• Journal of the Korean Mathematical Society
• /
• v.43 no.4
• /
• pp.885-897
• /
• 2006

A new mathematical model of pumping heart coupled to lumped compartments of blood circulation is presented. This lumped pulsatile cardiovascular model consists of eight compartments of the body that include pumping heart, the systemic circulation, and the pulmonary circulation. The governing equations for the pressure and volume in each vascular compartment are derived from the following equations: Ohm's law, conservation of volume, and the definition of compliances. The pumping heart is modeled by the time-dependent linear curves of compliances in the heart. We show that the numerical results in normal case are in agreement with corresponding data found in the literature. We extend the developed lumped model of circulation in normal case into a specific model for arrhythmia. These models provide valuable tools in examining and understanding cardiovascular diseases.

• Journal of Institute of Control, Robotics and Systems
• /
• v.10 no.12
• /
• pp.1181-1188
• /
• 2004

This paper reviews the main aspects of cardiovascular system dynamics with emphasis on modeling hemodynamic characteristics using a lumped parameter approach. Methodological and physiological aspects of the circulation dynamics are summarized with the help of existing mathematical models: The main characteristics of the hemodynamic elements, such as the heart and arterial and venous systems, are first described. Lumped models of micro-circulation and pulmonary circulation are introduced. We also discuss the feedback control of cardiovascular system. The control pathways that participate in feedback mechanisms (baroreceptors and cardiopulmonary receptors) are described to explain the interaction between hemodynamics and autonomic nerve control in the circulation. Based on a set-point model, the computational aspects of reflex control are explained. In final chapter we present the present research trend in this field and discuss the future studies of cardiovascular system modeling.

• Journal of Chest Surgery
• /
• v.50 no.2
• /
• pp.105-109
• /
• 2017

Coronary arterial involvement in Takayasu arteritis (TA) is not uncommon. Herein, we describe a case of TA with celiac trunk and superior mesenteric artery occlusion combined with coronary artery disease. Bilateral huge internal thoracic arteries (ITAs) and the inferior mesenteric artery provided the major visceral collateral circulation. After percutaneous intervention to the right coronary artery, off-pump coronary artery bypass grafting for the left coronary territory was done using a right ITA graft and its large side branch because of its relatively minor contribution to the visceral collateral circulation.

• Biomedical Science Letters
• /
• v.7 no.1
• /
• pp.7-15
• /
• 2001

Although extracorporeal circulation (ECC) has been routinely used for cardiovascular surgery, hyperoxemia during ECC may produce oxygen toxicity and cellular injury. This study was performed to investigate the clinical influences of hyperoxemic ECC during cardiovascular operation. 40 adult patients scheduled for elective cardiovascular surgery were classified into normoxemic (arterial oxygen tension: 115 mmHg, n＝20) and hyperoxemic (arterial oxygen tension: 380 mmHg, n＝20) ECC. At preoperative and postoperative period, total leukocyte and neutrophil counts, platelet counts, iron, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine in peripheral arterial blood, malondialdehyde (MDA) and troponin-T concentration (TnT) in coronary sinus blood, pulmonary vascular resistance (PVR), and postoperative blood loss volume (BLS) were measured and compared between groups. Hyperoxemic group had postoperatively higher total leukocyte and neutrophil counts, MDA, TnT, PVR total BLS, iron, glucose, AST, ALT, BUN, and creatinine than normoxemic group (p<0.05).0 conclusion, hyperoxemic ECC results in greater inflammatory response and oxidative damaging effects on the heart lung, liver and kidney, probably being adverse to postoperative patient recovery. For reducing these deleterious effects and improving postoperative outcomes, management lowering oxygen tension during ECC is recommended.

• Proceedings of the KSME Conference
• /
• 2002.08a
• /
• pp.713-716
• /
• 2002

Aging effect on the cardiovascular circulation is simulated by lumped parameter model. Aging phenomena can be hemodynamically explained as (1) the increase of flow resistance induced by remodeling of artery vessels and increased viscosity of blood and (2) the reduction of the vessel capacitance caused by arteriosclerosis. Appropriate physiological parameters are evaluated from the clinical data of adults and old men. Simulation results well explain the hypertension with aging of cardiovascular system.

• Korean Circulation Journal
• /
• v.48 no.11
• /
• pp.1028-1029
• /
• 2018

• Journal of the Korean BIBLIA Society for library and Information Science
• /
• v.27 no.1
• /
• pp.111-134
• /
• 2016

The purpose of this study is to investigate and compare the intellectual structure of cardiovascular research area in Korea and the United States. For the purpose of this study, a data set was collected; one journal Korean Circulation Journal is in Korea and two journals Circulation, and Circulation Research are in the United States. Based on the frequency of citation counts, 45 authors and 53 authors were selected for author co-citation analysis. By multidimensional scaling, clustering, and factor analyses, the results demonstrate that researchers in both countries commonly tend to work on several, rather than focus on certain sub-areas. In both countries, the core areas are revealed as 'cardiovascular disease treatment', 'cardiovascular disease diagnose', 'cardiovascular disease fundamentals', and 'cardiovascular disease preventives'. One of distinctive differences between two is that research in Korea is likely to focus on clinical medicines while research in the United States tends to be on fundamental medicines. While the area of 'Disorders of Rhythm' is revealed in Korea, 'Pharmacology of the Cardiovascular System' area is found in the United States. In addition, the sub-areas of fundamental medicines such as 'Epidemiology of Cardiovascular Disease', 'Biology', 'Biochemistry', 'Physiology' are revealed distinctively in the United States.

• Korean Circulation Journal
• /
• v.48 no.12
• /
• pp.1160-1162
• /
• 2018

• Korean Circulation Journal
• /
• v.53 no.2
• /
• pp.106-108
• /
• 2023

• Korean Circulation Journal
• /
• v.53 no.2
• /
• pp.112-112
• /
• 2023