• Title/Summary/Keyword: Challenge test

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Immune response and efficacy of pigeon pox virus vaccine and fowl pox virus vaccine in chickens

  • Shil, Niraj Kanti;Rahman, Md Siddique;Hossain, M.T.;Islam, M.T.;Rahman, M.M.;Islam, K.B.M. Saiful;Cha, Se-Yeoun;Jang, Hyung-Kwan;Song, Hee-Jong
    • Korean Journal of Veterinary Service
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    • v.30 no.4
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    • pp.497-503
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    • 2007
  • The humoral immune response of chicken vaccinated with fowl and pigeon pox virus vaccines was determined with the protective potentiality of the two vaccines in field condition of Bangladesh. Different aged Fayoumi chicks were subjected for the study. To assess the relationship with better immune response among experimental groups, the average percentage of 'take reaction' was examined and recorded to 97.77% in group A, 93.33% in group B and 100.0% in group C. The level of immune status induced by different vaccinated group was measured by passive hemagglutination (PHA) microplate test method. The mean PHA titer levels after primary vaccination were $33.06{\pm}14.13$ in group A, $32.0{\pm}14.81$ in group B, and $33.0{\pm}13.66$ in group C. Following booster vaccination, the mean PHA titer levels in prior of challenge were increased to $55.46{\pm}14.64$ in groups A and C, and $46.93{\pm}16.52$ in group B. The recorded PHA titer levels of each group at two weeks after challenge were significantly increased to $106.66{\pm}31.22$, $93.86{\pm}33.04$ and $110.93{\pm}29.29$, respectively. The PHA titer levels after vaccination and challenge were significantly increased compared to pre-vaccination titer levels (P<0.01). Although the PHA titer levels among three groups administrated different vaccine combinations in prior of challenge were significantly varied (P<0.01), it was observed that all of the vaccinated chicks were highly protected against challenge infection.

An Empirical Study on the Flow Experience Affected by Characteristics of Mobile Internet (모바일 인터넷 특성이 플로우 경험에 미치는 영향에 관한 연구)

  • Yoo, Sang-Jin;Choi, Eun-Bin;Kim, Hyo-Jung
    • Information Systems Review
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    • v.8 no.1
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    • pp.125-139
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    • 2006
  • Recently, as mobile internet users grow rapidly, mobile internet companies are experiencing a fierce competition to capture new customers. Under this business environment, they try to identify factors that make people use mobile internet in order to satisfy customers by providing better and diversified services. There has been enormous effort to analyze customers' behavior in choose and use mobile internet services. However, there is no one best methodology to identify factors to attract customers yet. Thus, the study applied the flow construct proposed by Csikszentmihalyi(1977) and expanded by Hoffman and Novak(1996) to identify environmental factors of internet which has impact on users' mobile internet usage. To implement the study, the following activities have been done: literature reviews on service acceptance model and flow structure, questionnaire survey, suggestion of the flow model on mobile internet, and hypothesis test. For the study, 242 out of 307 samples collected were statistically analyzed using SPSS 10.0, AMOS 4.0 statistics package. The findings of this study are as follows: First, mobile internet environment factors influencing on challenge of flow antecedent were media characteristics(use of convenience, transmission quality), contents characteristics(uniqueness, timeliness, simplicity). Second, mobile internet environment factors influencing on skill of flow antecedent were contents(uniqueness, timeliness, simplicity), charge(definiteness and diversity of charge), usage(security, instant connectivity). Third, challenge of flow antecedent had a significant effect on flow of mobile internet usage. But it was not statistically significant that skill has an influence on flow. This study discovered the relationship between mobile internet environment factors(media characteristics, contents characteristics, charge characteristics, usage characteristics) and flow experience of mobile internet users which would be a valuable insight for marketing strategies. Results shows that challenge of flow antecedent have a significant impact on flow experience in mobile internet environment. Additional, media characteristics, contents characteristics of mobile internet environment factors is positively correlated with challenge of flow antecedent. In other words, mobile internet companies should provide customers with diverse service and take a challenging attitude to get customers show aggressive attitude in mobile internet usage.

