• Journal of Korea Game Society
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• v.11 no.6
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• pp.115-125
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• 2011

Recently, a sharp increases of users of smartphone is not only cause an rapid growth smartphone-games market, but also secured it's position as a high value market. thus have to begets a multilateral study to the smartphone of newly-rising. however the earlier studies were researched previous smartphone, despite extended research is needed for smartphone-games. therefore the study's purpose is to draw a main factors it has a decisive effect for recommendation and sustainable-usage through recognizing the cause-and-effect relationship with purchase intention, purchase action, satisfaction, recommendation, and sustainable usage that based purchase-effect-factors of smartphone-games. for this study the questionnaire of 293 was taken. and structural equation model was adopted to analyze this study.

• Nutrition Research and Practice
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• v.18 no.4
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• pp.464-478
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• 2024

BACKGROUND/OBJECTIVES: Chronic alcohol consumption causes oxidative stress in the body, which may accumulate excessively and cause a decline in memory; problem-solving, learning, and exercise abilities; and permanent damage to brain structure and function. Consequently, chronic alcohol consumption can cause alcohol-related diseases. MATERIALS/METHODS: In this study, the protective effects of Phyllostachys edulis (Carrière) J. Houz (PE) against alcohol-induced neuroinflammation and cognitive impairment were evaluated using a mouse model. Alcohol (16%, 5 g/kg/day for 6 weeks) and PE (100, 250, and 500 mg/kg/day for 21 days) were administered intragastrically to mice. RESULTS: PE showed a protective effect against memory deficits and cognitive dysfunction caused by alcohol consumption, confirmed through behavioral tests such as the T-maze, object recognition, and Morris water maze tests. Additionally, PE attenuated oxidative stress by reducing lipid oxidation, nitric oxide, and reactive oxygen species levels in the mice's brains, livers, and kidneys. Improvement of neurotrophic factors and downregulation of apoptosis-related proteins were confirmed in the brains of mice fed low and medium concentrations of PE. Additionally, expression of antioxidant enzyme-related proteins GPx-1 and SOD-1 was enhanced in the liver of PE-treated mice, related to their inhibitory effect on oxidative stress. CONCLUSION: This suggests that PE has both neuroregenerative and antioxidant effects. Collectively, these behavioral and histological results confirmed that PE could improve alcohol-induced cognitive deficits through brain neurotrophic and apoptosis protection and modulation of oxidative stress.

• Geomechanics and Engineering
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• v.15 no.3
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• pp.851-859
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• 2018

There are two primary causes of the ground movement due to tunnelling in urban areas; firstly the lost ground and secondly the groundwater depression during construction. The groundwater depression was usually not considered as a cause of settlement in previous research works. The main purpose of this study is to analyze the combined effect of these two phenomena on the transverse settlement trough. Centrifuge model tests and numerical analysis were primarily selected as the methodology. The characteristics of settlement trough were analyzed by performing centrifuge model tests where acceleration reached up to 80g condition. Two different types of tunnel models of 180 mm diameter were prepared in order to match the prototype of a large tunnel of 14.4 m diameter. A volume loss model was made to simulate the excavation procedure at different volume loss and a drainage tunnel model was made to simulate the reduction in pore pressure distribution. Numerical analysis was performed using FLAC 2D program in order to analyze the effects of various groundwater depression values on the settlement trough. Unconfined fluid flow condition was selected to develop the phreatic surface and groundwater level on the surface. The settlement troughs obtained in the results were investigated according to the combined effect of excavation and groundwater depression. Subsequently, a new curve is suggested to consider elastic settlement in the modified Gaussian curve. The results show that the effects of groundwater depression are considerable as the settlement trough gets deeper and wider compared to the trough obtained only due to excavation. The relationships of maximum settlement and infection point with the reduced pore pressure at tunnel centerline are also suggested.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.9
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• pp.2073-2085
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• 2012

