• 한국노년학
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• v.31 no.2
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• pp.195-209
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• 2011

This study examined the prevalence of and factors associated with unmet care need among community-dwelling middle-aged and older people in Korea. Data were from the 2006 Korean Longitudinal Study on Ageing (KLoSA), a national survey of 10,254 non-institutionalized adults aged 45 or older. Having unmet care needs was defined as needing personal assistance with activities of daily living (ADL) or instrumental activities of daily living (IADL) but having no available helper. Weighted logistic regressions were fitted to examine factors associated with unmet care needs. Overall, 7.3%, 14.5%, and 41.8% of subjects among the middle-aged, younger old, and older old, respectively, reported care needs of these, 34%, 33%,and 24% had unmet needs. Factors associated with unmet needs differed among the three groups: Education and income level were negatively associated with unmet needs among the middle-aged, but living alone was the only factor positively associated with unmet needs in both the younger and older old. The prevalence of and factors associated with unmet care needs differ by life-stage. Needed are home- and community-based care and services to meet the need for personal assistance among the elderly living alone in a community.

• Molecules and Cells
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• v.41 no.4
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• pp.282-289
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• 2018

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine mainly derived from T helper 17 cells and is known to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) has been considered as a primary risk factor of COPD. However, the interaction between CS and IL-17A and the underlying molecular mechanisms have not been clarified. In the current study, we investigated the effects of cigarette smoke extract (CSE) on IL-17A-induced IL-8 production in human bronchial epithelial cells, and sought to identify the underlying molecular mechanisms. IL-8 production was significantly enhanced following treatment with both IL-17A and CSE, while treatment with either IL-17A or CSE alone caused only a slight increase in IL-8 production. CSE increased the transcription of IL-17RA/RC and surface membrane expression of IL-17R, which was suppressed by an inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt pathway (LY294002). CSE caused inactivation of glycogen synthase $kinase-3{\beta}$ ($GSK-3{\beta}$) via the PI3K/Akt pathway. Blockade of $GSK-3{\beta}$ inactivation by overexpression of constitutively active $GSK-3{\beta}$ (S9A) completely suppressed the CSE-induced up-regulation of IL-17R expression and the CSE-induced enhancement of IL-8 secretion. In conclusion, inactivation of $GSK-3{\beta}$ via the PI3K/Akt pathway mediates CSE-induced up-regulation of IL-17R, which contributes to the enhancement of IL-17A-induced IL-8 production.

• The Korean journal of internal medicine
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• v.33 no.6
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• pp.1210-1223
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• 2018

Background/Aims: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin can potentially be used to treat asthma in obese patients by inhibiting interleukin 17 (IL-17) expression. This study investigated the combined effects of pravastatin and anti-IL-17 antibody treatment on allergic inflammation in a mouse model of obesity-related asthma. Methods: High-fat diet (HFD)-induced obesity was induced in C57BL/6 mice with or without ovalbumin (OVA) sensitization and challenge. Mice were administered the anti-IL-17 antibody, pravastatin, or both, and pathophysiological and immunological responses were analyzed. Results: HFD exacerbated allergic airway inflammation in the bronchoalveolar lavage fluid of HFD-OVA mice as compared to OVA mice. Blockading of the IL-17 in the HFD-OVA mice decreased airway hyper-responsiveness (AHR) and airway inflammation compared to the HFD-OVA mice. Moreover, the administration of the anti-IL-17 antibody decreased the leptin/adiponectin ratio in the HFD-OVA but not the OVA mice. Co-administration of pravastatin and anti-IL-17 inhibited airway inflammation and AHR, decreased goblet cell numbers, and increased adipokine levels in obese asthmatic mice. Conclusions: These results suggest that the IL-17-leptin/adiponectin axis plays a key role in airway inflammation in obesity-related asthma. Our findings suggest a potential new treatment for IL-17 as a target that may benefit obesity-related asthma patients who respond poorly to typical asthma medications.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.1-8
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• 2020

