• Journal of Chest Surgery
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• v.32 no.2
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• pp.151-157
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• 1999

Background: Increasing evidences from experimental studies indicate that apoptosis may be inversely related to angiogenesis in tumor progression. Material and Method: To explore how apoptosis correlates with tumor angiogenesis, we measured the apoptotic index(AI) using the terminal deoxynucleotidyl transferase method(Apop Tag In Situ Apoptosis Detection Kit, ONCOR) and the intratumoral microvessel density using the anti-CD31 monoclonal antibody in non-small cell lung cancer. Result: Statistical analysis revealed an inverse correlation between AIs and intratumoral microvessel densities in squamous cell lung carcinoma(Spearman rank correlation coefficient r=- 0.229, p=0.047). Conclusion: The results of this study demonstrated that the amount of apoptosis in squamous cell lung carcinoma may be influenced by the extent of neovascularization. This suggests that tumor angiogenesis may contribute to a reduction of apoptosis in tumor cells.

• Korean Journal of Bronchoesophagology
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• v.4 no.2
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• pp.197-204
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• 1998

Human papillomavirus(HPV) is epitheliotrophic virus invading the anogenital tract and the upper aerodigestive tract HRV produces a diversity of benign and maljgnant tumors. In this study, the author determined the frequency of association of human papillomavirus(HPV) and laryngeal carcinomas and investigated the significance of HRV infection of different subtypes in the tumorigenesis of laryngeal carcinoma. Laryngeal squamous cell cancinomas from 34 patients who did not have preexisting papillomas by clinical history were retrieved from formalin-fixed, paraffin-embedded blocks and analyzed for HPV. Nineteen cases were tumors of the true vocal folds, 11 were supraglottic and 4 were transglottic. HPV detection was dane using polymerase chain reaction amplification with HPV L$_1$consensus primer. HPV type was determined by the same method using HPV-6, 11 and 16,-18 type-specific E6 primers. The results were as follows : 1) HPV DNA was detected in 7 cases among the 34 patients(20.6%). According to the type of HPV DNA HPV-11 was detected in 3 cases, HPV-16 was detected in 2 cases and HPV-6 and HPV-18 were detected in 1 case, respectively. 2) These 7 HPV-positive patients were advanced cancinoma cases. From these results, we concluded that HPV was thought to be the etiological factor of laryngeal squamous cell carcinomas.

• KIEE International Transactions on Electrophysics and Applications
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• v.11C no.2
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• pp.6-11
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• 2001

Abstract- In this paper, a new Partial Discharge (PD) detection using Pockels cell was proposed and considerable apparent chaotic characteristics were discussed. For this purpose, PD was generated from needle-plane electrode in air and detecte by optical measuring system using Pockels cell, based on Mach-Zehner interferometer, consisting of He-Ne laser, single mode optical fiber, 50/50 beam splitter and photo detector. In addition, the presence of chaos of the PD signals has been investigated by examining their means of qualitative and quantitative information. For the former, return map and 3-dimensional strange attractor have been drawn in order to investigate the presence of chaotic characteristics relevant to PD signals, detected through CT and Peckels sensor respectively, in the normalized time series. The presence of strange attractor indicates the existence of fractal structures in it's phase space. For the latter, several dimension values of strange attractor were verified sequentially. Throughout this paper, it is likely that the chaotic characteristics regarding the PD signals under air are verified.

• Journal of Electrochemical Science and Technology
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• v.12 no.4
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• pp.415-423
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• 2021

For a battery module where single cells are connected in series, the single cells should each have a similar state of charge (SOC) to prevent them from being exposed to an overcharge or over-discharge during charge-discharge cycling. To detect the existence of unbalanced SOC cells in a battery module, we propose a simple measurement method using a single-frequency response of electrochemical impedance spectroscopy (EIS). For a commercially available graphite/nickel-cobalt-aluminum-oxide lithium-ion cell, the cell impedance increases significantly below SOC20%, while the impedance in the medium SOC region (SOC20%-SOC80%) remains low with only minor changes. This impedance behavior is mostly due to the elementary processes of cathode reactions in the cell. Among the impedance values (Z, Z', Z"), the imaginary component of Z" regarding cathode reactions changes heavily as a function of SOC, in particular, when the EIS measurement is performed around 0.1 Hz. Thanks to the significant difference in the time constant of cathode reactions between ≤SOC10% and ≥SOC20%, a single-frequency EIS measurement enlarges the difference in impedance between balanced and unbalanced cells in the module and facilitates an ~80% improvement in the detection signal compared to results with conventional EIS measurements.

• The Korean Journal of Food And Nutrition
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• v.26 no.4
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• pp.936-944
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• 2013

Cronobacter muytjensii is an important foodborne pathogen as a potential risk in infant formula powder (IFP). To develop a new and sensitive method for the detection of Cronobacter spp. in IFP, an immunoglobulin G (IgG) specific for C. muytjensii (formerly known as Enterobacter sakazakii ATCC 51329) was developed. Further, an indirect noncompetitive enzyme-linked immunosorbent assay (INC-ELISA) was developed by using the anti-C. muytjensii IgG. As a result, this newly developed INC-ELISA method was found very sensitive for C. muytjensii with detection limit of $6.5{\times}10^3CFU/ml$ in pure culture and 1 cell/25 g of IFP. This INC-ELISA method also displayed excellent specificity for C. muytjensii showing no cross-reactivity with other strains of Cronobacter genus and 11 other foodborne pathogenic strains. These results show that the developed INC-ELISA method was very sensitive, efficient, and rapid for the detection of C. muytjensii. Hence, this method could be applied to the development of diagnostic kits for the rapid and easy detection of C. muytjensii.

