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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Modulation of Life and Death by the Tumor Necrosis Factor Receptor-Associated Factors (TRAFs)

  • Lee, Na-Kyung (Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University) ;
  • Lee, Soo-Young (Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University)
  • Published : 2002.01.31
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Abstract

The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-${\kappa}B$ and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.

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References

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