• Title/Summary/Keyword: Censored survival data

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Kernel Estimation of Hazard Ratio Based on Censored Data

  • Choi, Myong-Hui;Lee, In-Suk;Song, Jae-Kee
    • Journal of the Korean Data and Information Science Society
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    • v.12 no.2
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    • pp.125-143
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    • 2001
  • We, in this paper, propose a kernel estimator of hazard ratio with censored survival data. The uniform consistency and asymptotic normality of the proposed estimator are proved by using counting process approach. In order to assess the performance of the proposed estimator, we compare the kernel estimator with Cox estimator and the generalized rank estimators of hazard ratio in terms of MSE by Monte Carlo simulation. Two examples are illustrated for our results.

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Two-Sample Inference for Quantiles Based on Bootstrap for Censored Survival Data

  • Kim, Ji-Hyun
    • Journal of the Korean Statistical Society
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    • v.22 no.2
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    • pp.159-169
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    • 1993
  • In this article, we consider two sample problem with randomly right censored data. We propse two-sample confidence intervals for the difference in medians or any quantiles, based on bootstrap. The bootstrap version of two-sample confidence intervals proposed in this article is simple to apply and do not need the assumption of the shift model, so that for the non-shift model, the density estimation is not necessary, which is an attractive feature in small to moderate sized sample case.

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A Test For Trend Change in Failure Rate Using Censored Data

  • Kim, Jae-Joo;Jeong, Hai-Sung;Na, Myung-Hwan
    • Proceedings of the Korean Reliability Society Conference
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    • 2000.11a
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    • pp.365-371
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    • 2000
  • The problem of trend change in the failure rate is great interest in the reliability and survival analysis. In this paper we develop a test statistic for testing whether or not the failure rate changes its trend using random censored data. The asymptotic normality of the test statistic is established. We discuss the efficiency values of loss due to censoring.

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A Test For Trend Change in Failure Rate Using Censored Data

  • Kim, Jae Joo;Jeong, Hai Sung;Na, Myung Hwan
    • International Journal of Quality Innovation
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    • v.1 no.1
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    • pp.58-63
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    • 2000
  • The problem of trend change in the failure rate is great interest in the reliability and survival analysis. In this paper we develop a test statistic for testing whether or not the failure rate changes its trend using random censored data. The asymptotic normality of the test statistic is established. The efficiency values of loss due to censoring are discussed.

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Robust Regression for Right-Censored Data

  • Kim, Chul-Ki
    • Journal of Korean Society for Quality Management
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    • v.25 no.2
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    • pp.47-59
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    • 1997
  • In this paper we develop computational algorithms to calculate M-estimators of regression parameters from right-censored data that are naturally collected in quality control. In the case of M-estimators, a new statistical method is also introduced to incorporate concomitant scale estimation in the presence of right censoring on the observed responses. Furthermore, we illustrate this by simulations.

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Comparing Survival Functions with Doubly Interval-Censored Data: An Application to Diabetes Surveyed by Korean Cancer Prevention Study (이중구간중도절단된 생존자료의 생존함수 비교를 위한 검정: 한국인 암 예방연구 중 당뇨병에의 응용)

  • Jee, Sun-Ha;Nam, Chung-Mo;Kim, Jin-Heum
    • The Korean Journal of Applied Statistics
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    • v.22 no.3
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    • pp.595-606
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    • 2009
  • Two tests were introduced for comparing several survival functions with doubly interval-censored data and illustrated with data surveyed by Korean Cancer Prevention Study (Jee et al., 2005). The test which extended Kim et al. (2006)'s test to the doubly interval-censored data has an advantage over Sun (2006)'s test in terms of saving computation time because the proposed test only depends on the size of risk set, and also the proposed test is applicable to continuous failure time data as well as discrete failure time data unlike Sun's test. Comparing male with female groups on the incubation time of diabetes was highly different and the survival of female group was longer than that of male one. Regardless of gender, the difference in survival functions of four age groups was highly significant with p-value of less than 0.001. This trend was more remarkable for female group than for male one. Simulation results showed that the significance level of both tests was well controlled and the proposed test was better than Sun's test in terms of power.

