• Proceedings of the IEEK Conference
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• 1998.06a
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• pp.335-338
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• 1998

We have calculated ultra-low energy silicon-self ion implantations and silicon damages through classical molecular dynamics simulation using empirical potentials. We tested whether the recently developed environment-dependent interatomic ptential (EDIP) was suitable for ultra low ion implantation simulation, and found that point defects formation energies were in good agrrement with other theoretical calculations, but the calculated vacancy migration energy was overestimated. The number of isolated defects that are produced by collision cascades are onlya few of the total number of defects, and fmost of the damages are concentrated into amorphous-like pockets.

• IMMUNE NETWORK
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• v.9 no.2
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• pp.53-57
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• 2009

Engagement of the immunoreceptors initiates signaling cascades resulting in lymphocyte activation and differentiation to effector cells, which are essential for the elimination of pathogens from the body. For the transduction of these immunoreceptor-mediated signals, several linker proteins termed transmembrane adaptor proteins (TRAPs) were shown to be required. TRAPs serve as platforms for the assembly and membrane targeting of the specific signaling proteins. Among seven TRAPs identified so far, LAT and LIME were shown to act as a positive regulator in TCR-mediated signaling pathways. In this review, we will discuss the functions of LAT and LIME in modulating T cell development, activation and differentiation.

• The KSFM Journal of Fluid Machinery
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• v.4 no.3 s.12
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• pp.46-52
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• 2001

This paper describes a turbine test program conducted at Seoul National University(SNU). To measure blades' aerodynamic performance, either linear(2-Dimensional) or annular(3-Dimensional) cascades are often used. However, neither cascade can consider effects such as those due to rotation or rotor-stator interaction. Therefore, a rotating test facility for axial turbines has been designed and built at SNU, and its description is given in this paper. The results from an axial turbine performance test are presented. At the design point, the measured efficiency agrees with the efficiency predicted by a meanline analysis. At off design points, however, the measured and predicted efficiencies diverge. The most likely cause is hypothesized to be the inaccuracy of correlations used in the meanline analysis at off design points.

• BMB Reports
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• v.35 no.1
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• pp.61-66
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• 2002

The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-${\kappa}B$ and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.

• BMB Reports
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• v.41 no.4
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• pp.267-277
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• 2008

Insects mount a robust innate immune response against a wide array of microbial pathogens. The hallmark of the Drosophila humoral immune response is the rapid production of anti-microbial peptides in the fat body and their release into the circulation. Two recognition and signaling cascades regulate expression of these antimicrobial peptide genes. The Toll pathway is activated by fungal and many Gram-positive bacterial infections, whereas the immune deficiency (IMD) pathway responds to Gram-negative bacteria. Recent work has shown that the intensity and duration of the Drosophila immune response is tightly regulated. As in mammals, hyperactivated immune responses are detrimental, and the proper down-modulation of immunity is critical for protective immunity and health. In order to keep the immune response properly modulated, the Toll and IMD pathways are controlled at multiple levels by a series of negative regulators. In this review, we focus on recent advances identifying and characterizing the negative regulators of these pathways.

• Journal of computational fluids engineering
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• v.1 no.1
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• pp.19-25
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• 1996

A multiblock grid generation has been developed to be reliably used for a Navier-Stokes simulation of the turbomachinery flow-fields A multiblock structure simplifies the creation of structured H-grids about complex turbomachinery geometries and facilitate the creation of a grid in the tip flow region. The numerical algorithm adopts the combination of the algebraic and elliptic method to create the internal grids efficiently and quickly. The grid refinement process is enhanced by developing strategies to utilized Bezier curves and splines along with weighted transfinite interpolation technique and by formulating the grid-imbedding method for the viscous boundary-layer meshes. For purposes of illustration, the grid generator is applied to the high turning turbine rotor blades. Two different types of computational grids are provided to be compared with respect to the grid adaptation to the flow simulations. Extension to three-dimensions was done to show the possibility of its application to the tip-flow simulations. The grid quality of the multiblock structure is good in the passages, with gloval orthogonality and adequate smoothness.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.21 no.6
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• pp.813-821
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• 1997

Three-dimensional turbulent incompressible flow through the tip clearance of a linear turbine rotor cascade with high turning angle has been analyzed numerically. As a preliminary study to predict the tip clearance loss realistically, a generalized k-.epsilon. model derived by RNG (renormalized group) method is used for the modeling of Reynolds stresses to account for the strain rate of turbulent flow. The effects of the tip clearance flow on the passage vortex, the total pressure loss are considered qualitatively. The existences of vena contract and tip clearance vortex have been confirmed and it has been shown that as the size of the tip clearance increases, the accumulated flow through the tip clearance and the total pressure loss downstream of the cascade increase.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.2
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• pp.445-451
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• 1993

For the calculation of transonic laminar flow fields in cascades of turbomachinery, a finite volume method employing Jameson's Runge-Kutta integration scheme as a basic algorithm is presented. The cell-vertex scheme introducing half-spacing mesh cells is developed. For the velocity gradients in the stress terms the integration with divergence theorem is used for the average concept. Some numerical results show good agreement with experimental data.

• Toxicological Research
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• v.18 no.3
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• pp.275-283
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• 2002

Fungal metabolite, gliotoxin is an epipolythiodioxopiperazin (ETP) class and has various roles including immunomodulatory and apoptotic effects. This study was designed to evaluate the mechanism by which gliotoxin exerts the apoptosis on human promyelocytic leukemic HL-60 cells. Herein, we demonstrated that the gliotoxin decreased the cell viability in a time-dependent manner Gliotoxin-induced cell death was confirmed us apoptosis characterized by chromatin condensation and ladder-pattern fragmentation of genomic DNA. Gliotoxin increased the catalytic activities of caspase-3 and caspase-9. Activation of caspase-3 was further confirmed by degradation of procaspase-3 and poly(ADP-ribose) polymerase (PARP) by gliotoxin in HL-60 cells. Furthermore, gliotoxin induced the changes of mitochondrial transmembrane potential (MTP). Antioxidants, including GSH and NAC, markedly inhibited apoptosis with conistent suppression of enzymatic activity of caspase-3, caspase-9, and MTP loss in gliotoxin-treated cells. Taken together, we suggest that gliotoxin function as an oxidant and ploys proapoptotic roles in HL-60 cells via activation of intrinsic caspase cascades as well as mitochondrial dysfunction.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.4843-4847
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• 2015

To date, cytotoxic effects of flavonoids in various cancer cells are well accepted. However, the intracellular signaling cascades triggered by these natural compounds remain largely unknown and elusive. In this mini-review, the multiplicity of molecular targets of flavonoids in blood cancer cells is discussed by demonstrating the involvement of various signaling pathways in induction of apoptotic responses. Although these data reveal a great potential of flavonoids for the development of novel agents against different types of hematological malignancies, the pleiotropic nature of these compounds in modulation of cellular processes and their interactions certainly need unraveling and further investigation.