• Journal of Embryo Transfer
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• v.27 no.4
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• pp.193-203
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• 2012

The development of embryos reconstructed by nuclear transfer is dependent upon numerous factors including the type of recipient cell, method of enucleation, the type of donor cell, method of reconstruction, activation, the cell cycle stage of both the donor nucleus and the recipient cytoplasm and the method of culture of the reconstructed embryos. Many of these points which have been reviewed extensively elsewhere (Sun and Moor, 1995; Colman, 1999; Oback and Wells, 2002; Renard et al., 2002; Galli et al., 2003b), here we will concentrate on main area, the production of suitable cytoplast and nuclear donor, nuclear-cytoplasmic coordination, oocyte activation, culture of reconstructed embryos, and the effects that this may have on development.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.48 no.3
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• pp.36-40
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• 2011

OFDM technology is already commonplace in the current mobile communication system environment. However, inter-cell interference causes many problems in the cellular system as seen from the problem caused by the surge in the use of smart phones. In this paper, we will research how user distribution influences a performance of a conventional proposed algorithm in the certain cell area and confirm it through computer simulations. As a result, we proved that there is an appropriate user distribution in the cell. In addition, it has an effect on the performance of inter-cell interference coordination.

• The Korean Journal of Physiology and Pharmacology
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• v.3 no.3
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• pp.283-291
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• 1999

We have synthesized novel platinum (II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore, nitrate was added to improve the water-solubility. A new series of [Pt(cis-DACH)(DPPE)] $2NO_3(PC)$ was evaluated its antitumor activity on various MKN-45 human gastric adenocarcinoma cell-lines and normal primary cultured kidney cells. The new platinum complex demonstrated high efficacy in the cytotoxicity on MKN-45 cell-lines as well as adriamycin-resistant (MKN-45/ADR) and cisplatin-resistant (MKN-45/CDDP) cells. The cytotoxicities of PC were found quite less than those of cisplatin in rabbit proximal renal tubular cells, human renal cortical cells and human renal cortical tissues using MTT assay, $[^3H]-thymidine$ uptake and glucose consumption tests. Based on these results, this novel platinum (II) coordination complex, was considered as better a valuable lead for improving antitumor activities with low nephrotoxicities in the development of a new clinically available anticancer chemotherapeutic agents.

• Journal of electromagnetic engineering and science
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• v.15 no.1
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• pp.14-19
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• 2015

In multicellular wireless networks, intercell interference limits system performance, especially cell edge user performance. One promising approach to solve this problem is the intercell interference coordination (ICIC) scheme. In this paper, we propose a new ICIC scheme based on a resource partitioning approach to enhance cell edge user performance in a wireless multicellular system. The most important feature of the proposed scheme is that the algorithm is performed at each base station in a distributed manner and therefore minimizes the required information exchange between neighboring base stations. The proposed scheme has benefits in a practical environment where the traffic load distribution is not uniform among base stations and the backhaul capacity between the base stations is limited.

• Microbiology and Biotechnology Letters
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• v.47 no.2
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• pp.183-194
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• 2019

The consumption of fresh vegetables has been related to recurrent outbreaks of foodborne diseases (FBD) worldwide. Therefore, the development of effective alternative technologies is necessary to improve the safety of these products. This study aimed to isolate and identify epiphytic lactic acid bacteria (LAB) from fresh fruits and leafy vegetables and characterize their antagonistic capacity due to their ability to produce bacteriocins or antibacterial compounds. For this, 92 LAB isolates from fruits and leafy vegetables were screened for antagonistic activity. Two strains with the highest and broadest antagonistic activities were selected for further characterization; one from cantaloupe melon (strain CM175) and one from cilantro leaves (strain C15). The cell-free supernatants (CFS) of CM175 and C15 were found to exhibit antagonistic activity against FBD-causing pathogens. The CM175 and C15 strains were identified as Pediococcus pentosaceus and Lactobacillus graminis, respectively. Notably, the P. pentosaceus CM175 CFS stopped the growth of Salmonella Typhimurium, Salmonella Saintpaul, Staphylococcus aureus, and Listeria monocytogenes, and delayed Escherichia coli O157:H7 growth. Moreover, L. graminis C15 CFS delayed the growth of all indicator pathogens, but did not completely stop it. Organic acids and bacteriocin-like molecules were determined to be possibly exerting the observed antagonistic activity of the identified LAB strains. Thus, application of the antagonistic compounds produced by Pediococcus pentosaceus and Lactobacillus graminis could be a novel and ecological strategy in developing antimicrobial biopreservatives for the food industry and mitigating FBD by reducing the biological contamination in fruit and vegetable orchards, mainly via their potential in controlling both gram-negative and gram-positive pathogenic bacteria.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.6
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• pp.9-17
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• 2014

