• Proceedings of the Korean Biophysical Society Conference
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• 한국생물물리학회 1998년도 학술발표회
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• pp.13-13
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• 1998

The molecular mechanisms that arrest cardiomyocytes in the cell cycle during postnatal period remain largely unknown. The activity of CDKs control cell cycle progression, and this activity is regulated positively and negatively by association of CDKs with cyclins and cyelin dependent kinase inhibitors (CKIs) respectively.(omitted)

• Journal of the Korea Academia-Industrial cooperation Society
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• 제7권6호
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• pp.1116-1121
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• 2006

We studied on some techniques which are able to discriminate the difference between normal and infarcted myocardium by consecutive image analysis in B-mode echocardiogram. In order to analyze two-dimensional echocardiogram, we presented inter-frame and intra-frame analysis method throughout the complete heart cycle in closed-chest human and proposed new analysis parameters which are named HGE and LT. The analysis technique using the proposed parameters revealed quantitatively dominant features between normal and infarcted regions. The infarcted areas yield regions of higher intensity throughout the entire cardiac cycle, but normal tissue demonstrates greater variability throughout the entire cardiac cycle. Hence, we could verify that these parameters varying over the entire cardiac cycle are good indicators for the state of myocardium.

• Proceedings of the KOSOMBE Conference
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• 대한의용생체공학회 1990년도 추계학술대회
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• pp.25-28
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• 1990

We tested the ability of two-dimensional echocardiograms of complete heart cycle in closed-chest human to discriminate between normal and infarcted myocardium using fixed window, Inter- and Intra-frame analysis. The results show that statistical parameter, MEAN, second order gray level statistics parameter, ASM and proposed parameter, HGE, I.T, can quantitatively distinguish between normal and Infarcted regions. The manner in which these parameters vary over the cardiac cycle is also a good indicator of the state of myocardium. The infarcted areas yield regions of higher Intensity throughout the cardiac cycle. Whereas, normal tissue demonstrates greater variability throughout the cardiac cycle.

• The Korean Journal of Emergency Medical Services
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• 제25권3호
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• pp.111-125
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• 2021

Purpose: This study aimed to analyze the impact of rapid cycle deliberate practice (RCDP) simulation education on advanced cardiac life support knowledge, confidence, satisfaction, and performance ability among paramedic students, and provide basic data on the appropriate methods of educational instruction. Methods: The 48 subjects to be instructed were divided into the traditional simulation education group and the RCDP simulation education group. Six participants were randomly assigned to each group and pre-surveyed. They were then exposed to a lecture about advanced cardiac life support related theories for 60 min and post-surveyed through questionnaires with the same learning goals and scenarios. Results: The advanced cardiac life support knowledge (t=-4.813, p=.000) and performance ability (t=-2.903, p=.006) were significantly different between the traditional simulation education and RCDP simulation education groups The results also showed a significant difference in attach monitor (z=6.857, p=.009), analyze EKG rhythm (z=11.111, p=.001), and defibrillation (z=12.632, p=.000), indicating differences in performance capabilities between the two groups. Conclusion: To improve advanced cardiac life support knowledge, performance ability, and confidence in the paramedic students who receive RCDP simulation education, simulation education methods that are appropriate for the subjects being taught, and detailed learning goals and feedback are necessary.

• Proceedings of the KOSOMBE Conference
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.314-316
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• 1996

To diagnose cardiac malfunctions, various imaging techniques have been applied to heart : DSA(Digital Subtracted Angiography), Doppler Ultrasound, MR Angio. But it is difficult to observe three dimensional heart motion which is the most intuitive tool for diagnosis, only by using these methods. In this research, we have suggested 4-Dimensional reconstruction scheme of heart motion images that can be acquired by ECG-gated cine MR imaging. One cardiac cycle was devided into $9\sim15$ phases and for each phase 3D reconstructed volumn heart was made. We can observe 3D volumns along the cardiac cycle, time. So the results were 4-D reconstructed data.

• Parasites, Hosts and Diseases
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• 제39권3호
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• pp.227-232
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• 2001

Eight dogs were experimentally infected with Sarcocystis by oral inoculation of cardiac muscle from naturally infected cattle. The infected dogs commenced discharging of sporocysts in the feces after 10 to 12 days of inoculation, and continued until 20 and 35 days after inoculation. Three dogs were reinfected with cardiac muscle from the naturally infected cattle. Sporocysts reappeared in the feces on 12 to 13 days after reinfection. Sarcosystis sporocysts collected from the experimentally infected dogs were fed to each of the two 30-day-old Korean native calves. The infected calves remained clinically normal, except for the high fever (${\geq}{\;} 40^{\circ}C$) and decreased hematocrit values on day 30 to 40 post inoculation. Muscular cysts of Sarcocystis were found from infected calves on day 40 post inoculation. Proliferative forms of Sarcocystis were also observed in the muscle of infected calves. These results suggest that the Sarcocystis cruzi found in Korean native cattle has a 2-host life cycle with dogs as the definitive host and Korean native calves as the intermediate host.

