• CELLMED
• /
• v.13 no.13
• /
• pp.49.1-49.6
• /
• 2023

Objective: A Case report on the improvement of dermatitis through implementation of OCNT. Methods: OCNT was implemented for 3 months for a Korean man in his 70's with dermatitis with unknown cause since 2015. Results: Following the implementation of OCNT, fever that accompanied dermatitis subsided, occurrence of itchiness and abscess decreased, and the stratum corneum of the palm although displayed improvement of being thinned. As the result of visual follow-up observation upon discontinuation of OCNT, damaged skin due to inflammation was restored to the level of normal skin. Conclusion: OCNT can provide assistance to those experiencing inconvenience due to dermatitis.

• CELLMED
• /
• v.13 no.15
• /
• pp.56.1-56.7
• /
• 2023

Objective: Improvement of the symptoms of restless leg syndrome patient by using OCNT. Methods: OCNT was implemented on a 50-year-old Korean female patient with symptoms of chronic fatigue and chronic gynecologic disease as well as sufferance from insomnia due to numbness in the legs following hysterectomy in the past. Results: Following the implementation of OCNT, the symptom of numbness in the legs improved along with other symptoms that caused inconveniences to the patient such as sleep disorder, fatigue and gynecology disease. Conclusion: Application of OCNT to patient suffering restless leg syndrome can be helpful in alleviation of the symptoms.

• CELLMED
• /
• v.14 no.3
• /
• pp.67.1-67.3
• /
• 2024

Objective: A Case study on improvement of ICE syndrome through the use of OCNT. Methods: OCNT was performed on a 45-year-old Korean female who had difficulty in opening the eyes widely due to painful and xerophthalmias, and suffered inconvenience in daily life due to myodesopsia. Results: After the implementation of OCNT, the intraocular pressure (IOP) level was restored to normal, and the pain, dryness and myodesopsia symptoms were alleviated. This resulted in improvement in depressive symptoms and quality of life. Conclusion: For patients suffering from problems such as elevated intraocular pressure, myodesopsia, and xerophthalmia, OCNT can be helpful in improvement and treatment of symptoms.

• CELLMED
• /
• v.14 no.4
• /
• pp.72.1-72.3
• /
• 2024

Objective: Improvement of symptoms in patients with rheumatoid arthritis using OCNT Methods: The patient was a Korean woman in her 50s who was experiencing foot pain due to rheumatoid arthritis and was experiencing discomfort in her daily life. OCNT was applied to the patient for approximately 6 months. Results: After starting OCNT, the patient's joint pain and chest pain gradually decreased, and after about six months, she no longer felt discomfort due to these symptoms. Conclusion: For rheumatoid arthritis patients suffering from joint pain and chest pain, OCNT can help relieve symptoms.

• IMMUNE NETWORK
• /
• v.20 no.6
• /
• pp.45.1-45.16
• /
• 2020

IL-9 has been reported to play dual roles in the pathogenesis of autoimmune disorders and cancers. The collaboration of IL-9 with microenvironmental factors including the broader cytokine milieu and other cellular components may provide important keys to explain its conflicting effects in chronic conditions. In this review, we summarize recent findings on the cellular sources of, and immunological responders to IL-9, in order to interpret the role of IL-9 in the regulation of immune responses. This knowledge will provide new perspectives to improve clinical benefits and limit adverse effects of IL-9 when treating pathologic conditions.

• IMMUNE NETWORK
• /
• v.20 no.6
• /
• pp.44.1-44.19
• /
• 2020

The human body is continuously threatened by pathogens, and the immune system must maintain a balance between fighting infection and becoming over-activated. Mucosal surfaces cover several anatomically diverse organs throughout the body, such as the respiratory and gastrointestinal tracts, and are directly exposed to the external environment. Various pathogens invade the body through mucosal surfaces, making the mucosa the frontline of immune defense. The immune systems of various mucosal tissues display distinctive features that reflect the tissues' anatomical and functional characteristics. This review discusses the cellular components that constitute the respiratory and gastrointestinal tracts; in particular, it highlights the complex interactions between epithelial and immune cells to induce Ag-specific immune responses in the lung and gut. This information on mucosal immunity may facilitate understanding of the defense mechanisms against infectious agents that invade mucosal surfaces, such as severe acute respiratory syndrome coronavirus 2, and provide insight into effective vaccine development.

• IMMUNE NETWORK
• /
• v.16 no.1
• /
• pp.33-43
• /
• 2016

Cell-penetrating peptides (CPPs) are short amino acids that have been widely used to deliver macromolecules such as proteins, peptides, DNA, or RNA, to control cellular behavior for therapeutic purposes. CPPs have been used to treat immunological diseases through the delivery of immune modulatory molecules in vivo. Their intracellular delivery efficiency is highly synergistic with the cellular characteristics of the dendritic cells (DCs), which actively uptake foreign antigens. DC-based vaccines are primarily generated by pulsing DCs ex vivo with various immunomodulatory antigens. CPP conjugation to antigens would increase DC uptake as well as antigen processing and presentation on both MHC class II and MHC class I molecules, leading to antigen specific CD4⁺ and CD8⁺ T cell responses. CPP-antigen based DC vaccination is considered a promising tool for cancer immunotherapy due to the enhanced CTL response. In this review, we discuss the various applications of CPPs in immune modulation and DC vaccination, and highlight the advantages and limitations of the current CPP-based DC vaccination.

• 대한예방의학회:학술대회논문집
• /
• 2000.10a
• /
• pp.330-331
• /
• 2000

• Proceedings of the Korea Contents Association Conference
• /
• 2006.11a
• /
• pp.355-359
• /
• 2006

Mobile network evolution and development of USN technologies introduce new business model based on context awareness. Cellular operators provide friend finding service using cell based location information and telematics service using GPS location information. Recently cellular operators provide yellow page service based cell based location information. In this paper, we develop mobile tour application on WIPI platform based on location information. Mobile tour information services provide the best information based on context awareness using user location information from LBSP (Location Based Service Platform), season, weather conditions, time from Web server, and personal preference information stored in database. Mobile tour information service application is developed on WIPI platform.

• Animal cells and systems
• /
• v.13 no.1
• /
• pp.9-15
• /
• 2009

Eph receptors and their ephrin ligands have been implicated in a variety of cellular processes such as cellular morphogenesis and motility. Our previous studies demonstrated that Odin, one of the Anks family proteins, functions as a scaffolding protein of the EphA8 signaling pathway leading to modulation of cell migration or axonal outgrowth. Here we show that WDR7 is associated with Odin and that it is possibly implicated in the EphA8 signaling pathway. WD40 repeats present in the COOH-terminal region of WDR7 appear to be crucial for its association with Odin, whereas the binding motif of Odin is located in between ankyrin repeats and PTB domain. Co-immunoprecipitation experiments revealed that association of WDR7 with Odin is enhanced by ephrin ligand treatment, possibly through forming large protein complexes including both EphA8 and ephrin-A5. Consistently, immunofluorescence staining experiments suggested that WDR7 constitute a component of the large protein complexes containing Odin, EphA8 and ephrin-A5. Taken together, our results suggest the WDR7-Odin complexes might be involved in the signaling pathway downstream of the EphA8 receptor.