Recently, the International Telecommunication Union allocated the 470-862 MHz band to the digital broadcasting (DB) service. Moreover, the 790-862 MHz sub-band will be allocated to the next-generation mobile system, known as the International Mobile Telecommunication - Advanced (IMT-A), and to the DB on a co-primary basis in the year 2015. Currently, two candidate technologies are available to represent the IMT-A system; the Mobile WiMAX and Long Term Evolution - Advanced (LTE-A). One of the main criteria of the IMT-A candidate is to not cause additional interference to the primary service (i.e., DB). In this paper, we address the spectrum sharing issue between the IMT-A candidates and the DB service. More precisely, we investigate the interference effect between the DB service and the mobile network, which could be either LTE-A or WiMAX. Our study proposes a spectrum sharing model to take into account the impact of interference and evaluates the spectrum sharing requirements such as frequency separation and separation distance. This model considers three spectrum sharing scenarios: co-channel, zero guard band, and adjacent channel. A statistical analysis is performed, by considering the interferer spectrum emission mask and victim receiver blocking techniques. The interference-to-noise ratio is used as an essential spectrum sharing criterion between the systems. The model considers the random distribution of the users, antenna heights, and the bandwidth effect as well as the deployment environment in order to achieve spectrum sharing. The results show that LTE-A is preferable to WiMAX in terms of having less interference impact on DB; this can eventually allow the operation of both services without performance degradation and thus will lead to efficient utilization of the radio spectrum.

• Korean Journal of Social Welfare
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• v.63 no.2
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• pp.179-205
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• 2011

Recently, problems regarding marital adjustment of cancer patients are recognized as serious matter of concern for it had been reported that these issues have severe negative effects on relationship stability within marriage. It is noteworthy how marital adjustment is found to be critical for the cancer patient's mental stability, healing process and chances of survival as reported in the research. Thus, the ultimate goal of this research is to contribute to improvement of the stable relationship and also to formulate the social service related strategy for marriage adjustment for married cancer patient married couples in Korea. Actor and Partner Interdependence Model was formed in order to observe how the communication of the married couple affects marital adjustment and how this has an actor effect as well as partner effect. In order to authenticate this research model, dyadic data which sample the cancer patient and the spouse as a pair. Survey was conducted as the cancer patients who had been diagnosed with cancer and their respective spouses. The survey was taken from 160 married couples which totals to 320 people all together. Results indicated the cancer patient and the spouse have a significant relationship in marital adjustment. Through this, it had been concluded that marital adjustment is not separated but co-dependent with dynamic relationship. And the mutual constructive communication had proven to have a significant positive effect on one's marital adjustment. In demand-withdrawal communication, its negative effect on the self effect was found to be significant in both the patient and the spouse to both of their marital adjustment. Mutual avoidance communication had shown to only cause significant negative effect on self effect to the patient. In verifying the partner effect, significant negative effect was caused by patient's demand-withdrawal communication in partner effect on the spouse's marital adjustment. The results of this study are discussed in term of their implications for clinical interventions for the betterment of marital adjustment among cancer patients and their spouses. The suggestions for future research are discussed also.

• BMB Reports
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• v.40 no.4
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• pp.475-485
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• 2007

Methamphetamine is an illicit drug that is often abused and can cause neuropsychiatric and neurotoxic damage. Repeated administration of psychostimulants such as methamphetamine induces a behavioral sensitization. According to a previous study, Bax was involved in neurotoxicity by methamphetamine, but the function of Bax in rewarding effect has not yet been elucidated. Therefore, we have studied the function of Bax in a rewarding effect model. In the present study, we treated chronic methamphetamine exposure in a Bax-deficient mouse model and examined behavioral change using a conditioned place preference (CPP) test. The CPP score in Bax knockout mice was decreased compared to that of wild-type mice. Therefore, we screened for Bax-related genes that are involved in rewarding effect using microarray technology. In order to confirm microarray data, we applied the RT-PCR method to observe relative changes of Bcl2, a pro-apoptotic family gene. As a result, using our experiment microarray, we selected genes that were associated with Bax in microarray data, and eventually selected the Tgfbr2 gene. Expression of the Tgfbr2 gene was decreased by methamphetamine in Bax knockout mice, and the gene was overexpressed in Bax wild-type mice. Additionally, we confirmed that Creb, FosB, and c-Fos were related to rewarding effect and Bax using immunohistochemistry.