• BMB Reports
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• 제49권5호
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• pp.270-275
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• 2016

The Ubiquitin proteasome system (UPS) plays roles in protein degradation, cell cycle control, and growth and inflammatory cell signaling. Dysfunction of UPS in cardiac diseases has been seen in many studies. Cholesterol acts as an inducer of cardiac hypertrophy. In this study, the effect of proteasome inhibitors on the cholesterol-induced hypertrophic growth in H9c2 cells is examined in order to observe whether UPS is involved in cardiac hypertrophy. The treatment of proteasome inhibitors MG132 and Bortezomib markedly reduced cellular surface area and mRNA expression of β-MHC in cholesterol-induced cardiac hypertrophy. In addition, activated AKT and ERK were significantly attenuated by MG132 and Bortezomib in cholesterol-induced cardiac hypertrophy. We demonstrated that cholesterol-induced cardiac hypertrophy was suppressed by proteasome inhibitors. Thus, regulatory mechanism of cholesterol-induced cardiac hypertrophy by proteasome inhibitors may provide a new therapeutic strategy to prevent the progression of heart failure.

• Journal of Society of Preventive Korean Medicine
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• 제14권2호
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• pp.105-120
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• 2010

Objectives : This study aims to evaluate the effects of expiration-to-inspiration time ratio (E/I-ratio) on heart rate, which represents cardiac autonomic function, and cold-heat in the healthy people. Methods : 49 healthy young volunteers(male : female = 32 : 17) were recruited in the study. The participants completed the questionnaire for yin-yang pattern identification and then we measured the chest plethysmogram for respiration signal and the electrocardiogram for NN intervals during different E/I-ratio from 1 to 2. We compared heart rate variability including RMS-SD, VLF, LF and HF, and the trend-cycle factors decomposed from NN interval data by time series analysis among the respective E/I-ratio. We also confirmed the difference on the trend-cycle factors according to the score of the questionnaire for cold and heat pattern identification. Results : There were differences on the trend-cycle factors from NN interval data, but no significant difference on heart rate variability, among the respective E/I-ratio. We also found significant relationship between the trend-cycle factors and the heat pattern identification scores. Conclusions : The results indicate that cardiac autonomic function can be modulated by the E/I-ratio and the modulation will be slower and more tendencious than respiratory sinus arrhythmia.

• Korean Journal of Radiology
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• 제23권2호
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• pp.172-179
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• 2022

Objective: We aimed to evaluate the ostium of right coronary artery of anomalous origin from the left coronary sinus (AORL) with an interarterial course throughout the cardiac cycle on CT and analyze the clinical significance of the ostial findings. Materials and Methods: From January 2011 to December 2015, 68 patients (41 male, 57.3 ± 12.1 years) with AORL with an interarterial course and retrospective cardiac CT data were included. AORL was classified as high or low ostial location based on the pulmonary annulus in the diastolic and systolic phases on cardiac CT. In addition, the height, width, height/width ratio, area, and angle of the ostium were measured in both cardiac phases. After cardiac CT, patients were followed until December 31, 2020 for major adverse cardiac events (MACE). Clinical and CT characteristics associated with MACE were explored using Cox regression analysis. Results: During a median follow-up period of 2071 days (interquartile range, 1180.5-2747.3 days), 13 patients experienced MACE (19.1%, 13/68). Seven (10.3%, 7/68) had the ostial location change from high in the diastolic phase to low in the systolic phase. In the univariable analysis, younger age (hazard ratio [HR] = 0.918, p < 0.001), high ostial location (HR = 4.008, p = 0.036), larger height/width ratio (HR = 5.621, p = 0.049), and smaller ostial angle (HR = 0.846, p = 0.048) in the systolic phase were significant predictors of MACE. In multivariable cox regression analysis, younger age (adjusted HR = 0.917, p = 0.002) and high ostial location in the systolic phase (adjusted HR = 4.345, p = 0.026) were independent predictors of MACE. Conclusion: The ostial location of AORL with an interarterial course can change during the cardiac cycle, and high ostial location in the systolic phase was an independent predictor of MACE.

• BMB Reports
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• 제47권4호
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• pp.192-196
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• 2014

RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases are a newly emerging family of phosphatases that are members of DXDX (T/V). The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP. Extensive study of SCP1 has elicited the diversified roles of the small C terminal domain phosphatase. The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. This short review offers an explanation of the mechanism of action of small CTD phosphatases, in different biological activities and metabolic processes.