Browse > Article

Cellular-level Biomechanics of Ultrasound  

Ohm, Won-Suk (School of Mechanical Engineering, Yonsei University)
Abstract
This article reviews recent developments in the emerging field of cellular-level biomedical ultrasonics with the specific focus on the mechanics of ultrasound-cell interaction. Due to the nature of the field at its relative infancy, the review poses more questions than it provides answers. Discussed are topics such as the basic structure of a biological cell, the origin of cell's elasticity, a theoretical framework for ultrasound-cell interaction, and shape deformation of cells and its measurement, Some interesting problems for future study are proposed.
Keywords
ultrasound; cell; biomechanics; deformation; sonoporation; bubble;
Citations & Related Records
연도 인용수 순위
  • Reference
1 T.-J. Kim, S.-J. Kim, and H.-I. Jung, "Physical stimulation of mammalian cells using micro-bead impact within a microfluidic environment to enhance growth rate." Microfluid, Nanofluid., vol. 6, no. 1, pp. 131-138, 2009.   DOI   ScienceOn
2 T. D, Brown, "Techniques for mechanical stimulation of cells in vitro: a review." J. Biomech., vol. 33, no. 1, pp. 3-14, 2000.   DOI   ScienceOn
3 T. Laurell, F. Petersson, and A. Nilsson, "Chip integrated strategies for acoustic separation and manipulation of cells and particles," Chem. Soc. Rev., vol. 36, no. 3, pp. 492-506, 2007.   DOI   ScienceOn
4 M. Ogura, S. Paliwal, and S. Mitragotri, "Low-frequency sonophoresis: current status and future prospects," Adv. Drug Detiv, Rev., vol. 60, no. 10, pp, 1218-1223, 2008.   DOI   ScienceOn
5 A. van Wamel, A. Bouakaz, M. Versluis. and N. de Jong, "Micromanipulation of endothelial cells: ultrasound-microbubble cell interaction." Ultrasound Med, Biol., vol. 30, no. 9, pp. 1255-1258, 2004.   DOI   ScienceOn
6 L. D. Landau and E. M. Lifschitz, Theory of Elasticity, 3rd ed., Butterworth-Heinemann, Oxford, 1986.
7 AIUM/NEMA. Standard for real-time display of thermal and mechanical acoustic indices on diagnostic ultrasound equipment. AIUM, Laurel. MD. 1998.
8 K. Ebisawa, K.-I. Hsta, K. Okada. K. Kimata. M. Ueda, S, Torii, and H. Watanabe, "Ultrasound enhances transforming growth factor $\beta$-mediated chondrocyte differentiation of human mesenchymal stem cells." Tissue Eng., vol. 10, no. 5/6, pp. 921-929, 2004.   DOI
9 P. V. Zinin. J, S. Allen III, and V. M. Levin, "Mechanical resonances of bacteria cells," Phys. Rev. E. vol. 72, no. 6, paper no. 061907, 2005.
10 P. V. Zinin and J. S. Allen III, "Deformation of biological cells in the acoustic field of an oscillating bubble," Phys. Rev. E, vol. 79, no. 2, paper no. 021910, 2009.
11 P. L. Marston and R. E, Apfel. "Quadrupole resonance of drops driven by modulated acoustic radiation pressure-experimental properties," J. Acoust. Soc. Am., vol. 67, no. 1, pp. 27-37, 1980.   DOI   ScienceOn
12 R. K. Schlicher, H. Radhakrishna. T. P. Tolentino, R. P. Apkarian, V. Zarnitsyn, and M. R. Prausnitz, "Mechanism of intracellular delivery by acoustic cavitation," Ultrasound Med. Biol., vol. 32, no. 6, pp. 915-924, 2006.   DOI   ScienceOn
13 J. Wu and W. L. Nyborg. "Ultrasound, cavitation bubbles and their interaction with cells," Adv. Drug Deliv. Rev., vol. 60, no. 10, pp. 1103-1116, 2008.   DOI   ScienceOn
14 M. Hadjiargyrou, K. McLeod, J. P. Ryaby, and C. Rubin, "Enhancement of fracture healing by low intensity Ultrasound,"Clin. Orthop, Rel. Res., vol. 355, suppl.. pp, 8216-8229, 1998.
15 D. Boal, Mechanics of the Cell. Cambridge University Press, Cambridge, 2002.
16 J. Wu and W. Nyborg. eds., Emerging Therapeutic Ultrasound, World Scientific. New Jersey, 2006.
17 K. Tachibana, T. Uchida. K. Ogawa, N. Yamashita. and K. Tamura. "Induction at cell-membrane porosity by ultrasound," Lancet. vol. 353, no. 9162, p. 1409, 1999.
18 H. Azuma, N. Tomita, Y. Kaneda, H. Koike, T. Ogihara, Y. Katsuoka, and R. Morishita, Transfection of NF$\kappa$B-decoy oligodeoxy nucleotides using efficient ultrasound-mediated gene transfer into donor kidneys prolonged survival of rat renal allografts," Gene Ther., vol. 10, no. 5, pp. 415-425, 2003.   DOI   ScienceOn
19 N. Y, Rapoport, D. A. Christensen, H. D. Fain, L. Barrows, and Z. Gao, "Ultrasound-triggered drug targeting of tumors in vitro and in vivo," Ultrasonics, vol. 42, no. 1-9, pp. 943-950, 2004.   DOI   ScienceOn
20 S. Mitragotri, "Healing sound: the use of ultrasound in drug delivery and other therapeutic applications," Nature Rev. Drug Discov., vol. 4, no. 3, pp, 255-260, 2005.   DOI   ScienceOn
21 W.-S. Ohm, Y. Choi and Y.-T. Kim, "Development of cellular-level efficacy/safety index for biomedical ultrasound," Korea Research Institute of Standards and Science, Tech. Rep., 2009.
22 I. V, Volkov, S. T, Zavtrak, and I. S. Kuten, "Theory of sound amplification by stimulated emission of radiation with consideration for coagulation," Phys. Rev. E, vol. 56. no. 1, pp. 1097-1101, 1997.   DOI   ScienceOn
23 J. G. Abbott, "Rationale and derivation of MI and TI-a review," Ultrasound Med. Biol., vol. 25. no. 3, pp. 431-441, 1999.   DOI   ScienceOn
24 A. E. Pellinq, S. Sehati, E. B. Gralla, J. S. Valentine. J. K. Girnzewski, "Local nanomechanical motion of the cell wall of Saccharomyces cerevisiae," Science. vol. 305, no. 5687, pp, 1147-1150, 2004.   DOI
25 Y. Furusawa, Q.-L, Zhao, M. A. Hassan, Y, Tabucni, I. Takasakl, S. Wada, and T. Kondo, "Ultrasound-induced apoptosis in the presence of Sonazoid and associated alterations in gene expression levels: A possible therapeutic application." Cancer Lett., vol. 288, no. 1, pp. 107-115, 2010.   DOI   ScienceOn
26 D. T. Blackstock, Fundamentals of Physical Acoustics, Wiley. New York. 2000.