• Journal of The Korean Society of Clinical Toxicology
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• v.16 no.2
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• pp.102-107
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• 2018

Purpose: This study examined the association between smoking and delayed neuropsychological sequelae (DNS) in acute carbon monoxide (CO) poisoning. Methods: Patients admitted to the medical center emergency department from March 2016 to March 2017 because of CO poisoning were examined retrospectively. The patients were divided into two groups: DNS and Non-DNS group. Multiple factors were analyzed to explain DNS, which was assessed by motor disturbances, cognitive impairment, dysphagia, Parkinson-like syndromes, epilepsy, and emotional lability in CO poisoning. Results: A total of 120 patients were included. The factors related to DNS were smoking (pack-years) (p=0.002) and initial carbon monoxide-hemoglobin level (p=0.015). On the other hand, after multivariate logistic regression analysis, smoking (Odds ratio 1.07; 95% CI, 1.02-1.13; p=0.004) was the only factor associated with DNS. Conclusion: Smoking is a very reliable factor for predicting the occurrence of DNS. A history of smoking in patients who suffer from CO intoxication is important. If a patient smokes, treatment should be started actively and as soon as possible.

• The Journal of Internal Korean Medicine
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• v.43 no.2
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• pp.159-165
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• 2022

Objective: This clinical study describes the effect of Korean medicine on a patient with Delayed Neuropsychiatric Sequelae after Carbon Monoxide Poisoning. Case presentation: A patient with the delayed neuropsychiatric effects of carbon monoxide exposure was treated with herbal medicine, acupuncture, moxibustion, and cupping. Clinical symptoms were measured with the Korean Mini Mental State Examination (K-MMSE), Functional Independence Measure (FIM), and the Modified Barthel Index (MBI). After 32 days of treatment, the patient's K-MMSE score increased from 11 to 21 points, the FIM score from 52 to 94 points, and the MBI score from 46 to 84 points. There were no side effects. Conclusion: According to this case study, Korean medicine may be considered an effective treatment for delayed neuropsychiatric sequelae, although more studies are needed to confirm its validity.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.2
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• pp.125-133
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• 2022

Carbon monoxide (CO) is a known gaseous bioactive substance found across a wide array of body systems. The administration of low concentrations of CO has been found to exert an anti-inflammatory, anti-apoptotic, anti-hypertensive, and vaso-dilatory effect. To date, however, it has remained unknown whether CO influences atrial natriuretic peptide (ANP) secretion. This study explores the effect of CO on ANP secretion and its associated signaling pathway using isolated beating rat atria. Atrial perfusate was collected for 10 min for use as a control, after which high atrial stretch was induced by increasing the height of the outflow catheter. Carbon monoxide releasing molecule-2 (CORM-2; 10, 50, 100 μM) and hemin (HO-1 inducer; 0.1, 1, 50 μM), but not CORM-3 (10, 50, 100 μM), decreased high stretch-induced ANP secretion. However, zinc porphyrin (HO-1 inhibitor) did not affect ANP secretion. The order of potency for the suppression of ANP secretion was found to be hemin > CORM-2 >> CORM-3. The suppression of ANP secretion by CORM-2 was attenuated by pretreatment with 5-hydroxydecanoic acid, paxilline, and 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one, but not by diltiazem, wortmannin, LY-294002, or NG-nitro-L-arginine methyl ester. Hypoxic conditions attenuated the suppressive effect of CORM-2 on ANP secretion. In sum, these results suggest that CORM-2 suppresses ANP secretion via mitochondrial K_ATP channels and large conductance Ca²⁺-activated K⁺ channels.

• Journal of environmental and Sanitary engineering
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• v.18 no.2
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• pp.67-74
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• 2003

In 15 schools where were chosen each location (East, West, South, North, Central) of Seoul area, 9 items were measured such as thermo circumstance(temperature, relative humidity, air current, intensity of illumination) particulate matter, carbon monoxide, sulfur dioxide, and nitrogen dioxide being based on the school indoor environment standard. It was showed that indoor temperature, relative humidity and air movement were suitable in comparison with school indoor environment standard. Intensity of illumination was suitable in comparison with all schools, only exception 2 schools. In all investigated schools were adequate for carbon monoxide, sulfur dioxide and nitrogen dioxide, in which each indoor environment standard (10ppw, 0.25ppm/hr, 0.15ppm/hr), but in 5 schools the carbon dioxide were exceeded for standard limit 1,000ppm of Korea. Indoor concentration of dust(PM-10) induced from respiration dust the standard of Korea ($150{\mu}g/m^3$) at all schools.

