밝혀졌다.

• 한국터널지하공간학회 논문집
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• 제25권6호
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• pp.479-493
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• 2023

터널과 공동구와 같은 지하구조물의 공용연수가 증가하고 노후화로 인한 사고로 인하여 안전 관리의 필요성이 대두되고 있다. 다만, 민간이 관리 주체인 일반 지하구의 경우 시설물 안전 및 유지관리 세부지침이 미흡하여 안전 관리가 부실한 상황이다. 또한 일반 지하구는 기본 설계 정보가 부족하고 안전 관리자가 안전 진단을 수행하기 위한 공간이 협소하여 기존 비파괴 검사법들의 적용에 한계가 있다. 따라서 본 연구에서는 박스형 일반 지하구의 안전 진단을 위한 기초 자료로 사용될 수 있는 구조물의 두께·철근 유무와 철근 깊이·내부 결함의 유무 및 깊이 등을 판단할 수 있는 품질 평가를 위한 초음파법과 충격 반향 기법 바탕의 비파괴 검사 방법을 제안하였다. 일반 지하구의 실제 현장 조건에서의 제안한 방법의 유효성을 검토하기 위해 콘크리트 벽체 모형 실험체들을 제작하여, 본 연구를 통해 제안한 방법론을 검증하였다. 초음파 신호와 충격 신호를 활용하여 신호를 인가하여, 다채널로 구성된 가속도계를 통해 신호를 수집하고, 최종적으로 모사된 시편의 두께 및 내부에 삽인 된 철근과 구현된 결함의 깊이를 도출하였으며, 실측치와의 비교를 통해 예측한 깊이가 설계한 깊이와 효과적으로 부합하는 것을 확인하였다. 본 연구 결과를 통해 일반 지하구 현장에서 활용할 수 있는 안전 진단 방법의 도출에 기여할 것으로 기대된다.

• 동의생리병리학회지
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• 제17권2호
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• pp.529-541
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• 2003

Yukmijihwang-tang has been widely used as an and-aging herbal medicine for hundred years in Asian countries. Numerous studies show that Yukmijihwangtang has anti-oxidative effect both in vivo and in vitro. It has been reported that Moutan Cortex Radicis extract (MCR) was the most effective herb in Yukmijihwang-tang on undifferentiated PC12 cells upon oxidative-stressed with hydrogen peroxide. The purpose of this study is to; 1) evaluate the recovery of neuronal damage by assessing the anti-oxidant effect of MCR on PC12 cells differentiated with nerve growth factor (NGF), 2) identify candidate genes responsible for anti-oxidative effect on differentiated PC12 cells by oligonucleotide chip microarray. PC12 cells, which were differentiated by treating with NGF, were treated without or with hydrogen peroxide in the presence or absence of various concentration of MCR. Cell survival was determined by using MTS assay. Measurement of intracellular reactive oxygen species (ROS) generation was determined using the H2DCFDA assay The viability of cells treated with MCR was significantly recovered from stressed PC12 cell. In addition, wide rage of concentrations of MCR shows dose-dependent inhibitory effect on ROS production in oxidative-stressed cells. Total RNAs of cells without treatment(Control group), only treated with H₂O₂ (stressed group) and treated with both H₂O₂ and of MCR (MCR group) were isolated, and cDNAs was synthesized using oligoT7(dT) primer. The fragmented cRNAs, synthesized from cDNAs, were applied to Affymetrix GeneChip Rat Neurobiology U34 Array. mRNA of Calcium/calmodulin-dependent protein kinase II delta subunit(CaMKII), neuron glucose transporter (GLUT3) and myelin/oligodendrocyte glycoprotein(MOG) were downregulated in Stressed group comparing to Control group. P2X2-5 receptor (P2X2R-5), P2X2-4 receptor (P2X2R-4), c-fos, 25 kDa synaptosomal attachment protein(SNAP-25a) and GLUT3 were downregulated, whereas A2 adenosine receptor (A2AR), cathechol-O-methyltransferase(COMT), glucose transporter 1 (GLUT1), EST223333, heme oxygenase (HO), VGF, UI-R-CO-ja-a-07-0-Ul.s1 and macrophage migration inhibitory factor (MIF) were upregulated in MCA group comparing to Control group. Expression of Putative potassium channel subunit protein (ACK4), P2X2A-5, P2X2A-4, Interferon-gamma inducing factor isoform alpha precursor (IL-18α), EST199031, P2XR, P2X2 purinoceptor isoform e (P2X2R-e), Precursor interleukin 18 (IL-18) were downregulated, whereas MOO, EST223333, GLUT-1, MIF, Neuronatin alpha, UI-R-C0-ja-a-07-0-Ul.s1, A2. adenosine receptor, COMT, neuron-specific enolase (NSE), HO, VGF, A rat novel protein which is expressed with nerve injury (E12625) were upregulated in MCR group comparing to Stressed group. The results suggest that decreased viability and AOS production of PC12 cell by H₂O₂ may be, at lease, mediated by impaired glucose transporter expression. It is implicated that the MCR treatment protect PC12 cell from oxidative stress via following mechanisms; improving glucose transport into the cell, enhancing expression of anti-oxidative genes and protecting from dopamine cytotoxicity by increment of COMT and MIF expression. The list of differentially expressed genes may implicate further insight on the action and mechanism behind the anti-oxidative effects of herbal extract Moutan Cortex Radicis.