Heterogeneous network (HetNet) is a network consisting of macrocells overlaid with small cells. In HetNet, the interference from macrocell to small cell users is a major cause of performance degradation of small cell users and enhanced inter-cell interference coordination (eICIC) is needed to mitigate the interference. Previous works on eICIC gives limited performance gain because these works focus on maximizing long-term throughput and rarely consider varying channel conditions over frames. This paper proposes a new algorithm which dynamically coordinates interference and schedules users on each frame to maximize the total utility of the network with lower computational complexity than exhaustive search. Simulation results show that the proposed algorithm achieves higher total throughput than the throughput with the conventional algorithm, and has higher fairness index than the conventional algorithm when there large number of users.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.8
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• pp.16-21
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• 2009

OFDM is a key technology for 4G cellular systems in the future. But when OFDM is used in cellular system environment, it has severe inter-cell interference problems. In this paper, we propose an ICIC scheme that can reduce inter-cell interference for OFDM-based 4G cellular systems. and we analyze the efficiency of the proposed scheme. Simulation is carried out according to the simplified 3GPP LTE system level simulation parameters. We have confirmed the improvement of Geometry efficiency about 4dB at the results.

• Childhood Kidney Diseases
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• v.19 no.2
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• pp.176-179
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• 2015

Rituximab (RTX), a monoclonal antibody against the B-cell marker CD20, is commonly used as a treatment for antibody-mediated diseases or B-lymphocyte-mediated diseases. Destruction of B cells may reverse the disease course in many conditions; however, patients who are treated with RTX cannot respond appropriately to de novo infection due to lack of B lymphocytes. Here, we report one such case. A 7-year-old renal allograft recipient presented with severe anemia due to parvovirus infection after RTX treatment. The patient had focal segmental glomerulosclerosis and had received cadaveric kidney transplantation 6 months previously. She was treated with high-dose steroid for acute rejection and RTX for Epstein Barr Virus infection 3 months previously. At presentation, her hemoglobin level was 5.4 g/dL and leukocyte and platelet counts were normal. She had microcytic normochromic anemia and high viral load of parvovirus B19(70,578 copies/mL). Intravenous immunoglobulin ($200mg/kg{\cdot}d$) treatment controlled the progression of anemia and parvovirus infection. De novo parvovirus infection during the B lymphocyte-depletion period may have precipitated the severe anemia in this case. Close monitoring of infection is required after RTX therapy.

• Journal of Communications and Networks
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• v.11 no.1
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• pp.26-35
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• 2009

In this paper, we investigate how to do resource allocation to guarantee a minimum user data rate at low signaling overhead in multi-cell orthogonal frequency division multiple access (OFDMA) wireless systems. We devise dynamic resource allocation (DRA) algorithms that can minimize the QoS violation ratio (i.e., the ratio of the number of users who fail to get the requested data rate to the total number of users in the overall network). We assume an OFDMA system that allows dynamic control of frequency reuse factor (FRF) of each sub-carrier. The proposed DRA algorithms determine the FRFs of the sub-carriers and allocate them to the users adaptively based on inter-cell interference and load distribution. In order to reduce the signaling overhead, we adopt a hierarchical resource allocation architecture which divides the resource allocation decision into the inter-cell coordinator (ICC) and the base station (BS) levels. We limit the information available at the ICC only to the load of each cell, that is, the total number of sub-carriers required for supporting the data rate requirement of all the users. We then present the DRA with limited coordination (DRA-LC) algorithm where the ICC performs load-adaptive inter-cell resource allocation with the limited information while the BS performs intra-cell resource allocation with full information about its own cell. For performance comparison, we design a centralized algorithm called DRA with full coordination (DRA-FC). Simulation results reveal that the DRA-LC algorithm can perform close to the DRA-FC algorithm at very low signaling overhead. In addition, it turns out to improve the QoS performance of the cell-boundary users, and achieve a better fairness among neighboring cells under non-uniform load distribution.

• IMMUNE NETWORK
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• v.23 no.4
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• pp.33.1-33.13
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• 2023

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccine-induced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARS-CoV-2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4⁺ T cells exhibited substantial responses against both ancestral and Omicron spike proteins. Notably, CD4⁺ T cell responses against both ancestral and Omicron strains were preserved at 3 months after two shots of the BNT162b2 vaccine without waning. Polyfunctionality of vaccine-induced memory T cells was also preserved in response to Omicron spike protein. The present findings characterize the protective immunity of vaccination for adolescents in the era of continuous emergence of variants/subvariants.