• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.10A
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• pp.1695-1705
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• 2001

기존의 셀룰러 IP (CIP : Cellular IP) 프로토콜을 개선하기 위해, 본 논문에서는 각 노드에 통합된 페이징 및 루트 정보관리 캐시(PRC)를 구성하고, 그리고 각 노드 및 이동호스트가 핸드오프-상태모드를 갖는 개선된 셀룰러 IP(ECIP : Enahnced CIP) 프로토콜을 제안하였다. ECIP 프로토콜에 대하여 패킷 유실, 핸드오프 지연 및 네트워크 내 트래픽 부하 특성 등을 고찰한 결과, ECIP는 액세스 네트워크 내 노드와 이동호스트의 수, 노드 내 다운링크의 수, 그리고 네트워크 내 페이징 캐시의 분포비율이 증가할수록 CIP와 비교하여 크게 개선되었다.

• Journal of Communications and Networks
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• v.7 no.2
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• pp.178-191
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• 2005

Fourth-generation (4G) wireless networks will be the IP-based cellular networks integrating Internet with the existing cellular networks. Two important issues should be concerned in the IP-based cellular networks, IP mobility, and quality-of-service (QoS) guarantees. In this paper, we proposed two mechanisms to solve the problems with IP mobility and RSVP-based QoS provisioning. First, virtual-IP (VIP) allocation scheme in areas with a large rate of handoff can minimize the wireless signaling overhead due to IP mobility. The access routers (ARs) create dynamically the VIP zone by using the measured handoff rate derived from the history of the handoff into neighboring ARs. We show that VIP allocation scheme reduces the binding update messages in the wireless link than hierarchical mobile IPv6. Second, the new advance resource reservation protocol called proportional aggregate RSVP (PA-RSVP) can minimize waste of bandwidth and soft state refresh overhead due to IP mobility. It allocates the bandwidth in advance between the mobility anchor point and neighboring ARs using proportional aggregate reservation. We also show that PA-RSVP provides an improved performance over existing protocols.

• The Journal of the Korea Contents Association
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• v.4 no.4
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• pp.113-121
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• 2004

Existing Cellular IP increases the network traffic load, packet loss and handoff latency because of duplicate packet. In this paper, we propose using a Combined Cache that unites a pasing cache with a routing cache and a Improved Adaptive Semi-soft handoff that minimizes to occur the duplicate packet. As a computer simulation, we consider packet loss, handoff latency and traffic load in network. In proportion the number of nodes, mobile hosts and downlinks of node in access network increased, the proposed method is largely improved in comparison with existing Cellular If that uses semi-soft handoff.

• Molecules and Cells
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• v.42 no.7
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• pp.546-556
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• 2019

Protein phosphatase 4 (PP4) is a crucial protein complex that plays an important role in DNA damage response (DDR), including DNA repair, cell cycle arrest and apoptosis. Despite the significance of PP4, the mechanism by which PP4 is regulated remains to be elucidated. Here, we identified a novel PP4 inhibitor, protein phosphatase 4 inhibitory protein (PP4IP) and elucidated its cellular functions. PP4IP-knockout cells were generated using the CRISPR/Cas9 system, and the phosphorylation status of PP4 substrates (H2AX, KAP1, and RPA2) was analyzed. Then we investigated that how PP4IP affects the cellular functions of PP4 by immunoprecipitation, immunofluorescence, and DNA double-strand break (DSB) repair assays. PP4IP interacts with PP4 complex, which is affected by DNA damage and cell cycle progression and decreases the dephosphorylational activity of PP4. Both overexpression and depletion of PP4IP impairs DSB repairs and sensitizes cells to genotoxic stress, suggesting timely inhibition of PP4 to be indispensable for cells in responding to DNA damage. Our results identify a novel inhibitor of PP4 that inhibits PP4-mediated cellular functions and establish the physiological importance of this regulation. In addition, PP4IP might be developed as potential therapeutic reagents for targeting tumors particularly with high level of PP4C expression.

