• 한국임상약학회지
• /
• 제12권1호
• /
• pp.7-12
• /
• 2002

Pharmacokinetic parameters and dosage of aminoglycosides (AGs) were studied retrospectively in 36 patients with neutropenic fever after stem cell transplantation in Seoul National University Hospital from July 1996 to June 2001. AGs pharmacokinetic parameters were calculated with steady-state peak and trough serum drug concentrations by the method of Sawchuk and Zaske et at. The calculated aminoglycosides volume of distribution and clearance were greater than population value $(0.36\pm0.06\;L/kg,\;116\pm32\;ml/min/1.73\;m^2,\;respectively)$. The average dosage of aminoglycosides required to maintain optimal serum AGs concentration was also greater than recommended dose in insert paper. The average dosage of amikacin was $11\pm2.1$ mg/kg every 12 hours (In case of tobramycin, $2.09\pm0.37$ mg/kg every 8 hours or $2.59\pm0.20$ mg/kg every 12 hours). The relationship between AGs volume of distribution and sex, serum albumin (g/dl), body mass index $(kg/m^2)$, body weight change $(\%)$, the amount of fluid inpu (ml/kg/day), the degree of hematocrit decrease $(\%)$ were studied respectively. Univariate anlysis revealed that body mass index $(kg/m^2)$, the amount of fluid input (ml/kg/day) and the degree of hematocrit decrease $(\%)$ had significant correlation with aminoglycosides volume of distribution. But sex, serum albumin, body weight change $(\%)$ had no significant correlation with aminoglycosides volume of distribution.

• 한국식품영양학회지
• /
• 제27권3호
• /
• pp.470-477
• /
• 2014

The purpose of this study was to investigate the association of homocysteine and antioxidant nutrients with obesity in Korean middle aged women. The study subjects included were middle-aged obese women (n=36) whose body mass index (BMI) was greater than $25kg/m^2$. A total of 36 participants were randomly divided into two groups. They were assigned to either the Nutritional Management and Exercise (NME) program or the Exercise Management (EM) program, which were both conducted for 3 months. We measured serum homocysteine, total cholesterol and HDL cholesterol levels of the participant. We also measured the dietary intakes of antioxidant nutrient, cholesterol, body weight, body mass index, blood pressure, and $VO_2$. At the end of both programs, please confirm this change. It was unclear when these measurements were shown to have decreased. The body weight and BMI of NME group were decreased compared to those of EM group. The serum total cholesterol levels of the participants in NME group were significantly decreased, in contrast to EM group. Also, serum homocysteine levels of NME group participants were decreased compared to EM group, but the difference was not statistically significant. In the NME group, there were significant differences in the change of dietary cholesterol and vitamin C intake. These results showed that participating NME program will continuously promote the healthy status of the middle aged obese women, compared to participating only in the EM program.

• 한방비만학회지
• /
• 제17권1호
• /
• pp.10-19
• /
• 2017

Objectives: The aim of study was to investigate the effect of herbal medicine on obesity and to define which seasonal factor could be utilized to make an obesity treatment program more effective. Methods: Three hundred and forty-four subjects were recruited and data were analyzed for weight, body fat, muscular volume, body fat ratio, body mass index (BMI) change and treatment duration. At first, age classification was performed for the comparisons. Moreover, starting season of treatment was categorized to determine it's influence over the treatment. Results: It was found the administration of herbal medicine could diminish every analyzed fields of entire patients. Compared among age groups, there were no significant differences of all fields. However, the categorization of start season showed significant differences of weight, BMI change and treatment duration. In addition, the analysis of assumed 10% weight loss elicited patients started treatment in spring and winter should spend 12 and 13 weeks and summer would be 9.5 weeks. Conclusions: It was found herbal medicine would be effective for female obesity and expected patients could achieve 5.91 kg weight loss for 65.88 days treatment. Summer group had significant shorter treatment duration and it was presumed summer group had more concentration for achievement. Days required for assumed 10% weight loss was calculated to be 84 days in spring, 67 days in summer, 96 days in winter. Hereafter, further controlled study with more numbers of patients should be needed to determine the goal of medical treatment for obesity.

