• 생물정신의학
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• 제23권3호
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• pp.80-88
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• 2016

Vascular dementia is a very frequent form of dementia. Debates over classification and diagnostic criteria, and controversy over identifiable treatment targets will continue until distinct pathophysiological mechanism of vascular dementia is found. Clinical diagnostic criteria are sufficiently strong to be useful for clinical trials, but need further refinement. Cognitive changes in vascular dementia are more variable than other disorders, and are dependent on the vascular pathology. Accurate diagnosis of vascular dementia is known to need the presence of reliable cerebrovascular disease on brain imaging. Although it seems obvious that cerebrovascular disease causes pathological damage and impaired cognition, it is very difficult to find the accurate contribution of cerebrovascular pathology to cognitive decline. Most studies have shown a small but significant benefit of cholinesterase inhibitors on cognition, the significance of this effect has been slight and benefits on global functioning, activities of daily living, and behaviour have not been consistently reported. Management of vascular dementia should focus on identifying and managing vascular risk factors.

• 분석과 대안
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• 제2권2호
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• pp.143-162
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• 2018

This paper focuses on the policy framework about "Quantitative and Qualitative Easing (QQE)" of Japan, and analyzes reasons why the policy goal was not reached. The QQE was introduced by the Bank of Japan in 2013 with the purpose of meeting the price stability target of 2% and getting out of deflation that prevents sustained price decline. However, despite the implementation of the bold monetary easing policy unprecedented in the world, the policy goal was not achieved as of June 2018. As a result of analyzing the causes, the following three structural factors were confirmed. 1) The rise in prices by QQE was limited because Japan's consumer price is strongly depending on import price. 2) The effect is high degree of uncertainty and limited because theoretical framework of reflationist which adopted QQE depends on "expectation formation" by "self-fulfilling expectation" and "multiple equilibria". 3) It was confirmed that the expansion of the monetary base did not lead to money stock due to the existence of Japanese liquidity trap, long-term low interest rate policy.

• International Journal of Contents
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• 제13권2호
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• pp.66-74
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• 2017

Patent classification is becoming more critical as patent filings have been increasing over the years. Despite comprehensive studies in the area, there remain several issues in classifying patents on IPC hierarchical levels. Not only structural complexity but also shortage of patents in the lower level of the hierarchy causes the decline in classification performance. Therefore, we propose a new method of classification based on different criteria that are categories defined by the domain's experts mentioned in trend analysis reports, i.e. Patent Landscape Report (PLR). Several experiments were conducted with the purpose of identifying type of features and weighting methods that lead to the best classification performance using Support Vector Machine (SVM). Two types of features (noun and noun phrases) and five different weighting schemes (TF-idf, TF-rf, TF-icf, TF-icf-based, and TF-idcef-based) were experimented on.

• Advances in Traditional Medicine
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• 제6권4호
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• pp.264-273
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• 2006

Epidemiological evidences and clinical as well as experimental observations have suggested a link between asthma and occupations. This relationship also involves other aspects like nonimmunologic exposures in the environment that can increase the chance of developing work related asthma and respiratory diseases. The purpose of this pamphlet is to supply information of work related diseases, which will give patients suffering with asthma, an intelligent understanding of their disease, and thus stimulate their interest so that they will cooperate more readily with their allergist. Recognizing the symptoms, causes, risk factors, diagnosis and treatment is an important part of managing occupational asthma and related diseases, so that it helps in decline of this rapidly increasing prevalence throughout the world.

• 한국막학회:학술대회논문집
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• 한국막학회 1995년도 추계 총회 및 학술발표회
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• pp.80-93
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• 1995

Membrane Technology, which has been in use for over twenty five years, has established itself as one of the principle separation methods. With improved technology, Reverse Osmosis ("RO") has been applied to large volume water treatment facilities. UF and MF Membrane Technology has, up until recently, been applied to small scale water treatment facilities. The fouling of membrane has restricted the growth of Membrane Technology in Water Treatment. Membrane fouling compound found in water causes the loss of flux across the membrane by absorbing to membrane and plugging their pores. Various methods have been used in the reduction and prevention of membrane fouling. For RO, a conventional pre-treatment system removes the pollutants, preventing the function decline of RO membrane by keeping SDI < 4 as the standard condition of feed water. UF and MF Membrane Technology that must have pre-treatment function within itself, are required to keep its ability not to be influenced by fouling.y fouling.

