• Journal of Yeungnam Medical Science
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• 제3권1호
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• pp.279-285
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• 1986

가토의 Ouabain유발 부정맥에 미치는 Carbamazepine의 영향을 검색한 결과 다음과 같은 결론을 얻었다. 1. Ouabain을 지속적으로 정맥 주사하여 64+$8.8{\mu}g/kg$이 투여되었을 때 부정맥이 발생 했으며, 이 양을 부정맥 유발 가능용량으로 정했다. 2. Ouabain $64{\mu}g/kg$을 단회 정맥 주사했을 때 발생한 부정맥은 약 7~9분간 지속된 후 모든 예에서 자연 소실되었고, 정상 심박동으로 회복된 지 20분 후 다시 동량의 Ouabain을 정맥 주사했을 때 모든 예에서 다시 나타났다. 3. 부정맥 유발 용량($64{\mu}g/kg$)의 Ouabain을 단회 정맥 주사한 후 부정맥이 나타난 것을 관찰 즉시 Carbamazepine을 투여한 결과 즉시 정상 신박동으로 환원되었으며 어느 정도 지속된 후 모든 예에서 부정맥이 발생했으나 즉시 동량의 Carbamazepine 투여로 다시 정상 심박동으로 환원되었다. 한편, Carbamazepine의 양이 증가되면서 항 부정백 작용의 기간은 길어졌으나 항 부정맥 작용없이 사망한 예가 많아졌다. 4. Carbamazepine을 단독 투여 해 본 결과 그 양이 증가함에 따라 심한 서맥, A-V block, 심방 세동 등이 나타나면서 심장이 정지함을 볼 수 있었다. 이상의 실험 결과로 미루어 Carbamazepine은 Ouabain의 독작용에 의한 심한 부정맥을 일시적으로 억제할 수 있으며, 보다 대량에서는 그 항 부정맥 작용이 보다 오래 지속할 수 있으나 Carbamazepine 자체의 심장에 대한 부작용이 발현될 위험이 존재한다고 생각된다.

• Journal of Chest Surgery
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• 제24권10호
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• pp.951-959
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• 1991

The level of serum potassium concentration is very important aspect in postoperative cardiac patients The postoperative cardiac arrhythmia and digitalis intoxication are known to be closely related with hypokalemia and also to cause the irreversible cardiac dysfunction. In this study, the changes of the level in serum and urine concentrations during, after extracorporeal circulation[EGG], Predict and Postdict periods are analyzed and compared statistically with postoperative cardiac patients 46 persons according to divided 8 groups. 1. There was no difference significantly in concentrations of serum and urine potassium in each period according to age, sex and disease types. 2. There was no difference significantly in concentrations of serum and urine potassium in each period according to the use of normothermia and hypothermia. 3. There was no difference significantly in concentrations of serum and urine potassium in each period according to the length of extracorporeal circulation time and aortic cross clamping time. 4. There was no difference significantly in concentrations of serum and urine potassium in each period according to the amount of the infused cardioplegic solution and level of Hct.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.52-52
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• 2003

Junctate is a newly identified integral ER/SR membrane $Ca^{2+}$ binding protein, which is an alternative splicing form of the same gene generating aspartyl $\square$-hydroxylase and junctin. To elucidate the functional role of junctate in heart, transgenic (TG) mice overexpressing mouse cardiac junctate-1 under the control of mouse $\square$$^{~}$ myosin heavy chain promoter were generated. Overexpression of junctate in mouse heart resulted in cardiac hypertrophy, increased fibrosis, bradycardia, arrhythmias and impaired contractility. Overexpression of junctate also led to down-regulation of SERCA2, calsequestrin, calreticulin and RyR, but to up-regulation of NCX and PMCA. The SR $Ca^{2+}$ content decreased and the L-type $Ca^{2+}$ current density and the action potential durations increased in TG cardiomyocytes, which could be the cause for the bradycardia in TG heart. The present work has provided an important example of pathogenesis leading to cardiac hypertrophy and arrhythmia, which was caused by impaired $Ca^{2+}$ handling by overexpression of junctate in heart.n heart.

• Journal of Chest Surgery
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• 제38권6호
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• pp.438-440
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• 2005

원발성 심장종양은 드문 것으로 알려져 있으며, 더구나 부정맥을 동반하는 경우는 매우 드문 것으로 알려져 있다. 저자들은 발작성 심방성 빈맥을 동반한 심장지방종 환자를 치험하여 보고하는 바이다.

