• Proceedings of the KSME Conference
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• 2003.11a
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• pp.857-862
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• 2003

Numerical investigations have been performed to examine the effects of the computational grids on the prediction of the flow characteristics inside the turbine cascades. Three kinds of grid system based on H-type grid are applied to the high-turning transonic turbine rotor blades and comparisons with the experimental data and the numerical results of each grid structure have been done. In addition, the grid sensitivity on the estimation of the blade performances has been investigated.

• Clinical and Experimental Pediatrics
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• v.54 no.6
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• pp.241-245
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• 2011

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that results from mutations in the TSC1 or TSC2 genes, and is associated with hamartomas in several organs, including subependymal giant cell tumors. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. The TSC1- and TSC2-encoded proteins modulate cell function via the mammalian target of rapamycin (mTOR) signaling cascade, and are key factors in the regulation of cell growth and proliferation. The mTOR pathway provides an intersection for an intricate network of protein cascades that respond to cellular nutrition, energy levels, and growth factor stimulation. In the brain, TSC1 and TSC2 have been implicated in cell body size, dendritic arborization, axonal outgrowth and targeting, neuronal migration, cortical lamination, and spine formation. The mTOR pathway represents a logical candidate for drug targeting, because mTOR regulates multiple cellular functions that may contribute to epileptogenesis, including protein synthesis, cell growth and proliferation, and synaptic plasticity. Antagonism of the mTOR pathway with rapamycin and related compounds may provide new therapeutic options for TSC patients.

• Biomolecules & Therapeutics
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• v.22 no.3
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• pp.167-175
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• 2014

Chemotherapy has long been considered as one of useful strategies for cancer treatment. It is primarily based on the apoptosis that can selectively kill cancer cells. However, cancer cells can progressively develop an acquired resistance to apoptotic cell death, rendering refractory to chemo- and radiotherapies. Although the mechanism by which cells attained resistance to drug remains to be clarified, it might be caused by either pumping out of them or interfering with apoptotic signal cascades in response to cancer drugs. In case that cancer cells are defective in some part of apoptotic machinery by repeated exposure to anticancer drugs, alternative cell death mechanistically distinct from apoptosis could be adopted to remove cancer cells refractory to apoptosis-inducing agents. This review will mainly deal with harnessing of necrotic cell death, specifically, programmed necrosis and practical uses. Here, we begin with various defects of apoptotic death machinery in cancer cells, and then provide new perspective on programmed necrosis as an alternative anticancer approach.

• Nuclear Engineering and Technology
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• v.36 no.3
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• pp.229-236
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• 2004

Radiation hardening is a multiscale phenomenon involving various processes over a wide range of time and length. We present a multiscale model for estimating the amount of radiation hardening in pressure vessel steel in the environment of a light water reactor. The model comprises two main parts: molecular dynamics (MD) simulation and a point defect cluster (PDC) model. The MD simulation was used to investigate the primary damage caused by displacement cascades. The PDC model mathematically formulates interactions between point defects and their clusters, which explains the evolution of microstructures. We then used a dislocation barrier model to calculate the hardening due to the PDCs. The key input for this multiscale model is a neutron spectrum at the inner surface of reactor pressure vessel steel of the Younggwang Nuclear Power Plant No.5. A combined calculation from the MD simulation and the PDC model provides a convenient tool for estimating the amount of radiation hardening.

• Proceedings of the Botanical Society of Korea Conference
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• 1998.07a
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• pp.83-96
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• 1998

