• 한국식품영양과학회지
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• 제35권9호
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• pp.1121-1126
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• 2006

In the present study, the potential hepatoprotective effects of poly herbal formulation, Hepa-1000, against oxidative damages induced by t-BHP were evaluated in HepG2 cells in order to relate in vitro antioxidant activity with cytoprotective effects. The t-BHP induced considerable cell damage in HepG2 cells was shown by significant glutamic oxaloacetic transaminase (GOT) and lactate dehydrogenase (LDH) leakage, and increased lipid peroxidation. Hepa-1000-treated cells showed an increased resistance to oxidative challenge, as revealed by higher survival capacity than the one of control cells against t-BHP induced oxidative stress and hepatotoxicity. In addition, the Hepa-1000 had hepatoprotective effects lowering the activity of GOT and LDH, simultaneously. That is, it could inhibit the cell membrane damages resulting in the increased activities of GOT and LDH in the cell culture media. Furthermore, the Hepa-1000 could reduce t-BHP enhanced lipid peroxidation, which was evaluated by measuring the production of malonedialdehyde. Based on the data described above, it could be suggested that the Hepa-1000 has significant hepatoprotective effects and plays a protective role against lipid peroxidation by free radicals.

• 디지털산업정보학회논문지
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• 제15권1호
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• pp.133-155
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• 2019

The economic growth has made our lives more prosperous than the past, and the development of science fueled the era of 100-year lifespan. It is now distinct to us that preparation for life after retirement is not a choice but an imperative. In the meantime, outplacement programs have driven many to challenge and start a new chapter in life. This paper measures the characteristics of outplacement programs based on the self-determination factors; empirically examines how those characteristics influence on learning performance through self-efficacy and psychological well-being; concludes by proposing effective and productive ways for young adults and senior employees who are in search for new jobs. To test the research hypothesis, a survey was conducted among job searchers who have been previously provided with outplacement programs. The results are as follows: First, self-perceived autonomy has significant influences on self-efficacy and psychological well-being. Second, self-perceived competency has significant influences on self-efficacy and psychological well-being. Third, perceived relationship has no significant influence on self-efficacy and psychological well-being. Fourth, self-efficacy showed significant influences on psychological well-being, while not showing on learning performance. Fifth, psychological well-being has no significant influence on learning performance. This paper finds its academic significance in its theory-based approach to outplacement service program; research variables and examination are not based on researcher's arbitrary choice. This paper is also practically significant in that it discovered that outplacement service alleviates psychological stress caused by job relocation, and guarantees stable life after retirement.

• International Journal of Computer Science & Network Security
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• 제22권3호
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• pp.276-284
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• 2022

The research aims to study the dynamics of academic procrastination and its impact on the mental health of students during the transition to distance learning during the COVID-19 pandemic. At the beginning of the COVID-19 pandemic, it was identified a declining tendency of overall rates of academic procrastination and at the same time increase in the number of carriers of mid and high levels of academic procrastination. The decline in the general rates of academic procrastination at the beginning of 2021 testifies to the adaptation processes experienced by students to the conditions of distance learning. It was documented that students' academic procrastination is accompanied by a steady negative emotional tension. During the transition to distance learning, the intensity of students' learning activity has increased, which altogether causes stress as one of the main reasons for the academic procrastination among future psychologists. The study identified a risk of academic procrastination manifestation among students for their mental health, which provides a basis for developing and testing a program to prevent the phenomenon of academic procrastination among degree-seeking students.

