• International Journal of Oral Biology
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• v.37 no.1
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• pp.37-41
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• 2012

Pancreatic acinar cells exhibit a polarity that is characterized by the localization of secretory granules at the apical membrane. However, the factors that regulate cellular polarity in these cells are not well understood. In this study, we investigated the effect of Mist1, a basic helix-loop-helix transcription factor, on the cellular architecture of pancreatic acinar cells. Mist1-null mice displayed secretory granules that were diffuse throughout the pancreatic acinar cells, from the apical to basolateral membranes, whereas Mist1 heterozygote mice showed apical localization of secretory granules. Deletion of the Mist1 gene decreased the expression of type 3 inositol 1,4,5-triphosphate receptors ($IP_3R$) but did not affect apical localization and expression of $IP_3R2$. Mist1-null mice also displayed an increase in luminal areas and an increase in the expression of zymogen granules in pancreatic acinar cells. These results suggest that Mist1 plays a critical role in polar localization of cellular organelles and in maintaining cellular architecture in mouse pancreatic acinar cells.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.40
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• pp.44.1-44.17
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• 2018

Background: Coffee extract has been investigated by many authors, and many minor components of coffee are known, such as polyphenols, diterpenes (kahweol and cafestol), melanoidins, and trigonelline, to have anti-inflammatory, anti-oxidant, anti-angiogenic, anticancer, chemoprotective, and hepatoprotective effects. Therefore, it is necessary to know its pharmacological effect on hepatocytes which show the most active cellular regeneration in body. Methods: In order to determine whether coffee extract has a beneficial effect on the liver, 20 C57BL/6J mice were intraperitoneally injected once with dialyzed coffee extract (DCE)-2.5 (equivalent to 2.5 cups of coffee a day in man), DCE-5, or DCE-10, or normal saline (control), and then followed by histological observation and IP-HPLC (immunoprecipitation high performance liquid chromatography) over 24 h. Results: Mice treated with DCE-2.5 or DCE-5 showed markedly hypertrophic hepatocytes with eosinophilic cytoplasms, while those treated with DCE-10 showed slightly hypertrophic hepatocytes, which were well aligned in hepatic cords with increased sinusoidal spaces. DCE induced the upregulations of cellular proliferation, growth factor/RAS signaling, cellular protection, p53-mediated apoptosis, angiogenesis, and antioxidant and protection-related proteins, and the downregulations of NFkB signaling proteins, inflammatory proteins, and oncogenic proteins in mouse livers. These protein expression changes induced by DCE were usually limited to the range ± 10%, suggesting murine hepatocytes were safely reactive to DCE within the threshold of physiological homeostasis. DCE-2.5 and DCE-5 induced relatively mild dose-dependent changes in protein expressions for cellular regeneration and de novo angiogenesis as compared with non-treated controls, whereas DCE-10 induced fluctuations in protein expressions. Conclusion: These observations suggested that DCE-2.5 and DCE-5 were safer and more beneficial to murine hepatocytes than DCE-10. It was also found that murine hepatocytes treated with DCE showed mild p53-mediated apoptosis, followed by cellular proliferation and growth devoid of fibrosis signaling (as determined by IP-HPLC), and subsequently progressed to rapid cellular regeneration and wound healing in the absence of any inflammatory reaction based on histologic observations.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.2C
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• pp.123-130
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• 2002

To cope with the Internet host mobility in a cellular network environment, we propose an adaptive mobility management scheme that can compensate drawbacks of Mobile IP. We also propose protocol that supports the proposed scheme. Our proposed scheme determines foreign agent care-of addresses adaptively according to user mobility. Consequently, it is different from other proposals for micro mobility, which statically assign the gateway in the domain as a foreign agent. Using such a scheme, it is possible to effectively meet the users demands for different service qualities in the various environments considered in the cellular network and to reduce signaling overhead due to frequent handovers occurred in Mobile IP. The performance of the proposed scheme is examined by simulation. The results of simulation show that the proposed scheme can provide relatively stable points of attachment to the mobile node.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.12B
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• pp.1063-1069
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• 2004

There are some problems with the methods of paging and routing cache(PRC) and quasi soft handoff that are proposed to improve the performance for the transmission of real time data. This paper proposed a reasonable solution of these problems by proposing a new method using a combined cache(CC) and applying a different handoff procedure according to each type of data. The combined cache dose not maintain the handoff state but the idlle/active state. The simulation results in a better performance than the above methods in terms of the control packet traffic load, initial recevied data packet traffic load and arrival tune of real time packet at the epoch of handoff.

• Proceedings of the IEEK Conference
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• 2004.06a
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• pp.261-264
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• 2004

We propose a location management with adaptive binding idle lifetime scheme for IP-based wireless network. In our proposed scheme, the binding idle lifetime value is adaptively varied according to user characteristics. The main idea is that the mobile node (MN) does location update (LU) even in idle state. Furthermore a sequential paging scheme is used to reduce the paging cost. The proposed scheme can be used in both cellular network and IP-based network.

