• 한국산업보건학회지
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• 제24권2호
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• pp.137-145
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• 2014

Objectives: The study examines the relation between urinary arsenic concentration and blood pressure, which is a risk factor of cardiovascular disease. Materials: In this study, the urinary arsenic concentration, history of diagnosed disease, and blood pressure of 782 local residents in Gwangyang, Yeosu, and Hadong regions from May 2007 to July 2007. Results: The urinary arsenic concentration of total participants was $9.06{\mu}g/g-ct$. The logistic regression analysis of medical diagnosed history and urinary arsenic concentration, showed statistically significance (p<0.05) of high urinary arsenic concentration in participants with diagnosed hypertension. In addition, diagnosed hypertension it was observed that the high blood pressure was related with the pulse pressure. Conclusions: The arsenic concentration level was low in this study, but the exposure to low levels of arsenic has an effect on hypertension. Also, hypertension is related to pulse pressure and mean arterial blood pressure as well as being risk factor of cardiovascular disease. Therefore, close supervision of low -level arsenic exposure is needed.

• 보건교육건강증진학회지
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• 제20권2호
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• pp.113-125
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• 2003

Background： Recently, adolescent obesity was increased and tended to become obese adults, facing increased risk for diabetes, cardiovascular disease. Even before reaching adulthood, adolescent obesity already was experiencing hypertension, dyslipidemia, and diabetes mellitus. The purpose of this study was to find prevalence of obesity of high school students in Jeju island and association between obesity and cardiovascular risk factors and association between childhood obesity and adolescent obesity. Method： The study subjects were 6,064 students of twenty-two high school in Jeju island and health survey data was gathered from high school health examination data and hospital health examination data from Aug. 1999 to Dec. 1999. Adolescent obesity was evaluated by ideal body weight method in 1998 and body mass index. Cardiovascular risk factors were checked total cholesterol, systolic and diastolic blood pressure, fasting blood sugar. In 1,534 students, obesity at primary school is checked by primary and middle school health record. Results： Prevalence of obesity in Jeju island high school students is 12.6% in male students, 13.3% in female students by ideal body weight method and 8.7% in male students, 8.5% in female students by body mass index. Prevalence of obesity of male students in city area and district area of Jeju island were each 12.9%, 10.3% and that of male students in city area was significantly higher. Prevalence of obesity of female students in city area and district area of Jeju island were each 12.9%, 14.2% and not significantly different. Prevalence of obesity of male students in general and commercial school group were each 13.9%, 10.1% and that of general school group was significantly higher. In female students, Prevalence of obesity general and commercial school group was not significantly different. Total cholesterol, systolic and diastolic blood pressure were significantly associated with degree of obesity in male and female students(p＜0.05) and fasting blood sugar was only significantly associated with degree of obesity in male students(p＜0.05). In 1,514 students checked by health record, Odds ratio of obesity at primary and middle school that at high school were 12.96∼22.77 and was significantly associated. Conclusion： Prevalence of obesity of high school students in Jeju island is very high and adolescent obesity was significantly associated with cardiovascular risk factors. Mostly childhood obesity tended to become adolescent obesity and program of control of obesity at childhood and adolescence is required.

• 사상체질의학회지
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• 제20권3호
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• pp.94-106
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• 2008

1. Objective The purpose of this study was to prove the correlation between risk factor of cardiovascular disease and sasang constitution. 2. Methods We analyzed the data of 200 patients who visited Cheonan oriental medical hospital from Apr 1, 2007 until September 31, 2007, for medical examination, which includes sasang constitution examination, blood chemistry test and physical examination. And we classified their results into 3 groups based on with NCEP-ATP III diagnostic criterions. 3. Results and Conclusion The results were as follows : 1. The frequency of dyslipoproteinemia(Hypertriglycemia) was significantly higher in Teaumin group than other constitutions. 2. The frequency of Metabolic syndrome was significantly higher in Taeumin group than other constitutions. 3. The risk of coronary heart disease was higher in Teaumin than other constitutions.