• Geomechanics and Engineering
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• 제28권2호
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• pp.117-133
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• 2022

Determination of the mechanical behaviour of jointed rock masses has been a challenge for rock engineers for decades. This problem is more pronounced for non-persistent jointed rock masses due to complicated interaction of rock bridges on the overall behaviour. This paper aims to study the effect of a non-persistent joint set configuration on the mechanical behaviour of rock materials under both uniaxial and biaxial compression tests using a discrete element code. The numerical simulation of biaxial compressive strength of rock masses has been challenging in the past due to shortcomings of bonded particle models in reproducing the failure envelope of rock materials. This problem was resolved in this study by employing the flat-joint contact model. The validity of the numerical model was investigated through a comprehensive comparative study against physical uniaxial and biaxial compression experiments. Good agreement was found between numerical and experimental tests in terms of the recorded peak strength and the failure mode in both loading conditions. Studies on the effect of joint orientation on the failure mode showed that four zones of intact, transition to block rotation, block rotation and transition to intact failure occurs when the joint dip angle varies from 0° to 90°. It was found that the applied confining stress can significantly alter the range of these zones. It was observed that the minimum strength occurs at the joint dip angle of around 45 degrees under different confining stresses. It was also found that the joint orientation can alter the post peak behaviour and the lowest brittleness was observed at the block rotation zone.

• Journal of Hospice and Palliative Care
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• 제25권2호
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• pp.55-65
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• 2022

Caring for patients with cancer is highly stimulating and rewarding, attracting health professionals to the field who enjoy the challenge of managing a complex illness. Health professionals often form close bonds with their patients as they confront ongoing disease or treatment impacts, which may be associated with multiple losses involving function and/or eventual loss of life. Ongoing exposure to patient loss, along with a challenging work setting, may pose significant stress and impact health professionals' well-being. The prevalence rates of burnout and compassion fatigue (CF) are significant, yet health professionals have little knowledge on these topics. A 6-week continuing education program consisting of weekly small-group video-conferencing sessions, case-based learning, and an online community of practice was delivered to health care providers providing oncology care. Program content included personal, organization and team-related risk and protective factors associated with CF, grief models, and strategies to mitigate against CF. Content analysis was completed as part of the program evaluation. In total, 189 participants (93% nurses) completed the program, which was associated with significant improvements in confidence and knowledge of CF and strategies to support self and team resilience. Qualitative themes and vignettes from experiences with the program are presented. Key themes included knowledge gaps, a lack of support related to CF and strategies to support resilience, organization-and team-based factors that can inhibit expression about the impacts of clinical work, the health professional as a "person" in caregiving, and the role of personal variables, self-skill practices, and recommendations for education and support for self and teams.

• 생명과학회지
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• 제24권12호
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• pp.1371-1377
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• 2014

활성산소종(ROS)은 환경 스트레스 및 병원체의 침입에 의한 산화 대사의 자연적인 산물로써 생물에서 생산된다. 산화적 스트레스에 의해 생성되는 superoxide 음이온 및 과산화수소와 같은 ROS는 세포와 조직에 독성을 나타낼 수 있고, 이 과정에 관여하는 superoxide dismutase (SOD)는 중요한 metalloenzyme이다. 최근 연구는 올리브 넙치(Paralichthys olivaceus)에서 SOD의 부분 유전자가 benzo[a]pyrene에 의해 강하게 발현이 유도되고 산화 스트레스 반응의 지표라고 확인하였지만, 바이러스성 감염에 대한 전사적 반응에 대해서는 조사되지 않았다. 본 연구에서는 항바이러스 반응에서 넙치 SOD의 기능을 알아보기 위해 공간 및 시간적 발현 프로파일을 분석하였다. 넙치 SOD 전사체는 정도의 차이는 있지만 다양한 기관에서 보편적으로 발현되었으며, 근육, 간, 뇌에서는 높게 발현되었고, 위와 비장에서는 상대적으로 낮게 발현되었다. VHSV 감염 후 넙치 콩팥에서 SOD 발현은 3시간 이내에 증가하였으며 점차적으로 감소하여 감염 2일째 원래 수준으로 돌아갔다. 검사 조직에 따라 발현이 유도되는 시간의 차이는 있지만 근육, 간, 뇌에서도 콩팥과 유사한 발현양상을 보였으며, 공통적으로 급성적 면역반응에서는 발현이 증가하지만 만성적 면역반응에서는 감소하였다. 이상의 결과들을 종합해 볼 때, 넙치 SOD는 넙치(P. olivaceus)의 면역 방어 시스템에 중요한 역할을 하고 넙치의 산화 스트레스에 대한 보호 효과에 기여할 것으로 기대할 수 있다.

