• Journal of the Korean Institute of Telematics and Electronics A
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• v.31A no.6
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• pp.9-17
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• 1994

ATM (Asynchronous Transfer Mode) has a fixed-length packet transport scheme. It is one of the promising proposals in B-ISDN.Since the packet length is fixed, it can be potentially to perform the various service to users. In this paper, a queueing model for an ATM multip`exer loaded by CBR and ON/OFF input sources is considered, and the two-queue system which each type of input sources has a queue with a finite capacity is analyzed. The cell loss probabilities for a performance measures of ATM multiplexer are derived, and are also evaluated through numerical examples. As a result, the cell loss probability of ON/OFF sources for the queue size is rapidly decreased when the multiplexed number and burstiness are increased. Since cells of the CBR source have lower priority than cells of the ON/OFF source, cell loss probabilities of CBR sources are accordingly high independently of CBR cell arrival rate when the number of CBR sources is large.

• Journal of Chest Surgery
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• v.54 no.6
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• pp.460-465
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• 2021

Background: Metastasis and recurrence of primary cancer are the main causes of cancer mortality. Disseminated tumor cells refer to cancer cells that cause metastasis from primary cancer to other organs. Several recent studies have suggested that circulating tumor cells (CTCs) are associated with the clinical stage, cancer recurrence, cancer metastasis, and prognosis. There are several methods of isolating CTCs from whole blood; in particular, using a membrane filtration system is advantageous due to its cost-effectiveness and availability in clinical settings. In this study, an animal model of lung cancer was established in nude mice using the human large cell lung cancer cell line H460. Methods: Six-week-old nude mice were used. The H460 lung cancer cell line was injected subcutaneously into the nude mice. Blood samples were obtained from the orbital area before cell line injection, 2 weeks after injection, and 2 weeks after tumor excision. Blood samples were filtered using a polycarbonate 12-well Transwell membrane (Corning Inc., Corning, NY, USA). An indirect immunofluorescence assay was performed with the epithelial cell adhesion molecule antibody. The number of stained cells was counted using fluorescence microscopy. Results: The average size of the tumor masses was 35.83 mm. The stained cells were counted before inoculation, 2 weeks after inoculation, and 2 weeks after tumor excision. Cancer cells generally increased after inoculation and decreased after tumor resection. Conclusion: The CTC detection method using the commercial polycarbonate 12-well Transwell (Corning Inc.) membrane is advantageous in terms of cost-effectiveness and convenience.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.24 no.4
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• pp.348-356
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• 2014

To understand the relationship between road-traffic noise and urban components such as population, building, road-traffic and land-use, the city of Cheongju that already has road-traffic noise maps of daytime and nighttime was selected for this study. The whole area of the city is divided into square cells of a uniform size and for each cell, the urban components are estimated. A spatial representative noise level for each cell is determined by averaging out population-weighted facade noise levels for noise exposure population within the cell during nighttime. The relationship between the representative noise level and the urban components is statistically modeled at the cell level. Specially, we introduce a spatial auto regressive model and a spatial error model that turns out to explain above 85 % of the noise level. These findings and modeling methods can be used as a preliminary tool for environmental planning and urban design in modern cities in consideration of noise exposure.

• The Journal of Korean Society of Virology
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• v.30 no.2
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• pp.141-150
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• 2000

The effectiveness of noninfectious recombinant adenovirus encoding murine granulocyte-macrophage colony stimulating factor (mGM-CSF) for the treatment of Meth A fibrosarcoma was investigated in syngeneic BALB/C model. Meth A and HeLa cells transduced with the recombinant adenovirus (Ad.mGM-CSF) produced substantial amounts of mGM-CSF, while WEH1164 cells transduced with the virus did not produce mGM-CSF. Mice inoculated subcutaneously with $1{\times}10^6$ Meth A cells, followed by injection of Ad.dE1 as a control, developed large tumors that reached a mean tumor size of 22 mm by day 30. However, tumor development and tumorigenicity were significantly inhibited in mice with a single intratumoral injection of Ad.mGM-CSF at $1{\times}10^8\;pfu$. Histological examination of the tumors injected with Ad.mGM-CSF revealed dense infiltrates of neutrophils, histiocytes, lymphocytes, and eosinophils associated with apoptotic cell death. The results suggest that the recombinant adenovirus encoding GM-CSF have a potential use for cancer gene therapy.

• Applied Chemistry for Engineering
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• v.10 no.1
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• pp.173-176
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• 1999

The production of fine metal oxide particles in supercritical water has been studied. Cobalt nitrate solution and manganese nitrate solution have been selected as model solutions for metal salt aqueous solution and the particles of cobalt oxide and manganese oxide have been produced. It was observed that the production of fine metal oxide particles in supercritical water was feasible and the dehydration rate was remarkably high in supercritical water. In spite of a short residence time (3~100 seconds), fine particles ($0.5{\sim}2{\mu}m$) have been produced. In the supercritical water process, the temperature of mixer had a significant effect on particle size and size distribution. It was observed that a change in reaction temperature resulted in the control of particle size.

