The Journal of Korean Society of Virology (대한바이러스학회지)
- Volume 30 Issue 2
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- Pages.141-150
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- 2000
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- 1225-2344(pISSN)
Adenovirus-mediated mGM-CSF in vivo Gene Transfer Inhibits Tumor Growth in a Murine Meth A Fibrosarcoma Model
- Kim, Sang-Hyeon (Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
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Suh, Kwang-Sun
(Department of Pathology, Chungnam National University School of Medicine) ;
- Seong, Young-Rim (Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
- Choi, See-Young (Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
- Rho, Jae-Rang (Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
- Yoo, Jin-Sang (Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
- Hwang, Kyeng-Sun (Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
- Cho, Won-Kyung (Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
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Im, Dong-Soo
(Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology)
- Published : 2000.06.30
Abstract
The effectiveness of noninfectious recombinant adenovirus encoding murine granulocyte-macrophage colony stimulating factor (mGM-CSF) for the treatment of Meth A fibrosarcoma was investigated in syngeneic BALB/C model. Meth A and HeLa cells transduced with the recombinant adenovirus (Ad.mGM-CSF) produced substantial amounts of mGM-CSF, while WEH1164 cells transduced with the virus did not produce mGM-CSF. Mice inoculated subcutaneously with