• 한국응용곤충학회지
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• 제50권1호
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• pp.39-46
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• 2011

본 연구는 상이한 음파 처리에 따라 파밤나방(Spodoptera exigua) 유충의 소화와 면역 생리반응에 대한 교란 효과를 분석하였다. 조사한 모든 주파수의 음파 처리가 파밤나방 산란에는 뚜렷한 효과를 주지 않았지만, 95 dB 소리세기에서 100-5,000 Hz 주파수의 음파 처리는 유충의 섭식량을 저하시키고, 중장의 소화효소 활성을 억제시켰다. 이 스트레스 음파 처리에 따른 중장 내강에 존재하는 단백질을 이차원전기영동으로 분리하였으며, 무처리구와 상이한 단백질 패턴을 발견하였다. 또한 가장 스트레스 효과를 크게 주는 95 dB의 5,000 Hz 주파수 음파 처리를 받은 유충은 곰팡이 감염에 대해서 혈구의 소낭형성이 억제되었다. 이 음파 처리 받은 유충의 혈구와 혈장에서 인지질분해효소(phospholipase $A_2$: $PLA_2$)의 활성은 현격하게 감소하였다. 스트레스 음파 처리에 따라 파밤나방 유충은 살충제에 대한 감수성이 증가했다. 이러한 상이한 주파수에 따른 생리교란 효과는 소리세기의 차이에 따라 뚜렷하게 차등을 보였다. 이러한 결과는 음파처리가 파밤나방의 생리과정에 스트레스를 주어 비화학적 해충 방제 관리 기술 개발에 적용될 수 있다고 본 연구는 제시한다.

• Biomolecules & Therapeutics
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• 제27권3호
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• pp.327-335
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• 2019

As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials have been conducted and have failed, the development of new theraphies for AD with fewer adverse effects remains a challenge. In this study, we examined the effects of Theracurmin on cognitive decline using 5XFAD mice, an AD mouse model. Theracurmin is more bioavailable form of curcumin, generated with submicron colloidal dispersion. Mice were treated with Theracurmin (100, 300 and 1,000 mg/kg) for 12 weeks and were subjected to the novel object recognition test and the Barnes maze test. Theracurmin-treated mice showed significant amelioration in recognition and spatial memories compared those of the vehicle-treated controls. In addition, the antioxidant activities of Theracurmin were investigated by measuring the superoxide dismutase (SOD) activity, malondialdehyde (MDA) and glutathione (GSH) levels. The increased MDA level and decreased SOD and GSH levels in the vehicle-treated 5XFAD mice were significantly reversed by the administration of Theracurmin. Moreover, we observed that Theracurmin administration elevated the expression levels of synaptic components, including synaptophysin and post synaptic density protein 95, and decreased the expression levels of ionized calcium-binding adapter molecule 1 (Iba-1), a marker of activated microglia. These results suggest that Theracurmin ameliorates cognitive function by increasing the expression of synaptic components and by preventing neuronal cell damage from oxidative stress or from the activation of microglia. Thus, Theracurmin would be useful for treating the cognitive dysfunctions observed in AD.

• 대한핵의학회지
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• 제37권5호
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• pp.278-287
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• 2003