• 대한한방내과학회지
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• 제16권2호
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• pp.146-177
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• 1995

The purpose of this study was to investigate the relationship between the teeth and Zhang-Fu(臟腑), dental diseases, and the hygiene of the mouth through the literature of oriental medicine. First, the relatonship between the teeth and Zhang-Fu is reviewed as follows: The teeth are influenced by Shen(腎) because they are the end of bone and Biao(標) of Shen. Gingiva is related to Wei(胃) and Da-Chang(大腸) because it is passed by Yangming-Channel(陽明經). The growth and nutrition of teeth depends on Shen. The pathological condition of Shen causes the gingival atrophy, the loose of teeth, dedentition due to aging, withering of teeth, and tartar: whereas the pathological condition of Wei and Da-Chang causes toothache, gingivitis, inflamed gums, bad breath, and gingival hemorrhage. Second, the causes and therapies of dental diseases through the literature can be summarized as follows: The major causes of toothache are the pathogenic condition of wind-heat and wind-cold, the heat syndrome of Wei, the damp-heat of intestine, flaring-up of fire of deficiency type, rotten tooth, etc... The principal causes of dedentition and the shaking and loose of teeth are the deficiency of Shen, and the rest of causes are the damp-heat of Yangming. Gingival atrophy is caused by the deficiency of Shen, whereas the gingival hemorrhage comes from the factors in the pathogenic factor of wind-heat of Yangming-Channel, the heat syndrome of stomach, and the deficiency of Shen. The causes of grinding of teeth during sleeping are stomach-heat, and the delayed dentition and the withering result from the deficiency of Shen-Jing.(腎精) The principal therapies of toothache are removing wind and heat, clearing away heat and prompting diuresis, clearing away the stomach-heat, replenishing vital essence to tonify the Shen, relieving superficial syndrome by wind-cold, and alleviating pain by destroying parasites. For the prescription of the principal therapies, there are Xijio Dihuang Tang, Jiajian Ganlu Yin, Qufeng Wan, Qingwei San, Tiaowei Chenggi Tang Shengong Wan, Liangge San Qingwei Tang Yunu Jian, Liuwei Dihuang Wan Zuogui Yin Bawei Wan Wanshao Dan, Xixin San Badou Wan Gianghuo Fuzi Tang, Jiuzi Tang Badou Wan, etc... The therapies of dedentition and the shaking and loose of teeth are replenishing vital essence to tonify the Shen, and warming and recuperating the Shen-Yang: as the prescription, there are Liuwei Dihuang Wana Zuogui Yin, and Bawei Wan Anshen Wan Wanshao Dan Yougui Wan etc... The therapies of gingival hemorrhage are clearing away the stomach-heat, replenishing vital essence to tonify the Shen, warming and recuperating the Shen-Yang(腎陽), and moisturing and purging intence heat with the prescription of Tiaowei Chenggi Tang Xijiao Dihuang Tang, Liuwei Dihuang Wan Zuogui Yin, Bawei Wan Anshen Wan, and Yunu Jian. The therapy of gingival atrophy is replenishing vital essence to tonify the Shen in the prescription of Liuwei Wan Bawei Wan Ziyin Dabu Wan. The therapies of grinding of teeth during sleeping are clearing away the stomach-heat and purging intense heat, and invigorating the spleen through eliminating dampness in the prescription of Qingwei San, Wumei Wan, etc... The therapy of delaed dentition is replenishing vital essence to tonify the Shen with the prescription of Liuwei Wan Buyin Jian, etc... Third, clinical treatment reports of dental diseases are reviewed as follows: The toothache due to stomach-heat was treated by medical herbs like Gypsum, Natrir Sulfas, Rehmanniae, Schizonepetal Herba, Menthae Folium, Cimicifugae Rhizoma, and Scrophulariae Radix. The therapies of toothache due to flaring-up of fire in deficiency type from deficiency of Shen provided with replenishment of vital essence to tonify the Shen and clean ministerial fire, and the prescription was the kind of Liuwei Wan, which worked very well. The therapy of dedentition and loose of teeth due to deficiency of Shen was done to stablize the teeth as tonifing the Shen with the prescription of Guchi Wan. The rate of imrovement was over 90%. The destruction of periodontal tissue due to periodonititis was cured of dispelling wind, reducing heat, and alleviating pain, It was improved by taking Zizhi Xingiong Tang, Guchi Xiaotong San, Yunii Jian, and Qingwei San about 3-7 days, and the rate of improvement was over 80%. Fourth, the prevention and regimens are reviewed as follows: As a physical and breathing exercise of the teeth, tapping teeth which stimulates the circulation of Qi(氣) and Xue(血) had been used. The tapping time of 14, 17, 36, etc... has been reported, and it should be applied based on the body condition. The medical herbs for gargling and brushing teeth have been used. Specifically, Cimicifugae Rhizoma, Gypsum, Gypsum Fibrosum, and Indigo pulrelrata Lereis have been used to reduce heat, Coptidis Rhizama and Yang Jinggu to eliminate damp-heat, Amomi Semen, Cyperi Rhizoma, Flos Caryophylli, Asari Radix, Piperis Longi Fructus, Santali Albae Lignum, Meliae Fructus, Moschus, Aquillaiae Lignum, and Borneol to promote the circulation of Qi and to relieve pain, Ligustici Radix, Angelice Radix, Rhizoma Nardostachydis, Tribuli Semen to relieve superficial syndrome by means of diaphiresis, and Cnidii Rhizoma, Angelicae sinensis Radix, and Olibanum to promote blood circulation to stop pain.