• Journal of Korean Society for Atmospheric Environment
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• v.25 no.3
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• pp.237-247
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• 2009

The combustion characteristics of car components have been investigated, The combustion parameters like heat release rate, smoke production, yield of carbon dioxide and carbon monoxide and mass loss rate were analyzed by cone-calorimeter for representative samples (seat, carpet, headrest, rubber mat, dash board and electric wire) collected from a used car. The results from sample combustion showed that cover and sponge in seat more quickly ignited and flamed than other parts. The heat released from the combustion of dash board sample was 144.29$kw/m^2$ and the smoke produced by the wire combustion was 6896.4 $m^2/m^2$. The yields of carbon dioxide and carbon monoxide were in the ranges of 1.09${\sim}$2.76 kg/kg and 0.0262${\sim}$0.1008 kg/kg, respectively.

• Journal of the korean Society of Automotive Engineers
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• v.5 no.1
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• pp.79-88
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• 1983

A prediction of emission concentrations was made by calculating chemical equilibrium on the basis of an indicated pressure diagram in spark ignition engine using methanol as a fuel. A prediction according to Otto cycle was also made and for carbon dioxide, carbon monoxide and nitric oxide, emission test was performed using a conventional SI engine that was modified a little considering fuel characteristics. An investigation was made for those three cases-results from an indicated pressure diagram, Otto cycle and emission test. A good agreement between the measured values and the predicted ones existed for carbon dioxide and carbon monoxide, but not for nitric oxide. And good results existed for the other emission concentrations.

• Journal of the Semiconductor & Display Technology
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• v.20 no.3
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• pp.161-166
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• 2021

To prevent accidents caused by changes in the surrounding environment or other factors, various protection facilities are installed at the photovoltaic connection module. The main causes of fire are sparks due to foreign substances inside the photovoltaic connection module through high temperature rise and dew condensation in the photovoltaic connection module, and fire due to heat from the power diode. The proposed method can predict the fire by measuring flame, carbon dioxide, carbon monoxide, temperature, humidity, input voltage, and current on the photovoltaic connection module, and when the fire conditions are reached, fire alarm and power off can be sent to managers and users in real time to prevent fire in advance.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.279-283
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• 2005

After initial recovery from acute carbon monoxide(CO) intoxication, some patients occasionally undergo severe neuropsychiatric deterioration, which is called postanomic delayed encephalopathy(sequelae). This is the clinical study about one patient, a 53-year-old woman, diagnosed with delayed encephalopathy after acute CO intoxication. The patient's symptoms were mental dysfunction including memory impairment and disorientation, aphasia, atrophy and weakness throughtout the body. She had completely recovered after an anomic episode, but the neurological symptoms that developed were preceded by an interval of apparent nomality.(the 'lucid interval'). She was characterized as suffering deficiency syndrome of the heart(心虛) and was prescribed for her an Ansinschungnoi-tang(安神淸腦湯), and thereafter her symptoms improved remarkably. For the evaluation of clinical improvement, we use the Modified Barthel Index(MBI).

• Journal of Oriental Neuropsychiatry
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• v.19 no.3
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• pp.205-217
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• 2008

After recovery from acute carbon monoxide poisoning, some patients suffer from neuropsychiatric problems such as cognitive impairement, movement disorder, change of personality and mental disorder after lucid interval in which the patient has no symptom. This sequela of carbon monoxide poisoning is called delayed post-anoxic encephalopathy(DPE). No neuroprotective drug has yet demonstrated ecfficacy and hyperbaric oxygen treatment's effect have little scientific evidence in preventing and improving DPE. In such situation, korean traditional treatment may be helpful in treating the patient suffering from DPE. In this case report, we will describe the patient that has suffered from severe DPE involving cognitive impairment, gait disturbance and incontinence but has been improved successfully by korean traditional medicine treatment, especially Jowiseungchungtang. This case could present how we will study about DPE.

• Journal of The Korean Society of Clinical Toxicology
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• v.4 no.2
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• pp.122-127
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• 2006

Purpose: It is not easy to detect carbon monoxide (CO) leakage, and CO-intoxicated patients do not show a specific set of symptoms. The aims of this study are to clinically evaluate patients with CO gas intoxication from a CO leak at an underground shopping center, and to discuss the establishment of a disaster prevention plan. Methods: A total of 51 patients intoxicated by CO gas exposure in a gas disaster at a underground shopping center in Seoul on September 8, 2006 were enrolled in this study, and the patients' medical records were retrospectively reviewed. Results: The mean patient age was $29.4{\pm}6.3$. The initial mean COHb level was $14.98{\pm}6.97%$. The number of patients with COHb greater than 25% was three, and six patients experienced a syncopal attack. Only one patient-was treated with hyperbaric oxygen therapy. However, none of the patients complained of severe neurologic or cardiovascular symptoms. Conclusion: The symptoms of CO intoxication are non-specific and difficult to define, and the detection of CO leak-age is difficult. Thus, workplaces should be equipped with leakage sensors and automatic alarm systems and should have develop disaster prevention plans.