The plant pigment proteins phytochromes are a molecular light sensor or switch for photomorphogenesis involving a variety of growth and developmental responses of plants to red and far-red wavelength light. Underscoring the photomorphogenesis mediated by phytochromes is the light signal transduction at molecular and cellular levels. For example, a number of genes activated by the phytochrome-mediated signal transduction cascade have been identified and characterized, especially in Arabidopsis thaliana. The light sensor/switch function of phytochromes are based on photochromism of the covalently linked tetrapyrrole chromophore between the two photoreversible forms, Pr and Pfr. The photochromism of phytochromes involves photoisomerization of the tetrapyrrole chromophore. The "photosensor" Pr-form ("switch off" conformation) of phytochromes strongly absorbs 660 nm red light, whereas the "switch on" Pfr-conformation preferentially absorbs 730 nm far-red light. The latter is generally considered to be responsible for eliciting transduction cascades of the red light signal for various responses of plants to red light including positive or negative expression of light-responsive genes in plant nuclei and chloroplasts. In this paper, we discuss the structure-function of phytochromes in plant growth and development, with a few examples of biotechnological implications.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.5
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• pp.103-110
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• 1998

In this paper we propose various rotation block realization method of MIMO LBR system. For this, we first discuss how to realize a given LBR system in the form of LBR two-pair cascades. Then we examine several systematic extraction procedures which enable to realize each LBR two-pair in the form of rotation block. Then we consider which realization methods we select for each two-pair block in view of the dynamci range of the coefficients of the rotation blocks. Finally, we demonstrate the LBR realization method using a detailed numerical example that converts a 4th order IIR filter function into a 4*4 transform domain transfer matrix, and then realizes it in a rotation-block cascade.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.391-397
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• 2004

The performance characteristics of partial admission supersonic turbines are analyzed by using the commercial CFD program FLUENT6.0. The governing equations were discretized with Euler implicit method in time and 2nd-order upwind scheme of FVM in space. The k-$\varepsilon$ turbulence model was utilized to describe the turbulent flow field. In order to investigate the nozzle--rotor interactions and the effect of partial admission, the flows in supersonic turbine rotor cascades with a nozzle are computed. Extensive computations of partial admission supersonic turbines provide the shock structures and flow patterns in the nozzle and rotor. It is clearly shown that the nozzle flow is highly affected by the shocks or expansion waves propagated from the rotor leading edge. And the rotor flow is also affected by the shocks or wakes originated from the nozzle.

• Molecules and Cells
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• v.41 no.8
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• pp.705-716
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• 2018

The endoplasmic reticulum (ER) is a critical organelle for protein synthesis, folding and modification, and lipid synthesis and calcium storage. Dysregulation of ER functions leads to the accumulation of misfolded- or unfolded-protein in the ER lumen, and this triggers the unfolded protein response (UPR), which restores ER homeostasis. The UPR is characterized by three distinct downstream signaling pathways that promote cell survival or apoptosis depending on the stressor, the intensity and duration of ER stress, and the cell type. Mammalian cells express the UPR transducers IRE1, PERK, and ATF6, which control transcriptional and translational responses to ER stress. Direct links between ER stress and immune responses are also evident, but the mechanisms by which UPR signaling cascades are coordinated with immunity remain unclear. This review discusses recent investigations of the roles of ER stress in immune responses that lead to differentiation, maturation, and cytokine expression in immune cells. Further understanding of how ER stress contributes to the pathogenesis of immune disorders will facilitate the development of novel therapies that target UPR pathways.

• Journal of Power System Engineering
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• v.2 no.1
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• pp.39-44
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• 1998

Computational grids used in the numerical simulation of multi staged turbomachinery flow fields are generated. A multiblock structure simplifies the creation of structured H-grids about complex turbomachinery geometries and facilitate the creation of a grid for multi-row topologies. The numerical algorithm adopts the combination of the algebraic and elliptic method to create the internal grids efficiently and quickly. The input module is made of the results of the preliminary design, i.e., flow-path, aerodynamic conditions along the spanwise direction, and the blade profile data. The final grids generated from each module of the system are used as the preprocessor for the performance prediction of the single row cascades and the flow simulation inside the multi staegd blade passage. Application to low pressure compressor of industrial gas turbine engines was demonstrated to be very reliable and practical in support of design activities.

• Proceedings of the Korean Society of Potoscience Conference
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• 2005.06a
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• pp.37-37
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• 2005