• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1997년도 추계학술대회 논문집
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• pp.519-522
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• 1997

In this study, the collision free path planning method of the articulated manipulator using sequential search is proposed. This method is to find the joint path of the manipulator with many degrees of freedom from the distal joint to the proximal one. To do this, the initial work space of the gantry manipulator, which is a remote maintenance equipment of the radioactive environment, is defined from the condition that the distal joint configuration is determined by the posture of maintenance. Then, 2-dimensional configuration space with the obstacle area is represented and the collision free path of manipulator is searched in the configuration space. And, this method is verified using the graphic simulation in virtual workcell for the spent fuel disassembling processes. The result of this study can be effectively used in implementing the maintenance processes for the hot cell equipment and enhance the reliability of the spent fuel management.

• 한국공간정보시스템학회 논문지
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• 제6권2호
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• pp.23-37
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• 2004

최근 GPS기능을 탑재한 휴대폰 PDA등의 모바일 장치를 사용하여 위치 기반 서비스를 이용하는 사용자가 급증하고 있다. 이에 위치 정보를 지닌 공간 데이타를 저장하고 관리하는 대용량의 공간 데이타베이스는 사용자의 다양한 질의 조건과 빠른 검색을 가능하게 하기 위한 색인이 필요하며 대표적인 색인 기법으로는 R-tree가 널리 사용되고 있다. 기존의 R-tree를 이용한 검색은 질의 영역과 관계없는 공간 데이타까지 검색하여 불필요한 입출력을 유발하기 때문에 응답시간이 늦어진다. 본 논문에서는 공간 데이타가 위치 기반 질의를 지원하기 위해 자신이 속한 노드의 전체(Union) MBR 영역에 따라 동적으로 셀 레벨 값을 구성하는 CLR-트리(Cell Leveling R-tree)를 제안한다. 또한, CLR-트리에서의 새로운 공간 데이타의 삽입, 분할, 삭제, 검색 알고리즘을 제안한다. 제안된 CLR-트리에서는 위치 기반 질의 시 사용자 질의 영역의 셀 레벨 값과 공간 데이타의 셀 레벨 값을 비교하여, 겹치지 않는 셀에 대해서는 검색 대상으로부터 제거하고 연관된 셀만을 검색하기 때문에 빠른 응답시간을 제공한다. 디스크 입출력 실험에서 CLR-트리가 기존 R-tree보다 디스크 접근 수를 $5{\sim}20%$ 감소시켜 사용자의 위치 기반 질의에 대해 빠르게 처리함을 알 수 있었다.

• Journal of Ginseng Research
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• 제45권2호
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• pp.273-286
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• 2021

Background: Prostate carcinoma is the second most common cancer among men worldwide. Developing new therapeutic approaches and diagnostic biomarkers for prostate cancer (PC) is a significant need. The Chinese herbal medicine Panax quinquefolius saponins (PQS) have been reported to show anti-tumor effects. We hypothesized that PQS exhibits anti-cancer activity in human PC cells and we aimed to search for novel biomarkers allowing early diagnosis of PC. Methods: We used the human PC cell line DU145 and the prostate epithelial cell line PNT2 to perform cell viability assays, flow cytometric analysis of the cell cycle, and FACS-based apoptosis assays. Microarray-based gene expression analysis was used to display specific gene expression patterns and to search for novel biomarkers. Western blot and quantitative real-time PCR were performed to demonstrate the expression levels of multiple cancer-related genes. Results: Our data showed that PQS inhibited the viability of DU145 cells and induced cell cycle arrest at the G1 phase. A significant decrease in DU145 cell invasion and migration were observed after 24 h treatment by PQS. PQS up-regulated the expression levels of p21, p53, TMEM79, ACOXL, ETV5, and SPINT1 while it down-regulated the expression levels of bcl2, STAT3, FANCD2, DRD2, and TMPRSS2. Conclusion: PQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1638-1642
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• 2008

Cell migration is one of the essential mechanisms responsible for complex biological processes. Intensive researches have begun to elucidate the mechanisms and search intriguing conditions for efficient control of cell migration. One general mechanism which is widely applicable for cells including neutrophil, Escherichia coli and endothelial cell is chemotaxis. Especially, understanding the chemotactic mechanics of cell crawling has important implications for various medical and biological applications. The single cell study for chemotaxis has an advantage over studies with the population of cells in providing a clearer observation of cell migration, which leads to more accurate assessments of chemotaxis. In this paper, we propose a three-dimensional model considering a single crawling cell to study its chemotaxis. The semi-implicit Fourier spectral method is applied for high efficiency and numerical stability. The simulation results reveal rich dynamics of cell.

• 경영과학
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• 제23권3호
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• pp.13-25
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• 2006

To reduce the signaling tost of paging in mobile communication, sequential paging schemes are proposed by partitioning a location area into several paging areas such that each area is paged sequentially. Necessary conditions for the optimal partition of cells with delay bound are examined by considering the mobiles location probability at each cell. The Optimal Cell Partitioning (OCP) is proposed based on the necessary conditions and the fathoming rule which trims off the unnecessary solution space and expedite the search process. Two Heuristics, BSG and BNC are also presented to further increase the computational efficiency in real-world paging scheme for the next generation mobile systems. The effectiveness of the 1)reposed paging schemes is illustrated with computational results. The Heuristic BSG that performs the search in the most promising solution group outperforms the best existing procedure with the 6-69% gain in paging cost in problems with 100 cells.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1431-1434
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• 2015

