• 한국노년학
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• 제31권2호
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• pp.195-209
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• 2011

이 연구는 지역사회에 거주하고 있는 중고령자의 미충족 돌봄요구 현황을 파악하고 관련요인을 밝히고자 수행한 이차자료 분석연구로, 전국의 45세 이상 일반가구 거주자를 대표하는 표본(n=10,254)을 표집하여 조사한 2006년 제 1차 고령화연구패널을 이용하였다. 미충족 돌봄요구는 기본적 일상생활수행과 도구적 일상생활수행에 있어 다른 사람의 도움을 필요로 하는 상태임에도 돌봐줄 수 있는 사람이 없는 경우로 정의하였다. 모든 분석은 대상 인구집단을 대표하는 추정 통계치를 구하고자 가중치를 적용하여 수행하였다. 연구 결과, 중장년의 7.3%, 젊은 노인의 14.5%, 그리고 고령 노인의 41.8%가 돌봄을 필요로 하는 상태였으나, 이 중 각각 34%, 33%, 24%가 돌봄요구를 충족받고 있지 못한 것으로 나타났다. 미충족 돌봄요구 관련요인은 연령 그룹에 따라 달랐는데, 중장년에서는 교육과 소득수준이 미충족 돌봄요구와 음의 상관관계를 갖고 있었던 반면, 젊은 노인과 고령 노인층에서는 독거만이 음의 상관관계를 가진 요인이었다. 결론적으로, 우리나라 지역사회 거주 중고령자 중 상당수가 미충족 돌봄요구가 있으며, 그 관련요인은 생애주기에 따라 차이가 있었다. 연구결과는 지역 사회 거주 중고령자의 미충족 돌봄요구를 최소화할 수 있도록 지역사회기반 재가서비스의 확충이 시급하며, 특히 교육수준이 낮은 중장년과 독거노인 대상의 서비스 개발 및 보급이 중요함을 시사한다.

• Molecules and Cells
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• 제41권4호
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• pp.282-289
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• 2018

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine mainly derived from T helper 17 cells and is known to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) has been considered as a primary risk factor of COPD. However, the interaction between CS and IL-17A and the underlying molecular mechanisms have not been clarified. In the current study, we investigated the effects of cigarette smoke extract (CSE) on IL-17A-induced IL-8 production in human bronchial epithelial cells, and sought to identify the underlying molecular mechanisms. IL-8 production was significantly enhanced following treatment with both IL-17A and CSE, while treatment with either IL-17A or CSE alone caused only a slight increase in IL-8 production. CSE increased the transcription of IL-17RA/RC and surface membrane expression of IL-17R, which was suppressed by an inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt pathway (LY294002). CSE caused inactivation of glycogen synthase $kinase-3{\beta}$ ($GSK-3{\beta}$) via the PI3K/Akt pathway. Blockade of $GSK-3{\beta}$ inactivation by overexpression of constitutively active $GSK-3{\beta}$ (S9A) completely suppressed the CSE-induced up-regulation of IL-17R expression and the CSE-induced enhancement of IL-8 secretion. In conclusion, inactivation of $GSK-3{\beta}$ via the PI3K/Akt pathway mediates CSE-induced up-regulation of IL-17R, which contributes to the enhancement of IL-17A-induced IL-8 production.

• The Korean journal of internal medicine
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• 제33권6호
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• pp.1210-1223
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• 2018

Background/Aims: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin can potentially be used to treat asthma in obese patients by inhibiting interleukin 17 (IL-17) expression. This study investigated the combined effects of pravastatin and anti-IL-17 antibody treatment on allergic inflammation in a mouse model of obesity-related asthma. Methods: High-fat diet (HFD)-induced obesity was induced in C57BL/6 mice with or without ovalbumin (OVA) sensitization and challenge. Mice were administered the anti-IL-17 antibody, pravastatin, or both, and pathophysiological and immunological responses were analyzed. Results: HFD exacerbated allergic airway inflammation in the bronchoalveolar lavage fluid of HFD-OVA mice as compared to OVA mice. Blockading of the IL-17 in the HFD-OVA mice decreased airway hyper-responsiveness (AHR) and airway inflammation compared to the HFD-OVA mice. Moreover, the administration of the anti-IL-17 antibody decreased the leptin/adiponectin ratio in the HFD-OVA but not the OVA mice. Co-administration of pravastatin and anti-IL-17 inhibited airway inflammation and AHR, decreased goblet cell numbers, and increased adipokine levels in obese asthmatic mice. Conclusions: These results suggest that the IL-17-leptin/adiponectin axis plays a key role in airway inflammation in obesity-related asthma. Our findings suggest a potential new treatment for IL-17 as a target that may benefit obesity-related asthma patients who respond poorly to typical asthma medications.

