Cellular-level Biomechanics of Ultrasound

초음파의 세포 단위 생체역학

  • Ohm, Won-Suk (School of Mechanical Engineering, Yonsei University)
  • Received : 2010.02.11
  • Accepted : 2010.03.16
  • Published : 2010.03.31

Abstract

This article reviews recent developments in the emerging field of cellular-level biomedical ultrasonics with the specific focus on the mechanics of ultrasound-cell interaction. Due to the nature of the field at its relative infancy, the review poses more questions than it provides answers. Discussed are topics such as the basic structure of a biological cell, the origin of cell's elasticity, a theoretical framework for ultrasound-cell interaction, and shape deformation of cells and its measurement, Some interesting problems for future study are proposed.

Keywords

References

  1. T.-J. Kim, S.-J. Kim, and H.-I. Jung, "Physical stimulation of mammalian cells using micro-bead impact within a microfluidic environment to enhance growth rate." Microfluid, Nanofluid., vol. 6, no. 1, pp. 131-138, 2009. https://doi.org/10.1007/s10404-008-0310-8
  2. K. Ebisawa, K.-I. Hsta, K. Okada. K. Kimata. M. Ueda, S, Torii, and H. Watanabe, "Ultrasound enhances transforming growth factor $\beta$-mediated chondrocyte differentiation of human mesenchymal stem cells." Tissue Eng., vol. 10, no. 5/6, pp. 921-929, 2004. https://doi.org/10.1089/1076327041348437
  3. Y. Furusawa, Q.-L, Zhao, M. A. Hassan, Y, Tabucni, I. Takasakl, S. Wada, and T. Kondo, "Ultrasound-induced apoptosis in the presence of Sonazoid and associated alterations in gene expression levels: A possible therapeutic application." Cancer Lett., vol. 288, no. 1, pp. 107-115, 2010. https://doi.org/10.1016/j.canlet.2009.06.029
  4. T. D, Brown, "Techniques for mechanical stimulation of cells in vitro: a review." J. Biomech., vol. 33, no. 1, pp. 3-14, 2000. https://doi.org/10.1016/S0021-9290(99)00177-3
  5. T. Laurell, F. Petersson, and A. Nilsson, "Chip integrated strategies for acoustic separation and manipulation of cells and particles," Chem. Soc. Rev., vol. 36, no. 3, pp. 492-506, 2007. https://doi.org/10.1039/b601326k
  6. S. Mitragotri, "Healing sound: the use of ultrasound in drug delivery and other therapeutic applications," Nature Rev. Drug Discov., vol. 4, no. 3, pp, 255-260, 2005. https://doi.org/10.1038/nrd1662
  7. M. Ogura, S. Paliwal, and S. Mitragotri, "Low-frequency sonophoresis: current status and future prospects," Adv. Drug Detiv, Rev., vol. 60, no. 10, pp, 1218-1223, 2008. https://doi.org/10.1016/j.addr.2008.03.006
  8. N. Y, Rapoport, D. A. Christensen, H. D. Fain, L. Barrows, and Z. Gao, "Ultrasound-triggered drug targeting of tumors in vitro and in vivo," Ultrasonics, vol. 42, no. 1-9, pp. 943-950, 2004. https://doi.org/10.1016/j.ultras.2004.01.087
  9. H. Azuma, N. Tomita, Y. Kaneda, H. Koike, T. Ogihara, Y. Katsuoka, and R. Morishita, Transfection of NF$\kappa$B-decoy oligodeoxy nucleotides using efficient ultrasound-mediated gene transfer into donor kidneys prolonged survival of rat renal allografts," Gene Ther., vol. 10, no. 5, pp. 415-425, 2003. https://doi.org/10.1038/sj.gt.3301882
  10. M. Hadjiargyrou, K. McLeod, J. P. Ryaby, and C. Rubin, "Enhancement of fracture healing by low intensity Ultrasound,"Clin. Orthop, Rel. Res., vol. 355, suppl.. pp, 8216-8229, 1998.
  11. J. Wu and W. Nyborg. eds., Emerging Therapeutic Ultrasound, World Scientific. New Jersey, 2006.
  12. K. Tachibana, T. Uchida. K. Ogawa, N. Yamashita. and K. Tamura. "Induction at cell-membrane porosity by ultrasound," Lancet. vol. 353, no. 9162, p. 1409, 1999.
  13. R. K. Schlicher, H. Radhakrishna. T. P. Tolentino, R. P. Apkarian, V. Zarnitsyn, and M. R. Prausnitz, "Mechanism of intracellular delivery by acoustic cavitation," Ultrasound Med. Biol., vol. 32, no. 6, pp. 915-924, 2006. https://doi.org/10.1016/j.ultrasmedbio.2006.02.1416
  14. J. Wu and W. L. Nyborg. "Ultrasound, cavitation bubbles and their interaction with cells," Adv. Drug Deliv. Rev., vol. 60, no. 10, pp. 1103-1116, 2008. https://doi.org/10.1016/j.addr.2008.03.009
  15. D. Boal, Mechanics of the Cell. Cambridge University Press, Cambridge, 2002.
  16. L. D. Landau and E. M. Lifschitz, Theory of Elasticity, 3rd ed., Butterworth-Heinemann, Oxford, 1986.
  17. P. V. Zinin. J, S. Allen III, and V. M. Levin, "Mechanical resonances of bacteria cells," Phys. Rev. E. vol. 72, no. 6, paper no. 061907, 2005.
  18. P. V. Zinin and J. S. Allen III, "Deformation of biological cells in the acoustic field of an oscillating bubble," Phys. Rev. E, vol. 79, no. 2, paper no. 021910, 2009.
  19. AIUM/NEMA. Standard for real-time display of thermal and mechanical acoustic indices on diagnostic ultrasound equipment. AIUM, Laurel. MD. 1998.
  20. D. T. Blackstock, Fundamentals of Physical Acoustics, Wiley. New York. 2000.
  21. W.-S. Ohm, Y. Choi and Y.-T. Kim, "Development of cellular-level efficacy/safety index for biomedical ultrasound," Korea Research Institute of Standards and Science, Tech. Rep., 2009.
  22. A. E. Pellinq, S. Sehati, E. B. Gralla, J. S. Valentine. J. K. Girnzewski, "Local nanomechanical motion of the cell wall of Saccharomyces cerevisiae," Science. vol. 305, no. 5687, pp, 1147-1150, 2004. https://doi.org/10.1126/science.1097640
  23. A. van Wamel, A. Bouakaz, M. Versluis. and N. de Jong, "Micromanipulation of endothelial cells: ultrasound-microbubble cell interaction." Ultrasound Med, Biol., vol. 30, no. 9, pp. 1255-1258, 2004. https://doi.org/10.1016/j.ultrasmedbio.2004.07.015
  24. P. L. Marston and R. E, Apfel. "Quadrupole resonance of drops driven by modulated acoustic radiation pressure-experimental properties," J. Acoust. Soc. Am., vol. 67, no. 1, pp. 27-37, 1980. https://doi.org/10.1121/1.383738
  25. I. V, Volkov, S. T, Zavtrak, and I. S. Kuten, "Theory of sound amplification by stimulated emission of radiation with consideration for coagulation," Phys. Rev. E, vol. 56. no. 1, pp. 1097-1101, 1997. https://doi.org/10.1103/PhysRevE.56.1097
  26. J. G. Abbott, "Rationale and derivation of MI and TI-a review," Ultrasound Med. Biol., vol. 25. no. 3, pp. 431-441, 1999. https://doi.org/10.1016/S0301-5629(98)00172-0