• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.105-106
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• 2008

As a carrier of malaria and sneak of blood, mosquitoes are an unpleasant insect. However, there are several unknown natural secretes related with mosquitoes. Among them, we focused on the blood sucking process of a female mosquito. The main objective of this study is to understand the mosquito's blood sucking mechanism that can be used to resolve the problem encountered in the injection or transport of infinitesimal biological fluids in a micro-chip. At first, the velocity fields of blood-sucking flow in a proboscis were measured using a micro-particle image velocimetry (PIV) technique. The velocity signals of flow in the proboscis show periodic variation. This seems to be resulted from the beating of the pharyngeal pump which works as driving power. To analyze the pumping mechanism, the temporal variation of the pharyngeal pump was visualized using the synchrotron X-ray micro-imaging technique. The volume variation was estimated by the help of digital image processing techniques. Once the main mechanism of blood sucking process was found, a effective micro-pumping system with high efficiency would be developed in near future.

• 한국전산유체공학회:학술대회논문집
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• 2005.10a
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• pp.21-26
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• 2005

Gas Chromatography (GC) is a wisely technique used for the separation and analysis of liquid and gas sample. Separation of the sample vapors is achieved via their differential migration through a capillary column with an insert carrier gas. The identity and quantity of each vapor in the mixer can be determined from its retention time in the column and a particular property of the gas, such as thermal conductivity, which can be related to the concentration of sample vapor in the carrier gas. Therefore, the flow characteristics in the spiral gas chromatographic column are numerically investigated in this study. Especially, different pressure drop between the front and the rear of GC column with various flow rates is estimated the governing equations are derived from making using of three-dimensional Naver-Stokes equation with incompressible and laminar model due to the nature of low Reynolds number flow. Using a commercial code, FLUENT, the pressure and flow fields in GC column are calculated with various flow rates. The characteristics of thermal cycling which is one of the most important factors affecting the column efficiency and analysis time is also estimated. Furthermore, numerical analyses are also carried out by using commercial code, ANSYS, with various values of power, which is applied to the heating element located at lower GC column.

• Journal of Pharmaceutical Investigation
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• v.6 no.3
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• pp.58-69
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• 1976

It is well established that dissolution is freruently the rate limiting step in the gastrointestinal absorpton of a drug from a solid dosage from. The relationship between the dissolution rate and absorption is particularly distinct when considering drugs of low solubility. Consequently, numerous attempts have been made to modify the dissolution characteristics of poorly water soluble drugs. Since dissolution rate is directly proportional to surface area, one may increase the rate by decreasing the particle size of the drug. Levy has considered a number of methods by which a drug may be presented to the GI fludids in finely divided from. The direct method is the utilization of microcrystalline or micronized particles. A second method involves the administration of solutions from which, upon dilution with gastric fluids, the dissolved drug will precipitate in the form of very fine particles. A more unique way of obtaining microcrystalline dispersions of a drug has been ercently suggested by Sekiguchi et al. They have first proposed the formation of a eutectic mixture of a poorly water soruble drug with a physiologically inert, easily soluble carrier. When such systems are exposed to water or GI fluids, the soluble carrier will dissolve rapidly and the finely dispersed drug particles will then be released. It has been suggested by Shefter and Higuchi that the formation of crystalline solvate could be a powerful tool in affecting rapid disslution of highly insoluble substances. Goldberg et al. have noted that the formation of solid solution could reduce the particle size to a minimum and increase the dissolution rate as well as the solubility of the durgs. It has also been shown that the rates of solution of drugs were appreciably increased by coprectipitating the drug with soluble polymers. The increase was found to be sensitive to the method of preparation, the molecular weight of polymer and the particular ratio of drugs to polymer. Although several investigations have demontrated that the solubility and/or dissolution rates of drugs can be increased in this manner, little information is available in the literature related to the in vivo absorption pattern of drugs orally administered as PVP coprecipitates. Recently, however, it was demonstrated that both the rate and extent of absorption of the insoluble drug could be markedly enhanced when orally administered to rats in the form of a coprecipitate with PVP. The purpose of the present investigation was to ascertain the general appility of soluble polymer coprectation technique as a method for enhancing the in vitro dissolution rate of hydrophobic indomethacin. To accomplish this aim, the dissolution characteristics of pure indomethacin, indomethcin-polymer physical mixtures and indomethacin-polymer coprecipitates were quantitatively studied by comparing their relative dissolution rates. The solubility and dissolution behavior of these systems were also examined.

• Korea-Australia Rheology Journal
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• v.11 no.3
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• pp.169-195
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• 1999

An electrorheological fluid (ERF) is typically a suspension of semi-conducting solid particles dispersed in an insulating carrier fluid, and shows a dramatic change in rheological properties when an external electric field is applied. This rapid and reversible change in flow properties has potential application in many electronically controlled mechanical devices, but the development of efficient devices and optimal materials for ERF is still hindered by incomplete understanding of the fundamental physical mechanisms involved. In recent years there have been considerable advances In relating microstructural models to the rheological behaviour, and these will form the basis of this review. Results of the theoretical calculations and simulations will be compared to the key experimental evidence available. An overview of the fundamental physical concepts behind electrorheological fluid behaviour will also be presented.

