• Radiation Oncology Journal
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• 제14권1호
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• pp.69-76
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• 1996

목적 : electronic portal imaging device(EPID)를 이용하여 폐암 환자에서 시행한 검증 영상을 분석하여 3차원 입체 조형치료계획 시 자세 오차(set-up error)와 종양의 이동 거리를 고려한 적절한 차폐 여유를 평가해 보고자 한다. 대상 및 방법 : 1995년 연세암센터 치료방사선과에 내원하여 EPID가 장착된 Clinac 2100C/D를 이용하여 치료받은 폐암 환자 10명을 대상으로 하였다. 환자 1인 당 1 port에 대한 검증 영상을 매일 얻어 random 오차와 systematic 오차를 구했고, 치료 1회 당 중복 영상을 얻어 종양의 움직임을 구했다. 매일 얻은 검증 영상은 103개이었고, 중복 영상은 10개이었다. 결과 : 전체 10 명의 환자의 x 축, y 축으로의 평균 이동은 각각 1.41 mm, 1.78 mm 이었고 systematic 이동은 표준편차가 x 축, y 축으로 각각 4.63 mm, 4.11 mm이었다. random 이동은 각 환자의 평균 이동으로부터 x 축, y 축으로 표준편차가 각각 4.17 mm, 3.31 mm 이었다. 호흡에 의한 y 축으로의 이동은 평균 12.2 mm이었고, 표준편차는 4.03 mm 이었다. 결론 : 폐암 환자에서 3차원 방사선치료를 시행하려고 할 경우 치료 계획 시 clinical target volume에서 x, y 축으로 각각 10 mm, 25 mm 정도의 여유가 필요하다고 보이며, 치료 초기에 각 환자별로 매일 EPID를 이용하여 얻은 검증 영상과, 중복 영상으로 차폐 여유를 적절히 조절해 주어야 할 것이다.

• 한국임상수의학회지
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• 제31권5호
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• pp.425-429
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• 2014

식욕부진, 호흡부전, 또는 비출혈을 보이는 두 마리 개가 내원하였다. 신체검사에서 호흡곤란, 개구호흡 및 커다란 구개 종양을 확인하였다. 신체검사 중 2 번 증례에서 호흡부전으로 인한 심정지가 발생하였고 심폐소생술과 산소 공급을 통해 안정화 되었다. 1 번 증례의 CT 촬영에서 경구개 연구개를 포함하는 구강 인두, 인두 내 입구, 인후두 부위의 종양을 확인하였다. 연하곤란 및 호흡부전 개선을 위해 보호자 동의 하에 완화 수술을 결정하였다. 종양 제거 후 발생한 결손 부위 재건을 위해 구강 내 점막을 사용하여 회전 및 전진 피판술과 양측 90o 자리바꿈 피판술을 1 및 2 번 증례에 각각 적용하였다. 조직 검사 결과, 두 마리의 개 모두에서 무멜라닌 색소성 흑색종이 진단되었다. 수술 후 7 일째 두 마리 모두에서 정상 연하와 호흡이 확인되었다. 수술 후 4 주째 1 번 증례의 수술 부위에서 재발된 종양이 관찰되었다. 보호자가 추가적인 치료를 원하지 않았고, 연락 두절로 인하여 수술 후 2 개월 이후의 확인은 불가능하였다. 수술 후 3 주째 2 번 증례의 신체검사 및 방사선 촬영에서 국소적인 재발 및 전이는 확인 되지 않았다. 수술 후 7 주째 유선상으로 확인한 결과, 2 번 증례에서 원인불명의 갑작스러운 사망이 확인되었다.

• Clinical and Experimental Pediatrics
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• 제51권1호
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• pp.93-97
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• 2008

갈색세포종은 부신 수질과 크롬친화성 조직에서 발생하는 소아기에는 드문 종양이다. 갈색세포종은 저산소증 상태와 연관이 있어, 단심실성 심장질환 수술 후에도 청색증이 지속되는 환자에서 병발하는 경우가 드물게 보고되고 있다. 갈색세포종의 증상이 애매할 뿐만 아니라 심장 질환 또는 치료 약제에 의하여 전형적인 증상들이 나타나지 않을 수 있다. 청색증형 선천성 심질환 환자에서 갑작스런 고혈압, 심장 상태의 악화, 또는 당뇨병 등을 포함한 애매한 증상들이 나타나는 경우에는 갈색세포종을 감별 진단하여야 한다. 저자들은 선천성 단심실성 심장질환과 갈색세포종이 동반된 2례를 보고한다.