• Journal of Nutrition and Health
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• 제38권6호
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• pp.445-454
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• 2005

The purpose of this study was to compare the validity of obese index among body mass index (BMI), waist to hip ratio (WHR), and waist circumference (WC) and to determine which is the best in relation to cardiovascular disease (CVD) risk in Korean elderly more than 65 ages. Data from the 1998 Korean Health and Nutrition Survey were used (n=1017). Anthropometric indices and CVD risk factors were measured, and chi-square test, analysis of variance following duncan's multiple range test, partial correlation analysis, and Receiver Operator Characteristic (ROC) curves were used in the analysis. Anthropometric values were decreased in both male and female when ages were goes up. In female elderly, it specially showed the characteristics of upper body fat and systolic blood pressure risk (p<0.05). Among life style factors the current smokers were prevalent in obese male (p<0.05), but not prevalent in female having obese or upper body fat. Also, person with upper body obesity have more exercise than that of normal group (p<0.01). Mean BMI values of the current smoker was lower than that of normal group in both sexes (p<0.01). Mean BMI value of person with other risk factors were higher than that of normal groups (p<0.05). Among 7 CVD risk factors in partial correlation analysis, WC had the highest correlation coefficient in 5 in male, whereas BMI in 4 in female. In ROC analyses of 12 risk factors and health conditions, the largest area under curve of obese indices for risk factors were WC>WHR>BMI in male and BMI>WHR>WC in female. The optimal cutoff values of each index (BMI : WHR : WC) for one or more risk factors were 19.02 : 0.84 : 71.3 in male and 19.04 : 0.88 : 85.6 in female. In conclusion, Most Korean elderly showed non-obese and abdominal obesity likewise other Asians. Also CVD risk factors were prevalent in Korean elderly within normal limits of obese indices. Therefore the upper body fat indices reflected in the aged whose muscle mass is replaced by fat must be used as an indicator of CVD risk together with BMI. Although WHR was the worst index based on partial correlation analysis and so located between BMI and WC in ROC curve analysis in both sexes, it need to be use with WC to screen the cardiovascular risk group.

• Korean Circulation Journal
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• 제48권12호
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• pp.1097-1119
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• 2018

Although elevated serum low-density lipoprotein-cholesterol (LDL-C) is without any doubts accepted as an important risk factor for cardiovascular disease (CVD), the role of elevated triglycerides (TGs)-rich lipoproteins as an independent risk factor has until recently been quite controversial. Recent data strongly suggest that elevated TG-rich lipoproteins are an independent risk factor for CVD and that therapeutic targeting of them could possibly provide further benefit in reducing CVD morbidity, events and mortality, apart from LDL-C lowering. Today elevated TGs are treated with lifestyle interventions, and with fibrates which could be combined with omega-3 fatty acids. There are also some new drugs. Volanesorsen, is an antisense oligonucleotid that inhibits the production of the Apo C-III which is crucial in regulating TGs metabolism because it inhibits lipoprotein lipase (LPL) and hepatic lipase activity but also hepatic uptake of TGs-rich particles. Evinacumab is a monoclonal antibody against angiopoietin-like protein 3 (ANGPTL3) and it seems that it can substantially lower elevated TGs levels because ANGPTL3 also regulates TGs metabolism. Pemafibrate is a selective peroxisome proliferator-activated receptor alpha modulator which also decreases TGs, and improves other lipid parameters. It seems that it also has some other possible antiatherogenic effects. Alipogene tiparvovec is a nonreplicating adeno-associated viral vector that delivers copies of the LPL gene to muscle tissue which accelerates the clearance of TG-rich lipoproteins thus decreasing extremely high TGs levels. Pradigastat is a novel diacylglycerol acyltransferase 1 inhibitor which substantially reduces extremely high TGs levels and appears to be promising in treatment of the rare familial chylomicronemia syndrome.