목적: 생존심근 진단에 있어 니트로글리세린 투여 Tc-99m-MIBI 게이트 심근SPECT의 진단성능을 휴식/지연재분포 Tl-201 심근SPECT와 비교하였다. 대상 및 방법: 22명의 관상동맥질환자에서 Tl-201 휴식/디피리다몰 부하 Tc-99m-MIBI 게이트 지연재분포 Tl-201 심근SPECT를 시행하였다. 이 때 게이트SPECT 시행 후 니트로글리세린 0.6 mg을 설하투여하고 연이어 그 자리에서 게이트SPECT를 1회 더 반복 시행하였다. 환자들에게 관상동맥우회로술을 시행하고 3개월 후 게이트 심근SPECT를 추적검사로 시행하였다. 20 분절 모델을 이용하여 각 분절에서 휴식, 지연재분포, 기저상태와 니트로글리세린투여 후의 심벽운동 및 수축기비후화 등을 정량하였다. 정량화된 생존심근 예측지표들 중, (1) 휴식기 Tl-201 섭취, (2) Tl-201 지연재분포, (3) 기저상태의 수축기비후화, (4) 니트로글리세린 투여 후의 수축 기비후화, 네 가지의 예측성능을 평가하고 비교하였다. 결과: 총 100개의 분절이 분석에 포함되었으며, 이 중 66개(66%)의 분절이 재관류 후 기능 회복을 보였다. 최적 기준점인 50%를 기준으로 하였을 때, ROC 곡선 분석에서 휴식기 Tl-201 섭취와 Tl-201 지연재분포의 민감도, 특이도는 각각 79%와 44%, 그리고 82%와 44%였다. 또한 15%를 기준으로 하여, 기저상태 수축기비후화와 니트로글리세린 투여 후 수축기비후화의 민감도, 특이도는, 각각 49%, 50%와 64%, 65%였다. ROC 곡선의 AUC는 니트로 글리세린 투여 후 수축기비후화가 기저시 수축기비후화에 비하여 유의하게 높았다(p=0.004). 결론: 니트로글리세린 투여 Tc-99m-MIBI 정량적 게이트 심근SPECT는 기능이상 심근에서 기능 회복을 예측하는데 유용한 검사이다.

• 대한간호학회지
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• 제36권4호
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• pp.596-603
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• 2006

Purpose. This study examined Korean clinical nurses' intentions to care for SARS patients and identify determinants of the intentions. Theory of planned behavior was the framework to explain the intentions of Korean nurses for SARS patients care. Methods. A convenient sample of six hundreds and seventy nine clinical nurses from four university-affiliated hospitals located in Seoul and in Kyung-gi province was used. Self-administered (83-items) questionnaire was used to collect data. Intentions, attitude, subjective norm, perceive behavioral control, behavioral beliefs, normative beliefs, and control beliefs were the study variables. All items were measured using 7point Likert scale (-3 to +3). Data were analyzed using descriptive statistics, Pearson correlation method, and stepwise multiple regression methods. Results. Intentions and attitudes toward SARS patient care among Korean clinical nurses were moderate, but their subjective norm and perceive behavioral control of SARS patients care were negative. Stepwise multiple regression analysis indicated that attitude toward SARS patient care, perceived behavioral control, subjective norm were the determinants of the intentions for SARS patients care as theory proposed. Among the behavioral beliefs, 'SARS-patient caring would be a new experience', 'during SARS-patient caring, I should be apart from my family', 'after completing SARS-patient caring, I would be proud of myself being able to cope with a stressful event' and 'with my SARS-patient caring, patients could recover from SARS' were the significant determinants. Among the normative beliefs, colleague approval, spouse approval, and physician approval were significant determinants of the intentions. Among the control beliefs, 'SARS-patient caring would be a challenge' 'SARS-patient caring is a professional responsibility', 'tension during the care of SARS patients' and 'support from team members' were the significant determinants of the intentions. Conclusions. Korean clinical nurses in this study were not willing to care for SARS patients and showed negative attitude toward the care. They believed their friends and family were not approved their care for SARS patients. Nurses were in conflicts between professional responsibilities to care for SARS patients and personal safety. This study was the first to understand stress and burden of Korean clinical nurses who are in front line to care for newly developed communicable disease such as SARS. Under the circumstance where several fatal communicable diseases are predictable, conflicts between professional responsibility and their personal risks should be taken into considerations by nurses themselves and by nursing administrators in order to improve quality of care.