• JSTS:Journal of Semiconductor Technology and Science
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• 제10권2호
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• pp.118-129
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• 2010

A lower-threshold-voltage (LVth) SRAM cell with an elevated cell biasing scheme, which enables to reduce the random threshold-voltage (Vth) variation and to alleviate the stability-degradation caused by word-line (WL) and cell power line (VDDM) disturbed accesses in row and column directions, has been proposed. The random Vth variation (${\sigma}Vth$) is suppressed by the proposed LVth cell. As a result, the LVth cell reduces the variation of static noise margin (SNM) for the data retention, which enables to maintain a higher SNM over a larger memory size, compared with a conventionally being used higher Vth (HVth) cell. An elevated cell biasing scheme cancels the substantial trade-off relationship between SNM and the write margin (WRTM) in an SRAM cell. Obtained simulation results with a 45-nm CMOS technology model demonstrate that the proposed techniques allow sufficient stability margins to be maintained up to $6{\sigma}$ level with a 0.5-V data retention voltage and a 0.7-V logic bias voltage.

• 한국자동차공학회논문집
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• 제18권6호
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• pp.114-121
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• 2010

This paper presents a design process of light-weighted fuel cell vehicle (FCV) frame to meet design target of natural frequency in early design stage. At first, using validated FE model for the current design, thickness optimization was carried out. Next. optimization process, comprised of beam model size optimization, shell model design and shell model thickness optimization, was investigated for two frame types. In addition, in order to ensure hydrogen tanks safety against rear impact load, structural collapse characteristics was estimated for the rear frame model finally produced from the previous optimization process and, with the target of equal collapse characteristics to the current design model, structural modification with small weight increase was studied through static structural collapse analyses. The same attempt was applied to the front side frame. The results explain that the proposed process enables to design light-weighted frames with high structural performance in early stage.

• Nuclear Engineering and Technology
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• 제45권7호
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• pp.839-846
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• 2013

This paper describes a finite element model of the microstructure of dispersion type nuclear fuels, which can be used to determine the effective thermal conductivity of the fuels during irradiation. The model simulates a representative region of the fuel as a prism shaped unit cell made of brick elements. The elements within the unit cell are assigned material properties of either the fuel or the matrix depending on position, in such a way as to represent randomly distributed fuel particles with a size distribution similar to that of the as manufactured fuel. By applying an appropriate heat flux across the unit cell it is possible to determine the effective thermal conductivity of the unit cell as a function of the volume fraction of the fuel particles. The presence of a fuel/matrix interaction layer is simulated by the addition of a third set of material properties that are assigned to the finite elements that surround each fuel particle. In this way the effective thermal conductivity of the material may also be determined as a function of the volume fraction of the interaction layer. Work is on going to add fission gas bubbles in the fuel as a fourth phase to the model.

• 환경영향평가
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• 제3권2호
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• pp.47-56
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• 1994

AGNPS model is an event-based model to analyze nonpoint-source and to examine potential water quality problems from agricultural watershed. This model uses a square grid-cell system to represent the spatial variability of watershed conditions, and simulates runoff, sediment, and nutrient transport for each cell. AGNPS model was applied on Yeonwha watershed, and the test results were compared with the measured data for runoff volume, peak runoff rate, suspended solids, and phosphorus concentration. The watershed of 278.8 ha was divided into 278 cells, each of which was 1 ha in size. The coefficients of determination for runoff volume and peak flow were (0.893 and 0.801 respectively from regression of the estimated values on the measured values. The concentration of suspendid solid was increased but decreased that of phosphate with runoff volume.

• 한국세라믹학회:학술대회논문집
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• 한국세라믹학회 2007년도 제34회 시멘트 심포지엄
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• pp.129-137
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• 2007

This paper presents a numerical model which can predict degree of hydration of cement mineral component, such as $C_{3}S$, $C_{2}S$, $C_{3}A$, $C_{4}AF$ and microstructure of hydrating cement as a function of water to cement ratio, cement particle size distribution, cement mineral components and temperature. In this model cement particles are parked randomly in cell space and hydration process is described using a multi-component integrated kinetic model. The simulation result of degree of hydration of cement mineral component agrees well with experiment result. The content of cement hydration product, such as CSH and CH can be obtained as an accompanied result during hydration process. By introducing of equal-area projection method, water withdrawl mechanism and contact area among cement particles can be considered in detail. By using proposed method, pore size distribution of hydrating cement is predicted.

• 시멘트 심포지엄
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• 통권34호
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• pp.129-137
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• 2007

This paper presents a numerical model which can predict degree of cement mineral component, such as $C_3S$, $C_2S$, $C_3A$, $C_4AF$ and microstructure of hydrating cement as a function of water to cement ratio, cement particle size distribution, cement mineral components and temperature. In this model cement particles are parked randomly in cell space and hydration process is described using a multi-component intergrated kinetic model. The simulation result of degree of hydration of cement mineral component agrees well with experiment result. The content of cement hydration product, such as CSH and CH can be obtained as an accompanied result during hydration process. By introducing of equal-area projection method, water withdrawl mechanism and contact area among cement particles can be considered in detail. By using proposed method, pore size distribution of hydrating cement is predicted.