• 생명과학회지
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• 제18권2호
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• pp.193-199
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• 2008

본 연구의 목적은 운동프로그램이 과체중 및 비만아동의 시기에 따른 C-반응성단백질 및 심혈관질환 위험인자의 변화에 미치는 영향을 알아보고자 과체중 및 비만 아동을 대상으로 12주 간의 걷기와 밴드운동을 실시하고, 운동전, 4주 후, 12주 후의 신체조성, 혈중지질, 인슬린, C-반응성단백질를 측정 분석하였다. 연구의 대상자는 연령과 성별에 따른 체질량지수 백분위 수 85 이상(BMI${\geq}$21.3)인 과체중 및 비만아동 16명을 프로그램에 참여하는 운동군에 8명, 대조군에 8명으로 무선배치 하였다. 운동군은 주 2회의 걷기운동 50분과 주 2회의 밴드저항운동을 12주 동안 실시하였다. 연구결과 운동군 내 에서는 체중(p<0.001), BMI (p<0.001), 체지방량(p<0.001), 체지방률(p<0.001), TC (p<0.05), 인슐린(p<0.05), HOMA-IR (p<0.05)이 감소하였고, 제지방률(p<0.001), HDL-C (p<0.01)는 증가하였다. 측정시기를 고려하여 집단간의 차이를 분석한 결과 체중(p<0.001), BMI (p<0.001), 체지방량(p<0.001), 체지방률(p<0.001), 제지방량(p<0.05), 제지방률(p<0.001), 인슐린(p<0.05), HOMA-IR (p<0.05)에서 통계적으로 유의한 차이가 있는 것으로 나타났다. 이상의 연구결과 12주 걷기와 밴드운동에 의해 과체중 및 비만아동의 심혈관질환 위험인자를 일부 개선되지만, C-반응성단백질 농도는 개선되지 않음을 알 수 있었다.

• 한국방사선학회논문지
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• 제15권3호
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• pp.337-344
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• 2021

관상동맥 석회화는 심혈관질환 위험인자와 연관이 있으며, 동맥경화반의 양과 밀접한 관계가 있음을 선행 연구에서 보고되고 있다. 이에 본 연구에서는 2020년 12월부터 2021년 2월까지 대구시 소재 S 영상의 학과 건강검진센터를 방문하여 관상동맥 Calcium scoring CT를 시행한 109명을 대상으로 혈액인자가 관상동맥 석회화 수치에 미치는 영향을 알아보고자 하였다. 연구결과 허리둘레 인자에서는 비정상 군이 정상군에 비해 석회화 발생 위험도가 1.113배 증가하였고, 공복혈당 인자에서는 비정상 군이 정상 군에 비해 석회화 발생 위험도가 1.036배 증가하였으며, 중성지방 인자에서는 비정상 군이 정상 군에 비해 석회화 발생 위험도가 1.008배 증가하였으므로 허리둘레 인자와 공복혈당인자, 중성지방 인자가 관상동맥 석회화 수치에 영향을 주는 인자임을 알 수 있었다. 석회화 수치 발생 위험도는 허리둘레 인자와 공복혈당인자, 중성지방 인자와 유의한 관계가 있으므로 석회화 수치와 연관성이 있는 위험 변수들의 수치를 줄이기 위하여 평소 건강관리에 관심을 갖고 건강검진을 통하여 사전에 예방하기 위해 노력한다면 심혈관질환의 발생률을 낮추고, 심혈관질환과 관련된 의료비를 줄이는데 도움이 될 수 있을 것이라 기대한다.

• 한국식품영양과학회지
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• 제15권2호
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• pp.191-200
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• 1986