Study on the Reliability Evaluation Method of Components when Operating in Different Environments (이종 환경에서 운용되는 부품의 신뢰도 평가 방법 연구)

  • Hwang, Jeong Taek;Kim, Jong Hak;Jeon, Ju Yeon;Han, Jae Hyeon
    • Journal of the Korean Society of Safety
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    • v.32 no.5
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    • pp.115-121
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    • 2017
  • This paper is to introduce the main modeling assumptions and data structures associated with right-censored data to describe the successful methodological ideas for analyzing such a field-failure-data when components operating in different environments. The Kaplan - Meier method is the most popular method used for survival analysis. Together with the log-rank test, it may provide us with an opportunity to estimate survival probabilities and to compare survival between groups. An important advantage of the Kaplan - Meier curve is that the method can take into account some types of censored data, particularly right-censoring. The above non-parametric method was used to verify the equality of parts life used in different environments. After that, we performed the life distribution analysis using the parametric method. We simulated data from three distributions: exponential, normal, and Weibull. This allowed us to compare the results of the estimates to the known true values and to quantify the reliability indices. Here we used the Akaike information criterion to find a suitable life time distribution. If the Akaike information criterion is the smallest, the best model of failure data is presented. In this paper, no-nparametrics and parametrics methods are analyzed using R program which is a popular statistical program.

Detecting survival related gene sets in microarray analysis (마이크로어레이 자료에서 생존과 유의한 관련이 있는 유전자집단 검색)

  • Lee, Sun-Ho;Lee, Kwang-Hyun
    • Journal of the Korean Data and Information Science Society
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    • v.23 no.1
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    • pp.1-11
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    • 2012
  • When the microarray experiment developed, main interest was limited to detect differentially expressed genes associated with a phenotype of interest. However, as human diseases are thought to occur through the interactions of multiple genes within a same functional category, the unit of analysis of the microarray experiment expanded to the set of genes. For the phenotype of censored survival time, Gene Set Enrichment Analysis(GSEA), Global test and Wald type test are widely used. In this paper, we modified the Wald type test by adopting normal score transformation of gene expression values and developed a parametric test which requires much less computation than others. The proposed method is compared with other methods using a real data set of ovarian cancer and a simulation data set.

Cure Rate Model with Clustered Interval Censored Data (군집화된 구간 중도절단자료에 대한 치유율 모형의 적용)

  • Kim, Yang-Jin
    • The Korean Journal of Applied Statistics
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    • v.27 no.1
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    • pp.21-30
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    • 2014
  • Ordinary survival analysis cannot be applied when a significant fraction of patients may be cured. A cure rate model is the combination of cure fraction and survival model and can be applied to several types of cancer. In this article, the cure rate model is considered in the interval censored data with a cluster effect. A shared frailty model is introduced to characterize the cluster effect and an EM algorithm is used to estimate parameters. A simulation study is done to evaluate the performance of estimates. The proposed approach is applied to the smoking cessation study in which the event of interest is a smoking relapse. Several covariates (including intensive care) are evaluated to be effective for both the occurrence of relapse and the smoke quitting duration.

Testing Log Normality for Randomly Censored Data (임의중도절단자료에 대한 로그정규성 검정)

  • Kim, Nam-Hyun
    • The Korean Journal of Applied Statistics
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    • v.24 no.5
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    • pp.883-891
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    • 2011
  • For survival data we sometimes want to test a log normality hypothesis that can be changed into normality by transforming the survival data. Hence the Shapiro-Wilk type statistic for normality is generalized to randomly censored data based on the Kaplan-Meier product limit estimate of the distribution function. Koziol and Green (1976) derived Cram$\acute{e}$r-von Mises statistic's randomly censored version under the simpl hypothesis. These two test statistics are compared through a simulation study. As for the distribution of censoring variables, we consider Koziol and Green (1976)'s model and other similar models. Through the simulation results, we can see that the power of the proposed statistic is higher than that of Koziol-Green statistic and that the proportion of the censored observations (rather than the distribution of censoring variables) has a strong influence on the power of the proposed statistic.