• The Korean Journal of Physiology and Pharmacology
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• 제28권4호
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• pp.313-322
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• 2024

Mutations within the SCN5A gene, which encodes the α-subunit 5 (Na_V1.5) of the voltage-gated Na⁺ channel, have been linked to three distinct cardiac arrhythmia disorders: long QT syndrome type 3, Brugada syndrome (BrS), and cardiac conduction disorder. In this study, we have identified novel missense mutations (p.A385T/R504T) within SCN5A in a patient exhibiting overlap arrhythmia phenotypes. This study aims to elucidate the functional consequences of SCN5A mutants (p.A385T/R504T) to understand the clinical phenotypes. Whole-cell patch-clamp technique was used to analyze the Na_V1.5 current (I_Na) in HEK293 cells transfected with the wild-type and mutant SCN5A with or without SCN1B co-expression. The amplitude of I_Na was not altered in mutant SCN5A (p.A385T/R504T) alone. Furthermore, a rightward shift of the voltage-dependent inactivation and faster recovery from inactivation was observed, suggesting a gain-of-function state. Intriguingly, the co-expression of SCN1B with p.A385T/R504T revealed significant reduction of I_Na and slower recovery from inactivation, consistent with the loss-of-function in Na⁺ channels. The SCN1B dependent reduction of I_Na was also observed in a single mutation p.R504T, but p.A385T co-expressed with SCN1B showed no reduction. In contrast, the slower recovery from inactivation with SCN1B was observed in A385T while not in R504T. The expression of SCN1B is indispensable for the electrophysiological phenotype of BrS with the novel double mutations; p.A385T and p.R504T contributed to the slower recovery from inactivation and reduced current density of Na_V1.5, respectively.

• 한국산학기술학회논문지
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• 제15권4호
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• pp.2217-2224
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• 2014

본 논문은 의료용 아날로그 프론트 앤드(analog front end; AFE)를 이용하여 12채널 심전도를 측정하고 신호 분석을 통해 부정맥을 판단할 수 있는 시스템 개발에 관한 논문이다. 최근 국내 급성 심정지 발생이 증가하고 있으며 이에 원인이 되는 부정맥을 진단할 수 있는 시스템의 필요성이 증가하고 있다. 기존의 12채널 심전도 시스템은 회로 구성이 복잡하고 큰 부피를 차지하는 단점이 있으며 이를 개선하기 위해 본 논문에서는 의료용 AFE와 부정맥을 판단 할 수 있는 알고리즘 및 신호 처리를 위한 DSP로 시스템을 구성하였다. 추가적으로 12채널 심전도의 파형 관찰과 부정맥 판별 결과를 7인치 LCD를 통해 출력하며 터치 패널을 통해 사용자 입력을 받는다. 본 논문에서 구현된 시스템을 검증하기 위해 심전도 시뮬레이터의 출력 신호(정상 신호/부정맥 신호)에 대한 판별 테스트와 부정맥 알고리즘을 임베디드 환경에 적용하기 위한 최적화 과정의 성능 평가를 진행하였다.

• 대한약리학회지
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• 제16권1호
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• pp.41-50
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• 1980

Chenodeoxycholic acid(CDCA) has been used as a gallstone dissolving agent since 1972. Recently, ursodeoxycholic acid(UDCA) has been reported to be effective in dissolving gallstones. Both bile acids increased bile flow. The increase in bile flow associated with an increase in cholesterol level in bile after CDCA or UDCA infusion was reported. In this study, using the smooth muscle strips of guinea pig and fowl, responses of the cholates were observed. In addition, the influence of adrenergic blocking agents on the response of the strips to cholates was investigated. Also the effects of cholates on cardiac function were examined by using isolated atria of rabbit and heart of anesthetized frog. The results are as follows: 1) All cholates, such as UDCA, CDCA, and CA produced a marked inhibitory effect on the motility in isolated duodenal strip of guinea pig and fowl, however, only UDCA showed the contraction in the isolated esophagus of fowl. These effects of cholates were blocked by propranolol. 2) In isolated guinea pig stomach strip and gall bladder, cholates exhibited a marked inhibitory effect on the motility and the effects due to UDCA and CA were blocked by phenoxybenzamine while CDCA was not affected. 3) The spontaneous and ouabain induced arrhythmia was partially abolished by cholates. However, concomitant administration of cholates with ouabain or epinephrine caused a marked prolongation in occurrence of atrial arrhythmia in comparison with ouabain or epinephrine alone in isolated rabbit atria. 4) In the heart of anesthetized frog, the epinephrine-induced arrhythmia was partially abolished by cholates. The combined treatment with cholates and ouabain or epinephrine produced a marked prolongation in occurrence of the arrhythmia in comparison with, ouabain or epinephrine alone. From the above results, it can be suggested that the effects of cholates on the smooth muscle of duodenum and esophagus are produced in response to adrenergic ${\beta}$-receptor and the effect or gall bladder and stomach is more likely due to the direct effect on the muscle. In addition, cholates exhibit a slight antiarrhythmic effect on heart, therefore, cholates can be classified as a nonselective antiarrhythmic drug, such as propranolol.