Background: Breast cancer is one of the most common cancers among women worldwide and the HER2 receptor plays an important role in its development and progression. This systematic review aimed to summarize the role of HER2 in brain metastasis in patients with breast cancer. Materials and Methods: We conducted a literature search by advanced search in title field using the Scopus, Pubmed, and Google scholar databases until the end of June 2014. With metastasis, metastatic, HER2, brain, and breast cancer, as terms of search we selected 31 articles, which were reviewed by two independent and blinded expert reviewers. The studies were first selected according to their titles and abstracts. Quality of the studies were then assessed using the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) protocol for observational studies and CONSORT(Consolidation of Standards for Reporting Trials) protocol for clinical trials. For statistical analyses, we used STATA, version 11.0 software. Forest and funnel diagrams were drawn and for heterogeneity, index was also considered. Also we used meta regression analysis. Results: Finally, we reviewed 10 studies. The prevalence of brain metastasis in HER2-positive breast cancer patients was 24.9%. There was publication bias in the reviewed studies. Meta regression analysis showed that follow up time had no significant effect (p=0.396) on the prevalence of brain metastasis. Conclusions: The results showed a high prevalence of brain metastasis in HER2 positive breast cancer patients.

• 한방안이비인후피부과학회지
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• 제16권3호
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• pp.164-184
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• 2003

Objectives : This study was designed to establish a characteristic discrimination of internal and external morphological standard of original plants and herbal states in Pogostemonis and Agastachis Herba. Methods : In this studies, the external-internal morphological standards were determined by using stereoscope and butanol series. Results : 1. The external characteristics: Pogostemon cablin has hairs and brown-like in stem, elliptical fruit. On the other hand, Agastache rugosa has no hairs and red-like in stem, obovatic trigone fruit. 2. The physical characteristics: Pogostemon cablin is gray in whole, has hairs in stem and numerous hairs of ash in leaf. On the other hand, Agastache rugosa is yellow-green in whole, has no hairs in stem. Specially the latter has deep-green colour and numerous hairs presenting mostly at lower epidermis in leaf. 3. The physical characteristics in currents: Pogostemon cablin is brown, has hairs and round-like stem. On the other hand, Agastache rugosa is green or yellow-green, has no hairs and tetragon in stem. 4. The internal characteristics: Pogostemon cablin has progressed spongy tissue in epidermal cell of leaf and many rank of epidermal cell in stem. On other hand, Agastache rugosa has I rank palisade tissue in leaf and few rank of epidermal cell in stem. In the external shape, it was possible that herbs were distinguished according to artificial cIassification and that same genus-degree of relatedness among herbs could be distinguished by more precise and active observation. In the shape of real herbs, I compared current herbs in market with original herbs which were just collected or were on the course of drying. In addition, it was possible that the internal shape could be identified by using microscope after butanol series. Conclusion : Though it was impossible to make distinction of herbs which are not current in my search contents, this search contents will be a standard for applying herbs in the future. An Additional standard establishment including physiochemical reaction and gene research is required in order to supplement the fault of this search.

• 한국정보통신학회논문지
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• 제26권3호
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• pp.412-421
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• 2022

5G NR 모든 기기는 기지국과 통신을 위해 가장 먼저 셀 탐색 및 동기화 과정을 진행해야 한다. 이 과정에서 PSS 검출이 제일 먼저 성공적으로 수행되어야 하므로, PSS 검출은 5G NR 통신에서 가장 중요하고 어려운 문제 중 하나이다. 다양한 PSS 검출 방법 중 본 논문에서는 교차상관관계 기반의 검출 방법에 대해 소개하고 복잡도와 검출 속도를 고려한 하드웨어 구조에 대해서 설명한다. 또한, PSS 검출기를 포함하는 시스템 구성을 위해 필요한 인터페이스와 효율적이고 유연한 동작을 위한 구동 소프트웨어 동작도 제안하고, 이를 구현하였을 때 Xilinx사의 UltraScale+ FPGA의 자원 사용량을 다양한 구조에 따라 비교 분석한다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.407-411
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• 2005

KUGI (Korean UniGene Information) database contains the annotation information of the cDNA sequences obtained from the disease samples prevalent in Korean. A total of about 157,000 5'-EST high throughput sequences collected from cDNA libraries of stomach, liver, and some cancer tissues or established cell lines from Korean patients were clustered to about 35,000 contigs. From each cluster a representative clone having the longest high quality sequence or the start codon was selected. We stored the sequences of the representative clones and the clustered contigs in the KUGI database together with their information analyzed by running Blast against RefSeq, human mRNA, and UniGene databases from NCBI. We provide a web-based search engine fur the KUGI database using two types of user interfaces: attribute-based search and similarity search of the sequences. For attribute-based search, we use DBMS technology while we use BLAST that supports various similarity search options. The search system allows not only multiple queries, but also various query types. The results are as follows: 1) information of clones and libraries, 2) accession keys, location on genome, gene ontology, and pathways to public databases, 3) links to external programs, and 4) sequence information of contig and 5'-end of clones. We believe that the KUGI database and search system may provide very useful information that can be used in the study for elucidating the causes of the disease that are prevalent in Korean.

• 경영과학
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• 제28권2호
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• pp.53-62
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• 2011

The objective of this paper is to propose a Binary Particle Swarm Optimization(BPSO) for design of reporting cell management system. The assignment of cells to reporting or non-reporting cells is an NP-complete problem having an exponential complexity in the Reporting Cell Location Management(RCLM) system. The number of reporting cells and which cell must be reporting cell should be determined to balance the registration(location update) and search(paging) operations to minimize the cost of RCLM system. Experimental results demonstrate that BPSO is an effective and competitive approach in fairly satisfactory results with respect to solution quality and execution time for the optimal design of location management system.