• Parasites, Hosts and Diseases
• /
• 제59권6호
• /
• pp.615-623
• /
• 2021

Human sparganosis is a food-borne parasitic disease caused by the plerocercoids of Spirometra species. Clinical diagnosis of sparganosis is crucial for effective treatment, thus it is important to identify sensitive and specific antigens of plerocercoids. The aim of the current study was to identify and characterize the immunogenic proteins of Spirometra erinaceieuropaei plerocercoids that were recognized by patient sera. Crude soluble extract of the plerocercoids were separated using 2-dimensional gel electrophoresis coupled with immunoblot and mass spectrometry analysis. Based on immunoblotting patterns and mass spectrometry results, 8 antigenic proteins were identified from the plerocercoid. Among the proteins, cysteine protease protein might be developed as an antigen for diagnosis of sparganosis.

• 제어로봇시스템학회논문지
• /
• 제14권9호
• /
• pp.886-892
• /
• 2008

In this paper, a closed-loop observer to extract the center of mass (CoM) of a bipedal robot is suggested. Comparing with the simple conversion method of just using joint angle measurements, it enables to get more reliable estimates by fusing both joint angle measurements and F/T sensor outputs at ankle joints. First, a nonlinear-type observer is constructed to estimate the flexible rotational motion of the biped in the extended Kalman filter framework. It adopts the flexible inverted pendulum model which is appropriate to address the flexible motion of bipeds, specifically in the single support phase. The predicted estimates of CoM in terms of the flexible motion observer are combined with measurements (that is, output of the CoM conversion equation with joint angles). Then, we have final CoM estimates depending on the weighting values which penalize the flexible motion model and the CoM conversion equation. Simulation results show the effectiveness of the proposed algorithm.

• Parasites, Hosts and Diseases
• /
• 제44권3호
• /
• pp.177-185
• /
• 2006

Soil-transmitted helminths (STH), namely Ascaris, Trichuris and hookworms (Ancylostoma and Necator), present a global health problem to about a half of the earth's population. In the Republic of Korea, STH were highly prevalent and were considered a high priority target for national control. To promote the control, a non-governmental organization named Korea Association for Parasite Eradication (currently Korea Association of Health Promotion) was founded in 1964, and mass fecal examination followed by selective mass chemotherapy with anthelmintics was performed twice a year from 1969 to 1995 targeting whole nationwide schoolchildren. Meanwhile, decreasing patterns of national STH infections have been monitored by 7 times' quinquennial national surveys targeting general population. In 1971, the overall intestinal helminth egg positive rate was 84.3% (Ascaris 58.2%, Trichuris 65.4%, and hookworms 10.7%), which became 63.2% in 1976, 41.1% in 1981, 12.9% in 1986, 3.8% in 1992, 2.4% in 1997, and 4.3% (Ascaris 0.03%, Trichuris 0.02%, and hookworms 0%) in 2004. During the control period, national economy rapidly developed, and living standards including environment, sanitation, and agricultural technology greatly improved, which undoubtedly boosted the STH control effects. Our experience indicates that social driving force to establish an eligible national control system to conduct repeated mass chemotherapy, together with improvement of environment and sanitation, is important for initiating and achieving STH control in a developing community.

• 로봇학회논문지
• /
• 제9권4호
• /
• pp.250-257
• /
• 2014

In this paper, a new mobile robot, so called a rollerbot, is presented, which has single body and rugby-ball shaped roller wheel. A rollerbot has single point contact on ground and low energy consumption in motion because of the reduced friction. By changing center of mass using a balancing weight, a rollerbot is able to get steering force. The vertical position of mass center of the rollerbot in this paper is designed to lie inside radius of the roller wheel, so that to have stable equilibrium position. Thus, the posture and the steering control of the rollerbot can be easily done by changing the center of mass. Kinematics of the rollerbot is derived by transformation of differential motion in this paper.

• 대한정형도수물리치료학회지
• /
• 제15권1호
• /
• pp.41-48
• /
• 2009

Purpose: to program introduction the effects of stability sling exercise and common exercise of high school in man volleyball player. Methods: This study divided the subjects into a sling-exercise group and a common exercise group to compare after practicing exercises twice per week for 8 weeks (total 16 times). To compare the means of the experimental group and the control group on each variable, the ANOVA for repeated measure was used and if there was any significant difference across the measurement times, post-hoc comparisons were conducted for the difference. Results: The T-tests for group difference according to exercise type on each of the variables showed the results as follows. The pain in cervical region is experimental and control groups pain correlation were not significant(p>0.05). But lumbar region experimental and control groups were significant(p<0.05). Muscle volume was increased during 8weeks in experimental and control groups. But experimental and control groups muscle volume correlation were not significant(p>0.05). Conclusion: Fat Mass composition was decreased during 8 weeks in experimental and control groups. But experimental and control groups mass composition correlation were not significant(p>0.05).