• 한국산학기술학회논문지
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• 제21권4호
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• pp.1-8
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• 2020

본 연구는 장애 아동을 전문으로 보육하는 2개 장애아 전문 어린이집을 대상으로 피난 훈련을 통해 피난 행태를 분석함으로서, 건축 및 피난 환경 개선 방안을 제시하는데 있다. 연구 결과 다음과 같은 결론을 도출하였다. 첫째, 장애아 전문 어린이집의 입지여건은 소방서 및 119 안전센터로부터 반경 1Km 또는 5분 이내 위치하고 있으나, 건축 및 피난 환경은 시설 여건에 따라 매우 상이하게 나타나고 있다. 둘째, 장애 아동의 피난 행태는 장애 유형에 따라, 안고 피난하는 경우, 안고 걸리고 피난하는 경우, 휠체어 피난, 그리고 매트로 피난하는 경우 등 다양한 피난 행태를 보이고 있다. 셋째, 피난 거리 및 피난 속도 분석결과, 장애 아동을 안고 피난하는 경우, 안고 걸리면서 피난하는 경우, 그리고 휠체어 피난의 경우 등으로 속도 차이를 보이고 있다. 특히 수직 피난이 어려운 장애 아동의 경우, 소방관이 구난할 때까지 기다릴 수 있는 임시 피난구역을 각 층별로 설치하는 것이 바람직해 보인다.

• 가정간호학회지
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• 제2권
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• pp.19-34
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• 1995

The purpose of this study was to analysis level on family caregiver's burden for the elderly with chronic disease in a rural area and to choose priority care group, thereby facilitating the development of interventions to reduce the caregiver's burden. For this purpose, data were collected by questionaire from June 10 to October 8, 1994. The instruments for data collection were Caregiver Burden Inventory by Novak(1989) and Zarit et al(1982), severity of dementia by Hughes Scales(1982), ADL by Lawton(1971), patients' family caregiving activity by pre-survey and reference review(Lee, 1993 ; Jang, 1990 ; Yoo, 1982). The subjects were 213 family caregiver of elderly with chronic disease in a rural area. The data was analysed by the use of t-test, ANOVA, correlation and multiple regression. The results were as follows ; 1. Total burden was evaluated below average, the mean of family burden was 46.98. By the diagnostic classification, Hypertension was 27.37, DM 32.46, CVA 62.96, Dementia 61.24. 2. Significant variables which were correlated to the family caregiver's burden were the patient's disease diagnosis (F=33.82, p<0.001), severity of dementia(F=30.52, p<0.001), the status of disease management(F=11.53, p<0.001), ADL(F=10.54, p<0.001), PADL(F=7.50, p<0.001), income(F=7.17, p<0.001), caregiver's health status(F=24.53, p<0.001), a view of patient's prognosis (F=22.17, p<0.001), relationship with the patient(F=33.82, p<0.001), the number of hours per day spent on caregiving(F=77.52, p<0.001), level of intimacy of caregiver and patients(F=8.75, p<0.001), level of helping(F=4.90, p<0.01), the frequency of caregiving activity(F=3.80, p<0.01), the number of admission(F=5.54, p<0.01), the length of caregiving(F=4.43, p<0.01), other chronic patient in family(t=2.81, p<0.01), caregiver's job(F=3.11, p<0.01), the duration of illness(F=2.98, p<0.05), caregiver's religion(F=2.93, p<0.05), medical security(F=3.89, p<0.05), caregiving's helper(t=2.42, p<0.05). 3. PADL was the most important predictor to family caregiver burden(R2=0.6611). In addition to this, IADL, caregiver's health status, the length of caregiving. level of intimacy of caregiver and patients, patient's age, the patient's disease diagnosis and patient's job accounted for 76% of family caregiver burden. 4. The criteria of priority care group were as follows ; the mean of family caregiver burden was above 58, above of moderate ADL, the number of hours per day spent on caregiving above of 8 hours, above of moderate dementia. By the diagnostic classification, number of priority care group, Hypertension was 4 (8.0%), DM 4(8.0%), CVA 34(64.1%), Dementia 45(75.0%).