• Biomolecules & Therapeutics
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• 제28권5호
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• pp.381-388
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• 2020

Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely abused drugs worldwide. The continuous use of METH eventually leads to drug addiction and causes serious health complications, including attention deficit, memory loss and cognitive decline. These neurological complications are strongly associated with METH-induced neurotoxicity and neuroinflammation, which leads to neuronal cell death. The current review investigates the molecular mechanisms underlying METH-mediated neuronal damages. Our analysis demonstrates that the process of neuronal impairment by METH is closely related to oxidative stress, transcription factor activation, DNA damage, excitatory toxicity and various apoptosis pathways. Thus, we reach the conclusion here that METH-induced neuronal damages are attributed to the neurotoxic and neuroinflammatory effect of the drug. This review provides an insight into the mechanisms of METH addiction and contributes to the discovery of therapeutic targets on neurological impairment by METH abuse.

• 생물정신의학
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• 제23권2호
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• pp.41-47
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• 2016

Dementia with Lewy bodies (DLB) is the second most common causes of dementia. It can exhibit a variety of clinical symptoms including cognitive decline, cognitive fluctuation, visual hallucinations, parkinsonism, REM sleep behavior disorder, hypersensitivity to neuroleptics and autonomic dysfunctions. Despite more well-known criteria for DLB, there are often misdiagnosis and inappropriate treatment. It gives a lot of clinical burden to the clinician as well as to patients and families. When reducing the misdiagnosis, the burden of all will be reduced. The special concern and solicitation are needed in order not to miss the diagnosis when the cardinal features of DLB may not be volunteered by patients and the caregivers. To control the symptoms, clinicians must find and reduce drugs that can have the negative effects on DLB symptoms. There is limited evidence about specific interventions but available data suggest cholinesterase inhibitors improve the cognitive and behavioral symptoms and menmantine slightly improves the global impression.

• 한국에너지공학회:학술대회논문집
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• 한국에너지공학회 1999년도 춘계 학술발표회 논문집
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• pp.145-150
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• 1999

As proven petroleum reserves decline through continued production. exploration for new oil and gas resources will extend into environments which present significant economic risks arid technical hurdles. Since safety is one of the biggest concerns in drilling operations. the oil industry routinely trains its personnel in areas which are critical for safe and economical drilling procedures. One of these major areas is well control. A kick is defined as an unscheduled flow of formation fluids into a wellhole. A kick occurs whenever the resultant wellbore pressure is less than the formation pressure in an exposed zone capable of producing kick fluids. The typical causes of reduced wellbore pressure are insufficient mud weight. inadequate fluid level in the hole, and swabbing.(omitted)

• KDI Journal of Economic Policy
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• 제38권4호
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• pp.1-21
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• 2016

This paper documents how the net profit margin of private firms improves when the CEOs of the companies relocate their primary residence to be closer to the corporate headquarters. By reviewing 127 Korean non-public companies belonging to 66 private business groups, we find that the top managers move closer to the headquarters when the profitability of the firms has recently deteriorated. A one basis point decline in the margin causes CEOs to relocate their homes approximately two kilometers closer to their corporate headquarters. The profit margin rebounds after their relocation. This finding implies that physical proximity can serve as a proxy for personal commitment.

• 한국병원경영학회지
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• 제23권1호
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• pp.51-64
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• 2018

Purposes : In February 2014, the government said that the National Health Insurance Service (NHIS) will enforce plan for reducing the financial burden from two major non-covered services including physician surcharges and private room charges, the main causes to increase uninsured, by 2017. The purpose of this study is to analyze the policy effect that performed so far by comparing out-of-pocket payment rates of policy process Methodology: This study analyzed admission medical expenses that occurred from January 2013 to March 2016 at a upper grade general hospitals in Daejeon. Number of study subjects were 134,924 and the data were analyzed with SPSS 22.0 program by using frequency, percentage, mean, standard deviation, ANOVA. The effect of two major non-payment improvement plan on out-of-pocket rates was ascertained via generalized estimating equation. Findings: Out-of-pocket payment rates was statistically significantly declined 2.7 percent than enforcement ago. Also, out-of-pocket payment, physician surcharge, the proportion of out-of-pocket payment of hospital room charge to out-of-pocket payment was statistically significantly declined. However, a further analysis of the cause of the decline in total medical costs is needed. Practical Implications: Physician surcharges and private room charges improvement policy had a positive effect on the decline of out-of-pocket payment rate. The policy of physician surcharges was very effective after the first policy enforcement but it was less effective to medical aids and near poor that was a more greater coverage than national health insurance. Since the policy has not been finalized, we have to continue a research for the successful implementation of the policy.