• 대기
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• 제22권3호
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• pp.357-365
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• 2012

High spatio-temporal resolution hydrologic components can give important information to monitor natural disaster. The objective of this study is to create high spatial-temporal resolution gridded hydrologic components using TOPLATS distributed land surface model and evaluate their accuracy. For this, Andong dam basin is selected as study area and TOPLATS model is constructed to create hourly simulated values in every $1{\times}1km^2$ cell size. The observed inflow at Andong dam and soil moisture at Andong AWS site are collected to directly evaluate the simulated one. RMSEs of monthly simulated flow for calibration (2003~2006) and verification (2007~2009) periods show 36.87 mm and 32.41 mm, respectively. The hourly simulated soil moisture in the cell located Andong observation site for 2009 is well fitted with observed one at -50 cm. From this results, the cell based hydrologic components using TOPLATS distributed land surface model show to reasonably represent the real hydrologic condition in the field. Therefore the model driven hydrologic information can be used to analyze local water balance and monitor natural disaster caused by the severe weather.

• Biotechnology and Bioprocess Engineering:BBE
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• 제8권4호
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• pp.246-251
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• 2003

The blood-brain barrier (BBB) is composed of the brain capillaries, which are lined by endothelial cells displaying extremely tight intercellular junctions. Several attempts at creating an in vitro model of the BBB have been met with moderate success as brain capillary endothelial cells lose their barrier properties when isolated in cell culture. This may be due to a lack of recreation of the in vivo endothelial cellular environment in these models, including nearly constant contact with astrocyte foot processes. This work is motivated by the hypothesis that growing endothelial cells on one side of an ultra-thin, highly porous membrane and differentiating astrocyte or astrogliomal cells on the opposite side will lead to a higher degree of interaction between the two cell types and therefore to an improved model. Here we describe our initial efforts towards testing this hypothesis including a procedure for membrane fabrication and methods for culturing endothelial cells on these membranes. We have fabricated a 1 $\mu\textrm{m}$ thick, 2.0 $\mu\textrm{m}$ pore size, and 55% porous membrane with a very narrow pore size distribution from low-stress silicon nitride (SiN) utilizing techniques from the microelectronics industry. We have developed a base, acid, autoclave routine that prepares the membranes for cell culture both by cleaning residual fabrication chemicals from the surface and by increasing the hydrophilicity of the membranes (confirmed by contact angle measurements). Gelatin, fibronectin, and a 50/50 mixture of the two proteins were evaluated as potential basement membrane protein treatments prior to membrane cell seeding. All three treatments support adequate attachment and growth on the membranes compared to the control.

• 한국농공학회지
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• 제44권7호
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• pp.25-35
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• 2002

In this study, the effect of DEM (Digital Elevation Model) resolution (15m, 30m, 50m, 70m, 100m, 200m, 300m) on the hydrological simulation was examined using the BASINS (Better Assessment Science Integrating point and Nonpoint Source) for the Heukcheon watershed (303.3 ㎢) data from 1998 to 1999. Generally, as the cell size of DEM increased, topographical changes were observed as the original range of elevation decreased. The processing time of watershed delineation and river network needed more time and effort on smaller cell size of DEM. The larger DEM demonstrated had some errors in the junction of river network which might affect on the simulation of water quantity and quality. The area weighted average watershed slope became milder but the length weighted average channel slope became steeper as the DEM size increased. DEM resolution affected substantially on the topographical parameter but less on the hydrological simulation. Considering processing time and accuracy on hydrological simulation, DEM grid size of 100m is recommended for this range of watershed size.

• Biomolecules & Therapeutics
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• 제30권2호
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• pp.151-161
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• 2022

This study elucidates the anti-cancer potential of gallic acid (GA) as a promising therapeutic agent that exerts its effect by regulating the PI3K/Akt pathway. To prove our research rationale, we used diverse experimental methods such as cell viability assay, colony formation assay, tumor spheroid formation assay, cell cycle analysis, TUNEL assay, Western blot analysis, xenograft mouse model and histological analysis. Treatment with GA inhibited cell proliferation in dose-dependent manner as measured by cell viability assay at 48 h. GA and cisplatin (CDDP) also inhibited colony formation and tumor spheroid formation. In addition, GA and CDDP induced apoptosis, as determined by the distribution of early and late apoptotic cells and DNA fragmentation. Western blot analysis revealed that inhibition of the PI3K/Akt pathway induced upregulation of p53 (tumor suppressor protein), which in turn regulated cell cycle related proteins such as p21, p27, Cyclin D1 and E1, and intrinsic apoptotic proteins such as Bax, Bcl-2 and cleaved caspase-3. The anti-cancer effect of GA was further confirmed in an in vivo mouse model. Intraperitoneal injection with GA for 4 weeks in an A549-derived tumor xenograft model reduced the size of tumor mass. Injection of them downregulated the expression of proliferating cell nuclear antigen and p-Akt, but upregulated the expression of cleaved caspase-3 in tumor tissues. Taken together, these results indicated that GA hindered lung cancer progression by inducing cell cycle arrest and apoptosis, suggesting that GA would be a potential therapeutic agent against non-small cell lung cancer.