Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.177-177
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- 2003
Adenovirus-Mediated Gene Delivery of Tissue Inhibitor of Metalloproteinase-1 Inhibits Migration of B16F10 Melanoma Cell in Wound Migration Assay
- Seungwan Jee (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Hoil Kang (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Park, Sehgeun (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Park, Misun (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Miok Eom (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Taikyung Ryeom (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Kim, Okhee (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration)
- Published : 2003.10.01
Abstract
Tumor cell invasion and metastasis are a complex multistep process that involves the degradation of extracellular matrix proteins by matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinase-1 (TIMP-1) acts as a negative regulator of matrix metalloproteinase and thus prevents tumor cell invasion and metastasis by preserving extracellular matrix integrity.(omitted)