• Tuberculosis and Respiratory Diseases
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• v.72 no.2
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• pp.156-162
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• 2012

Background: The main goal of this study was to evaluate the diagnostic efficacy of reverse transcription-nested polymerase chain reaction (RT-nested PCR) in bronchial washing fluid with MAGE A1-6 common primers for the detection of lung cancers invisible by bronchoscopy. Methods: To determine the expression of MAGE A1-6 gene in 189 lung cancers diagnosed by conventional fluoroscopy-guided lung biopsy and 89 cancer-free controls, RT-nested PCR was performed in bronchial washing specimens. We analyzed MAGE A1-6 RT-nested PCR data according to tumor histology, stage, size, and compared them with cytological data. Results: 189 patients (111 cases in adenocarcinoma, 47 cases in squamous cell carcinoma, 22 cases in small cell lung carcinoma, and 9 cases in other cancers) and 89 benign patients were investigated. The expression of MAGE was performed by nested RT-PCR using common MAGE primer. Among 189 cancer patients, the expression rate of MAGE was 49.2%, and the positive predictive value was 89.4%. However, the expression rate of MAGE in patients with benign lesions was 12.4%. In peripheral lung cancer, the positive rate of MAGE expression was 57.4% in squamous cell carcinoma, 44.1% in adenocarcinoma and 59.1% in small cell lung cancer. Whereas the expression rate of bronchial washing cytology in peripheral lung cancer was 9.0% (p=0.011). Conclusion: MAGE RT-PCR in bronchial washing fluid gave us promising data for the detection of peripheral lung cancer. It could be a useful method for selecting diagnostic tools for peripheral lesions.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.10
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• pp.162-170
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• 2013

In recent years, the interests and needs of the Pedestrian Protection System (PPS), which is mounted on the vehicle for the purpose of traffic safety improvement is increasing. In this paper, we propose a pedestrian candidate window extraction and unit cell histogram based HOG descriptor calculation methods. At pedestrian detection candidate windows extraction stage, the bright ratio of pedestrian and its circumference region, vertical edge projection, edge factor, and PCA reconstruction image are used. Dalal's HOG requires pixel based histogram calculation by Gaussian weights and trilinear interpolation on overlapping blocks, But our method performs Gaussian down-weight and computes histogram on a per-cell basis, and then the histogram is combined with the adjacent cell, so our method can be calculated faster than Dalal's method. Our PCA reconstruction error based pedestrian detection candidate window extraction method efficiently classifies background based on the difference between pedestrian's head and shoulder area. The proposed method improves detection speed compared to the conventional HOG just using image without any prior information from camera calibration or depth map obtained from stereo cameras.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.29 no.10
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• pp.791-798
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• 2018

The CFAR algorithm is mainly used for target detection in radar systems. In particular, OS CFAR is used in a non-uniform noise environment. However, it requires a large amount of computation, because it should sort reference cells in ascending order. This makes it difficult to apply the radar system in real time. In this paper, we describe how to reduce the computational burden of OS CFAR. We compared the power of the test cell and reference cell to determine only the presence or absence of target detection. The common reference cells overlapping in the reference cells of the three test cells are obtained. We first compare the test cell with the highest power value among the three test cells to the common reference cells. Next, we compare each test cell to general reference cells, excluding the common reference cells. The computation time is shortened by reducing the power comparison computation amounts.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.5C
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• pp.351-360
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• 2008

In cellular mobile radio systems with frequency reuse, the interference signals degrade the channel estimation and signal detection performance due to the low signal-to-interference ratio near coverage boundaries. When the preamble pilot sequences from different cells are orthogonal or located in disjointed positions, they can be used for multi-cell channel estimation and interference cancellation. In time-varying channels caused by Doppler spread, data pilot symbols are needed for channel estimations. However, data pilot symbols are usually located in identical positions for the overhead reduction, which degrades the channel estimation performance. In this paper, we demonstrate a significant amount of performance improvement is achieved by multiplying different pseudonoise(PN) sequences to the data pilot symbols from adjacent interference cells. In particular, for detection scheme using maximal ratio combining(MRC) and inter-cell spatial demultiplexing(ISD), quantitative performance gain of spectral efficiency for different values of Doppler frequency and interference power is presented.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.154.2-154.2
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• 2003

Mammalian cell cycles are tightly regulated by cyclins, cyclin dependent kinase (CDK), Retinoblatoma (Rb) protein, and cellular CDK inhibitors (CDKI). Cyelin dependent kinases (CDK) are key enzymes regulating eukaryotic cell cycle. And also it is recognized that the abnormal increase of CDK activities is one of the common events in human cancer and CDK inhibitors have therapeutic values in cancer treatment. Until now it is known that over 10 different CKDs participate in cell cycle regulation. (omitted)