• Journal of Chest Surgery
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• 제10권2호
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• pp.337-342
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• 1977

A clinical analysis was performed on 383 cases of chest injurjes experienced at Department of Thoracic Surgery, Seoul National University Hospital during 21 year period from 1957 to 1977. Of 383 patients of chest injuries, 209 cases were result from nonpenetrating injuries whereas 175 were from penetrating injuries, and there were 258 cases of hemothorax or/and pneumothorax, 162 of rib fracture, 33 of foreign body, 26 of clavicle fracture, 26 of lung contusion, 17 of diaphragmatic laceration, 14 of hemopericardium, 14 of flail chest and others. Stab wound was the most common in penetrating injuries and followed by gunshot and shell fragments. The majority of nonpenetrating chest injury patients were traffic accident victims. and fails accounted for the next largest group of accidents. Chest injuries were frequently encountered in the age group between 16 and 50 years, and 321 patients were male comparing to 62 of female. In blunt chest injuries the patients with five or more rib fractures had a 85 per cent incidence-of intrathoracic injury and 19 per cent had an intraabdominal organ damage, whereas those with four or less rib fractures had a 69 per cent and a 6 per cent incidence respectively. The principal associated injuries were cerebral contusion on 19 cases, renal contusion on 10, liver laceration on 7, peripheral vessel laceration on 5, spleen laceration on 3 and extremity fracture on 18 patients. The principles of therapy for early complications of chest trauma were rapid reexpansion of the lungs by thoracentesis [46 cases] and closed thoracotomy [125 cases] but open thoracotomy .had to be done on 90 cases [23-5%] because of massive bleeding or intrapleural hematoma, foreign body, cardiac injury, diaphragmatic laceration and bronchial rupture. The over all mortality was 2.87 per cent [11 among 383 cases], 8 cases were from penetrating injuries and 3 from nonpenetrating injuries.

• Journal of Chest Surgery
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• 제21권6호
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• pp.1040-1051
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• 1988

From 1959 through Jun. 1988, 2094 cases of various Cardiovascular diseases were operated, which were consisted of 1215 open heart surgery under extra-corporeal circulation or hypothermia and 879 conventional Cardiovascular Surgery at Department of Thoracic & Cardiovascular Surgery in National Medical Center. There were 1111 congenital heart anomalies and 983 acquired cardiovascular diseases. Among 1111 congenital cases, acyanotic cases were 748 and cyanotic cases were 363. In acquired heart cases, valvular heart diseases [702 cases] were the most frequent and a small No. of cardiac tumor and coronary artery diseases were included. Overall operative mortality was 9.3%, consisting of 4.6% for acyanotic anomaly, 20.6% for cyanotic anomaly and 8.7% for acquired heart diseases. In open heart surgery, overall mortality was 11.6% and 6% in conventional cardiovascular surgery.

• Journal of Chest Surgery
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• 제49권3호
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• pp.195-198
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• 2016

We report a 72-year-old male with known myelodysplastic syndrome who presented to the emergency department with a 7-day history of fever and dyspnea. Echocardiography revealed a round echogenic mass $13{\times}16mm$ in size attached to the atrial side of the tricuspid valve. Considering the high risk of infective endocarditis in the patient with a low absolute neutrophil count ($130/mm^3$), emergency surgery was performed. Intraoperatively, a single gelatinous neoplasm was resected, and subsequent reconstruction of the involved leaflet was accomplished using autologous pericardium. The tumor was pathologically confirmed as papillary fibroelastoma with no evidence of infective endocarditis. Papillary fibroelastoma is a rare cardiac neoplasm that occurs in either the mitral or aortic valves. Interestingly, a few cases of tricuspid valve papillary fibroelastoma have been reported so far. Similar echocardiographic findings between vegetation and tricuspid valve neoplasm make it difficult to distinguish these two disease entities.

• Journal of Chest Surgery
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• 제41권6호
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• pp.751-754
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• 2008

원발성 혈관육종은 매우 드물며 그 예후가 불량하다. 이전까지는 수술적 제거가 확립된 치료로 알려져 왔으나, 최근에는 수술 외에도 항암제 치료 및 방사선 치료 등을 병행하는 치료를 시도하고 있다. 저자들은 심장의 원발성 혈관육종의 빠른 진행으로 인하여 우심방의 파열을 일으켜 단시간 내에 환자의 사망을 일으킬 수도 있었던 드문 증례를 경험하여 보고하고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1981-1984
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• 2013

