• Journal of Korea Foundry Society
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• v.21 no.1
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• pp.41-47
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• 2001

Computer simulation of the solidification grain structure was applied to the casting process by using CA-DFDM. The Direct Finite Difference Method (DFDM) for temperature field calculation and latent heat treatment was coupled with Cellular Automaton (CA) method for the grain growth. 2-dimensional simulation of the solidification grain structures and calculation of the concentration fields were carried out and the calculated concentration distributions were compared with exact solution. Castings having complex geometries such as turbine blades were applied for 3-dimensional CA-DFDM. Effects of grain selector and mold extraction speed on the solidification grain structures in the turbine blade were examined.

• Molecules and Cells
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• v.21 no.3
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• pp.330-336
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• 2006

Since its identification in 1989, hepatitis C virus has been the subject of extensive research. The biology of the virus and the development of antiviral drugs are closely related. The RNA polymerase activity of nonstructural protein 5B was first demonstrated in 1996. NS5B is believed to localize to the perinuclear region, forming a replicase complex with other viral proteins. It has a typical polymerase structure with thumb, palm, and finger domains encircling the active site. A de novo replication initiation mechanism has been suggested. To date, many small molecule inhibitors are known including nucleoside analogues, non-nucleoside analogues, and pyrophosphate mimics. NS5B interacts with other viral proteins such as core, NS3, 4A, 4B, and 5A. The helicase activity of NS3 seems necessary for RNA strand unwinding during replication, with other nonstructural proteins performing modulatory roles. Cellular proteins interacting with NS5B include VAMP-associated proteins, heIF4AII, hPLIC1, nucleolin, PRK2, ${\alpha}$-actinin, and p68 helicase. The interactions of NS5B with these proteins might play roles in cellular trafficking, signal transduction, and RNA polymerization, as well as the regulation of replication/translation processes.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.2
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• pp.283-290
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• 2006

The cellular neural networks have the structure that consists of an array of the same cell which is a simple processing element, and each of the cells has local connectivity and space invariant template properties. So, it has a very suitable structure for the hardware implementation. But, it is impossible to have a one-to-one mapping between the CNN hardware processors and the pixels of the practical large image. In this paper, a $5{\times}5$ CNN hardware processor with pipeline input and output that can be applied to the time-multiplexing processing scheme, which processes the large image with a small CNN cell block, is designed. the operation of the implemented $5{\times}5$ CNN hardware processor is verified from the edge detection and the shadow detection experimentations.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.10
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• pp.3572-3590
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• 2014

Cellular automata (CA) based cryptosystem has been studied for almost three decades, yet most of previously reported researches focus on the symmetric key encryption schemes. Up to now, few CA based public key encryption scheme has been proposed. To fill the gap, in this paper, we propose a new public key encryption scheme based on layered cellular automata (LCA). Specifically, in the proposed scheme, based on the T-shaped neighborhood structure, we combine four one-dimensional reversible CAs (set as the private key) to form the transition rules of a two-dimension CA, where the two-dimension CA is set as the corresponding public key. Based on the hardness assumption of the Decisional Dependent CA problem in LCA, we formally prove the proposed scheme is indistinguishably secure against the chosen-plaintext attack (IND-CPA). In addition, we also use a numeric example to demonstrate its feasibility. Finally, analysis of key space and time efficiency are also carried out along with RSA-1024, and the simulation results demonstrate that our proposed scheme is more efficient.

• The Plant Pathology Journal
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• v.17 no.3
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• pp.115-122
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• 2001