• 성인간호학회지
• /
• 제17권1호
• /
• pp.149-159
• /
• 2005

Purpose: The purpose of this study was to examine the relationship among the levels of total serum cholesterol level, blood pressure, body mass index, and lifestyle. Method: This study was designed as a descriptive correlation study. Subjects were 972 adults participated voluntarily living in GyeongNam. The height, weight, blood pressure and fasting serum cholesterol were measured. Body mass index was caculated. Information on general characteristics (age, gender, education, job, family history) and life style(cigarette, alchol, sleeping time, regular exercise, meal pattern, peppery, salty, sweetness, vegetable diet, meat diet) were collected using a questionnaire by interviewing method. Result: The mean value of total serum cholesterol was $197{\pm}36.4mg/dl$(mean; $189{\pm}36.7mg/dl$, women; $202{\pm}35.1mg/dl$). By simple analysis, the serum total cholesterol according to general characteristics features was statistically significant in age(F= 6.765, p=000) and gender (t=5.372, p=.000). Total serum cholesterol levels increased significantly with increasing BMI. The serum total cholesterol according to life style features was statistically significant in cigarette(${\chi}^2=12.12$, p=.016), exercise(${\chi}^2=6.335$, p=.042), salty taste(${\chi}^2=18.801$, p=016), vegetable diet (${\chi}^2=19.488$, p=012). The most affecting factor which total serum cholesterol factor was BMI(${\beta}=.151$, p=.000). Conclusion: The significant risk factors relating to serum total cholesterol were age, gender, BMI, smoking, and exercise. Therefore, for the reduction of serum total cholesterol level, it is recommended that nursing intervention for the prevention of obesity, change of life style should be implemented.

• 한국산학기술학회논문지
• /
• 제20권1호
• /
• pp.362-370
• /
• 2019

이 연구는 12주간 여성노인 실험참가자들의 혈류제한 복합운동 프로그램 참가 여부가 신체조성(몸무게, 체지방률, 근육량, 신체질량지수)와 심혈관인자(맥파속도와 혈관협착도)에 어떠한 영향을 미치는가에 대하여 연구 하고자 총 43명의 실험참가자가 혈류제한 복합운동(14명), 일반복합운동(14명)과 통제집단(15명)으로 무선할당 배분되어 본 연구를 참여하였다. 본 연구는 반복측정분산분석(Repeated Measure ANOVA)과 대비검증(contrast)을 이용하여 통계를 분석하였고, 모든 자료의 유의수준은 ${\alpha}=0.5$로 설정하였다. 연구결과 혈류제한 복합운동 집단의 신체조성(몸무게, 체지방률, BMI)에 통계적으로 유의한 변화가 나타났고, 일반복합운동 집단의 체지방률만 통계적으로 유의하게 감소하였다. 그리고 혈류제한 복합운동 집단의 오른쪽과 왼쪽의 맥파속도가 통계적으로 유의하게 감소하였고, 일반 복합운동 집단의 왼쪽 맥파속도만 통계적으로 유의하게 감소되었다. 또한 혈류제한 복합운동 집단의 사전과 사후 변화량($%{\Delta}$)과 효과크기(effect size)가 높이나왔다. 이는 동일한 운동(복합운동)을 수행하였지만 혈류제한 방법을 추가한 집단이 더욱 교감신경이 활성화된 운동을 실시하게 되어 여성노인들에게 신체조성과 심혈관 요인에 일반 복합운동 보다 더욱 긍정적인 영향을 미쳤음을 나타내고 있다.

• 한국정보통신학회논문지
• /
• 제24권9호
• /
• pp.1209-1214
• /
• 2020

최근 고령화 시대가 되면서 사람들의 건강한 삶에 관한 관심이 높아지고 있다. 사람들은 잘못된 생활, 식습관, 신체활동 저하 등으로 인하여 성인병을 유발하거나 비만 인구수가 증가하고 있다. 이에 정보통신 분야에서 의료분야 정보를 활용하여 피부 미용 연구가 진행되고 있다. 기존의 시스템들은 다양한 관련 측정 항목들에 대해 결합하여 표현되지 않아서 원활한 정보를 제공받지 못하였다. 본 논문에서 제안하는 시스템은 3D 스캐너와 피부미용기기를 사용하여 사용자의 체형을 스캔하고, 3D 이미지 데이터를 사용하여 BMI(Body Mass Index) 지수를 계산하고 수집된 데이터를 한눈에 볼 수 있는 웹 서비스 시스템을 제공한다. 이는 지속적인 신체 변화 데이터를 비교하여 제공하므로 관리되는 내용을 사용자에게 제공하게 될 것이다. 이는 다양한 U-헬스 및 미용분야에서 널리 활용될 것으로 사료된다.