• 분석과학
• /
• 제8권2호
• /
• pp.139-159
• /
• 1995

몇 가지 종류의 corticosteroid에 대하여 액체 크로마토그래피-질량분석법으로 양이온 질량 스펙트럼을 얻었다. 화학구조에 따라 수소 첨가된 분자이온 [$MH^+$], 암모늄 첨가이온 [${MNH_4}^+$], 또는 ($MH^+-60$) 이온이 base peak였고 [$MH^+-18$] 또는 [${MNH_4}^+-18$] 이온 등이 특성적으로 나타났다. Methylprednisolone acetate를 male Sprague-Dawley rat에 경구투여한 다음 24시간 동안 배설된 뇨로부터 유리상태 또는 접합상태의 대사물질들을 가수분해, 추출 및 농축하고, thermospray LC/MS를 사용하여 양이온과 음이온 질량토막이온을 분석하였다. Methylprednisolone acetate의 C-21 위치에서의 탈아세틸화(deacetylation), C-20 위치에서 C=0의 -CHOH로의 환원, C-11 위치에서 CHOH의 C=0로의 산화 또는 C-17과 C-20 사이의 bond cleavage등에 의해 생성되는 것으로 추정되는 10여종의 대사물질을 검출하였다. 그 중에 20-hydroxymethylprednisolone(20-HMP), methylprednisolone(MP), methylprednisone(11-KMP)등은 표준물질과 비교 확인하였다.

• Archives of Pharmacal Research
• /
• 제19권6호
• /
• pp.566-569
• /
• 1996

A sensitivity method has been developed for the detection and determination of niflmic acid(NA) in human urine. Samples were extracted with diethylether. Flunixin (FN) was added to the sample prior to extraction as an internal standard. Niflumic acid was converted to its methyl derivative and analyzed by capillary gas chromatography/negative chemical isonization mass spectrometry. Using selected ion monitoring (SIM), the levels of NA down to 5 pg/ml could be detected in 5 ml spiked urine sample. Calibration curve was linear over the range of 0.5 ppm-50 ppm. The recovery of niflumic acid from urine at 40 pg/ml was to be $91.7{\pm}3.8(n=3)$ and the coefficient of variation was 4.1%.

• Geomechanics and Engineering
• /
• 재33권6호
• /
• pp.553-565
• /
• 2023

As the structure of broken rock mass is complex, with obvious discontinuity and anisotropy, it is generally necessary to reinforce broken rock mass using grouting in underground construction. The purpose of this study is to experimentally investigate the mechanical properties of broken rock mass after grouting reinforcement with consideration of the characteristics of broken rock mass (i.e., degree of fragmentation and shape) and a range of reinforcement methods such as relative strength ratio between the broken rock mass and cement-based grout stone body (λ), and volumetric block proportion (VBP) representing the volumetric ratio of broken rock mass and the overall cement grout-broken rock mass mixture after the reinforcement. The experimental results show that the strength and deformation of the reinforced broken rock mass is largely determined by relative strength ratio (λ) and VBP. In addition, the enhancement in compressive strength by grouting is more obvious for broken rock mass with spherical shape under a relatively high strength ratio (e.g., λ=2.0), whereas the shape of rock mass has little influence when the strength ratio is low (e.g., λ=0.1). Importantly, the results indicate that columnar splitting failure and inclined shear failure are two typical failure modes of broken rock mass with grouting reinforcement.

• 제어로봇시스템학회논문지
• /
• 제4권6호
• /
• pp.713-721
• /
• 1998

In this paper a new modeling and an optimal pole-placement control for the suspension system of Macpherson type are investigated. The rotational motion of the unsprung mass is emphasized in the new modeling. The two generalized coordinates selected in the new model are the vortical displacement of sprung mass and the angular displacement of control arm. Both variables are measured from their static equilibrium points. It is shown that the conventional model is a special case of the new model since the transfer function of the new model coincides with that of the conventional one if the lower support point of the shock absorber is located at the mass center of the unsprung mass. It is also shown that the resonance frequencies of the new model agree better with experimental results. Therefore, the new model is more general in the sense that it Provides an extra degree of freedom in determining the plant model for control system design. An optimal pole-placement control which combines LQ control and pole-placement technique is applied to the new model. Simulations are provided.

• Bulletin of the Korean Chemical Society
• /
• 제31권2호
• /
• pp.483-486
• /
• 2010