• 한국정보통신설비학회:학술대회논문집
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• 2008.08a
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• pp.97-101
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• 2008

Voice over IP is a telephone service which sends and receives the voices through the Internet. Because the infrastructure of wireless and mobile communication networks such as 3G, Wi-Fi and WiMAX has expanded, the study about Mobile VoIP, which provides the voice service from wireless network, has been actively in progress. Since Rei 6 HSPA in 3GPP and Rev A lxEVDO in 3GPP2, VoIP through the data channel is more efficient than circuit switch. It is predicted that VoIP over 4G will be more effective and 4G mobile VoIP business will be vitalized in the future. In addition, there are businesses which offer VoWLAN by using software such as Skype and Fring. They provide services which cheapen the price of international calls and long distance calls. This paper will present the Korean and other countries' mobile VoIP trends, its classification along the network connection, the study on techniques, and conditions of mobile VoIP. It also will be described a view of terminal convergence and service convergence.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2006.05a
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• pp.495-500
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• 2006

본 논문에서는 셀 환경에서 QoS를 보장하기 위해 통합된 페이징과 루프 정보 관리 캐시를 사용하는 Cellular IP 특성을 가진 Cellular-IP/PRC 네트워크를 제안한다. 제안한 호 수락 방식은, 이동 노드의 홈 기지국 용량이 충분하고, 인접 셀 이동 노드가 흠 기지국에서 호가 수락되었다고 가정할 경우 받을 간섭의 증가량을 고려해 통화 품질이 보장될 때, 홈 기지국은 새로운 호를 이동 노드의 송신 전력 예측에 기반을 둔 호 수락 방식이다. 무선인터넷 네트워크 내의 페이징과 라우터를 관리하기 위해 사용되었던 PC(Paging Cache)와 RC(Routing Cache)를 하나의 PRC(Paging Router Cache)로 통합 관리하고, 모든 노드 내에 구성하여 운용토록 하고, 이동 노드의 핸드 오프 및 로밍 상태를 효율적으로 관리 할 수 있도록 이동 노드에 핸드오프 상태 머신을 추가하고, 노드에서 관련 기능을 수행하도록 하였다. 시스템 환경에서 통화량에 영향을 주는 인자를 각 링크 통화권 및 불균형 정도를 예측, 하향링크에 의해 통화권이 제한을 판단하여 송수신 전력을 기반으로 한 알고리즘과 제안한 알고리즘을 비교하여 QoS가 호 차단 확률과 호 탈락 확률, GoS, 셀 용량의 효율을 예측할 수 있는 QoS로 성능 개선을 연구한다.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.11 s.353
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• pp.25-34
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• 2006

In this paper, we propose the new Cellular Ethernet System that supports faster handovers than IP layer handover scheme for WiBro Networks and analyze the performance of the proposed scheme. In WiBro Networks, it is very important for service providers that supports fast handovers for mobile users who want superior service. But in case of Mobile IPv6, which supports IP layer handovers, there exists very long latency for detecting movement and duplicated IP address. And besides, handovers in wired area must be carried out after completing handovers in wireless area. So, Mobile IPv6 cannot provide superior service to mobile users. To remedy these problems, we here propose the new Cellular Ethernet System that consists of MAC layer bridges for WiBro Networks and analyze the performance of Cellular Ethernet System handover scheme and show that it has better performance than Mobile IPv6.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.7
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• pp.4878-4883
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• 2015

The IP Multimedia Subsystem(IMS) is a framework that provides access to the content of Internet and Telecom services anytime and anywhere with guaranteed Quality of Service(QoS) and manageability by separating control functions from bearer and services. The Service Delivery Platform(SDP) provides common interfaces and protocols to deploy existing or new services in an efficient way. Therefore SDP over IMS plays a role of bridge between established network and new IMS network by simplifying the interaction among application services. In order to enrich the multimedia network communication, we try to deploy the Push-to-talk over Cellular(PoC) service which is considered as the outstanding and distinguished half-duplex Voice over IP(VoIP) application service among deployable candidate services over mobile network. In this paper we investigate the advantages of PoC service and PoC architecture firstly, and then focus on the its practical implementation for the prototype to validate the feasibility of its deployment and realization.

• Proceedings of the Korean Information Science Society Conference
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• 2002.04a
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• pp.334-336
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• 2002

이동성 지원 프로토콜에서 사용자의 이동에 따른 위치 등록 부담을 줄이려는 노력으로 IP 페이징에 대한 관심이 커지고 있다. IETF(Internet Engineering Task Force)에서는 IP 페이징 프로토콜을 개발하기로 결정하여 seamoby 워킹그룹에서 이를 담당하도록 하고 HAWAII와 Cellular IP에서의 몇몇 IP 페이징 프로토콜이 제안되었다. 그러나 이는 미리 정의된 페이징 영역을 사용하기 때문에 호스트에 최적화된 페이징 영역을 만들기 어렵다. 본 논문은 페이징 영역을 결정하는데 중요한 요소인 크기와 모양을 설정하기 위하여 각 이동 호스트가 자신의 이동을 캐쉬하고 셀간 이동 횟수가 많이 발생하는 지역에서는 캐쉬된 내용에 근거하여 자신의 페이징 영역을 설정한다. 또한 이동 호스트의 방문이 거의 일어나지 않은 지역은 네트워크에 의해 설정된 페이징 영역을 적용하여 호스트에 의한 페이징 영역과 이중모드로 동작한다.