• Diabetes and Metabolism Journal
• /
• 제42권6호
• /
• pp.488-495
• /
• 2018

Background: Skeletal muscle plays a major role in glucose metabolism. We investigated the association between thigh muscle mass, insulin resistance, and incident type 2 diabetes mellitus (T2DM) risk. In addition, we examined the role of body mass index (BMI) as a potential effect modifier in this association. Methods: This prospective study included 399 Japanese Americans without diabetes (mean age 51.6 years) who at baseline had an estimation of thigh muscle mass by computed tomography and at baseline and after 10 years of follow-up a 75-g oral glucose tolerance test and determination of homeostasis model assessment of insulin resistance (HOMA-IR). We fit regression models to examine the association between thigh muscle area and incidence of T2DM and change in HOMA-IR, both measured over 10 years. Results: Thigh muscle area was inversely associated with future HOMA-IR after adjustment for age, sex, BMI, HOMA-IR, fasting plasma glucose, total abdominal fat area, and thigh subcutaneous fat area at baseline (P=0.033). The 10-year cumulative incidence of T2DM was 22.1%. A statistically significant interaction between thigh muscle area and BMI was observed, i.e., greater thigh muscle area was associated with lower risk of incident T2DM for subjects at lower levels of BMI, but this association diminished at higher BMI levels. Conclusion: Thigh muscle mass area was inversely associated with future insulin resistance. Greater thigh muscle area predicts a lower risk of incident T2DM for leaner Japanese Americans.

• 대한물리의학회지
• /
• 제12권1호
• /
• pp.103-112
• /
• 2017

PURPOSE: Regular physical activity in the elderly population has significant benefits for health. The purpose of this study was to investigate the effects of aquatic group exercise on body composition and mental health of the elderly females. METHODS: This study included 40 elderly women. The aquatic group exercise program was performed for an hour a day, 3 times a week for 12 weeks with moderate-intensity level. The body composition, physical fitness mental health instruments were used to measure the outcome variables before and after the program. Data was analyzed with SPSS using descriptive statistics and the t-test. RESULTS: It was found that the 12 week aquatic group exercise program had effects on body mass and BMR were significantly improved after the intervention of this study. In health related physical fitness, flexibility and sense of balance were significantly increased in the participants. In the mental health of the female elderly participants were evaluated in areas such as depression, sense of isolation, interpersonal anxiety, and sociality. They showed significant change in a positive way. CONCLUSION: It is suggested that aquatic group exercise should be activated and encouraged to enhance physical and mental health of elderly women and various types of manuals should be developed according to characteristics of programs to operate this exercise more effectively.

• Nutrition Research and Practice
• /
• 제7권5호
• /
• pp.385-392
• /
• 2013

Although several studies have assessed the influence of the glycemic index on body weight and blood pressure among adults, limited evidence exists for the pediatric age population. In the current study, we compared the effects of low glycemic index (LGI) diet to the healthy nutritional recommendation (HNR)-based diet on obesity and blood pressure among adolescent girls in pubertal ages. This 10-week parallel randomized clinical trial comprised of 50 overweight or obese and sexually mature girls less than 18 years of age years, who were randomly assigned to LGI or HNR-based diet. Macronutrient distribution was equivalently prescribed in both groups. Blood pressure, weight and waist circumference were measured at baseline and after intervention. Of the 50 participants, 41 subjects (include 82%) completed the study. The GI of the diet in the LGI group was $42.67{\pm}0.067$. A within-group analysis illustrated that in comparison to the baseline values, the body weight and body mass index (not waist circumference and blood pressure) decreased significantly after the intervention in both groups (P = 0.0001). The percent changes of the body weight status, waist circumference and blood pressure were compared between the two groups and the findings did not show any difference between the LGI diet consumers and those in the HNR group. In comparison to the HNR, LGI diet could not change the weight and blood pressure following a 10-week intervention. Further longitudinal studies with a long-term follow up should be conducted in this regard.

• 한방재활의학과학회지
• /
• 제19권2호
• /
• pp.289-302
• /
• 2009

Objectives : This study was performed in order to investigate the relation of body composition analysis and radiological parameter(lumbosacral angle, lumbar lordortic angle, lumbar gravity line). Methods : This study was carried out with the data from comprehensive medical testing. 75 subject aged 20-59 performed the segmental bioelectrical impedance analysis, questionnaire. And lumbosacral angle, lumbar lordortic angle and lumbar gravity line were measured in the standing position x-ray. Then we analyzed the data. Results : Low back pain(LBP) prevalence in high obesity index(Body Mass Index(BMI), Percentage of Body Fat(PBF), Waist Hip Ratio(WHR)) group was higher than LBP prevalence in normal obesity index group(p<0.01). In LBP group, lumbosacral angle, lumbar lordortic angle were significantly lager than Non-LBP group(p<0.001). And 75% of LBP group indicated abnormal lumbar gravity line ratio(0.67 < Normal lumbar gravity line ratio <1.00). When it comes to analyze relation between obesity index and radiological parameter, no-significant change was seen. Conclusions : This study carried as following research after the study on relation of obesity, LBP and trunk muscle strength. Results from this investigation showed positive correlation between obesity and LBP prevalence. But obesity index didn't indicate significant correlation with structural changes of lumbar vertebrae. When considering prior research, trunk muscle strength changes were more related to LBP prevelence in obese people. This results are expected to explain causes of LBP in obese group.