It is now generally accepted that individuals at increased risk for cardiovascular disease may be identified by certain traits or habbits. The factors such as high blood pressure, elevated blood cholestrol, age, sex and obesity are associated with increseaed frequency of disease. The blood cholesterol level lowering will decrease cardiovascular disease risk. The regression of atherosclerosis can be achieved by lowering the level of circulating cholesterol. Those things are connected with the quantity and quality of protein, fats, carbohydrates, especially soluble and non-soluble fiber, magnesium and calcium. The lipoprotein and lipid metabolism are connected with the lipid transport. The factors on lipid absorption and blood serum lipid pattern of human are exist. The factors have a variety of materials with different chemical and physical properties. The soluble fiber diet make a low blood and liver lipids. Many kind of soluble fiber results in a lowering of blood cholesterol and triglyceride levels. The cholesterol lowering effects of dietery fiber may be a results of alterations of in intestinal handling of fats, hepatic metabolism of fatty acid or triglyceride acid metabolism of lipoprotein. It is investigated that the high density lipoprotein (HDL) is inversely related to coronary artery disease. It has been postulated that HDL may be an important factor in cholesterol efflux from the tissues, therby reducing the amount of cholesterol deposited there. Alternatively, the HDL may pick up cholestyl ester and phospholipid during normal VLDL lipolysis in the plasma. The HDL levels are relatively insensitive to diet. At present time, the cause-and -diet effect of HDL's inverse relation to CHD remains unclear.

• 대한방사선기술학회지:방사선기술과학
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• 제39권1호
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• pp.81-88
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• 2016

인체의 지방조직이 증가하여 비만해지면 심혈관계 질환, 당뇨병, 대사성질환과 이상지질혈증 등의 위험인자로 나타난다. 이러한 대사성질환에는 심혈관 및 뇌혈관질환, 고혈압, 고지혈증 등이 있고, 췌장의 지방조직 증가는 이러한 질환의 위험요인으로 알려져 있다. 그리고 췌장암에 대한 진단과 치료에 대한 연구는 활발히 이루어졌으나, 췌장지방증에 관한 연구 사례는 많지 않다. 본 연구에서는 초음파 검사의 결과로 진단된 췌장지방군과 정상대조군으로 나누어 신체 특성과 혈청학적 검사와 혈압 및 동맥경화도검사를 평가하였다. 정상대조군과 췌장지방군 사이에서 연령이나 허리둘레, 체질량 지수, 총 콜레스테롤, HDL 콜레스테롤과 LDL 콜레스테롤, 수축기와 이완기혈압, 공복혈당, 대동맥 맥파전파속도는 췌장지방군에서 높게 나타났다. 그리고 족관절상완협착비와 HDL-콜레스테롤은 낮을수록 혈관에 유해하므로 췌장지방군이 정상대조군보다 낮게 나타났다(p < 0.05). 정상대조군과 췌장지방군의 차이가 통계적으로 유의함을 확인할 수 있었다. 결론적으로 복부초음파 검사에서 췌장지방증은 대사성 질환의 위험을 예측할 수 있으며 심혈관계 질환과 연관성이 있었다.

• 한국방사선학회논문지
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• 제13권5호
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• pp.729-737
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• 2019

지방췌장(Fatty pancreas)은 세포 내에 비정상적으로 지질이 침착되는 과정으로 지방조직이 증가하여 축척되고, 그 결과 심혈관 및 대사성 질환의 위험인자로 나타난다. 이에 본 논문에서는 췌장 초음파검사에서 췌장 지방이 심혈관계 질환 및 대사증후군의 예측 인자로서의 유용성을 알아보고자 한다. 부산에 위치한 W 병원 건강검진센터에서 2018년 9월 2일부터 2018년 12월 31일까지 종합검진을 시행한 407명을 대상으로 복부초음파검사 결과 중 췌장에 지방이 침착된 정도를 경도, 중등도, 고도 3단계로 분류하였다. 췌장의 지방 침착과 심혈관 질환 및 대사성증후군의 연관성을 알아보기 위하여 비폐쇄성 죽상경화, BMI, 고지혈증, 고혈압, 당뇨병의 데이터를 수집하였고 추가적으로 지방췌장의 정도가 증가될수록 간기능 이상과 갑상선 기능 이상과의 상관관계를 분석하고자 하였다. 지방췌장을 가진 환자 중 비폐쇄성 죽상경화, BMI, 고지혈증, 고혈압, 당뇨병, 간기능이상, 갑상선기능이상 등 6가지 매개변수의 관련성을 살펴보았고 이 중 심혈관질환 위험인자인 비폐쇄성 중상경화의 경동맥 내중막두께가 지방췌장과 가장 밀접하게 연관되어 있음을 확인하였다.