Clomiphene Citrate Challenge Test and Its Clinical Correlation with Prognostic Factors of Ovarian Response (Clomiphene Citrate 부하검사와 난소 반응 예측 인자와의 연관성에 관한 연구)

  • Moon, Shin-Yong;Chae, Hee-Dong;Kim, Kwang-Rye;Suh, Chang-Suk;Kim, Seok-Hyun;Choi, Young-Min;Shin, Chang-Jae;Kim, Jung-Gu;Lee, Jin-Yong
    • Clinical and Experimental Reproductive Medicine
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    • v.23 no.3
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    • pp.283-292
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    • 1996
  • Objective: To determine the cutoff value of clomiphene citrate challenge test(CCCT) that can predict the normal and abnormal(diminished) ovarian response group and to assess the usefulness of CCCT as a predictor of ovarian reserve. Materials and Methods: From March 1994 to Februry 1996, CCCT was performed to 129 infertile patients and among them, 20 patients whose basal FSH on the third day of menstrual cycle was more than 20 mIU/ml were excluded. At the same time, the same CCCT was performed to the fifteen healthy volunteers with proven fertility to determine the cutoff value of CCCT. Results; 1) A FSH value higher than 23.4 mIU/ml, measured on the 10th day of menstrual cycle, was defined as a abnormal ovarian response. The cutoff value of 23.4 mIU/ml is more than 2 standard deviations(SD) above the mean value of 15 healthy women after CCCT. 2) The abnormal CCCT group, the subpopulation with a FSH value of 23.4 mIU/ml or more, was 7.3%(8/109) and their mean age was higher than the normal CCCT group($36.5{\pm}4.5$ vs. $32.9{\pm}4.8$, P = 0.059). And the percentage of the patients older than 35 years of the abnormal CCCT group was significantly higher than that of the normal CCCT group(62.5% vs. 38.6%, p <0.05). 3) There was no correlation between the hormone values of the third day and the 10th day of menstrual cycle before and after CCCT except between FSH of the third day and the 10th day. Conclusion: The CCCT is a good method to predict the individual ovarian response to COH for ART, especially in the patients who has no other abnormal findings that predict poor prognosis. And it is neccessary to determine the cutoff value of CCCT by the large numbers of randomized study, and combining the previously proven prognostic factors, it can be applicated in many individual centers for evaluate the ovarian response before ART program.

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Antimicrobial Activity, Quantification and Bactericidal Activities of Licorice Active Ingredients (감초 성분의 항균활성, 정량 및 방부력에 관한 연구)

  • Kim, Hye Jin;Jang, Ha Na;Bae, Jeong Yun;Ha, Ji Hoon;Park, Soo Nam
    • Microbiology and Biotechnology Letters
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    • v.42 no.4
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    • pp.386-392
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    • 2014
  • The present study was aimed at investigating the antimicrobial activities of licorice's active ingredients. Four samples of licorice ingredients (glycyrrhizin, liquiritin, liquiritigenin, and isoliquiritigenin) were evaluated for their antimicrobial activities against six skin microorganisms. The bioassay applied for determining the antimicrobial effects employed a disc diffusion assay, the minimum inhibitory concentration, and the challenge test. The ingredients showed antibacterial activities. Especially, isoliquiritigenin has significant antimicrobial activities against two Gram-positive (Bacillus subtilis, Propionobacterium acnes) and two Gramnegative (Escherichia coli, Pseudomonas aeruginosa) bacteria. These samples had much higher antimicrobial activities than synthetic preservatives. Our results reveal that liquiritigenin and isoliquiritigenin could be useful compounds for the development of antibacterial agents for the preservation of cosmetics and foods. The two flavonoids, liquiritigenin and isoliquiritigenin, sourced from Korea, China, Uzbekistan, were quantified using HPLC. The results demonstrated that Korean licorice has two flavonoids (liquiritigenin, isoliquiritigenin) in much higher quantities than was observed in the licorice obtained from the two other countries. Thus, isoliquiritigenin and Korean licorice extract represent new candidates for antimicrobial agents.