• Preventive Nutrition and Food Science
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• v.16 no.3
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• pp.217-223
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• 2011

Ischemic stroke constitutes about 80% of all stroke incidences. It is characterized by brain cell death in a region where cerebral arteries supplying blood are occluded. Under these ischemic conditions, apoptosis is responsible for the cell death, at least in part. Goat's-beard (Aruncus dioicus var. kamtschaticus) is a perennial plant that grows naturally in the alpine regions of Korea. In the present study, we first determined whether water extract of goat's-beard (HY1646) and some of its fractions prepared by partitioning with organic solvents could improve the viability of human hepatocellular carcinoma cells (HepG2) cultured under hypoxic condition by blocking apoptotic pathways. Based on the in vitro findings, we subsequently investigated whether HY1646 and the ethyl acetate fraction (EA) selected from cell culture-based screening could attenuate brain injury in a rat middle cerebral artery occlusion (MCAO) model of ischemia (2 hr), followed by 22 hours of reperfusion. The cell number was sustained close to that initially plated in the presence of HY1646 even after 24 hr of cell culture under hypoxic condition (3% $O_2$), at which time the cell number reached almost zero in the absence of HY1646. This improvement in cell viability was attributed to the delay in apoptosis, identified by the formation of DNA ladder in gel electrophoresis. Of fractions soluble in hexane, ethyl acetate (EA) and butanol, EA was chosen for the animal experiments because EA demonstrated the best cell viability at the lowest concentration (10 ${\mu}g$/mL). HY1646 (200 mg/kg) and EA (10 and 20 mg/kg) significantly reduced infarct size, an index of brain injury, by 16.6, 40.0 and 61.0%, respectively, as assessed by 2,3,5-triphenyl tetrazolium chloride staining. The findings suggest that prophylactic intake of goat's beard might be beneficial for preventing ischemic stroke.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.6
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• pp.1085-1094
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• 1994

We propose a traffic flow control scheme of B-NT with temporary cell buffering and selective cell discarding to prevent congestion state of the network nodes in B-ISDN systems to reduce or suppress output cell strams towards T interface. We define the states of the network nodes as normal, pre-congestion, and congestion. In a pre-congestion state, the loss-sensitive traffic is temporarily buffered to slow down the rate of the output traffic streams. In a congestion state, the delay-sensitive traffic is selectively discarded to suppress the output traffic streams as possible in addition to the cell buffering. We model the input cell streams and the states of the network nodes with Interrupted Bernoulli Process and 3-state Markov chain to analyze the performance of the proposed scheme in the B-NT system. The appropriate size of the cell buffer is explored by means of simulation and the influence on the performance of the proposed scheme by the network node state is discussed. As results, more than 2,00 cells of buffer size is needed for the control of medium of lower than the medium, degree of congestion occurrence in the network node while the control of high degree of congestion occurrence is nearly impossible.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.53 no.4
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• pp.309-316
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• 2017

In this paper, numerical modeling is conducted to analyze the tension of an anchor line by varying the size and drag coefficient of a buoy when the trapnet is influenced by the wave and the current simultaneously. A mass-spring model was used to analyze the behavior of trapnet underwater under the influence of waves and current. In the simulation of numerical model, wave height of 3, 4, 5 and 6 m, a period of 4.4 s, and the flow speed of 0.7 m/s were used for the wave and current condition. The drag coefficients of buoy were 0.8, 0.4 and 0.2, respectively. The size of buoy was 100, 50 and 25% based on the cylindrical buoy ($0.0311m^3$) used for swimming crab trap. The drag coefficient of the trapnet, the main model for numerical analysis, was obtained by a circular water channel experiment using a 6-component load cell. As a result of the simulation, the tension of the anchor line decreased proportional to buoy's drag coefficient and size; the higher the wave height, the greater the decrease rate of the tension. When the buoy drag coefficient and size decreased to one fourth, the tension of the anchor line decreased to a half and the tension of the anchor line was lower than the holding power of the anchor even at 6 m of wave height. Therefore, reducing the buoy drag coefficient and size appropriately reduces the trapnet load from the wave, which also reduces the possibility of trapnet loss.

• The Journal of the Korean Society for Microbiology
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• v.17 no.1
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• pp.7-14
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• 1982

A model of induction of neoplasia by viruses has develpoed from experimental studies in animals and in cultured cells and oncogenic transformation of cells is the result of integration of viral genetic information into the cellular DNA. The evidence for these associations was derived primarily from seroepidemiologic investigation. However, data indicating that the relation between HSV-2 and cervical cancer fits the model derived from experimental animal studies are not yet sufficient to draw conclusion with regard to the etiologic role the virus in the development of the neoplasms. In other hand, the K562 tumor cell is highly susceptible target for natural killer cell lysis by the lymphocytes of human and murine periperal blood. The characteristics of this effector cell type has been investigated. A study on natural killer cell mediated cytotoxicity(NKMC) against $^{51}Cr$-K562 as target cell was studed in HSV-2 infected ICR mouse. We have studied for susceptibility of HSV-2 against mouse embryo fibroblast(MEF) cells and NKMC from HSV-2 infected mouse. The results obtained that the mouse embryo fibroblast cells culture, the number and size of the cells were markedly increased and formed a monolayers relatively rapid, and become complete monolayer sheet around 72 hrs. Duration of cytopathic effect on MEF cells was rapid by serial passing of HSV-2. The morphology of the HSV-2 infected cells appear to be mainly round, ovium, spindle form and some of them was forming large giant cells. The NKMC was decrease in mouse with HSV-2 and comparison between effector/target cells ratio as 25:1 and 50:1 respectively, the NKMC was found to be more significantly decreased than normal control we have concluded that the natural killer cell activity of the viral infected mouse was shown as a suppressed during the HSV-2 infection, day 7th and 14th.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.91-94
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• 2002

It is important to develop new effective technologies for increasing the interruption capacity and reducing the size of a GCB (Gas Circuit Breaker). It is not easy to test the real GCB model in practice as in theory. Therefore, a simulation tool based on a CFD (Computational Fluid Dynamics) algorithm has been developed to facilitate an optimization of the interrupter. But the choice of grid is not at all trivial in the complicated geometries like a GCB. In this paper, we have applied a CFD-CAD integration using Cartesian cut-cell method, which is one of the grid generation techniques for dealing with complex and multi-component geometries.