• 융합신호처리학회논문지
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• 제24권4호
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• pp.205-212
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• 2023

심장 질환 가운데에서 부정맥은 방치할 경우에 뇌졸중, 심장 마비, 심부전과 같은 심각한 합병증이 발생할 수 있기 때문에 지속적이고 정확한 심전도 관리에 의한 건강 상태의 확인은 임상적 치료에 매우 중요한 요소이다. 그러나, 심전도(Electrocardiogram; ECG) 데이터의 정확한 해석은 전적으로 의료 전문가에 의존하기 때문에 부가적인 시간과 비용을 요구한다. 따라서 본 논문에서는 라이프로그 기반의 비정상적인 맥파 파형의 분석을 통한 의료 플랫폼 개발을 목적으로 부정맥 인식 모듈을 제안한다. 제안하는 방법은 ECG 데이터를 시계열 데이터가 아닌 이미지 형식으로 처리하여 시각적 패턴 인식 기술을 적용한 후, CNN 모델을 이용하여 부정맥을 탐지하는 방법을 제안한다. 본 논문에서 제안한 ECG 데이터의 이미지 타입 변환에 의한 CNN 모델의 부정맥 분류의 유효성 검증하기 위해 MIT-BIH 부정맥 데이터셋을 사용한 결과, 97%의 정확도를 보였다.

• Investigative Magnetic Resonance Imaging
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• 제23권2호
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• pp.100-113
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• 2019

Sarcoidosis is a multisystem disease characterized by noncaseating granulomas. Cardiac involvement is known to have poor prognosis because it can manifest as a serious condition such as the conduction abnormality, heart failure, ventricular arrhythmia, or sudden cardiac death. Although early diagnosis and early treatment is critical to improve patient prognosis, the diagnosis of CS is challenging in most cases. Diagnosis usually relies on endomyocardial biopsy (EMB), but its diagnostic yield is low due to the incidence of patchy myocardial involvement. Guidelines for the diagnosis of CS recommend a combination of clinical, electrocardiographic, and imaging findings from various modalities, if EMB cannot confirm the diagnosis. Especially, the role of advanced imaging such as cardiac magnetic resonance (CMR) imaging and positron emission tomography (PET), has shown to be important not only for the diagnosis, but also for monitoring treatment response and prognostication. CMR can evaluate cardiac function and fibrotic scar with good specificity. Late gadolinium enhancement (LGE) in CMR shows a distinctive enhancement pattern for each disease, which may be useful for differential diagnosis of CS from other similar diseases. Effectively, T1 or T2 mapping techniques can be also used for early recognition of CS. In the meantime, PET can detect and quantify metabolic activity and can be used to monitor treatment response. Recently, the use of a hybrid CMR-PET has introduced to allow identify patients with active CS with excellent co-localization and better diagnostic accuracy than CMR or PET alone. However, CS may show various findings with a wide spectrum, therefore, radiologists should consider the possible differential diagnosis of CS including myocarditis, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy, amyloidosis, and arrhythmogenic right ventricular cardiomyopathy. Radiologists should recognize the differences in various diseases that show the characteristics of mimicking CS, and try to get an accurate diagnosis of CS.

• Journal of Chest Surgery
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• 제19권4호
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• pp.672-677
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• 1986

From April, 1984 to August, 1986, 214 cases of cardiovascular surgeries had been performed at Yeungnam University Hospital consisting 158 open heart surgeries and 56 non-open heart surgeries. The leading cardiac anomaly of open heart surgeries was ventricular septal defect which was 43% of congenital heart diseases, and most of remaining non-open heart surgeries were ligating patent ductus arteriosus. We had observed 33 postoperative complications such as wound problems, transient arrhythmia, postpericardiotomy syndrome, bleeding requiring reoperation and so on. 3 cases of surgical mortality were present [2 in congenital heart diseases and 1 in acquired heart disease], which resulting 1.9% of surgical mortality rate in the open heart surgeries.