• 대한가정학회지
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• 제31권3호
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• pp.1-13
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• 1993

This study examined the expenditure on time-saving services and related variables. The time-saving services are food away from home, delivery food, dry cleaning, clothing care, helper and total service. The specific objectives of this study were: (1) to investigate the differences in the expenditure on time saving services according to social economic and demographic variables. (2) to investigate the differences in the expenditure on time-saving services according to role-overload, home goal orientation and work goal orientation. (3) to investigate the independent influence of variables related to the expenditure on time-saving services. For this objectives survey was conducted using interview. The data used in this study included 160 women living in Seoul from employed professional housewives, employed non-professional housewives and non-employed housewives. Statistical analyses were conducted using frequencies, percentiles, mean, oneway ANOVA, DUNCAN-test and multiple regression. The major findings were: (1) Wife's education, wife's age, income, tenure, level of living and employment status were significantly related to the expenditure on time-saving services by using the one-way ANOVA. (2) Income, education, level of living, number of children, and employment status explained the variance of the expenditures on time-saving services about 20%-39% by using a multiple regression method.

• 전기전자학회논문지
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• 제20권2호
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• pp.128-135
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• 2016

스마트 케어 감시 시스템은 사용자로부터 제공받은 GPS 위치 정보를 이용하여 사용자 주변의 CCTV 카메라를 검색하고 촬영 가능한 가장 가까운 CCTV 카메라를 이용하여 사용자를 자동으로 추적하는 시스템이다. 이 시스템은 사용자가 위험한 상황에 있거나, 또는 사용자가 보호를 받고자 할 때 자신의 GPS 위치 정보를 스마트 기기를 이용하여 전달하기 때문에 구조자의 빠른 대응을 기대할 수 있다. 그러나 기존의 시스템은 사용자가 위치 정보를 전송할 때 마다 관리하고 있는 전체 CCTV 카메라를 검색하여 사용자의 촬영을 수행하기 때문에 관리 영역이 확장될수록 CCTV 카메라의 선택 시간이 급격히 증가하였다. 본 논문에서는 사용자의 추적에 이용되었던 CCTV 카메라의 인접 카메라만 검색하는 방법을 이용하여 사용자 추적을 위한 CCTV 카메라의 선택 시간을 단축시키기 위한 방법을 제안한다.

• 가정과삶의질연구
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• 제19권4호
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• pp.49-68
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• 2001

The purpose of this study was 1) to review communal housing in the UK, 2) to consider the policy implications for elderly communal housing in Korea. The research methods used were 1) literature review about communal housing and related policy in the UK 2) field survey in the UK 3) interpretative suggestion for the proper policy implication to develope communal housing for the elderly in Korea. Sheltered housing in the UK had been developed as communal housing for the elderly with special needs since the 1970s. The type of sheltered housing were category 1 and category 2. Very sheltered housing with more facilities and meal services was added in 1980s. Sheltered housing was evaluated as the most humanistic solution for older people in the UK in 1980s. Because of the policy of moving institutional care to community care, sheltered housing became less in demand because of more options for older people including being able to stay in their own home. So new completion of sheltered housing by registered social landlords reduced saliently. Sheltered housing already totalled over half million units in which 5% of all elderly over 65 still lived and a small quantity of private sector for sale schemes emerged in the 1990s. The reason why the residents moved to sheltered housing was for sociable, secure, and manageable living arrangements. In general the residents were satisfied with these characteristics but dissatisfied with the service charge and quality of meals, especially in category 2.5 schemes. The degree of utilisation of communal spaces and facilities depended on the wardens ability and enthusiasm. Evaluation of sheltered housing indicated several problems such as wardens duty as a \"good neighbour\" ; difficult-to-let problems with poor location or individual units of bedsittiing type with shared bathroom ; and the under use of communal spaces and facilities. Some ideas to solve these problems were suggested by researchers through expanding wardens duty as a professional, opening the scheme to the public, improving interior standards, and accepting non-elderly applicants who need support. Some researchers insisted continuing development of sheltered housing, but higher standards must be considered for the minority who want to live in communal living arrangement. Recently, enhanced sheltered housing with greater involvement of relatives and with tied up policy in registration and funding suggested as an alternative for residential care. In conclusion, the rights of choice for older people should be policy support for special needs housing. Elderly communal housing, especially a model similar to sheltered housing category 2 with at least 1 meal a day might be recommended for a Korean Model. For special needs housing development either for rent or for sale, participation of the public sector and long term and low interest financial support for the private sector must be developed in Korea. Providing a system for scheme managers to train and retrain must be encouraged. The professional ability of the scheme manager to plan and to deliver services might be the most important factor for the success of elderly communal housing projects in Korea. In addition the expansion of a public health care service, the development of leisure programs in Senior Citizens Centre, home helper both for the elderly in communal housing and the elderly in mainstream housing of the community as well. Providing of elderly communal housing through the modified general Construction Act rather than the present Elderly Welfare Act might be more helpful to encourage the access of general people in Korea. in Korea.