• 한국가시화정보학회:학술대회논문집
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• 2007.11a
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• pp.114-115
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• 2007

As a carrier of malaria and sneak of blood, mosquitoes are regarded as an unpleasant insect. However, there are novel phenomena that happen inside a mosquito. Among them, we focused on the blood sucking function of a female mosquito. The main objective of this study was to investigate the mosquito's pumping mechanism in order to resolve the problem encountered when we inject or transport biologic fluids into a micro-chip. To analyze the pumping mechanism, we visualized the blood sucking process inside a female mosquito. Flow characteristics of blood flow in a proboscis were investigated experimentally using a micro-PIV velocity field measurement technique. The anatomical variation of head, thorax, abdomen which work as pumps and valves, was visualized using the syncrotron X-ray micro-imaging technique.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1873-1876
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• 2003

Magneto-rheological polishing is a new technology used in precision polishing. It utilizes magneto-rheological fluid. nonmagnetic polishing abrasive, aqueous carrier fluids in magnetic field to remove material from a part surface. Silicon micro channel as work piece is fixed in the slurry which is made of MR fluid and CeO$_2$(10 vol%) abrasive particles. And permanent magnet rotate in the slurry to transfers magnetic force to abrasive particles by increasing yield strength of MR fluid. so, the obtained bottom surface roughness of micro channel by experiment reduced to Ra 0.010 $\mu\textrm{m}$ Rmax 0.103 $\mu\textrm{m}$ and finwall surface roughness of micro channel reduced to Ra 0.018 $\mu\textrm{m}$ Rmax 0.468 $\mu\textrm{m}$. At optimum conditions of variables, the workpiece as silicon micro channel have about 24 times smaller surface roughness than before polishing.

• 한국전산유체공학회:학술대회논문집
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• 2011.05a
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• pp.187-193
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• 2011

In this report, We compared the actual test with the result of pow calculation and Resistance/Self-propulsion of the ship using STAR-CCM+ which is the commercial Reynolds Averaged Navier-Strokes(RANs) Solver. The calculation model was the KRISO Container Ship and 205K Bulk Carrier of Sungdong shipbuilding company. For this calculation, We used Realizable K-Epsilon model for flaw analysis, VOF method for the free surface creation, Moving Reference Frame method for reducing the POW calculation time, and Sliding Mesh method for Self-Propulsion analysis. Calculation of Resistance and Self-Propulsion includes the free-surface. And all calculations in this report were based on unstructured grids.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.54-60
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• 2008

The atomization characteristics of the dual air supplying twin-fluid nozzle were investigated experimentally using PIV and PDA systems. The two-fluid nozzle is composed of three main parts: the feeding injector to supply fluid that is controlled by a PWM (pulse-width modulation) mode, the adaptor as a device with the ports for supplying the carrier and assist air and the main nozzle to produce the spray. The main nozzle has the swirl tip with four equally spaced tangential slots, which give the injecting fluid an angular momentum. The angle of the swirl tip varied with 0$^{\circ}$ 30$^{\circ}$, 60$^{\circ}$ and 90$^{\circ}$, and the ratios of carrier air to assist air and ALR(total air to liquid) were 0.55 and 1.23, respectively. The macroscopic behavior of the spray was investigated using PIV system, and the mean velocity, turbulent intensity and SMD distributions of the sprays were measured using PDA system. As the results, the mean axial velocity at the spray centerline decrease with the increase of the swirl angle. The turbulent intensities of the axial and radial velocity were increased with the increase of the swirl angle. The mean SMD (Sauter mean diameter) of the radial direction along the axial distance shows the lowest value at the swirl angle of 60$^{\circ}$.

• Journal of the Korean Society of Visualization
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• v.9 no.2
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• pp.54-60
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• 2011

This paper is a basic study on volatile organic compounds(VOC) recovery system in a crude oil carrier. VOC is easily evaporated in cargo tankers during loading and transportation of crude oil, causes serious environmental contamination and a huge economic loss. An ejector system is designed to mix VOC gas into crude oil flow to reduce VOC concentration. Detail two-phase flow inside the ejector is simulated using a commercial CFD code. To verify the numerical prediction, a scale-down experiment is conducted. Instead of crude oil and VOC, water and air are used as the working fluids. Flow characteristics and main parameters are obtained by two-phase flow visualization and PIV measurements. Air volume flow rate induced by the ejector is compared with respect to the volume flow rate of water using experimental and numerical results. Overall performance of the two-phase ejector predicted by the CFD simulation agrees well with that of the experiment.

• Molecules and Cells
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• v.22 no.2
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• pp.175-181
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• 2006

Delivery of DNA vaccines to airway mucosa would be an ideal method for mucosal immunization. However, there have been few reports of a suitable gene delivery system. In this study we used a cationic emulsion to immunize mice via the intranasal route with pCMV-S coding for Hepatitis B virus surface antigen (HBsAg). Complexing pCMV-S with a cationic emulsion dramatically enhanced HBsAg expression in both nasal tissue and lung, and was associated with increases in the levels of HBs-specific Abs in serum and mucosal fluids, of cytotoxic T lymphocytes (CTL) in the spleen and cervical and iliac lymph nodes, and of delayed-type hypersensitivity (DTH) against HBsAg. In contrast, very weak humoral and cellular immunities were observed following immunization with naked DNA. In support of these observations, a higher proliferative response of spleenocytes was detected in the group immunized with the emulsion/pCMV-S complex than in the group immunized with naked pCMV-S. These findings may facilitate development of an emulsion-mediated gene vaccination technique for use against intracellular pathogens that invade mucosal surfaces.