Potato virus X (PVX) is a flexuous rod-shaped virus containing a single plus-strand RNA. Viral RNA synthesis is precisely regulated by regulatory viral sequences and by viral and/or host proteins. RNA sequence element as well as stable RNA stem-loop structure in the 5' end of the genome affect accumulation of genomic RNA and subgenomic RNA (sgRNA). The putative sgRNA promoter regions upstream of the PVX triple gene block (TB) and coat protein (CP) gene were critical for both TB and CP sgRNA accumulation. Mutations that disrupted complementarity between a region at the 5' end of the genomic RNA and the sequences located upstream of each sgRNA initiation site is important for PVX RNA accumulation. Compensatory mutations that restore complementarity restored sgRNA accumulation levels. However, the extent of reductions in RNA levels did not directly correlate with the degree of complementarity, suggesting that the sequences of these elements are also important. Gel-retardation assays showed that the 5' end of the positive-strand RNA formed an RNA-protein complex with cellular proteins, suggesting possible involvement of cellular proteins for PVX replication. Future studies on cellular protein binding to the PVX RNA and their role in virus replication will bring a fresh understanding of PVX RNA replication.

• Molecules and Cells
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• v.27 no.6
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• pp.667-671
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• 2009

Visfatin (Nampt/PBEF) plays a pivotal role in the salvage pathway for $NAD^+$ biosynthesis. Its potent inhibitor, FK866, causes cellular $NAD^+$ levels to decline, thereby inducing apoptosis in tumor cells. In an effort to improve the solubility and binding interactions of FK866, we designed and synthesized IS001, in which a ribose group is attached to the FK866 pyridyl ring. Here, we report the crystal structure of rat visfatin in complex with IS001. Like FK866, IS001 is positioned at the dimer interface, and all of the residues that interact with IS001 are involved in hydrophobic or ${\pi}-{\pi}$-stacking interactions. However, we were unable to detect any strong interactions between the added ribose ring of IS001 and visfatin, which implies that a bulkier modifying group is necessary for a tight interaction. This study provides additional structure-based information needed to optimize the design of visfatin inhibitors.

• Journal of Microbiology and Biotechnology
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• v.32 no.12
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• pp.1515-1526
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• 2022

Eukaryotic chromatin is highly organized in the 3D nuclear space and dynamically regulated in response to environmental stimuli. This genomic organization is arranged in a hierarchical fashion to support various cellular functions, including transcriptional regulation of gene expression. Like other host cellular mechanisms, viral pathogens utilize and modulate host chromatin architecture and its regulatory machinery to control features of their life cycle, such as lytic versus latent status. Combined with previous research focusing on individual loci, recent global genomic studies employing conformational assays coupled with high-throughput sequencing technology have informed models for host and, in some cases, viral 3D chromosomal structure re-organization during infection and the contribution of these alterations to virus-mediated diseases. Here, we review recent discoveries and progress in host and viral chromatin structural dynamics during infection, focusing on a subset of DNA (human herpesviruses and HPV) as well as RNA (HIV, influenza virus and SARS-CoV-2) viruses. An understanding of how host and viral genomic structure affect gene expression in both contexts and ultimately viral pathogenesis can facilitate the development of novel therapeutic strategies.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.115.3-115
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• 2001

In this paper, discrete-time cellular neural networks are designed in order to function as associative memories by using Hebbian learning rule and non-cloning template. The proposed method has a very simple structure to design and to learn. Weights are updated by the connection between the neuron and its neighborhood. In the simulation, the proposed method is applied to the classification of a traffic sign pattern.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.34S no.8
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• pp.37-44
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• 1997

We implemented a code searcher which is used for the PN(pseudo noise) code acquisition in CDMA cellular mobile station. To reduce the reuired hardware and the code acquisition time, we used the double dwell structure which is an effective serial code acquisition metho. We designed a code acquisition has acquired within 1/2 PN chip range. The code searcher is implemented using 0.8 micron code searcher is successfully working in CDMA cellular mobile station and it satisfies the code acquisition time specified in IS-95 standard.

• The Journal of the Acoustical Society of Korea
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• v.29 no.1E
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• pp.28-37
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• 2010

This article reviews recent developments in the emerging field of cellular-level biomedical ultrasonics with the specific focus on the mechanics of ultrasound-cell interaction. Due to the nature of the field at its relative infancy, the review poses more questions than it provides answers. Discussed are topics such as the basic structure of a biological cell, the origin of cell's elasticity, a theoretical framework for ultrasound-cell interaction, and shape deformation of cells and its measurement, Some interesting problems for future study are proposed.