• 한국응급구조학회지
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• 제16권1호
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• pp.7-18
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• 2012

Purpose: The purpose of this study is to help care workers to do their best as first respondents by analysing their recognition, knowledge, and self-efficacy on basic CPR (cardiopulmonary resuscitation) that is directly connected to the lives of patients and thus their education and methods can be improved for their positive basic lifesaving work. Method: For this purpose 360 structured questionnaires were used to the subjects in the eastern area of Jeonnam province from June 20 to July 4, 2011. Of these questionnaires 217 were used excluding 113 incomplete, 27 error, and 3 male ones. The collected data were analysed by the real number, the percentage, the average, the standard deviation, t-test, ANOVA, and Tukey with SPSS WIN 18.0. Results: 1. In the view of subjects, those aged over 51 accounted for 96(44.2%) as the majority, high school graduates, 95(43.8%), worked for 1 or more than 1 year-less than 2 years, 66(30.4%), experienced to see persons collapsed losing their consciousness, 46(21.2%), took the education, 184(85.7%), had 1 session of education, 80(43%), got the last education for 2 or more than 2 years 68(37%), and practiced through mannequin for the education aids, 86(46.7%). 2. There was significant difference in the view of recognition with the length of work (p=.010) and experienced to see persons collapsed losing their consciousness (p=.020), in the view of knowledge with academic background (p=.040) and the length of work, and in the view of self-efficacy with academic background (p=.002), the length of work (p=.010) and experienced to see persons collapsed losing their consciousness (p=.000). 3. There was significant difference in the session of education (p=.000), last education (p=.025) and education aids for basic CPR. Self-efficacy had significant difference according to the session of education for basic CPR (p=.001) and the time of education (p=.000). 4. There was correlation between recognition and self-efficacy (r=.41). The higher the recognition is, the better the self-efficacy improves. However the correlation between knowledge and self-efficacy was so low that the former did not have influence on self-efficacy. Conclusions: It needs to offer education to the lifesaving workers based on their experiences. If there is education more than 2 sessions in a year with mannequin and the simulation providing sufficient hours, care workers' recognition would be increased resulting in higher self-efficacy and thus they could keep the role of active lifesaving worker at the first practical site.

• 미생물학회지
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• 제38권3호
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• pp.205-212
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• 2002

주정중독환자에서 초기 비특이적 면역력의 주된 반응인 백혈구 탐식작용을 이용하여 이들 환자들의 건강관리를 용이하게 할 수 있는지를 알아 보기위하여 백혈구 탐식 작용력을 측정하고자 실시하였고, 연구대상은 주정중독 의존형으로 진단된 남자 95명, 여자 3명과 대조군으로서는 건강한 헌혈자 32명을 대상으로 실시하였다. 또한 주정중독환자의 건강상태를 확인하기 위하여 백혈구수, 혈색소, 적혈구 평균용적, 혈청 단백질 전기영동, 림프구 아형 분리 및 림파구 유약화 시험도 실시하였따. 분석결과에서 혈색소와 적혈구 평균용적은 대조군에 비하여 신, 장기 입원 환자군에서 유의할만한 차이를 보였으며(P<0.05), 총 T와 B 림프구는 감소하였고, $T_{Helper}/T_{suppressor}$ 비율은 $1.6{\pm}0.8%$로 증가하였다. 특히 신, 장기입원 주정중독자의 Staphylococcus aureus Cowan I을 사용한 백혈구의 phagocytic plaque 형성력에서도 대조군에 비하여 현저하게 저하되었고, 이제까지 보고된 바 없는 특이한 strange body, 사슬상 탐식현상을 관찰 할 수 있었다. 따라서 Staphylococcus aureus Cowan I을 사용한 백혈구의 phagocytic plaque 형성 시험은 특별한 기구가 없이 간단하게 이용 가능하여 주정중독환자의 초기 면역력 측정에 매우 유용한 방법임을 알 수 있었다.