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A 40 Kb Genomic Deletion Including tmie (Transmembrane Inner Ear Protein) Gene Causes Deafness, Circling and Head Tossing in Circling Mice

  • Kyoung In Cho;Jeong Woong Lee;Eun Ju Lee;Sol Ha Hwang;Myoung Ok Kim;Sung Hyun Kim;Jun Hong Park;Boo Kyoung Jung;Hee Chul Kim
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.226-226
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    • 2004
  • Circling (cir) mouse is a spontaneous mutant in the inner ear that was first reported in Korea. The mutation is transmitted by an autosomal recessive gene with 100 %- penetrance.. Homozygous mice are characterized by head-tossing, bi-directional circling behavior and deafness. Histologicalexamination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. (omitted)

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Transgene Expression of Biologically Active Human Follicle-Stimulating Hormone in Milk and Histological Analysis

  • Myoung-Ok Kim;Kil-Soo Kim;Eun-Ju Lee;Sung-Hyun Kim;Jun-Hong Park;Kyoungin-Cho;Boo-Kyung Jung;Hee-Chul Kim;Sol-ha Hwang
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.214-214
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    • 2004
  • Follicle stimulating hormone (FSH) is a pituitary glycoprotein composed of two post translationally modified subunits, which must properly assemble to be biologically active. We developed a transgenic (TG) mouse model that overexpresses the human Follicle-Stimulating hormone (FSH) -subunit under the bovine -casein promoter, displaying in females an excessive levels express in mammary gland. (omitted)

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Microvascular Anastomosis in Neurosurgical Field (신경외과 영역에서의 미세혈관 문합술)

  • Rha, Hyoung-Kyun;Lee, Kyung-Jin;Cho, Kyung-Keun;Park, Sung-Chan;Park, Hae-Kwan;Cho, Jung-Ki;Ji, Chul;Choi, Chang-Rak
    • Archives of Reconstructive Microsurgery
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    • v.8 no.2
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    • pp.170-175
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    • 1999
  • Objective : Extracranial-intracranial(EC-IC) microvascular anastomosis was performed in 18 patients with hemodynamic cerebral ischemia and traumatic cerebral aneurysm, the aim of this retrospective study was to assess its value in neurosurgical field. Method : Of 18 cases, 17 case were hemodynamic cerebral ischemia and one was traumatic cerebral aneurysm. There were 14 superficial temporal artery(STA)-to-middle cerebral artery(MCA) anastomosis, 3 saphenous vein graft bypass(2 external carotid artery(ECA)-to-MCA, 1main trunk of the STA-to-MCA) and 1 radial artery bypass(ECA-to-MCA). Results : Bypass patency was confirmed by postoperative angiography in all cases except for two cases, postoperative cerebral blood flow of ischemic brain showed significant increased in all cases with good patency through bypass. Conclusion : Revascularization by EC-IC microvascular anastomosis to the ischemic brain eliminated ischemia and was associated with excellent good outcome and good patency rates.

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Solitary Plasmacytoma of the Skull - A Case Report - (두개골에 발생한 고립성 형질세포종 - 증례보고 -)

  • Han, Jeong Hoon;Park, Hae Kwan;Min, Chang Ki;Cho, Jung Ki;Park, Sung Chan;Cho, Kyung Keun;Lee, Kyung Jin;Rha, Hyoung Kyun;Choi, Chang Rak;Kang, Joon Ki
    • Journal of Korean Neurosurgical Society
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    • v.29 no.5
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    • pp.701-705
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    • 2000
  • Solitary plasmacytomas are rare and account for 5-10% of all plasma cell disorders. These tumors are categorized as solitary plasmacytomas of bone(osseous) or extramedullary plasmacytomas(non-osseous). About a half of solitary plasmacytomas of bone occur in the spine but rarely in the skull. We report a case of solitary plasmacytoma of the skull presented with a painless palpable left parietal calvarial mass in an otherwise asymptomatic 38- year-old man. Skull radiographs showed a large radiolucent lesion with well defined non-sclerotic margins. Computed tomograph scan demonstrated a markedly enhancing mass extending from the epidural to the subcutaneous space. The patient underwent surgery and tumor was completely excised. Pathological examination showed tumor to be a plasmacytoma synthesizing IgG. Postoperatively, the patient received radiotherapy. There was no evidence of systemic involvement on postoperative laboratory wokups. Our recommended treatment is a complete surgical excision combined with postoperative radiation therapy. The patient should be follwed carefully for more than 10 years because of either local recurrence or possible progression to multiple myeloma.

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Safety of Laparoscopic Radical Gastrectomy in Gastric Cancer Patients with End-Stage Renal Disease

  • Lee, Hayemin;Park, Cho Hyun;Park, Seung Man;Kim, Wook;Chin, Hyung Min;Kim, Jin Jo;Song, Kyo Young;Kim, Sung Geun;Jun, Kyong Hwa;Kim, Jeong Goo;Lee, Han Hong;Lee, Junhyun;Kim, Dong Jin
    • Journal of Gastric Cancer
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    • v.18 no.3
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    • pp.287-295
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    • 2018
  • Purpose: The surgical outcomes of end-stage renal disease (ESRD) patients undergoing radical gastrectomy for gastric cancer were inferior compared with those of non-ESRD patients. This study aimed to evaluate the short- and long-term surgical outcomes of ESRD patients undergoing laparoscopic gastrectomy (LG) and open gastrectomy (OG) for gastric cancer. Materials and Methods: Between 2004 and 2014, 38 patients (OG: 21 patients, LG: 17 patients) with ESRD underwent gastrectomy for gastric cancer. Comparisons were made based on the clinicopathological characteristics, surgical outcomes, and long-term survival rates. Results: No significant differences were noted in the clinicopathological characteristics of either group. LG patients had lower estimated blood loss volumes than OG patients (LG vs. OG: 94 vs. 275 mL, P=0.005). The operation time and postoperative hospital stay were similar in both the groups. The postoperative morbidity for LG and OG patients was 41.1% and 33.3%, respectively (P=0.873). No significant difference was observed in the long-term overall survival rates between the 2 groups (5-year overall survival, LG vs. OG: 82.4% vs. 64.7%, P=0.947). Conclusions: In ESRD patients, LG yielded non-inferior short- and long-term surgical outcomes compared to OG. Laparoscopic procedures might be safely adopted for ESRD patients who can benefit from the advantages of minimally invasive surgery.