This paper proposes architectural and evacuation recommendations through evacuation experiments of two child care centers with disabilities. To achieve these purposes, a survey on the architectural characteristics and evacuation experiments was carried out. The results were as follows: (1) the child care center with disabilities were located within one kilometer or five minutes from a fire station and 119 safety center, but the architectural characteristics and the ratio of self-moving children in a care center were very different conditions. (2) The evacuation behavior patterns of children with a disability were as follows: hugging a child by a teacher with the arms, walking with hugging and holding the child by a teacher, moving a wheelchair with a helper, and drag-out a cerebral palsied child with a mat wrapping. (3) The speed of the evacuation was fast in the following order: drag-out with a mat wrapping a child with a disability, hugging the child with the arms, walking with hugging and holding child, and moving with a wheelchair. In the case of difficulties in the vertical evacuation, a temporal evacuation area was essential for children with disability.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.2
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• pp.19-34
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• 1995

The purpose of this study was to analysis level on family caregiver's burden for the elderly with chronic disease in a rural area and to choose priority care group, thereby facilitating the development of interventions to reduce the caregiver's burden. For this purpose, data were collected by questionaire from June 10 to October 8, 1994. The instruments for data collection were Caregiver Burden Inventory by Novak(1989) and Zarit et al(1982), severity of dementia by Hughes Scales(1982), ADL by Lawton(1971), patients' family caregiving activity by pre-survey and reference review(Lee, 1993 ; Jang, 1990 ; Yoo, 1982). The subjects were 213 family caregiver of elderly with chronic disease in a rural area. The data was analysed by the use of t-test, ANOVA, correlation and multiple regression. The results were as follows ; 1. Total burden was evaluated below average, the mean of family burden was 46.98. By the diagnostic classification, Hypertension was 27.37, DM 32.46, CVA 62.96, Dementia 61.24. 2. Significant variables which were correlated to the family caregiver's burden were the patient's disease diagnosis (F=33.82, p<0.001), severity of dementia(F=30.52, p<0.001), the status of disease management(F=11.53, p<0.001), ADL(F=10.54, p<0.001), PADL(F=7.50, p<0.001), income(F=7.17, p<0.001), caregiver's health status(F=24.53, p<0.001), a view of patient's prognosis (F=22.17, p<0.001), relationship with the patient(F=33.82, p<0.001), the number of hours per day spent on caregiving(F=77.52, p<0.001), level of intimacy of caregiver and patients(F=8.75, p<0.001), level of helping(F=4.90, p<0.01), the frequency of caregiving activity(F=3.80, p<0.01), the number of admission(F=5.54, p<0.01), the length of caregiving(F=4.43, p<0.01), other chronic patient in family(t=2.81, p<0.01), caregiver's job(F=3.11, p<0.01), the duration of illness(F=2.98, p<0.05), caregiver's religion(F=2.93, p<0.05), medical security(F=3.89, p<0.05), caregiving's helper(t=2.42, p<0.05). 3. PADL was the most important predictor to family caregiver burden(R2=0.6611). In addition to this, IADL, caregiver's health status, the length of caregiving. level of intimacy of caregiver and patients, patient's age, the patient's disease diagnosis and patient's job accounted for 76% of family caregiver burden. 4. The criteria of priority care group were as follows ; the mean of family caregiver burden was above 58, above of moderate ADL, the number of hours per day spent on caregiving above of 8 hours, above of moderate dementia. By the diagnostic classification, number of priority care group, Hypertension was 4 (8.0%), DM 4(8.0%), CVA 34(64.1%), Dementia 45(75.0%).