• Tunnel and Underground Space
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• v.31 no.6
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• pp.440-459
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• 2021

Roadheaders have begun to be adopted in Korean tunneling sites. The performance prediction models proposed by the manufacturer are used by Korean construction companies. The models use UCS (uniaxial compressive strength) value to predict the net cutting rate, but the rock specimens conducted for the uniaxial compression test have 1.0 of the diameter to length ratio. It has been reported that the specimen shape generally influences the rock strength. The previous references studying the shape effect were cited, and the UCS data of Korean rocks are also updated to analyze the shape effect on UCS. The cause of effect was discussed by previous theory. The change amount of UCS values of Korean rocks was estimated by the data, and the modified prediction model for NCR was finally suggested.

• Journal of Integrative Natural Science
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• v.10 no.2
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• pp.85-94
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• 2017

Fibroblast growth factor receptor (FGFR) belongs to the family of receptor tyrosine kinase. They play important roles in cell proliferation, differentiation, development, migration, survival, wound healing, haematopoiesis and tumorigenesis. FGFRs are reported to cause several types of cancers in humans which make it an important drug target. In the current study, HQSAR analysis was performed on a series of recently reported 1H-Pyrazolo [3,4-b]pyridine derivatives as FGFR antagonists. The model was developed with Atom (A) and bond (B) connection (C), chirality (Ch), hydrogen (H) and donor/acceptor (DA) parameters and with different set of atom counts to improve the model. A reasonable HQSAR model ($q^2=0.701$, SDEP=0.654, NOC=5, $r^2=0.926$, SEE=0.325, BHL=71) was generated which showed good predictive ability. The contribution map depicted the atom contribution in inhibitory effect. A contribution map for the most active compound (compound 24) indicated that hydrogen and nitrogen atoms in the side chains of ring B as well as hydrogen atoms in the side chain of ring C and the nitrogen atom in the ring D contributed positively to the activity in inhibitory effect whereas, the lowest active compound (compound 04) showed negative contribution to inhibitory effect. Thus results of our study can provide insights in the designing potent and selective FGFR kinase inhibitors.

• Journal of the Korean Geotechnical Society
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• v.23 no.6
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• pp.77-84
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• 2007

One of the most sensitive design specifications to be considered is infiltration and external pore-water pressures on underground structure construction. Development of pore-water pressure may accelerate leakage and consequently cause deterioration of the lining. In this paper, the development of pore-water pressure due to malfunctioning of drainage system and its potential effect on the linings are investigated using physical model tests. The deterioration procedure was simulated by controlling both permeability and flow rate. Development of pore-water pressure was monitored on the lining using pore pressure measurement cells. Test results identified the mechanism of pore-water pressure development on the tunnel lining. In addition, they showed that controlling flow rate is more effective method fur simulating deterioration procedure than permeability control. The laboratory model tests were reproduced using coupled numerical method, and showed that the effect of deterioration of drainage system can be theoretically expected using coupled numerical modeling method.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.10
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• pp.543-553
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• 2020

This paper examines the effect of COVID-19 pandemic on the Philippine stock exchange, peso-dollar rate and retail price of diesel using robust least squares regression and vector autoregression (VAR). The robust least squares regression using MM-estimation method concluded that COVID-19 daily infection has negative and statistically significant effect on the Philippine stock exchange index, peso-dollar exchange rate and retail pump price of diesel. This is consistent with the results of correlation diagnostics. As for the VAR model, the lag values of the independent variable disclose significance in explaining the Philippine stock exchange index, peso-dollar exchange rate and retail pump price of diesel. Moreover, in the short run, the impulse response function confirmed relative effect of COVID-19 daily infections and the variance decomposition divulge that COVID-19 daily infections have accounted for only minor portion in explaining fluctuations of the Philippine stock exchange index, peso-dollar exchange and retail pump price of diesel. In the long term, the influence levels off. The Granger causality test suggests that COVID-19 daily infections cause changes in the Philippine stock exchange index and peso-dollar exchange rate in the short run. However, COVID-19 infection has no causal link with retail pump price of diesel.