A Study on Test & Evaluation Technique of RWR/CMDS for Survivability Improvement (생존성 향상을 위한 RWR/CMDS 시험평가 기술 연구)

  • Kim, Chanjo;Jang, Youngbae;Kim, Hyeongkyeong
    • Journal of Aerospace System Engineering
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    • v.10 no.4
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    • pp.84-89
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    • 2016
  • Electronic Warfare (EW) is the mission area responsible to establish and maintain a favorable position in the electromagnetic domain. Testing and Evaluation of EW devices on modern military aircraft to pursue this critical mission area require the use of a wide range of techniques and analytical methods to assure users of the readiness of EW system to meet the challenge of a combat environment. This paper is intended as an introductory text dedicated to EW systems (especially RWR, CMDS) test and evaluation techniques and will serve experienced engineers and program managers, as well as novice engineers, as a concise reference for EW systems' test and evaluation processes and testing resources.

A Study on Implementation of Automatic Evaluation System for Static Performance of 6 DOF MEMS Inertial Sensor (6자유도 MEMS 관성센서 정적성능 자동 평가 시스템 구현에 관한 연구)

  • Ji Won Park;Hussamud Din;Byeung Leul Lee
    • Journal of the Semiconductor & Display Technology
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    • v.22 no.3
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    • pp.62-66
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    • 2023
  • With the advancement in technology and rapid increase in the demand for microelectromechanical systems (MEMS) based inertial measurement units (IMUs), high-volume production and test system remain a major challenge for the MEMS industry. To compete with the challenging market of Industry 4.0, here we developed an automatic test system to evaluate the performance of the ovenized IMU sensors as well as analyze the data. The automatic test system was developed by interfacing a commercial MEMS IMU (BMI 088) using LabVIEW. The BMI 088 was tested experimentally for long-term bias stability, ON/OFF bias repeatability, and root mean square (rms) noise. Furthermore, the data was analyzed through the developed test system. The results show that the automatic test system has improved the test time and reduced human effort. The developed automatic test system is a significant approach to MEMS research and development (R&D) to increase and improve the mass production of IMUs.

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Lung function tests in preschool children (5세 미만의 폐기능 검사)

  • Park, Yong-Mean
    • Clinical and Experimental Pediatrics
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    • v.50 no.5
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    • pp.422-429
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    • 2007
  • Measurement of lung function is an integral component of respiratory physiology and of clinical assessment of lung diseases in school age children and adults. Pulmonary function test of infants and children under the age of 2 years have now been standardised and are being used both in research and as an adjunct to clinical management. By contrast, until recegntly, children of preschool age, i.e. between 2-6 years represented a major challenge for pulmonary function test assessment, this particular period commonly being referred to as the 'dark ages' of Pediatric Pulmonology. Measurement of lung function in preschool-aged children is now feasible. However, much work remains to be done in standardizing how these tests are performed, and in understanding the most appropriate role for the various tests in the study of growth and development of the respiratory system and in the clinical management of children in this age group. As the field develops and the knowledge of respiratory physiology in this age group expands, investigation of different and more appropriate algorithm use in preschool children, together with development of more appropriate reference data, may result in improved disease discrimination.

OPTIMIZATION OF THE TEST INTERVALS OF A NUCLEAR SAFETY SYSTEM BY GENETIC ALGORITHMS, SOLUTION CLUSTERING AND FUZZY PREFERENCE ASSIGNMENT

  • Zio, E.;Bazzo, R.
    • Nuclear Engineering and Technology
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    • v.42 no.4
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    • pp.414-425
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    • 2010
  • In this paper, a procedure is developed for identifying a number of representative solutions manageable for decision-making in a multiobjective optimization problem concerning the test intervals of the components of a safety system of a nuclear power plant. Pareto Front solutions are identified by a genetic algorithm and then clustered by subtractive clustering into "families". On the basis of the decision maker's preferences, each family is then synthetically represented by a "head of the family" solution. This is done by introducing a scoring system that ranks the solutions with respect to the different objectives: a fuzzy preference assignment is employed to this purpose. Level Diagrams are then used to represent, analyze and interpret the Pareto Fronts reduced to the head-of-the-family solutions.