• Journal of the Korean Home Economics Association
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• v.31 no.3
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• pp.1-13
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• 1993

This study examined the expenditure on time-saving services and related variables. The time-saving services are food away from home, delivery food, dry cleaning, clothing care, helper and total service. The specific objectives of this study were: (1) to investigate the differences in the expenditure on time saving services according to social economic and demographic variables. (2) to investigate the differences in the expenditure on time-saving services according to role-overload, home goal orientation and work goal orientation. (3) to investigate the independent influence of variables related to the expenditure on time-saving services. For this objectives survey was conducted using interview. The data used in this study included 160 women living in Seoul from employed professional housewives, employed non-professional housewives and non-employed housewives. Statistical analyses were conducted using frequencies, percentiles, mean, oneway ANOVA, DUNCAN-test and multiple regression. The major findings were: (1) Wife's education, wife's age, income, tenure, level of living and employment status were significantly related to the expenditure on time-saving services by using the one-way ANOVA. (2) Income, education, level of living, number of children, and employment status explained the variance of the expenditures on time-saving services about 20%-39% by using a multiple regression method.

• Journal of IKEEE
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• v.20 no.2
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• pp.128-135
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• 2016

Smart care surveillance system provides the services to track users automatically by using the nearest CCTV cameras which are capable of monitoring them after the system searches for CCTV cameras around them by using the GPS location information received from them. Because users send their GPS location information with using their smart device when they are in emergency situation or want to be cared for, they may expect quick response of helper in this system. However, in the previous system, the selection time of camera which is capable of monitoring is increased rapidly as the management area is expended because the area management server selects the camera by sorting the distance between all of CCTV cameras and users, and then monitors them whenever they send the location information. In this paper, we propose the method to reduce the selection time of the CCTV cameras for tracking the users by searching only the cameras near to the CCTV cameras used to track them.

• Journal of Families and Better Life
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• v.19 no.4
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• pp.49-68
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• 2001

The purpose of this study was 1) to review communal housing in the UK, 2) to consider the policy implications for elderly communal housing in Korea. The research methods used were 1) literature review about communal housing and related policy in the UK 2) field survey in the UK 3) interpretative suggestion for the proper policy implication to develope communal housing for the elderly in Korea. Sheltered housing in the UK had been developed as communal housing for the elderly with special needs since the 1970s. The type of sheltered housing were category 1 and category 2. Very sheltered housing with more facilities and meal services was added in 1980s. Sheltered housing was evaluated as the most humanistic solution for older people in the UK in 1980s. Because of the policy of moving institutional care to community care, sheltered housing became less in demand because of more options for older people including being able to stay in their own home. So new completion of sheltered housing by registered social landlords reduced saliently. Sheltered housing already totalled over half million units in which 5% of all elderly over 65 still lived and a small quantity of private sector for sale schemes emerged in the 1990s. The reason why the residents moved to sheltered housing was for sociable, secure, and manageable living arrangements. In general the residents were satisfied with these characteristics but dissatisfied with the service charge and quality of meals, especially in category 2.5 schemes. The degree of utilisation of communal spaces and facilities depended on the wardens ability and enthusiasm. Evaluation of sheltered housing indicated several problems such as wardens duty as a \"good neighbour\" ; difficult-to-let problems with poor location or individual units of bedsittiing type with shared bathroom ; and the under use of communal spaces and facilities. Some ideas to solve these problems were suggested by researchers through expanding wardens duty as a professional, opening the scheme to the public, improving interior standards, and accepting non-elderly applicants who need support. Some researchers insisted continuing development of sheltered housing, but higher standards must be considered for the minority who want to live in communal living arrangement. Recently, enhanced sheltered housing with greater involvement of relatives and with tied up policy in registration and funding suggested as an alternative for residential care. In conclusion, the rights of choice for older people should be policy support for special needs housing. Elderly communal housing, especially a model similar to sheltered housing category 2 with at least 1 meal a day might be recommended for a Korean Model. For special needs housing development either for rent or for sale, participation of the public sector and long term and low interest financial support for the private sector must be developed in Korea. Providing a system for scheme managers to train and retrain must be encouraged. The professional ability of the scheme manager to plan and to deliver services might be the most important factor for the success of elderly communal housing projects in Korea. In addition the expansion of a public health care service, the development of leisure programs in Senior Citizens Centre, home helper both for the elderly in communal housing and the elderly in mainstream housing of the community as well. Providing of elderly communal housing through the modified general Construction Act rather than the present Elderly Welfare Act might be more helpful to encourage the access of general people in Korea. in Korea.

