• The Transactions of the Korean Institute of Electrical Engineers
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• v.43 no.3
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• pp.492-503
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• 1994

In this study, the control and scheduling of the flexible manufacturing cell (FMC) is discussed, which can perform the mixed production and relieve the effect of machine failure. The control of the FMC isvery complex task due to the property of multiple jobs and the dynamically changing states. For effective control of proposed FMC, the hierarchical scheme is introduced and the functions of each levels are defined. Especially for the control functions of shop floor level and cell level, the intelligent scheduler is implemented. To show the efficiency of the intelligent scheduler, the production method fo the existing assembly lines was evaluated and compared with the proposed intelligent FMC method. The results from the production performance show that the proposed method is superior to the existing method in various performance indices.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.784-788
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• 2004

A visualization study of shock formation of the supersonic jet nozzle using a Shadowgraph Method (SM) was carried out to investigate the effect of the longitudinal variation of coaxial pipe end tip position inside the supersonic nozzle. The experiment was performed for the Mach number range from 1.1 to 1.2 at nozzle exit. The well known shock cell structure was shown with the pipe end located deep inside the nozzle for the studied Mach number. With the pipe end approaches nozzle exit, it was found that the shock cell structure disappeared and turned into complex formation. In order to understand the mechanism of the shock structural change, computational simulation was carried out using the Navier-Stokes solver, FLUENT. Topological sketch was added with an aid of the visualization and the numerical simulation.

• Animal cells and systems
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• v.2 no.2
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• pp.287-295
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• 1998

The Saccharomyces cerevisiae MGMT gene encodes a O6-methylguanine DNA methyltransferase that protects cells from mutation or death by DNA alkylating agents. Using an in vitro transcription system, we analyzed its promoter region to find regulatory elements for transcription initiation. DNase I footprinting and a transcription assay showed that a functional TATA box, 5'-TGATATAGCA-3', is located in the region spanning from -25 to -34. We also found one upstream repressing sequence (URS), -333 to -213, by promoter deletion and competition analysis. Gel mobility shift assays and Southwestern blot analysis using URS region indicate specific complex formations. These results indicate that several cis-acting and trans-acting elements might be involved in the transcriptional regulation of the S. cerevisiae MGMT gene.

• KSBB Journal
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• v.13 no.4
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• pp.456-460
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• 1998

Fed-batch fermentations were carried out in order to improve the efficiency of hirudin production by recombinant Saccharomyces cerevisiae. A fed-batch fermentation done with the optimized semi-synthetic medium resulted in a maximum hirudin concentration of 342mg/$\ell$ by keeping a galactose concentrations between 10 and 30g/$\ell$ which corresponded to a 11.4-fold increase in hirudin concentration compared with the simple bach fermentation done with the same medium. Comparison of the chromatographic pattern of proteins in the growth medium clearly showed that the use of the semi-synthetic medium is more advantageous for separation of hirudin than the case o fusing the complex medium. Continuous cell recycle fermentation done at dilution rate of 0.1h-1 and an inlet galactose concentration of 100g/$\ell$ yielded a maximum hirudin productivity of 19.1mg hirudin/$\ell$$.$h.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.4
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• pp.955-959
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• 2004

Existing Clustering Methods for spatial data mining process only Point objects, not spatial objects with polygonometry such as lines and areas. It is because that distance computation between objects with polygonometry for clustering is more complex than distance computation between point objects. To solve this problem, we design a clustering method based on regular grid cell structures. In details, it reduces cost and time for distance computation using cell relationships in grid cell structures.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2004.05b
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• pp.374-377
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• 2004

Existing Clustering Methods for spatial data mining process only point objects, not objects with polygonometry such as lines and areas. It is because that distance computation between objects with polygonomery for clustering is more complex than point objects. To solve this problem, we design a clustering method based on regular grid cell structures. In details, it refutes cost and time for distance computation using cell relationships in grid cell structures.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.177-177
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• 2003

Tumor cell invasion and metastasis are a complex multistep process that involves the degradation of extracellular matrix proteins by matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinase-1 (TIMP-1) acts as a negative regulator of matrix metalloproteinase and thus prevents tumor cell invasion and metastasis by preserving extracellular matrix integrity.(omitted)

• Microbiology and Biotechnology Letters
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• v.49 no.4
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• pp.478-484
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• 2021

Cellular resources including transcriptional and translational machineries in bacteria are limited, yet microorganisms depend upon them to maximize cellular fitness. Bacteria have evolved strategies for using resources economically. Regulatory networks for the gene expression system enable the cell to synthesize proteins only when necessary. At the same time, regulatory interactions enable the cell to limit losses when the system cannot make a cellular profit due to fake substrates. Also, the architecture of the gene expression flow can be advantageous for clustering functionally related products, thus resulting in effective interactions among molecules. In addition, cellular systems modulate the investment of proteomes, depending upon nutrient qualities, and fast-growing cells spend more resources on the synthesis of ribosomes, whereas nonribosomal proteins are synthesized in nutrient-limited conditions. A deeper understanding of cellular mechanisms underlying the optimal allocation of cellular resources can be used for biotechnological purposes, such as designing complex genetic circuits and constructing microbial cell factories.

• Archives of Plastic Surgery
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• v.49 no.2
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• pp.141-149
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• 2022

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a recently spotlighted T-cell origin non-Hodgkin's lymphoma with an increasing incidence of over 800 cases and 33 deaths reported worldwide. Development of BIA-ALCL is likely a complex process involving many factors, such as the textured implant surface, bacterial biofilm growth, immune response, and patient genetics. As the incidence of BIA-ALCL is expected to increase, it is important for all surgeons and physicians to be aware of this disease entity and acquire thorough knowledge of current evidence-based guidelines and recommendations. Early detection, accurate diagnosis, and appropriate treatment are the foundations of current care.

• Journal of Integrative Natural Science
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• v.15 no.4
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• pp.171-177
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• 2022

ROS1 (c-ros oncogene) is one of the gene with mutation in NSCLC (non-small cell lung cancer). The increased expression of ROS1 is leading to the increase proliferation of cell, cell migration and survival. Crizotinib and Entrectinib are the drugs that have been approved by FDA against ROS1 protein, but recently patients started to develop resistance against Crizotinib and there is a need of new drug that could act as an effective drug against ROS1 for NSCLC. In this study, we have performed virtual screening, where compounds are taken from Zinc 15 dataset and molecular docking was performed. The top compounds were taken based upon their binding affinity and their interactions with the residues. The compounds stability and chemical reactivity was also studied through Density Functional theory and their properties. Further study of these compounds could reveal the required information of ROS1-inhibitor complex and in the discovery of potent inhibitors.