An Animal Model to Evaluate the Protective Efficacy of Haemophilus influenzae Type b Conjugate Vaccines

  • Kim Hyun Sung;Yoo Tae Hyeon;Jang Yang Suk;Kim Hun;Park Jin Yong;Hur Byung Ki;Ryu Yeon Woo;Kim Jong Su
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.9 no.6
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    • pp.490-494
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    • 2004
  • An efficacy test of PRP (polyribosylribitol phosphate)-TT (Tetanus toxoid) conjugate vaccines was carried out using BALB/c mice as an animal model by inoculating Haemophilus in­fluenzae type b (Hib) with a virulence enhancement factor (VEF). Three administrations of the conjugate vaccines at 2-week intervals elicited a significantly high level of PRP antibodies (P>0.0001). The protective activity of the PRP immunization was challenged with either Hib with iron dextran (Hib/) or with a combination of mucin and hemoglobin (Hibmh) as a VEF. The me­dium lethal dose $(LD_{50})$ for Hibmh and Hibiwas measured as 10 CFU (Colony Forming Unit) and $2.5{\times}10^{8}$ CFU respectively. Each immunized animal was challenged with five or ten times the $LD_{50}$ level of bacteria with a VEF. A significant difference in mortality between the immunized and control mice (P> 0.01) was observed with the Hibmh challenge inoculation but not with the Hibi challenge inoculation. These results show that a combination of mucin and hemoglobin was able to enhance the virulence of Hib in BALB/c mice to cause a lethal infection, thus suggesting that BALB/c mice introduced to this method can be an effective model animal for testing the protective efficacy of H. influenzae conjugate vaccines.

Growth in Infants with Cow's Milk Protein Allergy Fed an Amino Acid-Based Formula

  • Vandenplas, Yvan;Dupont, Christophe;Eigenmann, Philippe;Heine, Ralf G.;Host, Arne;Jarvi, Anette;Kuitunen, Mikael;Mukherjee, Rajat;Ribes-Koninckx, Carmen;Szajewska, Hania;Berg, Andrea von;Zhao, Zheng-Yan
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.24 no.4
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    • pp.392-402
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    • 2021
  • Purpose: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy (CMPA). Methods: Non-breastfed, term infants aged 0-6 months with symptoms suggestive of CMPA were recruited from 10 pediatric centers in China. After enrollment, infants were started on AAF for two weeks, followed by an open food challenge (OFC) with cow's milk-based formula (CMF). Infants with confirmed CMPA remained on AAF until 9 months of age, in conjunction with a cow's milk protein-free complementary diet. Body weight, length, and head circumference were measured at enrollment and 9 months of age. Measurements were converted to weight-for-age, length-for-age, and head circumference-for-age Z scores (WAZ, LAZ, HCAZ), based on the World Health Organization growth reference. Results: Of 254 infants (median age 16.1 weeks, 50.9% male), 218 (85.8%) were diagnosed with non-IgE-mediated CMPA, 33 (13.0%) tolerated CMF, and 3 (1.2%) did not complete the OFC. The mean WAZ decreased from 0.119 to -0.029 between birth and enrollment (p=0.067), with significant catch-up growth to 0.178 at 9 months of age (p=0.012) while being fed the AAF. There were no significant changes in LAZ (0.400 vs. 0.552; p=0.214) or HCAZ (-0.356 vs. -0.284; p=0.705) from the time of enrollment to age 9 months, suggesting normal linear and head growth velocity. Conclusion: The amino acid-based study formula, in conjunction with a cow's milk proteinfree complementary diet, supported normal growth till 9 months of age in a cohort of Chinese infants with challenge-confirmed non-IgE-mediated CMPA.