• The Korean Journal of Emergency Medical Services
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• v.16 no.1
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• pp.7-18
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• 2012

Purpose: The purpose of this study is to help care workers to do their best as first respondents by analysing their recognition, knowledge, and self-efficacy on basic CPR (cardiopulmonary resuscitation) that is directly connected to the lives of patients and thus their education and methods can be improved for their positive basic lifesaving work. Method: For this purpose 360 structured questionnaires were used to the subjects in the eastern area of Jeonnam province from June 20 to July 4, 2011. Of these questionnaires 217 were used excluding 113 incomplete, 27 error, and 3 male ones. The collected data were analysed by the real number, the percentage, the average, the standard deviation, t-test, ANOVA, and Tukey with SPSS WIN 18.0. Results: 1. In the view of subjects, those aged over 51 accounted for 96(44.2%) as the majority, high school graduates, 95(43.8%), worked for 1 or more than 1 year-less than 2 years, 66(30.4%), experienced to see persons collapsed losing their consciousness, 46(21.2%), took the education, 184(85.7%), had 1 session of education, 80(43%), got the last education for 2 or more than 2 years 68(37%), and practiced through mannequin for the education aids, 86(46.7%). 2. There was significant difference in the view of recognition with the length of work (p=.010) and experienced to see persons collapsed losing their consciousness (p=.020), in the view of knowledge with academic background (p=.040) and the length of work, and in the view of self-efficacy with academic background (p=.002), the length of work (p=.010) and experienced to see persons collapsed losing their consciousness (p=.000). 3. There was significant difference in the session of education (p=.000), last education (p=.025) and education aids for basic CPR. Self-efficacy had significant difference according to the session of education for basic CPR (p=.001) and the time of education (p=.000). 4. There was correlation between recognition and self-efficacy (r=.41). The higher the recognition is, the better the self-efficacy improves. However the correlation between knowledge and self-efficacy was so low that the former did not have influence on self-efficacy. Conclusions: It needs to offer education to the lifesaving workers based on their experiences. If there is education more than 2 sessions in a year with mannequin and the simulation providing sufficient hours, care workers' recognition would be increased resulting in higher self-efficacy and thus they could keep the role of active lifesaving worker at the first practical site.

• Korean Journal of Microbiology
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• v.38 no.3
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• pp.205-212
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• 2002

This study was conducted to develop a method for direct determination of phagocytic activities in human circulatic systems and to measure the phagocytic activities in human leukocytes from the alcoholics, since phagocytic activity was considered to be very important in human immune mechanism at early stage for the health care of the alcoholics. The subjects for this study were 130 among which 95 males and 3 females were diagnosed as alcoholism and 32 was healthy blood donors. A thin layer of heat-killed Staphylococcus aureus Cowan I was placed on a plastic dish and reacted with whole blood to measure the phagocytic plaque formation by human leukocytes. In order to determine the health conditions of the subjects, some clinical laboratory tests, such as white blood cell counts, hemoglobin contents (Hgb), mean corpuscular volume of red blood cells(MCV), serum electrophoresis, B and T-lymphocytes, T-lymphocyte subtypes and phytohemagglutination test were also implemented. Compared to the non-alcoholism, new and old alcoholic inpatients showed statistically significant differences on levels of Hgb and MCV (p<0.05), but showed that T and B-lymphocyte numbers decreased and Helper T cell/Suppressor T cell ratio ($1.6{\pm}0.8$%) increased. Compared to non-alcoholism, phagocytic plaque activities of leukocytes from alcoholic patients decreased significantly and an unusual pattern in phagocytic plaque was observed, showing a strange body and chain shaped phagocytosis. Based upon these results, it is concluded that a phagocytic-plaques of Staphylococcus aureus Cowan I by leukocytes was very simple and useful method for the early immunological determination of phagocytic activities in alcoholic patients without requiring any special equipments.