• Proceedings of the Korean Information Science Society Conference
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• 2003.10c
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• pp.202-204
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• 2003

Mobile IP를 사용하는 이동 단말은 새로운 망으로 이동할 때마다 Home Agent에 등록요구 메시지를 전달해야만 하는데 이는 많은 양의 시그널링 트래픽을 생성 시키고 IP의 특징으로 인하여 일정한 시간 내에 등록할 수 있다는 보장을 받기가 어렵다. 이런 문제를 해결하기 위해서 미시적 이동성 지원 프로토콜이 제안되어 패킷 손실을 최소화 하며 컨트롤 패킷 양을 줄여 네트워크의 대역폭을 효율적으로 활용 할 수 있다. 본 논문에서는 Cellular IP에서 바이캐스팅 방법을 이용하는 세미소프트 핸드오프 방법을 개선하며 패킷손실과 중복 수신 패킷의 수를 극소화 시킬 수 있는 관리 기법과 핸드오프 지연을 최소화 하여 실시간 서비스를 제공받을 수 있는 방안을 제시한다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.5B
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• pp.388-403
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• 2003

RSVP was published as a resource reservation protocol to guarantee QoS for realtime applications in wired network environments. As mobile application services in wireless network environments are more popular, QoS guaranteeing problem becomes an important issue in mobile computing environments. Therefore, the researches about cooperation between RSVP and Mobile IP supporting mobility in mobile computing environments are activating today. In this paper, we propose I-MRSVP(Integrated-Mobile RSVP), a QoS guaranteed resource reservation protocol supporting the integrated mobility in mobile computing environments. I-MRSVP protocol supports the integrated mobility providing interoperability between Mobile IP-based macro cells and Cellular IP-based micro cells. To minimize resource reservation overheads, it provides efficient resource reservation functions by using the signal strength based predictive resource reservation scheme.

• Molecules and Cells
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• v.43 no.3
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• pp.222-227
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• 2020

Inositol polyphosphate multikinase (IPMK) is required for the biosynthesis of inositol phosphates (IPs) through the phosphorylation of multiple IP metabolites such as IP3 and IP4. The biological significance of IPMK's catalytic actions to regulate cellular signaling events such as growth and metabolism has been studied extensively. However, pharmacological reagents that inhibit IPMK have not yet been identified. We employed a structure-based virtual screening of publicly available U.S. Food and Drug Administration-approved drugs and chemicals that identified the antidepressant, vilazodone, as an IPMK inhibitor. Docking simulations and pharmacophore analyses showed that vilazodone has a higher affinity for the ATP-binding catalytic region of IPMK than ATP and we validated that vilazodone inhibits IPMK's IP kinase activities in vitro. The incubation of vilazodone with NIH3T3-L1 fibroblasts reduced cellular levels of IP5 and other highly phosphorylated IPs without influencing IP4 levels. We further found decreased Akt phosphorylation in vilazodone-treated HCT116 cancer cells. These data clearly indicate selective cellular actions of vilazodone against IPMK-dependent catalytic steps in IP metabolism and Akt activation. Collectively, our data demonstrate vilazodone as a method to inhibit cellular IPMK, providing a valuable pharmacological agent to study and target the biological and pathological processes governed by IPMK.

• The Journal of the Korea institute of electronic communication sciences
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• v.1 no.2
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• pp.120-126
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• 2006

In this paper, we propose for improving QoS in hospital wireless network using Cellular-IP/PRC(Paging Route Cache) with Paging Cache and Route Cache in Cellular-IP. Although the Cellular-IP/PRC technology is devised for mobile internet communication, it has its vulnerability in frequent handoff environment. This handoff state machine using differentiated handoff improves quality of services in Cellular-IP/PRC. Suggested algorithm shows better performance than existing technology in wireless mobile internet communication environment. When speech quality is secured considering increment of interference to receive in case of suppose that proposed acceptance method grooves base radio station capacity of transfer node is plenty, and most of contiguity cell transfer node was accepted at groove base radio station with a blow, groove base radio station new trench lake acceptance method based on transmission of a message electric power estimate of transfer node be. Do it so that may apply composing PC(Paging Cache) and RC(Routing Cache) that was used to manage paging and router in radio Internet network in integral management and all nodes as one PRC(Paging Router Cache), and add hand off state machine in transfer node so that can manage hand off of transfer node and Roaming state efficiently, and studies so that achieve connection function at node. Analyze benevolent person who influence on telephone traffic in system environment and forecasts each link currency rank and imbalance degree, forecast most close and important lake interception probability and lake falling off probability, GoS(Grade of Service), efficiency of cell capacity in QoS because applies algorithm proposing based on algorithm use gun send-receive electric power that judge by looking downward link whether currency book was limited and accepts or intercept lake and handles and displays QoS performance improvement.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 2004.07a
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• pp.395-395
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• 2004

• 한국ITS학회:학술대회논문집
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• 2005.11a
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• pp.169-172
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• 2005