Objective: The optimal duration of adjuvant trastuzumab treatment in patients with HER2-positive breast cancer is not known. The aim of this study was to evaluate the efficacy of 6 months of adjuvant trastuzumab treatment in patients with stage II or III HER2-positive breast cancer. Methods: The records of patients with HER2-positive stage II or III breast cancer who were admitted to the Breast Center of Taipei Medical University Hospital and Yuan's General Hospital between 2000 and 2008 were reviewed. All patients received adjuvant trastuzumab at an initial dose of 4 mg/kg followed by a maintenance dose of 2 mg/kg/week for 22 weeks in combination with chemotherapy. Results: A total of 51 patients were included with a mean age of 46.9 years. Approximately 55% of the patients had stage III disease. The mean follow-up time from initiation of treatment was 45.2 months (range, 0.9 to 85 months). During follow-up, 46 patients (90.2%) did not experience tumor recurrence. The mean estimated disease free survival was 80.2 months. The estimated 1-, 2-, 5-, and 7-year survival rates were 97.9%, 93.1%, 93.1%, and 93.1%, respectively. The most common adverse effects were gastrointestinal symptoms (21.6%), chills (17.6%), dizziness (9.8%), and bone pain (7.8%). No cardiac or hematologic adverse events occurred. Conclusion: Adjuvant therapy with trastuzumab for 6 months resulted in a clinical benefit in patients with HER2-positive breast cancer.

• 혜화의학회지
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• 제8권2호
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• pp.383-397
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• 2000

Background/Aims: Dong-Moo Lee Jae-Ma(1837-1900) confirmed the sasangchaejil theory based on the sasang-medicine. This theory has been the main-stem of oriental medicine during 100 years in Korea. But rarely anyone has tried to prove this theory systemicaly. So we have a trial to clarify any relationship between the sasangchaejil and the laboratory and clinical results of mass screening tests. Methods: We evaluated the laboratory values of 280 people who had taken many clinical and laboratory tests. The laboratory examinations were complete blood count, liver and kidney function test, ultrasonogram of the abdomen and breasts, gastrofiberscope, many tumor markers body mass index, blood pressure, glucose, and electrocardiogram, etc. Results: 1) Among the 280 subjects, 187/66.8% were sowumin, 58/20.7% were taewumin and 35/12.5% were soyangin. 2) Those who reacted positive to HBsAb were 22 subjects(62.8%) in soyangin, 57.2% in sowumin and 55.1% in raewumin. But there were no significant correlations. 3) 45 subjects(72.4%) in taewumin had obesity, fatty liver and hyperlipidemia.(P<0.05) 4) 20.6% in taewumin had abnormal LFT suggesting hepatic disease. It was statistically sigificant.(P<0.05) 5) An anemic state was present in women of soyangin and sowumin mostly. Since an iron deficiency anemia is common in women, there were no significant corelations among sasangchaejil. Also urinary tract infectons were common in women. 6) 6 subjects in taewumin(10.3%) had cardiac problems, while only one case(2.8%) occured in soyangin and 7 cases(3.7%) in sowumin. Taewumin was significantly high.(P<0.05) 7) In the case of gastric disease, there was no distinguishable difference among sasangchaejil.(taewumin 37.9%, soyangin 31.4% and sowumin 35.2% rrespectively) 8) There was no significant difference beteen subjects with different blood types using sasangchaejil. Conclusions: There were some significant relationship between sasangchaejil and diseases prevalent to them by the theory of sasang-medicine. But Lee didn't considered the differences of gender, the change of body status according to the development of culture, and circumstances of their lives. Also he didn't consider the existence of infectious agents. Now more systemic study with larger populations are requied.

• 한국동물위생학회지
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• 제38권4호
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• pp.249-252
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• 2015

Primary renal tumors are uncommon in dogs with prevalence rate of approximately 1%. Renal carcinoma originating from epithelium of proximal convoluted tubules are more likely to be affected to Middle-aged dogs (average age, 8y), males about twice as often as bitches. A 10-year-old, female, German Shepherd dog with history of anorexia, vomitting and hematuria was referred to the Animal Disease Diagnostic Division in Animal and Plant Quarantine Agency. The dog was necropsied and several organs were collected, fixed in 10% phosphate-buffered formalin, embedded in paraffin wax and sectioned for histopathology. Grossly, the kidneys were bilaterally enlarged ($18{\times}12{\times}8cm$; left, $18{\times}10{\times}8cm$; right). The numerous cysts varying sizes from 3 to 6 cm in diameter were protruding from the surface of both kidney. A large nodule ($10{\times}6{\times}6cm$) was discovered between cardiac and diaphragmatic lobe in the right lung. Immunohistochemical examination revealed strong positive reaction to cytokeratin and ki-67 in the nuclei of the epithelial tumor cells. But showed negative reactions to vimentin and CD10. Based on the pathological and immunohistochemical examination, we diagnosed as the bilateral renal cystadenocarcinoma in German shepherd dog.